{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:09:03Z","timestamp":1787594943049,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660589"],"award-info":[{"award-number":["81660589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903543"],"award-info":[{"award-number":["81903543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.tiv.2020.104812","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T02:40:15Z","timestamp":1582598415000},"page":"104812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Development of novel in silico prediction model for drug-induced ototoxicity by using na\u00efve Bayes classifier approach"],"prefix":"10.1016","volume":"65","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2020.104812_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1999.tb00277.x","article-title":"Global problem of drug-induced hearing loss","volume":"884","author":"Arslan","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tiv.2020.104812_bb0010","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/minf.201400026","article-title":"Exploring activity cliffs from a chemoinformatics perspective","volume":"33","author":"Bajorath","year":"2014","journal-title":"Mol. Inf."},{"key":"10.1016\/j.tiv.2020.104812_bb0015","series-title":"Ototoxic Drugs Exposed: The Shocking Truth About Prescription Drugs, Medications, Chemicals and Herbals That Can (and Do) Damage Our Ears","author":"Bauman","year":"2010"},{"key":"10.1016\/j.tiv.2020.104812_bb0020","series-title":"Statistical Decision Theory and Bayesian Analysis","author":"Berger","year":"2013"},{"key":"10.1016\/j.tiv.2020.104812_bb0025","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12070-011-0151-8","article-title":"Ototoxicity: the hidden menace","volume":"63","author":"Bisht","year":"2011","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.tiv.2020.104812_bb0030","series-title":"Bayesian Inference in Statistical Analysis","author":"Box","year":"2011"},{"key":"10.1016\/j.tiv.2020.104812_bb0035","first-page":"254","article-title":"Ototoxic drugs. Aminoglycoside antibiotics","volume":"56","author":"Buszman","year":"2003","journal-title":"Wiad. Lek."},{"key":"10.1016\/j.tiv.2020.104812_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.disamonth.2013.01.003","article-title":"Chemical exposure and hearing loss","volume":"59","author":"Campo","year":"2013","journal-title":"Dis. Mon."},{"key":"10.1016\/j.tiv.2020.104812_bb0045","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.heares.2006.05.008","article-title":"Aspirin attenuates gentamicin ototoxicity from the laboratory to the clinic","volume":"226","author":"Chen","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.tiv.2020.104812_bb0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00181963","article-title":"Experimental, clinical and preventive aspects of ototoxicity","volume":"251","author":"Chiodo","year":"1994","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.tiv.2020.104812_bb0055","first-page":"601","article-title":"Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide","volume":"15","author":"Cianfrone","year":"2011","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tiv.2020.104812_bb0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.brainres.2006.01.128","article-title":"The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death","volume":"1091","author":"Cunningham","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.tiv.2020.104812_bb0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/0194599811419082","article-title":"Oxymetazoline ototoxicity in a chinchilla animal model","volume":"146","author":"Daniel","year":"2012","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.tiv.2020.104812_bb0070","series-title":"Handbook of Genetic Algorithms","year":"1991"},{"key":"10.1016\/j.tiv.2020.104812_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/minf.201600023","article-title":"Advances in activity cliff research","volume":"35","author":"Dimova","year":"2016","journal-title":"Mol. Inf."},{"key":"10.1016\/j.tiv.2020.104812_bb0080","first-page":"145","article-title":"Ototoxic effects and mechanisms of loop diuretics","volume":"11","author":"Ding","year":"2016","journal-title":"J. Otolaryngol."},{"key":"10.1016\/j.tiv.2020.104812_bb0085","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1021\/acs.molpharmaceut.7b00317","article-title":"ADMET evaluation in drug discovery. Part 17: development of quantitative and qualitative prediction models for chemical-induced respiratory toxicity","volume":"14","author":"Lei","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.tiv.2020.104812_bb0090","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/neu.20054","article-title":"Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro","volume":"61","author":"Matsui","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.tiv.2020.104812_bb0095","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/cbdd.12115","article-title":"Activity cliffs: facts or Artifacts?","volume":"81","author":"Medina-Franco","year":"2013","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.tiv.2020.104812_bb0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/c160017a018","article-title":"The generation of a unique machine description for chemical structures - a technique developed at chemical abstracts service","volume":"5","author":"Morgan","year":"1965","journal-title":"J. Chem. Doc."},{"key":"10.1016\/j.tiv.2020.104812_bb0105","author":"OECD","year":"2007"},{"key":"10.1016\/j.tiv.2020.104812_bb0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2009.12.003","article-title":"Ototoxic drugs: difference in sensitivity between mice and guinea pigs","volume":"193","author":"Poirrier","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2020.104812_bb0115","series-title":"Guidance on Information Requirements and Chemical Safety Assessment, Part B: Hazard Assessment, version 2.1","author":"REACH","year":"2011"},{"key":"10.1016\/j.tiv.2020.104812_bb0120","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.tiv.2020.104812_bb0125","first-page":"513","article-title":"Effect of protective agents against cisplatin ototoxicity","volume":"21","author":"Rybak","year":"2000","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.tiv.2020.104812_bb0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.heares.2006.09.015","article-title":"Mechanisms of cisplatin induced ototoxicity and prevention","volume":"226","author":"Rybak","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.tiv.2020.104812_bb0135","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/ar.22578","article-title":"Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention","volume":"295","author":"Schacht","year":"2012","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tiv.2020.104812_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuro.2013.11.009","article-title":"Vestibular damage in chronic ototoxicity: a mini-review","volume":"43","author":"Sed\u00f3-Cabez\u00f3n","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tiv.2020.104812_bb0145","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1037\/a0016973","article-title":"An introduction to recursive partitioning: rationale, application, and characteristics of classification and regression trees, bagging, and random forests","volume":"14","author":"Strobl","year":"2009","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.tiv.2020.104812_bb0150","first-page":"35","article-title":"QuBiLS-MAS, open source multi-platform software for atom- and bond-based topological (2D) and chiral (2.5D) algebraic molecular descriptors computations","volume":"9","author":"Vald\u00e9s-Martin\u00ed","year":"2017","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.tiv.2020.104812_bb0155","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.tiv.2020.104812_bb0160","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1517\/17425255.2011.614231","article-title":"In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem","volume":"7","author":"Yorgason","year":"2011","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.tiv.2020.104812_bb0165","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.fct.2017.10.021","article-title":"Development of novelprediction model for drug-induced mitochondrial toxicity by using na\u00efve Bayes classifier method","volume":"110","author":"Zhang","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2020.104812_bb0170","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.compbiomed.2014.05.005","article-title":"A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method","volume":"51","author":"Zhou","year":"2014","journal-title":"Comput. Biol. Med."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233319307477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233319307477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:35:53Z","timestamp":1760135753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233319307477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":34,"alternative-id":["S0887233319307477"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104812","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of novel in silico prediction model for drug-induced ototoxicity by using na\u00efve Bayes classifier approach","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104812"}}