{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:18:47Z","timestamp":1773213527918,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.tiv.2019.06.008","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T20:57:42Z","timestamp":1560200262000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Membrane action of polyhexamethylene guanidine hydrochloride revealed on smooth muscle cells, nerve tissue and rat blood platelets: A biocide driven pore-formation in phospholipid bilayers"],"prefix":"10.1016","volume":"60","author":[{"given":"Konstantin O.","family":"Paliienko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana O.","family":"Veklich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg Ya.","family":"Shatursky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olexandr A.","family":"Shkrabak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem O.","family":"Pastukhov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim O.","family":"Galkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Krisanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Ju.","family":"Chunikhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew V.","family":"Rebriev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy V.","family":"Lysytsya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana A.","family":"Borisova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergiy O.","family":"Kosterin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2019.06.008_bb0005","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/bm0342180","volume":"4","author":"Albert","year":"2003","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.tiv.2019.06.008_bb0010","first-page":"47","volume":"481","author":"Benz","year":"1980","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.tiv.2019.06.008_bb0015","series-title":"Cholesterol and Presynaptic Glutamate Transport in the Brain","author":"Borisova","year":"2013"},{"key":"10.1016\/j.tiv.2019.06.008_bb0020","first-page":"89","volume":"14","author":"Borisova","year":"2014","journal-title":"Horizons Neurosci. Res."},{"key":"10.1016\/j.tiv.2019.06.008_bb0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1515\/revneuro-2015-0023","volume":"27","author":"Borisova","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.tiv.2019.06.008_bb0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1515\/revneuro-2015-0044","volume":"27","author":"Borisova","year":"2016","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.tiv.2019.06.008_bb0035","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.asr.2005.10.007","volume":"36","author":"Borisova","year":"2005","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.tiv.2019.06.008_bb0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tiv.2019.06.008_bb0045","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrmicro1098","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/srep23121","volume":"6","author":"Chindera","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2019.06.008_bb0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.funbio.2016.09.001","volume":"121","author":"Choi","year":"2016","journal-title":"Fungal Biol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-010-9313-y","volume":"238","author":"Cohen","year":"2010","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4236\/ajac.2016.75038","volume":"7","author":"Dadashev","year":"2016","journal-title":"AJAC"},{"key":"10.1016\/j.tiv.2019.06.008_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004041","volume":"9","author":"Firdessa","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.tiv.2019.06.008_bb0075","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1021\/bi9002309","volume":"48","author":"Flanagan","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.tiv.2019.06.008_bb0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mser.2007.03.002","volume":"57","author":"Gabriel","year":"2007","journal-title":"Mater. Sci. Eng. R. Rep."},{"key":"10.1016\/j.tiv.2019.06.008_bb0085","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2672.2005.02664.x","volume":"99","author":"Gilbert","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jnr.10569","article-title":"April","volume":"72","author":"Glushakov","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.tiv.2019.06.008_bb0095","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1073\/pnas.1620799114","volume":"114","author":"Habecka","year":"2017","journal-title":"PNAS"},{"key":"10.1016\/j.tiv.2019.06.008_bb0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1124\/jpet.111.186577","volume":"340","author":"Hensler","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tiv.2019.06.008_bb0105","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2174\/1381612043383926","volume":"10","author":"Hertelendy","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tiv.2019.06.008_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1113\/jphysiol.1977.sp011845","volume":"268","author":"Hunter","year":"1977","journal-title":"J. Physiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0115","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2004.03.007","volume":"45","author":"Hynd","year":"2004","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.tiv.2019.06.008_bb0120","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.tiv.2014.02.004","volume":"28","author":"Jung","year":"2014","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2019.06.008_bb0125","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2131\/jts.41.711","volume":"41","author":"Kim","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tiv.2019.06.008_bb0130","first-page":"50","