{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T18:49:40Z","timestamp":1794422980625,"version":"4.9.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.tiv.2023.105728","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:52:21Z","timestamp":1699577541000},"page":"105728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments"],"prefix":"10.1016","volume":"94","author":[{"given":"J.","family":"Bronsard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Savary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Massart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Viel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Moutaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Catheline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rioux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Corlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fromenty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Ferron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2023.105728_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.toxlet.2016.06.008","article-title":"Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-\u03b1","volume":"258","author":"Al-Attrache","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2023.105728_bb0010","series-title":"Advances in Pharmacology","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.apha.2019.01.003","article-title":"Drug-induced liver injury in obesity and nonalcoholic fatty liver disease","author":"Allard","year":"2019"},{"key":"10.1016\/j.tiv.2023.105728_bb0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10565-020-09537-1","article-title":"Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity","volume":"37","author":"Allard","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0020","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X231188831","article-title":"The burden of low back pain in children and adolescents with overweight and obesity: from pathophysiology to prevention and treatment strategies","volume":"15","author":"Ambrosio","year":"2023","journal-title":"Therap. Adv. Musculoskel."},{"key":"10.1016\/j.tiv.2023.105728_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1124\/dmd.105.006759","article-title":"Expression of cytochromes P450, conjugatin enzymes and nuclear receptors in human hepatoma HepaRG cells","volume":"34","author":"Aninat","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2023.105728_bb0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1124\/dmd.105.006759","article-title":"Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells","volume":"34","author":"Aninat","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2023.105728_bb0035","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.clinre.2011.04.015","article-title":"Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role","volume":"35","author":"Aubert","year":"2011","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.tiv.2023.105728_bb0040","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1124\/jpet.112.193813","article-title":"Differences in early acetaminophen hepatotoxicity between obese ob\/ob and db\/db mice","volume":"342","author":"Aubert","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tiv.2023.105728_bb0045","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2023.105728_bb0050","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-022-03292-4","article-title":"Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells","author":"Barranger","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0055","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/livers3010003","article-title":"Acetaminophen-induced hepatotoxicity in obesity and nonalcoholic fatty liver disease: a critical review","volume":"3","author":"Begriche","year":"2023","journal-title":"Livers"},{"key":"10.1016\/j.tiv.2023.105728_bb0060","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/dmd.116.074369","article-title":"Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury","volume":"45","author":"Bell","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2023.105728_bb0065","article-title":"Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists","author":"Boeckmans","year":"2020","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0070","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/tox.22301","article-title":"Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure","volume":"32","author":"Bucher","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24403-1","article-title":"Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo","volume":"8","author":"Bucher","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2023.105728_bb0080","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/hep.21536","article-title":"Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor","volume":"45","author":"Cerec","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.tiv.2023.105728_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.intimp.2014.08.002","article-title":"THP-1 cell line: an in vitro cell model for immune modulation approach","volume":"23","author":"Chanput","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tiv.2023.105728_bb0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/pds.4339","article-title":"Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose","volume":"27","author":"Chomchai","year":"2018","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.tiv.2023.105728_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40266-019-00658-9","article-title":"Safety of paracetamol in osteoarthritis: what does the literature say?","volume":"36","author":"Conaghan","year":"2019","journal-title":"Drugs Aging"},{"key":"10.1016\/j.tiv.2023.105728_bb0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcp.27175","article-title":"Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell","volume":"234","author":"Dornas","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tiv.2023.105728_bb0105","first-page":"15","article-title":"Update: use of the benchmark dose approach in risk assessment","author":"EFSA Scientific Committee","year":"2017","journal-title":"EFS2"},{"key":"10.1016\/j.tiv.2023.105728_bb0110","author":"FDA"},{"key":"10.1016\/j.tiv.2023.105728_bb0115","author":"FDA"},{"key":"10.1016\/j.tiv.2023.105728_bb0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/ijms23010082","article-title":"Molecular networking for drug toxicity studies: the case of hydroxychloroquine in COVID-19 patients","volume":"23","author":"Ferron","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0125","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/j.1460-2075.1985.tb03960.x","article-title":"Dependence of hepatocyte-specific gene expression on cell-cell interactions in primary culture","volume":"4","author":"Fraslin","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.tiv.2023.105728_bb0130","author":"French public data base of drugs"},{"key":"10.1016\/j.tiv.2023.105728_bb0135","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jhep.2012.12.018","article-title":"Drug-induced liver injury in obesity","volume":"58","author":"Fromenty","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tiv.2023.105728_bb0140","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1096\/fj.14-267393","article-title":"ILr1\u03b2 production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages","volume":"29","author":"Gicquel","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.tiv.2023.105728_bb0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jnutbio.2018.09.010","article-title":"Retroconversion of dietary trans-vaccenic (trans-C18:1 n-7) acid to trans-palmitoleic acid (trans-C16:1 n-7): proof of concept and quantification in both cultured rat hepatocytes and pregnant rats","volume":"63","author":"Guillocheau","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tiv.2023.105728_bb0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/toxsci\/kft021","article-title":"3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies","volume":"133","author":"Gunness","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0155","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2133\/dmpk.DMPK-10-RV-090","article-title":"Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case","volume":"26","author":"Ikeda","year":"2011","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.tiv.2023.105728_bb0160","first-page":"187","article-title":"Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI)","volume":"37","author":"Khadka","year":"2020","journal-title":"ALTEX"},{"key":"10.1016\/j.tiv.2023.105728_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2017.12.038","article-title":"Quantitation