{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:27:58Z","timestamp":1782512878271,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.tiv.2020.104827","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T13:44:16Z","timestamp":1584107056000},"page":"104827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["CdTe and CdTe@ZnS quantum dots induce IL-1\u00df-mediated inflammation and pyroptosis in microglia"],"prefix":"10.1016","volume":"65","author":[{"given":"Xue","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2020.104827_bb0005","first-page":"1","article-title":"Toxicity of nanoparticles and an overview of current experimental models","volume":"20","author":"Bahadar","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.tiv.2020.104827_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pneurobio.2017.10.003","article-title":"Nano- and neurotoxicology: an emerging discipline","volume":"160","author":"Bencsik","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.tiv.2020.104827_bb0015","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biomaterials.2011.10.070","article-title":"The cytotoxicity of cadmium-based quantum dots","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2020.104827_bb0020","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1002\/smll.201302825","article-title":"Polyhydroxylated metallofullerenols stimulate IL-1beta secretion of macrophage through TLRs\/MyD88\/NF-kappaB pathway and NLRP(3) inflammasome activation","volume":"10","author":"Chen","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.tiv.2020.104827_bb0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cdd.2011.159","article-title":"The inflammasome: in memory of Dr. Jurg Tschopp","volume":"19","author":"Dagenais","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tiv.2020.104827_bb0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tiv.2020.104827_bb0035","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/1547691X.2016.1159264","article-title":"Application of nanomedicine for crossing the blood-brain barrier: theranostic opportunities in multiple sclerosis","volume":"13","author":"Ghalamfarsa","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.tiv.2020.104827_bb0040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as mediators of inflammatory and degenerative diseases","volume":"22","author":"Gonzalez-Scarano","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.tiv.2020.104827_bb0045","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2007.07.009","article-title":"NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta","volume":"130","author":"Greten","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2020.104827_bb0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/smll.200900626","article-title":"In vivo quantum-dot toxicity assessment","volume":"6","author":"Hauck","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.tiv.2020.104827_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2013.03.003","article-title":"Quantum dots induced monocyte chemotactic protein-1 expression via MyD88-dependent toll-like receptor signaling pathways in macrophages","volume":"308","author":"Ho","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.tiv.2020.104827_bb0060","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/tox.22397","article-title":"Effects of silver nanoparticles on the interactions of neuron- and glia-like cells: toxicity, uptake mechanisms, and lysosomal tracking","volume":"32","author":"Hsiao","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tiv.2020.104827_bb0065","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.biotechadv.2013.12.009","article-title":"Toxicity of inorganic nanomaterials in biomedical imaging","volume":"32","author":"Li","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.tiv.2020.104827_bb0070","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3109\/17435390.2014.948090","article-title":"Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles","volume":"9","author":"Li","year":"2015","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tiv.2020.104827_bb0075","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/0748233717712409","article-title":"Reactive oxygen species trigger NF-kappaB-mediated NLRP3 inflammasome activation induced by zinc oxide nanoparticles in A549 cells","volume":"33","author":"Liang","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tiv.2020.104827_bb0080","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1166\/jnn.2014.9125","article-title":"Highly efficient multiple-layer CdS quantum dot sensitized III-V solar cells","volume":"14","author":"Lin","year":"2014","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.tiv.2020.104827_bb0085","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1166\/jnn.2010.2851","article-title":"Preparation and characterization of highly luminescent water-soluble CdTe quantum dots as optical temperature probes","volume":"10","author":"Liu","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.tiv.2020.104827_bb0090","article-title":"Determination of a threshold dose to reduce or eliminate CdTe-induced toxicity in L929 cells by controlling the exposure dose","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2020.104827_bb0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.biomaterials.2016.03.003","article-title":"CdSe\/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation","volume":"90","author":"Lu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2020.104827_bb0100","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1016\/j.actbio.2013.05.022","article-title":"Endocytotic uptake of iron oxide nanoparticles by cultured brain microglial cells","volume":"9","author":"Luther","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.tiv.2020.104827_bb0105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/toxsci\/kfv002","article-title":"Cell type-dependent changes in CdSe\/ZnS quantum dot uptake and toxic endpoints","volume":"144","author":"Manshian","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2020.104827_bb0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nmat1390","article-title":"Quantum dot bioconjugates for imaging, labelling and sensing","volume":"4","author":"Medintz","year":"2005","journal-title":"Nat. Mater."