{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:14:00Z","timestamp":1775114040344,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.tiv.2022.105329","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T20:29:41Z","timestamp":1644524981000},"page":"105329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of chlorpyrifos on non-cholinergic toxicity endpoints in immortalized and primary rat hepatocytes under normal and hepatosteatotic conditions"],"prefix":"10.1016","volume":"80","author":[{"given":"SandeepReddy","family":"Kondakala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Henein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"McDevitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew K.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"George Eli","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2022.105329_bb0005","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.chembiol.2007.11.006","article-title":"A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol","volume":"14","author":"Blankman","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.tiv.2022.105329_bb0010","doi-asserted-by":"crossref","first-page":"25879","DOI":"10.1016\/S0021-9258(18)47328-0","article-title":"Studies on the assembly of apolipoprotein B-100-and B-48-containing very low density lipoproteins in McA-RH7777 cells","volume":"269","author":"Boren","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2022.105329_bb0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/toxsci\/kfr081","article-title":"Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats","volume":"122","author":"Carr","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2022.105329_bb0020","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/tx0499259","article-title":"Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets","volume":"17","author":"Casida","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cbi.2005.10.036","article-title":"Serine hydrolase targets of organophosphorus toxicants","volume":"157-158","author":"Casida","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tiv.2022.105329_bb0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2012.11.022","article-title":"Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting","volume":"430","author":"Chamberlain","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2022.105329_bb0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/faat.1993.1079","article-title":"Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats","volume":"21","author":"Chambers","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0048-3575(89)90003-5","article-title":"An investigation of acetylcholinesterase inhibition and aging and choline acetyltransferase activity following a high level acute exposure to paraoxon","volume":"33","author":"Chambers","year":"1989","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.tiv.2022.105329_bb0045","doi-asserted-by":"crossref","first-page":"38041","DOI":"10.1074\/jbc.M112.377978","article-title":"Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene","volume":"287","author":"Chanda","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2022.105329_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.taap.2011.10.017","article-title":"Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon","volume":"258","author":"Crow","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0055","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/j.1478-3231.2010.02298.x","article-title":"Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes","volume":"30","author":"De Gottardi","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.tiv.2022.105329_bb0060","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00125-008-1048-2","article-title":"The endocannabinoid system in obesity and type 2 diabetes","volume":"51","author":"Di Marzo","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.tiv.2022.105329_bb0065","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/BF02631255","article-title":"Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes","volume":"30","author":"Donato","year":"1994","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.tiv.2022.105329_bb0070","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/S0140-6736(05)67598-8","article-title":"Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study","volume":"366","author":"Eddleston","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.tiv.2022.105329_bb0075","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bcp.2009.05.004","article-title":"Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF)","volume":"78","author":"Eyer","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0080","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2022.105329_bb0085","first-page":"49","article-title":"Xenobiotic metabolism and toxicity in primary monolayer cultures of hepatocytes","volume":"8","author":"Holme","year":"1985","journal-title":"NIPH Ann."},{"key":"10.1016\/j.tiv.2022.105329_bb0090","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bbalip.2009.08.008","article-title":"N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha","volume":"1791","author":"Howell","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2022.105329_bb0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tiv.2016.01.002","article-title":"Exposure to chlorpyrifos increases neutral lipid accumulation with accompanying increased de novo lipogenesis and decreased triglyceride secretion in McArdle-RH7777 hepatoma cells","volume":"32","author":"Howell","year":"2016","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2022.105329_bb0100","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/tox.22583","article-title":"Alterations in cellular lipid metabolism produce neutral lipid accumulation following exposure to the organochlorine compound trans-nonachlor in rat primary hepatocytes","volume":"33","author":"Howell","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tiv.2018.04.003","article-title":"Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells","volume":"50","author":"Howell","year":"2018","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2022.105329_bb0110","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.fct.2018.06.051","article-title":"Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL\/6J mice","volume":"118","author":"Howell","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0115","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.bbalip.2009.07.006","article-title":"Es-x\/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes","volume":"1791","author":"Ko","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2022.105329_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.taap.2017.10.019","article-title":"Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL\/6J mice","volume":"337","author":"Kondakala","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0125","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/ATVBAHA.111.241497","article-title":"Lumenal lipid metabolism: implications for lipoprotein assembly","volume":"32","author":"Lehner","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tiv.2022.105329_bb0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/abbi.1994.1531","article-title":"Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B)","volume":"315","author":"Morgan","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tiv.2022.105329_bb0135","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nchembio.86","article-title":"Activation of the endocannabinoid system by organophosphorus nerve agents","volume":"4","author":"Nomura","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tiv.2022.105329_bb0140","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"Osei-Hyiaman","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tiv.2022.105329_bb0145","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1172\/JCI34827","article-title":"Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice","volume":"118","author":"Osei-Hyiaman","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tiv.2022.105329_bb0150","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.25961","article-title":"Deficiency of carboxylesterase 1\/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia","volume":"56","author":"Quiroga","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2022.105329_bb0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/taap.2001.9175","article-title":"Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides","volume":"173","author":"Quistad","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2005.10.007","article-title":"Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice","volume":"211","author":"Quistad","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0165","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/kfj124","article-title":"Each lipase has a unique sensitivity profile for organophosphorus inhibitors","volume":"91","author":"Quistad","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2022.105329_bb0170","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","article-title":"Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes","volume":"24","author":"Ricchi","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.tiv.2022.105329_bb0175","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/0471140856.tx0424s33","article-title":"Enzymatic activity of human carboxylesterases","volume":"33","author":"Ross","year":"2007","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0180","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1584\/jpestics.R10-07","article-title":"Carboxylesterases: dual roles in lipid and pesticide metabolism","volume":"35","author":"Ross","year":"2010","journal-title":"J. Pestic. Sci."},{"key":"10.1016\/j.tiv.2022.105329_bb0185","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.tiv.2012.03.015","article-title":"Impacts of low doses of pesticide mixtures on liver cell defence systems","volume":"26","author":"Rouimi","year":"2012","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2022.105329_bb0190","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.pharmtox.38.1.257","article-title":"The mammalian carboxylesterases: from molecules to functions","volume":"38","author":"Satoh","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tiv.2022.105329_bb0195","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1289\/ehp.8133","article-title":"Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood","volume":"113","author":"Slotkin","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2022.105329_bb0200","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-4274(01)00543-4","article-title":"Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis","volume":"128","author":"Sogorb","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2022.105329_bb0205","series-title":"Properties and Uses of Chlorpyrifos in the United States, Ecological Risk Assessment for Chlorpyrifos in Terrestrial and Aquatic Systems in the United States","first-page":"13","author":"Solomon","year":"2014"},{"key":"10.1016\/j.tiv.2022.105329_bb0210","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0041-008X(84)90053-X","article-title":"The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos","volume":"73","author":"Sultatos","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105329_bb0215","first-page":"1201","article-title":"Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes","volume":"29","author":"Tang","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2022.105329_bb0220","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/tx1002194","article-title":"Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes\/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2","volume":"23","author":"Xie","year":"2010","journal-title":"Chem. Res. Toxicol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233322000261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233322000261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:41:31Z","timestamp":1760136091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233322000261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":44,"alternative-id":["S0887233322000261"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2022.105329","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chlorpyrifos on non-cholinergic toxicity endpoints in immortalized and primary rat hepatocytes under normal and hepatosteatotic conditions","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2022.105329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105329"}}