{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:27Z","timestamp":1791407007405,"version":"4.3.3"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.tiv.2024.105849","type":"journal-article","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T21:57:26Z","timestamp":1716155846000},"page":"105849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system"],"prefix":"10.1016","volume":"98","author":[{"given":"Melissa Dibbernn","family":"Ganzerla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia de Carvalho","family":"Indolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Cleres Moreira","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabata Renee","family":"Doratioto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayn\u00e1 Mendon\u00e7a","family":"Avelino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Junior","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Bueno","family":"Tofani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiara Ferreira","family":"Terra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Blazutti","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Layane","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Rodrigo","family":"Alborguetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Aparecida","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelen Fabiola","family":"Arroteia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Migliorini","family":"Figueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.tiv.2024.105849_bb0005","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1517\/14712598.2012.707181","article-title":"Advances in the formation. Use and understanding of multi-cellular spheroids","volume":"12","author":"Achilli","year":"2012","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijpharm.2013.10.003","article-title":"Towards the characterization of an in vitro triple co-culture intestine cell model for permeability studies","volume":"458","author":"Ara\u00fajo","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.tiv.2024.105849_bb0020","article-title":"Can animal models of disease reliably inform human studies?","author":"Bart van der Worp","year":"2010","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0025","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","author":"Berger","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.tiv.2024.105849_bb0030","series-title":"The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation-12th Revision-SCCS\/1647\/22","author":"Bernauer","year":"2023"},{"key":"10.1016\/j.tiv.2024.105849_bb0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2009.11.007","article-title":"Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A","volume":"29","author":"Beronius","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2024.105849_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/nbt.2989","article-title":"Microfluidic organs-on-chips","author":"Bhatia","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.tiv.2024.105849_bb0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/026119291304100504","article-title":"An analysis of the use of animal models in predicting human toxicology and drug safety","volume":"41","author":"Bailey","year":"2013","journal-title":"Altern Lab Anim"},{"key":"10.1016\/j.tiv.2024.105849_bb0045","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1289\/ehp.1205330","article-title":"Consortium-based science: the NIEHS\u2019s multipronged. Collaborative approach to assessing the health effects of bisphenol A","volume":"120","author":"Birnbaum","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"11","key":"10.1016\/j.tiv.2024.105849_bb0050","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1517\/17425255.2013.827170","article-title":"The current status of biomarkers for predicting toxicity","volume":"9","author":"Campion","year":"2013","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.tiv.2024.105849_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00112","article-title":"Estrogenic effects of several BPA analogs in the developing zebrafish brain","volume":"10","author":"Cano-Nicolau","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.tiv.2024.105849_bb0060","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00204-014-1301-z","article-title":"Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions","volume":"89","author":"Chen","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tiv.2024.105849_bb0065","series-title":"Kirk-Othmer Encyclopedia of Chemical Technology","article-title":"Sulfolane and Sulfones","author":"Clark","year":"2000"},{"issue":"suppl_1","key":"10.1016\/j.tiv.2024.105849_bb0070","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1093\/toxsci\/kfq365","article-title":"Chemical carcinogenesis","volume":"120","author":"Cohen","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"41","key":"10.1016\/j.tiv.2024.105849_bb0075","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1038\/onc.2010.323","article-title":"Analysis of the genome to personalize therapy for melanoma","volume":"29","author":"Davies","year":"2010","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.tiv.2024.105849_bb0080","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1039\/D3LC00546A","article-title":"Combining a microphysiological system of three organ equivalents and transcriptomics to assess toxicological endpoints for cosmetic ingredients","volume":"23","author":"de Carvalho Indolfo","year":"2023","journal-title":"Lab Chip"},{"key":"10.1016\/j.tiv.2024.105849_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/713696","article-title":"Endocrine-disrupting chemicals: associated disorders and mechanisms of action","volume":"2012","author":"De Coster","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"10.1016\/j.tiv.2024.105849_bb0090","doi-asserted-by":"crossref","DOI":"10.4155\/fsoa-2017-0002","article-title":"The ascendance