{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:03:05Z","timestamp":1782572585254,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"am","delay-in-days":250,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.tiv.2021.105156","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T23:00:45Z","timestamp":1617231645000},"page":"105156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells"],"prefix":"10.1016","volume":"74","author":[{"given":"Thomas J.","family":"DiProspero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Dalrymple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Lockett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2021.105156_bb0005","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1021\/acsabm.0c00558","article-title":"Paper-based cell culture: paving the pathway for liver tissue model development on a cellulose paper chip","volume":"3","author":"Agarwal","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.tiv.2021.105156_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204269","article-title":"Oxygenation in cell culture: critical parameters are routinely not reported","volume":"13","author":"Al-Ani","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2021.105156_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0090-9556(25)07338-6","article-title":"In vivo and in vitro effect of cimetidine, inflammation, and hypoxia on propofol kinetics","volume":"21","author":"Audibert","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2021.105156_bb0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/dmd.116.074369","article-title":"Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems of drug-induced liver injury","volume":"45","author":"Bell","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2021.105156_bb0025","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/CAD.0000000000000516","article-title":"Hypoxia as a target for drug combination therapy of liver cancer","volume":"28","author":"Bowyer","year":"2017","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.tiv.2021.105156_bb0030","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1039\/C7AN00806F","article-title":"Assessing chemotherapeutic effectiveness using a paper-based tumor model","volume":"142","author":"Boyce","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.tiv.2021.105156_bb0035","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1089\/ten.tea.2007.0434","article-title":"Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes","volume":"15","author":"Chang","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.tiv.2021.105156_bb0040","doi-asserted-by":"crossref","first-page":"10916","DOI":"10.1021\/acs.analchem.9b02102","article-title":"Tissue papers: leveraging paper-based microfluidics for the next generation of 3D tissue models","volume":"91","author":"Cramer","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tiv.2021.105156_bb0043","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mrrev.2018.10.002","article-title":"Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents","volume":"778","author":"Deng","year":"2018","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tiv.2021.105156_bb0045","doi-asserted-by":"crossref","first-page":"18457","DOI":"10.1073\/pnas.0910666106","article-title":"Paper-supported 3D cell culture for tissue-based bioassays","volume":"106","author":"Derda","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tiv.2021.105156_bb0050","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/carcin\/19.8.1361","article-title":"Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture","volume":"19","author":"Drahushuk","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tiv.2021.105156_bb0055","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1083\/jcb.116.4.1043","article-title":"Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation","volume":"116","author":"Dunn","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tiv.2021.105156_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/1389200043335577","article-title":"Effect of hypoxia on cytochrome P450 activity and expression","volume":"5","author":"Fradette","year":"2004","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.tiv.2021.105156_bb0065","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1039\/C6TX00101G","article-title":"Characterization of a functional C3A liver spheroid model","volume":"5","author":"Gaskell","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tiv.2021.105156_bb0070","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/mol.114.094797","article-title":"The WNT\/\u03b2-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes","volume":"86","author":"Gerbal-Chaloin","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tiv.2021.105156_bb0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tiv.2008.11.012","article-title":"Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach","volume":"23","author":"Gerets","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2021.105156_bb0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10565-011-9208-4","article-title":"Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins","volume":"28","author":"Gerets","year":"2012","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2021.105156_bb0085","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1124\/dmd.110.035873","article-title":"Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes","volume":"39","author":"Guo","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2021.105156_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/00498250310001657568","article-title":"Phase I and II enzyme characterization of two sources of HepG2 cell lines","volume":"34","author":"Hewitt","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1016\/j.tiv.2021.105156_bb0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/03602530601093489","article-title":"Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies","volume":"39","author":"Hewitt","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.tiv.2021.105156_bb0100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-3-642-00663-0_12","article-title":"Mechanisms of acetaminophen-induced liver necrosis","volume":"196","author":"Hinson","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tiv.2021.105156_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jbiotec.2010.01.012","article-title":"Multicellular tumor spheroids: an underestimated tool is catching up again","volume":"148","author":"Hirschhaeuser","year":"2010","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.tiv.2021.105156_bb0110","series-title":"Drug Interactions and Adverse Reactions, Drug Metabolism: Current Concepts","first-page":"295","author":"Ionescu","year":"2005"},{"key":"10.1016\/j.tiv.2021.105156_bb0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5507\/bp.2010.017","article-title":"Phase II drug metabolizing enzymes","volume":"154","author":"Jancova","year":"2010","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc, Czech Repub."