{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:12:05Z","timestamp":1786997525015,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-16-0033"],"award-info":[{"award-number":["APVV-16-0033"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.tiv.2023.105652","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T21:17:45Z","timestamp":1689974265000},"page":"105652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["STF-083010 an inhibitor of IRE1\u03b1 endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential"],"prefix":"10.1016","volume":"92","author":[{"given":"Zuzana","family":"Hatokova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Evinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Racay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2023.105652_bb0005","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111699","article-title":"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies","volume":"42","author":"Acin-Perez","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.tiv.2023.105652_bb0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.tiv.2023.105652_bb0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12079-020-00562-7","article-title":"Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cells","volume":"14","author":"Barez","year":"2020","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.tiv.2023.105652_bb0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41586-022-04747-5","article-title":"Mitochondrial uncouplers induce proton leak by activating AAC and UCP1","volume":"606","author":"Bertholet","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2023.105652_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174073","article-title":"Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells","volume":"902","author":"Brodnanova","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105652_bb0030","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11064-019-02759-8","article-title":"The effect of 2-Ketobutyrate on mitochondrial substrate-level phosphorylation","volume":"44","author":"Bui","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tiv.2023.105652_bb0035","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3389\/fphar.2018.01344","article-title":"Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 alleviates carbon tetrachloride induced liver injury and liver fibrosis in mice","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105652_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110069","article-title":"The emerging role of XBP1 in cancer","volume":"127","author":"Chen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tiv.2023.105652_bb0045","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.18632\/oncotarget.2051","article-title":"Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells","volume":"5","author":"Chien","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.tiv.2023.105652_bb0050","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1096\/fj.09-149898","article-title":"Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation","volume":"24","author":"Chinopoulos","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.tiv.2023.105652_bb0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/B978-0-12-416618-9.00017-0","article-title":"Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption","volume":"542","author":"Chinopoulos","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tiv.2023.105652_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.614556","article-title":"IRE1\u03b1-XBP1 affects the mitochondrial function of A\u03b225-35-treated SH-SY5Y cells by regulating mitochondria-associated endoplasmic reticulum membranes","volume":"15","author":"Chu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tiv.2023.105652_bb0065","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1007\/s12035-016-0114-x","article-title":"ER stress induced by Tunicamycin triggers \u03b1-Synuclein oligomerization, dopaminergic neurons death and locomotor impairment: a new model of Parkinson\u2019s disease","volume":"54","author":"C\u00f3ppola-Segovia","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tiv.2023.105652_bb0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/01616412.2018.1547856","article-title":"Both thapsigargin- and tunicamycin-induced endoplasmic reticulum stress increases expression of Hrd1 in IRE1-dependent fashion","volume":"41","author":"Dibdiakova","year":"2019","journal-title":"Neurol. Res."},{"key":"10.1016\/j.tiv.2023.105652_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00232-020-00107-4","article-title":"High-resolution Respirometry in assessment of mitochondrial function in neuroblastoma SH-SY5Y intact cells","volume":"253","author":"Evinova","year":"2020","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.tiv.2023.105652_bb0080","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s11010-021-04344-6","article-title":"Endoplasmic reticulum stress induces mitochondrial dysfunction but not mitochondrial unfolded protein response in SH-SY5Y cells","volume":"477","author":"Evinova","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tiv.2023.105652_bb0085","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.15252\/embj.201489897","article-title":"The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1b","volume":"34","author":"Fujita","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.tiv.2023.105652_bb0090","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cbpc.2008.09.006","article-title":"Cyclosporin a is unable to inhibit carboxyatractyloside-induced permeability transition in aged mitochondria","volume":"149","author":"Garc\u00eda","year":"2009","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105652_bb0095","doi-asserted-by":"crossref","first-page":"26494","DOI":"10.1074\/jbc.M110.143164","article-title":"Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss","volume":"285","author":"Hawkins","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2023.105652_bb0100","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tiv.2023.105652_bb0105","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tiv.2023.105652_bb0110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000334536","article-title":"Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease","volume":"10","author":"Hoozemans","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.tiv.2023.105652_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000333069","article-title":"Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells","volume":"20","author":"Koo","year":"2012","journal-title":"Neurosignals"},{"key":"10.1016\/j.tiv.2023.105652_bb0120","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.celrep.2018.02.055","article-title":"The