of microphysiological systems to solve the drug testing dilemma","author":"Dehne","year":"2017","journal-title":"Futur. Sci. OA"},{"key":"10.1016\/j.tiv.2024.105849_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117630","article-title":"Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers","volume":"287","author":"Deng","year":"2021","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tiv.2024.105849_bb0105","author":"EMA (European Medicines Agency)"},{"key":"10.1016\/j.tiv.2024.105849_bb0110","series-title":"Ullmann's Encyclopedia of Industrial Chemistry","article-title":"Phenol derivatives","author":"Fiege","year":"2000"},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0115","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1039\/C6TX00101G","article-title":"Characterization of a functional C3A liver spheroid model","volume":"5","author":"Gaskell","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tiv.2024.105849_bb0120","doi-asserted-by":"crossref","first-page":"122430","DOI":"10.1016\/j.envpol.2023.122430","article-title":"Modulatory effects of bisphenol A on the hepatic immune response","volume":"336","author":"Gebru","year":"2023","journal-title":"Environ Pollut."},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0125","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.3390\/ijms24043595","article-title":"Complexification of in vitro models of intestinal barriers, a true challenge for a more accurate alternative approach","volume":"24","author":"Haddad","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.tiv.2024.105849_bb0130","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2024.105849_bb0135","doi-asserted-by":"crossref","DOI":"10.14573\/altex.2013.3.275","article-title":"Food for thought; look back in anger \u2013 what clinical studies tell us about preclinical work","author":"Hartung","year":"2013","journal-title":"ALTEX"},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.tiv.2024.105849_bb0145","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1507\/endocrj.46.773","article-title":"Differential interactions of bisphenol A and17\u03b2-estradiol with estrogen receptor \u03b1 (ER\u03b1) and ER\u03b2","volume":"46","author":"Hiroi","year":"1999","journal-title":"Endocr. J."},{"key":"10.1016\/j.tiv.2024.105849_bb0150","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.envpol.2018.12.084","article-title":"Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7","volume":"246","author":"Huang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tiv.2024.105849_bb0155","first-page":"57","article-title":"A better and copacetic protocol for histopathological slide preparation using H&E stain: a review","volume":"2","author":"Iftakharul","year":"2021","journal-title":"J. Fish"},{"issue":"3","key":"10.1016\/j.tiv.2024.105849_bb0160","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3390\/ijerph9030698","article-title":"Biomarker genes for detecting estrogenic activity of endocrine disruptors via estrogen receptors","volume":"9","author":"Jung","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2015.06.009","article-title":"A review on endocrine disruptors and their possible impacts on human health","volume":"40","author":"Kabir","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2024.105849_bb0170","doi-asserted-by":"crossref","first-page":"S305","DOI":"10.33549\/physiolres.933723","article-title":"Prenatal exposure to bisphenols and parabens and impacts on human physiology","volume":"66","author":"Kolatorova","year":"2017","journal-title":"Physiol. Res."},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0175","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.3390\/ijerph20042877","article-title":"Migration of BPA from food packaging and household products on the Croatian Market","volume":"20","author":"Krivohlavek","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0180","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1507\/endocrj.49.465","article-title":"The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type","volume":"49","author":"Kurosawa","year":"2002","journal-title":"Endocr. J."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.etap.2004.05.009","article-title":"Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system","volume":"19","author":"Kuruto-Niwa","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0190","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-019-0273-8","article-title":"Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification","volume":"16","author":"La Merrill","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"11","key":"10.1016\/j.tiv.2024.105849_bb0195","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.300.11.1303","article-title":"Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults","volume":"300","author":"Lang","year":"2008","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.tiv.2024.105849_bb0200","doi-asserted-by":"crossref","first-page":"E133","DOI":"10.1152\/ajpendo.00626.2013","article-title":"Extranuclear estrogen receptor's roles in physiology: lessons from mouse models","volume":"307","author":"Levin","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tiv.2024.105849_bb0205","article-title":"The three-dimensional human skin reconstruct model: a tool to study normal skin and melanoma progression","volume":"54","author":"Li","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.tiv.2024.105849_bb0210","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1021\/es300876n","article-title":"Bisphenol S, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol A residues","volume":"46","author":"Liao","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.tiv.2024.105849_bb0215","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1021\/es301334j","article-title":"Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures","volume":"46","author":"Liao","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.tiv.2024.105849_bb0220","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1742-4658.2012.08712.x","article-title":"HuPho: