{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:37:37Z","timestamp":1790836657235,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006107","name":"Gil Medical Center, Gachon University","doi-asserted-by":"publisher","award":["FRD2015\u201313\u201302"],"award-info":[{"award-number":["FRD2015\u201313\u201302"]}],"id":[{"id":"10.13039\/501100006107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1D1A1B03035535"],"award-info":[{"award-number":["NRF-2017R1D1A1B03035535"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1A6A3A11047142"],"award-info":[{"award-number":["NRF-2018R1A6A3A11047142"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07048747"],"award-info":[{"award-number":["NRF-2018R1D1A1B07048747"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.tiv.2020.104883","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T17:15:34Z","timestamp":1588785334000},"page":"104883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract"],"prefix":"10.1016","volume":"67","author":[{"given":"Eun Suk","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Woong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hwan","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Kyung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2020.104883_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ccm.2013.10.004","article-title":"Cellular and molecular mechanisms of chronic obstructive pulmonary disease","volume":"35","author":"Barnes","year":"2014","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0010","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(02)11274-8","article-title":"Air pollution and health","volume":"360","author":"Brunekreef","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.tiv.2020.104883_bb0015","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1021\/tx010029w","article-title":"Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes","volume":"14","author":"Conaway","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2020.104883_bb0020","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1056\/NEJM199312093292401","article-title":"An association between air pollution and mortality in six U.S. cities","volume":"329","author":"Dockery","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/oem.60.5.313","article-title":"The biological effects of coarse and fine particulate matter","volume":"60","author":"Donaldson","year":"2003","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0030","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1128\/IAI.70.12.6672-6679.2002","article-title":"Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobactetium avium associated with decreased macrophage effector function and apoptosis","volume":"70","author":"Feng","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.tiv.2020.104883_bb0035","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1164\/rccm.201211-2004OC","article-title":"Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality","volume":"187","author":"Gan","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2020.104883_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/08958370701490379","article-title":"Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States","volume":"19","author":"Gilmour","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.tiv.2020.104883_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mam.2004.02.017","article-title":"Oxidant mechanisms in response to ambient air particles","volume":"25","author":"Gonz\u00e1lez-Flecha","year":"2004","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/09603123.2010.544033","article-title":"Short-term impact of particulate matter (PM(2.5)) on respiratory mortality in Madrid","volume":"21","author":"Guaita","year":"2011","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1016\/j.tiv.2020.104883_bb0055","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2147\/IJN.S76114","article-title":"Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK\/Nrf2 pathway and nuclear factor-kappaB signaling","volume":"10","author":"Guo","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2020.104883_bb0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/EDE.0b013e31818c7237","article-title":"Particulate air pollution and acute cardiorespiratory hospital admissions and mortality among the elderly","volume":"20","author":"Halonen","year":"2009","journal-title":"Epidemiology"},{"key":"10.1016\/j.tiv.2020.104883_bb0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2009.04.004","article-title":"Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers","volume":"284","author":"Hanlon","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tiv.2020.104883_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/rr172","article-title":"Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells","volume":"3","author":"Hellermann","year":"2002","journal-title":"Respir. Res."},{"key":"10.1016\/j.tiv.2020.104883_bb0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.tiv.2020.104883_bb0080","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/atmos10090530","article-title":"Regional inhaled deposited dose of urban aerosols in an eastern Mediterranean city","volume":"10","author":"Hussein","year":"2019","journal-title":"Atmosphere"},{"key":"10.1016\/j.tiv.2020.104883_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.33549\/physiolres.930884","article-title":"The association between oxidative stress and obstructive lung impairment in patients with COPD","volume":"56","author":"Kluchova","year":"2007","journal-title":"Physiol. Res."},{"key":"10.1016\/j.tiv.2020.104883_bb0090","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/thx.2006.076166","article-title":"Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong","volume":"62","author":"Ko","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.tiv.2020.104883_bb0095","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.pupt.2010.12.002","article-title":"What can in vitro models of COPD tell us?","volume":"24","author":"Krimmer","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.tiv.2020.104883_bb0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00038-017-0952-y","article-title":"Time to harmonize national ambient air quality standard","volume":"62","author":"Kutlar Joss","year":"2017","journal-title":"Int. J. Public Health"},{"key":"10.1016\/j.tiv.2020.104883_bb0105","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/toxsci\/kfr305","article-title":"The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells","volume":"125","author":"Lau","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2020.104883_bb0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/0022034511421200","article-title":"Cigarette smoking and inflammation: cellular and molecular mechanisms","volume":"91","author":"Lee","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.tiv.2020.104883_bb0115","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/j.bmcl.2007.06.096","article-title":"Anti-inflammatory property of the urinary metabolites of nobiletin in