},{"key":"10.1016\/j.tiv.2021.105156_bb0120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/hep.510310201","article-title":"Oxygen: modulation of metabolic zonation and disease of the liver","volume":"31","author":"Jungermann","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2021.105156_bb0125","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/bit.27225","article-title":"Progressive hypoxia-on-a-chip: an in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease","volume":"117","author":"Kang","year":"2020","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.tiv.2021.105156_bb0130","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1124\/dmd.118.082719","article-title":"Do in vitro assays predict drug candidate idiosyncratic drug-induced liver injury risk?","volume":"46","author":"Kenna","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2021.105156_bb0133","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1039\/C8AN01157E","article-title":"Paper-based Transwell assays: an inexpensive alternative to study cellular invasion","volume":"144","author":"Kenney","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.tiv.2021.105156_bb0135","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: the oxygen gradient revisited","volume":"11","author":"Kietzmann","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.tiv.2021.105156_bb0140","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/ten.tec.2010.0012","article-title":"A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures","volume":"16","author":"Kim","year":"2010","journal-title":"Tissue Eng. Part C"},{"key":"10.1016\/j.tiv.2021.105156_bb0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF01319006","article-title":"Alterations in the sequence of the gene 4 from a human rotavirus after multiple passages in HepG2","volume":"130","author":"Kitamoto","year":"1993","journal-title":"Arch. Virol."},{"key":"10.1016\/j.tiv.2021.105156_bb0150","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1021\/acs.chemrestox.6b00150","article-title":"Novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates","volume":"29","author":"Lauschke","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2021.105156_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.05.003","volume":"199","author":"Li","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tiv.2021.105156_bb0156","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative pcr and the 2(t)(-delta delta c) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tiv.2021.105156_bb0158","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/cpch.22","article-title":"Paper-based invasion assays for quantifying cellular movement in three-dimensional tissue-like structures","volume":"9","author":"Lloyd","year":"2017","journal-title":"Curr. Protocol. Chem. Biol."},{"key":"10.1016\/j.tiv.2021.105156_bb0160","doi-asserted-by":"crossref","first-page":"8239","DOI":"10.18632\/oncotarget.14158","article-title":"Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes","volume":"8","author":"Mughal","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tiv.2021.105156_bb0165","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1208\/s12248-018-0204-y","article-title":"Why drugs fail in late stages of development: case study analyses from the last decade and recommendations","volume":"20","author":"Parasrampuria","year":"2018","journal-title":"AAPS J."},{"key":"10.1016\/j.tiv.2021.105156_bb0170","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/13880209.2014.950675","article-title":"Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells","volume":"53","author":"Parikh","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.tiv.2021.105156_bb0175","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1152\/physiol.00022.2015","article-title":"Oxygen sensing and homeostasis","volume":"30","author":"Prabhakar","year":"2015","journal-title":"Physiol."},{"key":"10.1016\/j.tiv.2021.105156_bb0180","first-page":"1083","article-title":"A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies","volume":"88","author":"Ramaiahgari","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2021.105156_bb0185","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.toxlet.2011.05.1034","article-title":"Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor","volume":"205","author":"Ratajewski","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2021.105156_bb0190","first-page":"359","article-title":"Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity","volume":"138","author":"Roberts","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tiv.2021.105156_bb0195","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/sj.onc.1209377","article-title":"Cytochrome P450 pharmacogenetics and cancer","volume":"25","author":"Rodriguez-Antona","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.tiv.2021.105156_bb0200","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.tiv.2021.105156_bb0205","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00204-013-1080-y","article-title":"Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity","volume":"87","author":"Schyschka","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2021.105156_bb0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1152\/physiolgenomics.00104.2002","article-title":"Effect of hypoxia on gene expression by human hepatocytes (HepG2)","volume":"12","author":"Sonna","year":"2003","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.tiv.2021.105156_bb0215","doi-asserted-by":"crossref","first-page":"13801","DOI":"10.1073\/pnas.212494599","article-title":"Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)","volume":"99","author":"Sonoda","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tiv.2021.105156_bb0220","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1006\/bbrc.1999.2029","article-title":"Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR","volume":"267","author":"Sumida","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2021.105156_bb0225","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.tiv.2014.02.008","article-title":"Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes","volume":"28","author":"Vrba","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2021.105156_bb0230","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2131\/jts.27.229","article-title":"Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines","volume":"27","author":"Wang","year":"2002","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tiv.2021.105156_bb0235","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.tiv.2007.06.017","article-title":"Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells","volume":"21","author":"Westerink","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2021.105156_bb0240","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2174\/1389201017666160301103648","article-title":"Microfabricated devices for studying the metabolism and cytotoxicity of drug candidates","volume":"17","author":"Whitman","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.tiv.2021.105156_bb0245","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1248\/bpb.b17-00913","article-title":"Comparison of drug metabolism and its related hepatotoxic effects in HepaRG, cryopreserved human hepatocytes, and HepG2 cell cultures","volume":"41","author":"Yokoyama","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tiv.2021.105156_bb0250","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.yexcr.2016.11.027","article-title":"Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance","volume":"350","author":"Zeigerer","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tiv.2021.105156_bb0255","doi-asserted-by":"crossref","first-page":"231","DOI":"10.21037\/tcr.2018.02.14","article-title":"Genomic alterations across six hepatocellular carcinoma cell lines by panel-based sequencing","volume":"7","author":"Zhao","year":"2018","journal-title":"Transl. Cancer Res."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233321000813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233321000813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:37:35Z","timestamp":1760135855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233321000813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":55,"alternative-id":["S0887233321000813"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2021.105156","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2021.105156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105156"}}