{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:10:56Z","timestamp":1793621456968,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.tiv.2020.104922","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T21:07:46Z","timestamp":1592946466000},"page":"104922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment"],"prefix":"10.1016","volume":"67","author":[{"given":"Ramon Handerson Gomes","family":"Teles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica Ellen","family":"Graminha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosette M.","family":"Rivera-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Hideki","family":"Nakahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz Barboza","family":"Formiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Paulo","family":"Corbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marxa Le\u00e3o","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Regina","family":"Cominetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2020.104922_bb0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2018.01.009","article-title":"The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions","volume":"360","author":"Bergamo","year":"2018","journal-title":"Coord. Chem. Rev."},{"issue":"3","key":"10.1016\/j.tiv.2020.104922_bb0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtemb.2010.01.009","article-title":"Ctr1 transports silver into mammalian cells","volume":"24","author":"Bertinato","year":"2010","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"13","key":"10.1016\/j.tiv.2020.104922_bb0015","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1158\/1078-0432.CCR-09-0311","article-title":"Copper transporter 2 regulates the cellular accumulation and cytotoxicity of cisplatin and carboplatin","volume":"15","author":"Blair","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.tiv.2020.104922_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-015-0529-y","article-title":"CFAssay: statistical analysis of the colony formation assay","volume":"10","author":"Braselmann","year":"2015","journal-title":"Radiat. Oncol."},{"issue":"6","key":"10.1016\/j.tiv.2020.104922_bb0025","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.tiv.2020.104922_bb0030","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5MT00149H","article-title":"Targeting copper in cancer therapy: \u201ccopper that cancer\u201d","volume":"7","author":"Denoyer","year":"2015","journal-title":"Metallomics"},{"issue":"7","key":"10.1016\/j.tiv.2020.104922_bb0035","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1039\/c2mt20021j","article-title":"Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1)","volume":"4","author":"Du","year":"2012","journal-title":"Metallomics"},{"issue":"18","key":"10.1016\/j.tiv.2020.104922_bb0040","doi-asserted-by":"crossref","first-page":"29823","DOI":"10.18632\/oncotarget.16161","article-title":"Salicylate-Phenanthroline copper (II) complex induces apoptosis in triple-negative breast cancer cells","volume":"8","author":"Fan","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.tiv.2020.104922_bb0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5306\/wjco.v7.i1.106","article-title":"Role of copper transporters in platinum resistance","volume":"7","author":"Kilari","year":"2016","journal-title":"World J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.tiv.2020.104922_bb0050","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2967\/jnumed.114.141127","article-title":"Detection of increased 64Cu uptake by human copper transporter 1 gene overexpression using PET with 64CuCl2 in human breast Cancer xenograft model","volume":"55","author":"Kim","year":"2014","journal-title":"J. Nucl. Med."},{"issue":"2","key":"10.1016\/j.tiv.2020.104922_bb0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1124\/mol.108.052381","article-title":"The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs","volume":"75","author":"Larson","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tiv.2020.104922_bb0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3945\/an.110.000273","article-title":"Advances in the understanding of mammalian copper transporters","volume":"2","author":"Leone","year":"2011","journal-title":"Adv. Nutr."},{"issue":"Ii","key":"10.1016\/j.tiv.2020.104922_bb0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jinorgbio.2016.01.014","article-title":"The chemical biology of Cu(II) complexes with imidazole or thiazole containing ligands: synthesis, crystal structures and comparative biological activity","volume":"157","author":"Lewis","year":"2016","journal-title":"J. Inorg. Biochem."},{"issue":"4","key":"10.1016\/j.tiv.2020.104922_bb0070","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1124\/mol.109.056416","article-title":"Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin","volume":"76","author":"Liang","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.tiv.2020.104922_bb0075","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1124\/mol.62.5.1154","article-title":"The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae","volume":"62","author":"Lin","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"8","key":"10.1016\/j.tiv.2020.104922_bb0080","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","article-title":"Metallodrugs in medicinal inorganic chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tiv.2020.104922_bb0085","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ica.2017.01.015","article-title":"Synthesis, characterization and preliminary antimicrobial assays of copper(II) complexes with 2-(imidazole-2-yl)heteroaryl ligands","volume":"458","author":"Nakahata","year":"2017","journal-title":"Inorgan. Chim. Acta"},{"key":"10.1016\/j.tiv.2020.104922_bb0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jinorgbio.2018.07.011","article-title":"Sulfonamide-containing copper(II) metallonucleases: correlations with in vitro antimycobacterial and antiproliferative activities","volume":"187","author":"Nakahata","year":"2018","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.tiv.2020.104922_bb0095","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/acs.molpharmaceut.8b01154","article-title":"Transport of the ruthenium complex [Ru(GA)(dppe) 2 ]PF 6 into triple-negative breast cancer cells is facilitated by transferrin receptors","volume":"16","author":"Naves","year":"2019","journal-title":"Mol. Pharm."},{"issue":"46","key":"10.1016\/j.tiv.2020.104922_bb0100","doi-asserted-by":"crossref","first-page":"E4279","DOI":"10.1073\/pnas.1311749110","article-title":"Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain","volume":"110","author":"Ohrvik","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.tiv.2020.104922_bb0105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/jm300938r","article-title":"In vitro and in vivo anticancer activity of copper bis(thiosemicarbazone) complexes","volume":"56","author":"Palanimuthu","year":"2013","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.tiv.2020.104922_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/2162402X.2016.1208876","article-title":"Repurposing platinum-based chemotherapies for multi-modal treatment of glioblastoma","volume":"5","author":"Roberts","year":"2016","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.tiv.2020.104922_bb0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1039\/c9mt00187e","article-title":"Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis","volume":"12","author":"Rochford","year":"2020","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.tiv.2020.104922_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1124\/mol.66.1.25","article-title":"Modulation of the cellular pharmacology of cisplatin and its Analogs by the copper exporters ATP7A and ATP7B","volume":"66","author":"Samimi","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tiv.2020.104922_bb0125","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.chembiol.2018.02.010","volume":"25","author":"Shimada","year":"2018","journal-title":"Cell Chem. Biol."},{"issue":"9","key":"10.1016\/j.tiv.2020.104922_bb0130","doi-asserted-by":"crossref","first-page":"16036","DOI":"10.18632\/oncotarget.13917","article-title":"The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"issue":"16","key":"10.1016\/j.tiv.2020.104922_bb0135","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1021\/ja109413c","article-title":"Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells","volume":"133","author":"Tardito","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.tiv.2020.104922_bb0140","first-page":"987","article-title":"Copper efflux transporter (ATP7B) contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines","volume":"18","author":"Yoshizawa","year":"2007","journal-title":"Oncol. Rep."},{"issue":"8","key":"10.1016\/j.tiv.2020.104922_bb0145","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1039\/C4MT00035H","article-title":"A comprehensive biological insight of trinuclear copper(II)-tin(IV) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies","volume":"6","author":"Zaidi","year":"2014","journal-title":"Metallomics"},{"issue":"3","key":"10.1016\/j.tiv.2020.104922_bb0150","doi-asserted-by":"crossref","first-page":"C588","DOI":"10.1152\/ajpcell.00054.2010","article-title":"Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake","volume":"300","author":"Zimnicka","year":"2011","journal-title":"Am. J. Physiol. Physiol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320304720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233320304720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:35:30Z","timestamp":1760135730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233320304720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":30,"alternative-id":["S0887233320304720"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104922","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2020.104922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104922"}}