the human phosphatase portal","volume":"280","author":"Liberti","year":"2013","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4093\/dmj.2018.0045","article-title":"Association of bisphenol A and its substitutes, bisphenol F and bisphenol S, with obesity in United States children and adolescents","volume":"43","author":"Liu","year":"2019","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.tiv.2024.105849_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153178","article-title":"Bisphenol S promotes the progression of prostate cancer by regulating the expression of COL1A1 and COL1A2","volume":"472","author":"Liu","year":"2022","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0235","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0240","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1021\/acs.molpharmaceut.6b01165","article-title":"Usefulness of Caco-2\/HT29-MTX and Caco-2\/HT29-MTX\/Raji B coculture models to predict intestinal and colonic permeability compared to Caco-2 monoculture","volume":"14","author":"Lozoya-Agullo","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.tiv.2024.105849_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.959902","article-title":"The role of pregnane X receptor (PXR) in substance metabolism","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tiv.2024.105849_bb0250","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.isci.2018.03.015","article-title":"Bioprinted 3D primary human intestinal tissues model aspects of native physiology and ADME\/Tox functions","volume":"2","author":"Madden","year":"2018","journal-title":"IScience"},{"issue":"7","key":"10.1016\/j.tiv.2024.105849_bb0255","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/humrep\/dew088","article-title":"Does BPA alter steroid hormone synthesis in human granulosa cells in vitro?","volume":"31","author":"Mansur","year":"2016","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.tiv.2024.105849_bb0260","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role. Regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0265","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2013.05.015","article-title":"In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors","volume":"272","author":"Molina-Molina","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9\u201310","key":"10.1016\/j.tiv.2024.105849_bb0270","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.crvi.2017.07.004","article-title":"What is an endocrine disruptor?","volume":"340","author":"Monneret","year":"2017","journal-title":"C. R. Biol."},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4093\/dmj.2019.0027","article-title":"Concern about the safety of bisphenol A substitutes","volume":"43","author":"Moon","year":"2019","journal-title":"Diabetes Metab. J."},{"issue":"1\u20132","key":"10.1016\/j.tiv.2024.105849_bb0280","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann. Tim.","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"1\u20132","key":"10.1016\/j.tiv.2024.105849_bb0285","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jsbmb.2010.10.004","article-title":"Endocrine disrupting chemicals and other substances of concern in food contact materials: an updated review of exposure. Effect and risk assessment","volume":"127","author":"Muncke","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.tiv.2024.105849_bb0290","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2144\/000112591","article-title":"Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels","volume":"43","author":"Napolitano","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.tiv.2024.105849_bb0295","series-title":"Guidance Document on Using In Vitro Data to Estimate in Vivo Starting Doses for Acute Toxicity","author":"National Toxicology Program. and National Toxicology Program","year":"2001"},{"issue":"9","key":"10.1016\/j.tiv.2024.105849_bb0300","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1248\/bpb.24.1064","article-title":"Metabolism and interaction of bisphenol A in human hepatic cytochrome P450 and steroidogenic CYP17","volume":"24","author":"Niwa","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tiv.2024.105849_bb0305","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.scitotenv.2018.02.148","article-title":"Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography\u2013tandem mass spectrometry","volume":"628","author":"Owczarek","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2024.105849_bb0310","series-title":"Endocrine Disruptors: From Scientific Evidence to Human Health Protection","author":"Parliament","year":"2019"},{"issue":"9","key":"10.1016\/j.tiv.2024.105849_bb0315","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1021\/tx500087p","article-title":"Modulation of metabolizing enzymes by bisphenol A in human and animal models","volume":"27","author":"Quesnot","year":"2014","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.tiv.2024.105849_bb0320","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0023","article-title":"Exposure to endocrine disruptors during adulthood: consequences for female fertility","volume":"233","author":"Rattan","year":"2017","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.tiv.2024.105849_bb0325","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/toxics5030022","article-title":"Occupational exposure to bisphenol A (BPA): a reality that still needs to be unveiled","volume":"5","author":"Ribeiro","year":"2017","journal-title":"Toxics"},{"issue":"7","key":"10.1016\/j.tiv.2024.105849_bb0330","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.tiv.2024.105849_bb0335","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/1389200023337171","article-title":"Pharmacogenomics. Regulation and signaling pathways of phase I and II drug metabolizing enzymes","volume":"3","author":"Rushmore","year":"2002","journal-title":"Curr. Drug Metab."