mouse","volume":"17","author":"Li","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tiv.2020.104883_bb0120","article-title":"Nrf2 is a protective factor against oxidative stresses induced by diesel exhaust particle in allergic asthma","volume":"323607","author":"Li","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tiv.2020.104883_bb0125","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10565-010-9158-2","article-title":"Roles of oxidative stress in signaling and inflammation induced by particulate matter","volume":"26","author":"Mazzoli-Rocha","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2020.104883_bb0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.tiv.2011.12.001","article-title":"Combination effects of cigarette smoke extract and ambient ultrafine particles on endothelial cells","volume":"26","author":"Mo","year":"2012","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2020.104883_bb0135","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tiv.2009.08.004","article-title":"Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter","volume":"24","author":"Montiel-Davalos","year":"2010","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2020.104883_bb0140","series-title":"Ambient Air Pollution: A Global Assessment of Exposure and Burden of Disease, Ambient Air Pollution: A Global Assessment of Exposure and Burden of Disease","author":"Organization, W.H","year":"2016"},{"key":"10.1016\/j.tiv.2020.104883_bb0145","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/biom5031399","article-title":"Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms","volume":"5","author":"\u00d8vrevik","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.tiv.2020.104883_bb0150","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.287.9.1132","article-title":"Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution","volume":"287","author":"Pope","year":"2002","journal-title":"Jama"},{"key":"10.1016\/j.tiv.2020.104883_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/01.CIR.0000108927.80044.7F","article-title":"Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease","volume":"109","author":"Pope","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tiv.2020.104883_bb0160","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/10473289.2006.10464485","article-title":"Health effects of fine particulate air pollution: lines that connect","volume":"56","author":"Pope","year":"2006","journal-title":"J. Air Waste Manage. Assoc."},{"key":"10.1016\/j.tiv.2020.104883_bb0165","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.287.9.1132","article-title":"Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution","volume":"287","author":"Pope","year":"2002","journal-title":"Jama"},{"key":"10.1016\/j.tiv.2020.104883_bb0170","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11357-019-00061-7","article-title":"Sulforaphane-role in aging and neurodegeneration","volume":"41","author":"Santin-Marquez","year":"2019","journal-title":"Geroscience"},{"key":"10.1016\/j.tiv.2020.104883_bb0175","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1164\/ajrccm.151.5.7735614","article-title":"Subpopulations of alveolar macrophages in smokers and nonsmokers: relation to the expression of CD11\/CD18 molecules and superoxide anion production","volume":"151","author":"Schaberg","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2003.10.002","article-title":"Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents","volume":"195","author":"Schins","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2020.104883_bb0185","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tiv.2018.01.011","article-title":"Quercetogetin protects against cigarette smoke extract-induced apoptosis in epithelial cells by inhibiting mitophagy","volume":"48","author":"Son","year":"2018","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2020.104883_bb0190","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0891-5849(03)00280-6","article-title":"Reactive oxygen species in pulmonary inflammation by ambient particulates","volume":"35","author":"Tao","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tiv.2020.104883_bb0195","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/1471-2458-11-532","article-title":"Modification by antioxidant supplementation of changes in human lung function associated with air pollutant exposure: a systematic review","volume":"11","author":"Tashakkor","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.tiv.2020.104883_bb0200","article-title":"A joint ERS\/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework","volume":"1600419","author":"Thurston","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.tiv.2020.104883_bb0205","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.atherosclerosis.2009.08.007","article-title":"Probucol and antioxidant vitamins rescue ischemia-induced neovascularization in mice exposed to cigarette smoke: potential role of endothelial progenitor cells","volume":"208","author":"Turgeon","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tiv.2020.104883_bb0210","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.3390\/ijerph10093886","article-title":"Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms","volume":"10","author":"Valavanidis","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.tiv.2020.104883_bb0215","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/thx.2003.012468","article-title":"Acute effects of cigarette smoke on inflammation and oxidative stress: a review","volume":"59","author":"van der Vaart","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.tiv.2020.104883_bb0220","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.scitotenv.2017.01.027","article-title":"Particulate matter pollution over China and the effects of control policies","volume":"584\u2013585","author":"Wang","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2020.104883_bb0225","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2147\/COPD.S195794","article-title":"Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD","volume":"14","author":"Wang","year":"2019","journal-title":"Int. J. Chron. Obstruct. Pulmon Dis."},{"key":"10.1016\/j.tiv.2020.104883_bb0230","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00048.2006","article-title":"Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease","volume":"87","author":"Yoshida","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tiv.2020.104883_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2018.11.054","article-title":"Fine particulate matter (PM(2.5)) aggravates apoptosis of cigarette-inflamed bronchial epithelium in vivo and vitro","volume":"248","author":"Zhou","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320300138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320300138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:32:39Z","timestamp":1760135559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233320300138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":47,"alternative-id":["S0887233320300138"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104883","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104883"}}