{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:26:47Z","timestamp":1774139207662,"version":"3.50.1"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"am","delay-in-days":271,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.tiv.2022.105535","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T12:11:33Z","timestamp":1670933493000},"page":"105535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["An international validation study of the interleukin-2 luciferase leukocyte toxicity test (IL-2 Luc LTT) to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay (IL-2 Luc assay)"],"prefix":"10.1016","volume":"88","author":[{"given":"Kimura","family":"Yutaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuno","family":"Rie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizu","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ohmiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Corsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin L.","family":"Rogen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2022.105535_bb0005","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.3748\/wjg.v17.i37.4166","article-title":"Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease","volume":"17","author":"Bradford","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tiv.2022.105535_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2165\/00003088-200241020-00002","article-title":"Cellular and clinical pharmacology of fludarabine","volume":"41","author":"Gandhi","year":"2002","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.tiv.2022.105535_bb0015","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.tiv.2014.02.013","article-title":"Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs","volume":"28","author":"Kimura","year":"2014","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2022.105535_bb0020","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00204-018-2199-7","article-title":"Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the multi-immunotox assay and the IL-8 Luc assay","volume":"92","author":"Kimura","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2022.105535_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104832","article-title":"An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals","volume":"66","author":"Kimura","year":"2020","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2022.105535_bb0030","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s00204-021-03101-4","article-title":"Optimization of the IL-2 Luc assay for immunosuppressive drugs: a novel in vitro immunotoxicity test with high sensitivity and predictivity","volume":"95","author":"Kimura","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2022.105535_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/faat.1993.1074","article-title":"Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests","volume":"21","author":"Luster","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tiv.2022.105535_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.yrtph.2014.06.001","article-title":"Towards AOP application--implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization","volume":"69","author":"Patlewicz","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105535_bb0050","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/toxsci\/kfg188","article-title":"Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics","volume":"75","author":"Pessina","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2022.105535_bb0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.taap.2011.04.017","article-title":"Nickel differentially regulates NFAT and NF-kappaB activation in T cell signaling","volume":"254","author":"Saito","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2022.105535_bb0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/toxsci\/kfr237","article-title":"An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8","volume":"124","author":"Takahashi","year":"2011","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233322002338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233322002338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:42:05Z","timestamp":1760136125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233322002338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":11,"alternative-id":["S0887233322002338"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2022.105535","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An international validation study of the interleukin-2 luciferase leukocyte toxicity test (IL-2 Luc LTT) to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay (IL-2 Luc assay)","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2022.105535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105535"}}