{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T19:45:45Z","timestamp":1748634345430},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.tiv.2019.04.031","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T20:36:36Z","timestamp":1556829396000},"page":"292-299","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Proposed reduction of the in vivo pyrogen test by the in vitro LAL assay for the quality control of anticrotallic, antiscorpion, antirabies and antitetanus sera"],"prefix":"10.1016","volume":"59","author":[{"given":"Fernando F.","family":"Fingola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila R.G.","family":"Albertino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley de M.P.","family":"Abrantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena P.S.","family":"Zamith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2019.04.031_bb0005","series-title":"Di\u00e1rio Oficial [da] Rep\u00fablica Federatva do Brasil, Poder Executivo, Bras\u00edlia, DF, 02 jun. 2003","first-page":"56","article-title":"Resolu\u00e7\u00e3o RE n\u00b0 899, de 29 de maio de 2003","author":"ANVISA","year":"2003"},{"key":"10.1016\/j.tiv.2019.04.031_bb0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/S1516-93322004000300004","article-title":"Redu\u00e7\u00e3o, refinamento e substitui\u00e7\u00e3o do uso de animais em estudos toxicol\u00f3gicos: uma abordagem atual","volume":"40","author":"Cazarin","year":"2004","journal-title":"Revista Brasileira de Ci\u00eancias Farmac\u00eauticas"},{"key":"10.1016\/j.tiv.2019.04.031_bb0015","author":"European Commission"},{"key":"10.1016\/j.tiv.2019.04.031_bb3000","series-title":"EUROPEAN Pharmacopeia\u00a08.0","author":"European Pharmacopoeia","year":"2014"},{"key":"10.1016\/j.tiv.2019.04.031_bb0020","series-title":"Guideline on Validation of the Limulus Amebocyte Lysate Test: As an End-Product Endotoxin Test for Human and Animal Parenteral Drugs, Biological Products, and. Medical Devices","article-title":"U.S. Department of Health and Human Services","author":"FDA","year":"1992"},{"key":"10.1016\/j.tiv.2019.04.031_bb0025","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1016\/j.biomaterials.2005.04.063","article-title":"Endotoxin: the uninvited guest","volume":"26","author":"Gorbet","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2019.04.031_bb0030","series-title":"ICH Harmonised Tripartite Guideline","first-page":"1","article-title":"Validation of analytical procedures: Text and methodology Q2(R1)","author":"ICH Expert Working Group","year":"2005"},{"key":"10.1016\/j.tiv.2019.04.031_bb0035","series-title":"POP 65.3330.002: Ensaio de Pirog\u00eanio. Rev.13","author":"INCQS","year":"2017"},{"key":"10.1016\/j.tiv.2019.04.031_bb0040","series-title":"Animal Cell Culture Techniques","article-title":"Screening culture media and sera for endotoxin testing","author":"Keenan","year":"1998"},{"key":"10.1016\/j.tiv.2019.04.031_bb0045","series-title":"Limulus Amebocyte Lysate (LAL)","author":"LONZA","year":"2016"},{"key":"10.1016\/j.tiv.2019.04.031_bb0050","first-page":"2","article-title":"Snake antivenoms: adverse reactions and production technology","volume":"15","author":"Morais","year":"2009","journal-title":"J. Venom. Anim. Toxins Trop. Dis"},{"key":"10.1016\/j.tiv.2019.04.031_bb0055","first-page":"108","article-title":"Ensayo del lisado de ameb\u00f3citos del Limulus (LAL)","volume":"38","author":"Morales","year":"2004","journal-title":"Revista Cubana de Farmacia"},{"key":"10.1016\/j.tiv.2019.04.031_bb0060","first-page":"588","article-title":"Evaluation of the in vitro test system based on proinflammatory cytokine release from human monocytes: comparison with human blood culture test system and with the rabbit pyrogen test","volume":"9","author":"Nakagawa","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.tiv.2019.04.031_bb0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0168-1656(99)00185-6","article-title":"Endotoxin removal from protein solutions","volume":"76","author":"Petsch","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.tiv.2019.04.031_bb0070","series-title":"The State of the Animals","first-page":"121","article-title":"The first forty years of the alternatives approach: Refining, reducing, and replacement the use of laboratory animals","author":"Stephens","year":"2001"},{"key":"10.1016\/j.tiv.2019.04.031_bb2000","author":"USP, BACTERIAL endotoxin test","year":"2016"},{"key":"10.1016\/j.tiv.2019.04.031_bb0075","series-title":"Endotoxins: Pyrogens, LAL Testing and Depyrogenation","author":"Williams","year":"2007"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318307008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233318307008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T22:15:08Z","timestamp":1562278508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233318307008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":17,"alternative-id":["S0887233318307008"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2019.04.031","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proposed reduction of the in vivo pyrogen test by the in vitro LAL assay for the quality control of anticrotallic, antiscorpion, antirabies and antitetanus sera","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2019.04.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}