of trans-fatty acids in human blood via isotope dilution-gas chromatography-negative chemical ionization-mass spectrometry","volume":"1076","author":"Kuiper","year":"2018","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0170","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/00912700222011445","article-title":"Safety and pharmacokinetics of oral voriconazole in patients at risk of fungal infection: a dose escalation study","volume":"42","author":"Lazarus","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105728_bb0175","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1124\/jpet.117.246751","article-title":"Drug-induced alterations of mitochondrial DNA homeostasis in steatotic and nonsteatotic HepaRG cells","volume":"365","author":"Le Guillou","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tiv.2023.105728_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.026","article-title":"Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro","volume":"78","author":"Leite","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2023.105728_bb0185","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbalip.2016.06.009","article-title":"Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration","volume":"1861","author":"Lemari\u00e9","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tiv.2023.105728_bb0190","article-title":"Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity","author":"Massart","year":"2017","journal-title":"J. Clin. Translat. Res."},{"key":"10.1016\/j.tiv.2023.105728_bb0195","first-page":"212","article-title":"Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity","volume":"3","author":"Massart","year":"2017","journal-title":"J. Clin. Translat. Res."},{"key":"10.1016\/j.tiv.2023.105728_bb0200","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/ijms23031062","article-title":"Xenobiotic-induced aggravation of metabolic-associated fatty liver disease","volume":"23","author":"Massart","year":"2022","journal-title":"IJMS"},{"key":"10.1016\/j.tiv.2023.105728_bb0205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tiv.2019.06.002","article-title":"Bile salts regulate CYP7A1 expression and elicit a fibrotic response and abnormal lipid production in 3D liver microtissues","volume":"60","author":"Messner","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2023.105728_bb0210","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1111\/liv.12514","article-title":"Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease","volume":"34","author":"Michaut","year":"2014","journal-title":"Liver Int."},{"key":"10.1016\/j.tiv.2023.105728_bb0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.taap.2015.12.020","article-title":"A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen","volume":"292","author":"Michaut","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105728_bb0220","series-title":"Current Opinion in Toxicology, Systems Toxicology","first-page":"9","article-title":"Human in vitro models of nonalcoholic fatty liver disease","volume":"16","author":"M\u00fcller","year":"2019"},{"key":"10.1016\/j.tiv.2023.105728_bb0225","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.atherosclerosis.2019.02.028","article-title":"Statins and nonalcoholic fatty liver disease in the era of precision medicine: more friends than foes","volume":"284","author":"Nascimbeni","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tiv.2023.105728_bb0230","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.3748\/wjg.v23.i47.8263","article-title":"Clinical epidemiology and disease burden of nonalcoholic fatty liver disease","volume":"23","author":"Perumpail","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tiv.2023.105728_bb0235","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/KFS197","article-title":"Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria","volume":"129","author":"Porceddu","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0240","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","author":"Rinella","year":"2023","journal-title":"Hepatology."},{"key":"10.1016\/j.tiv.2023.105728_bb0245","article-title":"DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies","author":"Rose","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111188","article-title":"Towards improved hepatocyte cultures: progress and limitations","volume":"138","author":"Ruo\u00df","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2023.105728_bb0255","doi-asserted-by":"crossref","first-page":"12782","DOI":"10.3390\/ijms222312782","article-title":"Proteomic changes of activated hepatic stellate cells","volume":"22","author":"Schinagl","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0260","series-title":"Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2018","first-page":"265","article-title":"Cell detection with star-convex polygons","author":"Schmidt","year":"2018"},{"key":"10.1016\/j.tiv.2023.105728_bb0265","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1038\/s41598-022-17860-2","article-title":"Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models","volume":"12","author":"Sullivan","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2023.105728_bb0270","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1872-034X.2007.00072.x","article-title":"A prospective study of acute drug-induced liver injury in patients suffering from non-alcoholic fatty liver disease","volume":"37","author":"Tarantino","year":"2007","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.tiv.2023.105728_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120904","article-title":"A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids","volume":"275","author":"Teng","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2023.105728_bb0280","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ejca.2003.12.004","article-title":"Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil","volume":"40","author":"van Kuilenburg","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.tiv.2023.105728_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121817","article-title":"Modelling fatty liver disease with mouse liver-derived multicellular spheroids","volume":"290","author":"van Os","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2023.105728_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115732","article-title":"Benchmark dose-response analyses for multiple endpoints in drug safety evaluation","volume":"433","author":"Vieira Silva","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tiv.2023.105728_bb0295","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1021\/acsbiomaterials.0c00682","article-title":"Modeling human nonalcoholic fatty liver disease (NAFLD) with an organoids-on-a-chip system","volume":"6","author":"Wang","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.tiv.2023.105728_bb0300","article-title":"Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy","volume":"98","author":"Wy","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.tiv.2023.105728_bb0305","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.tiv.2023.105728_bb0310","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s13691-019-00394-2","article-title":"A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil","volume":"9","author":"Yaegashi","year":"2020","journal-title":"Int. Canc. Conf. J."},{"key":"10.1016\/j.tiv.2023.105728_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110679","article-title":"Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model","volume":"194","author":"Yan","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.tiv.2023.105728_bb0320","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-022-03265-7","article-title":"In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system","author":"Zahmatkesh","year":"2022","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233323001777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233323001777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:45:15Z","timestamp":1760136315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233323001777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":64,"alternative-id":["S0887233323001777"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2023.105728","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2023.105728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105728"}}