volume":"58","author":"Kondratuk","year":"1986","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.tiv.2019.06.008_bb0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/B:NEPH.0000008779.13901.74","volume":"35","author":"\u041aosterin","year":"2003","journal-title":"Neurophysiology"},{"key":"10.1016\/j.tiv.2019.06.008_bb0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/wnan.1199","volume":"5","author":"Kuroda","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(86)90579-2","volume":"368","author":"Larson","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2019.06.008_bb0145","doi-asserted-by":"crossref","first-page":"10585","DOI":"10.1074\/jbc.M609181200","volume":"282","author":"Liang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2019.06.008_bb0150","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/polym9100517","volume":"9","author":"Luo","year":"2017","journal-title":"Polymers"},{"key":"10.1016\/j.tiv.2019.06.008_bb0155","first-page":"56","volume":"3","author":"Lysytsya","year":"2010","journal-title":"Biotechnologiya"},{"key":"10.1016\/j.tiv.2019.06.008_bb0160","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1471-4159.1981.tb01701.x","volume":"36","author":"Mangano","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tiv.2019.06.008_bb0165","series-title":"Ion Channel Reconstitution","author":"Miller","year":"1986"},{"key":"10.1016\/j.tiv.2019.06.008_bb0170","first-page":"47","volume":"19","author":"Mollard","year":"1986","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.tiv.2019.06.008_bb0175","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/194979a0","volume":"194","author":"Mueller","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2019.06.008_bb0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1085\/jgp.200709849","volume":"131","author":"Nagle","year":"2007","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0185","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1099\/jmm.0.2008\/003350-0","volume":"57","author":"Qule","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0190","first-page":"140","volume":"3","author":"Qule","year":"2017","journal-title":"J. Antimicrob. Agents"},{"key":"10.1016\/j.tiv.2019.06.008_bb0195","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0003-2697(69)90198-5","volume":"28","author":"Rathbun","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tiv.2019.06.008_bb0200","series-title":"Biology and Human Behavior: The Neurological Origins of Individuality","first-page":"19","author":"Sapolsky","year":"2005"},{"key":"10.1016\/j.tiv.2019.06.008_bb0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00257500","volume":"15","author":"Sattelle","year":"1987","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.tiv.2019.06.008_bb0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0304-4157(77)90013-2","volume":"472","author":"Shamoo","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2019.06.008_bb0215","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00232-013-9626-8","volume":"247","author":"Shatursky","year":"2014","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0220","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.brainresrev.2004.04.004","volume":"45","author":"Shigeri","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.tiv.2019.06.008_bb0225","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.pnpbp.2006.06.013","volume":"30","author":"Shinohe","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.tiv.2019.06.008_bb0230","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/BF01945511","volume":"43","author":"Vassalle","year":"1987","journal-title":"Experientia"},{"key":"10.1016\/j.tiv.2019.06.008_bb0235","first-page":"66","volume":"77","author":"Veklich","year":"2005","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.tiv.2019.06.008_bb0240","first-page":"66","volume":"77","author":"Veklich","year":"2005","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.tiv.2019.06.008_bb0245","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s10295-014-1505-5","volume":"41","author":"Walczak","year":"2014","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0250","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.msec.2009.02.005","volume":"29","author":"Wei","year":"2009","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.tiv.2019.06.008_bb0255","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/1521-3773(20010119)40:2<457::AID-ANIE457>3.0.CO;2-F","volume":"40","author":"Yoshino","year":"2001","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tiv.2019.06.008_bb0260","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1365-2672.2009.04482.x","volume":"108","author":"Zhou","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.tiv.2019.06.008_bb0265","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/abbs\/gmr067","volume":"43","author":"Zhou","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233319302140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233319302140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:36:15Z","timestamp":1760135775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233319302140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":54,"alternative-id":["S0887233319302140"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2019.06.008","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane action of polyhexamethylene guanidine hydrochloride revealed on smooth muscle cells, nerve tissue and rat blood platelets: A biocide driven pore-formation in phospholipid bilayers","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2019.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}