},{"key":"10.1016\/j.tiv.2020.104827_bb0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12026-015-8751-0","article-title":"Atrial natriuretic peptide down-regulates LPS\/ATP-mediated IL-1\u03b2 release by inhibiting NF-kB, NLRP3 inflammasome and caspase-1 activation in THP-1 cells","volume":"64","author":"Mezzasoma","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.tiv.2020.104827_bb0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-60327-198-1_12","article-title":"Detection and quantitative evaluation of endotoxin contamination in nanoparticle formulations by LAL-based assays","volume":"697","author":"Neun","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tiv.2020.104827_bb0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/bio.3193","article-title":"Aqueous synthesis of highly stable CdTe\/ZnS Core\/Shell quantum dots for bioimaging","volume":"32","author":"Saikia","year":"2017","journal-title":"Luminescence"},{"key":"10.1016\/j.tiv.2020.104827_bb0130","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2020.104827_bb0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chemosphere.2017.08.130","article-title":"Assessment of toxicity of selenium and cadmium selenium quantum dots: a review","volume":"188","author":"Sharma","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2020.104827_bb0140","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1002\/jcp.27475","article-title":"Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes","volume":"234","author":"Shirasuna","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tiv.2020.104827_bb0145","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.aquatox.2016.05.001","article-title":"Toxicological impact of cadmium-based quantum dots towards aquatic biota: effect of natural sunlight exposure","volume":"176","author":"Silva","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.tiv.2020.104827_bb0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2017.09.003","article-title":"Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation","volume":"34","author":"Silva","year":"2017","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.tiv.2020.104827_bb0155","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s11671-016-1704-2","article-title":"Involvement of programmed cell death in neurotoxicity of metallic nanoparticles: recent advances and future perspectives","volume":"11","author":"Song","year":"2016","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.tiv.2020.104827_bb0160","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/c3mt20234h","article-title":"Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (danio rerio) liver cells exposed to cadmium sulfate, zinc sulfate and quantum dots","volume":"5","author":"Tang","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.tiv.2020.104827_bb0165","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.scitotenv.2017.12.334","article-title":"Review of in vitro toxicological research of quantum dot and potentially involved mechanisms","volume":"625","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2020.104827_bb0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2011.05.001","article-title":"Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure","volume":"205","author":"Wang","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2020.104827_bb0175","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2174\/1389557516666160211121247","article-title":"Cadmium-containing quantum dots: current perspectives on their application as nanomedicine and toxicity concerns","volume":"16","author":"Wang","year":"2016","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.tiv.2020.104827_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10040244","article-title":"Anionic long-circulating quantum dots for long-term intravital vascular imaging","volume":"10","author":"Wang","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tiv.2020.104827_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1507","article-title":"In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials","volume":"10","author":"Weldon","year":"2018","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.tiv.2020.104827_bb0190","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.2147\/IJN.S104985","article-title":"Impairments of spatial learning and memory following intrahippocampal injection in rats of 3-mercaptopropionic acid-modified CdTe quantum dots and molecular mechanisms","volume":"11","author":"Wu","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2020.104827_bb0195","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jat.3629","article-title":"Transcriptome analysis of different sizes of 3-mercaptopropionic acid-modified cadmium telluride quantum dot-induced toxic effects reveals immune response in rat hippocampus","volume":"38","author":"Wu","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2020.104827_bb0200","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tiv.2018.05.014","article-title":"MPA-modified CdTe quantum dots increased interleukin-1beta secretion through MyD88-dependent toll-like receptor pathway and NLRP3 inflammasome activation in microglia","volume":"52","author":"Wu","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.tiv.2020.104827_bb0205","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.nantod.2011.10.001","article-title":"Toxicology and clinical potential of nanoparticles","volume":"6","author":"Yildirimer","year":"2011","journal-title":"Nano Today"},{"key":"10.1016\/j.tiv.2020.104827_bb0210","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.2147\/IJN.S121075","article-title":"In vivo biodistribution and behavior of CdTe\/ZnS quantum dots","volume":"12","author":"Zhao","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2020.104827_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201602309","article-title":"Near-infrared fluorescent Ag2 se-cetuximab nanoprobes for targeted imaging and therapy of cancer","volume":"13","author":"Zhu","year":"2017","journal-title":"Small"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320300515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320300515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:37:27Z","timestamp":1760135847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233320300515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":43,"alternative-id":["S0887233320300515"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104827","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CdTe and CdTe@ZnS quantum dots induce IL-1\u00df-mediated inflammation and pyroptosis in microglia","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104827","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104827"}}