PERK arm of the unfolded protein response regulates mitochondrial morphology during acute endoplasmic reticulum stress","volume":"22","author":"Lebeau","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tiv.2023.105652_bb0125","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.29847","article-title":"Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice","volume":"68","author":"Lebeaupin","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2023.105652_bb0130","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1128\/MCB.23.21.7448-7459.2003","article-title":"XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response","volume":"23","author":"Lee","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2023.105652_bb0135","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1096\/fj.202000767R","article-title":"Mitochondrial spare respiratory capacity: mechanisms, regulation, and significance in non-transformed and cancer cells","volume":"34","author":"Marchetti","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.tiv.2023.105652_bb0140","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.1980.60.3.825","article-title":"Transport of protons across membranes by weak acids","volume":"603","author":"McLaughlin","year":"1980","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tiv.2023.105652_bb0145","doi-asserted-by":"crossref","first-page":"40692","DOI":"10.18632\/oncotarget.5827","article-title":"A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1\/XBP1","volume":"6","author":"Ming","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.tiv.2023.105652_bb0150","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1042\/BST0371385","article-title":"Spare respiratory capacity, oxidative stress and excitotoxicity","volume":"37","author":"Nicholls","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tiv.2023.105652_bb0155","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.mito.2013.09.005","article-title":"A bioenergetic profile of nontransformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity","volume":"13","author":"Nickens","year":"2013","journal-title":"Mitochondrion."},{"key":"10.1016\/j.tiv.2023.105652_bb0160","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ajpath.2020.01.010","article-title":"Endoplasmic reticulum stress signaling in Cancer cells","volume":"190","author":"Oakes","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tiv.2023.105652_bb0165","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1182\/blood-2010-08-303099","article-title":"Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma","volume":"117","author":"Papandreou","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.tiv.2023.105652_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.202","article-title":"Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival","volume":"6","author":"Pfleger","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tiv.2023.105652_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.906651","article-title":"A non-canonical role for IRE1\u03b1 links ER and mitochondria as key regulators of astrocyte dysfunction: implications in methamphetamine use and HIV-associated neurocognitive disorders","volume":"16","author":"Proulx","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tiv.2023.105652_bb0180","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.trecan.2020.07.006","article-title":"Pharmacological targeting of IRE1 in cancer","volume":"6","author":"Raymundo","year":"2020","journal-title":"Trends Cancer."},{"key":"10.1016\/j.tiv.2023.105652_bb0185","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1186\/s12885-022-09775-y","article-title":"Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK","volume":"22","author":"Salimi","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tiv.2023.105652_bb0190","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.18632\/oncotarget.7702","article-title":"Inhibition of IRE1\u03b1-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.tiv.2023.105652_bb0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(95)00487-T","article-title":"ATP synthesis catalyzed by the mitochondrial F1-F0 ATP synthase is not a reversal of its ATPase activity","volume":"366","author":"Syroeshkin","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tiv.2023.105652_bb0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1289\/ehp.9087213","article-title":"Uncouplers of oxidative phosphorylation","volume":"87","author":"Terada","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tiv.2023.105652_bb0205","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2022.10.014","article-title":"Dual role of inositol-requiring enzyme 1\u03b1-X-box binding protein 1 signaling in neurodegenerative diseases","volume":"505","author":"Wang","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.tiv.2023.105652_bb0210","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.1523\/JNEUROSCI.0212-07.2007","article-title":"Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone","volume":"27","author":"Yadava","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tiv.2023.105652_bb0215","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.intimp.2019.04.051","article-title":"Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy","volume":"73","author":"Zhan","year":"2019","journal-title":"Int. Immunopharmacol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233323001017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233323001017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:44:02Z","timestamp":1760136242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233323001017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":43,"alternative-id":["S0887233323001017"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2023.105652","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STF-083010 an inhibitor of IRE1\u03b1 endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2023.105652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105652"}}