},{"issue":"2","key":"10.1016\/j.tiv.2024.105849_bb0340","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202200169","article-title":"Comparative study between the 3D-liver spheroid models developed from hepg2 and immortalized hepatocyte-like cells with primary hepatic stellate coculture for drug metabolism analysis and anticancer drug screening","volume":"6","author":"Sae-be","year":"2023","journal-title":"Adv. Therap."},{"key":"10.1016\/j.tiv.2024.105849_bb0345","article-title":"Human liver spheroids from peripheral blood for liver disease studies","volume":"191","author":"Schott","year":"2023","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tiv.2024.105849_bb0350","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.reprotox.2015.09.006","article-title":"A review of the carcinogenic potential of bisphenol A","volume":"59","author":"Seachrist","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tiv.2024.105849_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.626805","article-title":"A critical perspective on 3D liver models for drug metabolism and toxicology studies","volume":"9","author":"Serras","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tiv.2024.105849_bb0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mrgentox.2017.12.005","article-title":"A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies","volume":"825","author":"Shah","year":"2018","journal-title":"Mutat. Res.\/Genetic Toxicol. Environ. Mutagen."},{"issue":"12","key":"10.1016\/j.tiv.2024.105849_bb0365","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2011-1682","article-title":"Relationship between urinary bisphenol A levels and diabetes mellitus","volume":"96","author":"Shankar","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.tiv.2024.105849_bb0370","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2567.2009.03054.x","article-title":"The aryl hydrocarbon receptor: a perspective on potential roles in the immune system","volume":"127","author":"Stevens","year":"2009","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.tiv.2024.105849_bb0375","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41575-020-00404-2","article-title":"The role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer","volume":"18","author":"Sun","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.tiv.2024.105849_bb0380","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/nu12020532","article-title":"Bisphenol S in food causes hormonal and obesogenic effects comparable to or worse than Bisphenol A: a literature review","volume":"12","author":"Thoene","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.tiv.2024.105849_bb0385","unstructured":"TissUse GmbH n.d.. HUMIMIC Chip3 und HUMIMIC Chip3plus. https:\/\/www.tissuse.com\/en\/humimic\/chips\/humimic-chip3\/.."},{"key":"10.1016\/j.tiv.2024.105849_bb0390","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.chemosphere.2018.12.189","article-title":"BPA. BADGE and analogues: a new multi-analyte LC-ESI-MS\/MS method for their determination and their in vitro (anti) estrogenic and (anti) androgenic properties","volume":"221","author":"van Leeuwen","year":"2019","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0395","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1210\/en.2006-0561","article-title":"Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland","volume":"148","author":"Vandenberg","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tiv.2024.105849_bb0400","doi-asserted-by":"crossref","first-page":"e26490","DOI":"10.4161\/endo.26490","article-title":"Low dose effects of bisphenol A","volume":"1","author":"Vandenberg","year":"2013","journal-title":"Endocrine Disruptors"},{"issue":"1","key":"10.1016\/j.tiv.2024.105849_bb0405","first-page":"54","article-title":"Routes of drug administration","volume":"1","author":"Verma","year":"2010","journal-title":"Int. J. Pharm. Stud. Res."},{"key":"10.1016\/j.tiv.2024.105849_bb0410","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00216-015-9215-z","article-title":"Troubleshooting of the determination of bisphenol A at ultra-trace levels by liquid chromatography and tandem mass spectrometry","volume":"408","author":"Wilczewska","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.tiv.2024.105849_bb0415","first-page":"85","article-title":"Roles for growth factors in cancer progression","volume":"25","author":"Witsch","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.tiv.2024.105849_bb0420","doi-asserted-by":"crossref","first-page":"11431","DOI":"10.1007\/s11356-018-1378-7","article-title":"Probing the toxic mechanism of bisphenol A with acid phosphatase at the molecular level","volume":"25","author":"Xu","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.tiv.2024.105849_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125391","article-title":"Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A","volume":"414","author":"Zhao","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"1\u20132","key":"10.1016\/j.tiv.2024.105849_bb0430","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2007.10.010","article-title":"Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells","volume":"283","author":"Zhou","year":"2008","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233324000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233324000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T18:53:02Z","timestamp":1717354382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233324000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":86,"alternative-id":["S0887233324000791"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2024.105849","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2024.105849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105849"}}