{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:49:23Z","timestamp":1775656163758,"version":"3.50.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001230","name":"Macquarie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.tiv.2025.106058","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:26:19Z","timestamp":1743272779000},"page":"106058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The cyanobacterial toxins BMAA and 2,4-DAB perturb the l-serine biosynthesis pathway and induce systemic changes in energy metabolism in human neuroblastoma cells: A proteomic study"],"prefix":"10.1016","volume":"106","author":[{"given":"Lisa","family":"Pu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel R.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor R.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake P.","family":"Violi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.tiv.2025.106058_bb0005","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: a conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/elps.201100335","article-title":"Bleach gel: a simple agarose gel for analyzing RNA quality","volume":"33","author":"Aranda","year":"2012","journal-title":"Electrophoresis"},{"issue":"sup2","key":"10.1016\/j.tiv.2025.106058_bb0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/17482960903278451","article-title":"Multiple neurotoxic items in the Chamorro diet link BMAA with ALS\/PDC","volume":"10","author":"Banack","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jep.2005.12.032","article-title":"Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands","volume":"106","author":"Banack","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0025","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12640-017-9741-x","article-title":"Studies of environmental risk factors in amyotrophic lateral sclerosis (ALS) and a phase I clinical trial of l-serine","volume":"33","author":"Bradley","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tiv.2025.106058_bb0030","series-title":"Biological Soil Crusts: An Organizing Principle in Drylands","first-page":"55","article-title":"Cyanobacteria and algae of biological soil crusts","author":"B\u00fcdel","year":"2016"},{"issue":"11","key":"10.1016\/j.tiv.2025.106058_bb0035","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.18632\/aging.101661","article-title":"Angiopoietin-1 and \u03b1\u03bd\u03b23 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis\/parkinsonism dementia complex model","volume":"10","author":"Cai","year":"2018","journal-title":"Aging"},{"issue":"sup2","key":"10.1016\/j.tiv.2025.106058_bb0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/17482960903278485","article-title":"A cluster of amyotrophic lateral sclerosis in New Hampshire: a possible role for toxic cyanobacteria blooms","volume":"10","author":"Caller","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/17482968.2011.621436","article-title":"Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA","volume":"13","author":"Caller","year":"2012","journal-title":"Amyotroph. Lateral Scler."},{"issue":"sup2","key":"10.1016\/j.tiv.2025.106058_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/17482960903273528","article-title":"Previous studies underestimate BMAA concentrations in cycad flour","volume":"10","author":"Cheng","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"issue":"23","key":"10.1016\/j.tiv.2025.106058_bb0055","doi-asserted-by":"crossref","first-page":"13380","DOI":"10.1073\/pnas.2235808100","article-title":"Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam","volume":"100","author":"Cox","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"14","key":"10.1016\/j.tiv.2025.106058_bb0060","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1073\/pnas.0501526102","article-title":"Diverse taxa of cyanobacteria produce \u03b2-N-methylamino-l-alanine, a neurotoxic amino acid","volume":"102","author":"Cox","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"sup2","key":"10.1016\/j.tiv.2025.106058_bb0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/17482960903286066","article-title":"Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among gulf war veterans","volume":"10","author":"Cox","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"issue":"1823","key":"10.1016\/j.tiv.2025.106058_bb0070","first-page":"20152397","article-title":"Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain","volume":"283","author":"Cox","year":"2016","journal-title":"Proc. Biol. Sci."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0075","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ana.10312","article-title":"Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis","volume":"52","author":"Cutler","year":"2002","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0080","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jnen\/nlaa002","article-title":"L-serine reduces spinal cord pathology in a Vervet model of preclinical ALS\/MND","volume":"79","author":"Davis","year":"2020","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00019052-200404000-00019","article-title":"Serine-deficiency syndromes","volume":"17","author":"de Koning","year":"2004","journal-title":"Curr. Opin. Neurol."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0090","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bj20021785","article-title":"L-serine in disease and development","volume":"371","author":"de Koning","year":"2003","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1574-6976.2012.12000.x","article-title":"Cyanobacterial toxins: biosynthetic routes and evolutionary roots","volume":"37","author":"Dittmann","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.tiv.2025.106058_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/ene.12663","article-title":"Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?","volume":"22","author":"Dohrn","year":"2015","journal-title":"Eur. J. Neurol."},{"issue":"10","key":"10.1016\/j.tiv.2025.106058_bb0105","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg2662","article-title":"The evolutionary consequences of erroneous protein synthesis","volume":"10","author":"Drummond","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"9","key":"10.1016\/j.tiv.2025.106058_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075376","article-title":"The non-protein amino acid BMAA is Misincorporated into human proteins in place of l-serine causing protein Misfolding and aggregation","volume":"8","author":"Dunlop","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.tiv.2025.106058_bb0115","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database","volume":"5","author":"Eng","year":"1994","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.tiv.2025.106058_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tox.2013.07.010","article-title":"The cyanobacterial amino acid \u03b2-N-methylamino-l-alanine perturbs the intermediary metabolism in neonatal rats","volume":"312","author":"Engskog","year":"2013","journal-title":"Toxicology"},{"issue":"23","key":"10.1016\/j.tiv.2025.106058_bb0125","doi-asserted-by":"crossref","first-page":"14595","DOI":"10.1074\/jbc.M114.603860","article-title":"L-serine deficiency elicits intracellular accumulation of cytotoxic Deoxysphingolipids and lipid body formation","volume":"290","author":"Esaki","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10142-007-0072-5","article-title":"Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency","volume":"8","author":"Furuya","year":"2008","journal-title":"Funct. Integr. Genom."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ana.410100405","article-title":"Amyotrophic lateral sclerosis and parkinsonism-dementia among Filipino migrants to Guam","volume":"10","author":"Garruto","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.tiv.2025.106058_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-023-00867-2","article-title":"The Amyotrophic Lateral Sclerosis Exposome: Recent Advances and Future Directions","author":"Goutman","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.tiv.2025.106058_bb0145","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0021-9258(17)49898-X","article-title":"The mechanism of beta-N-methylamino-l-alanine inhibition of tRNA aminoacylation and its impact on misincorporation","volume":"295","author":"Han","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.tiv.2025.106058_bb0150","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1038\/s41596-018-0014-9","article-title":"High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform","volume":"13","author":"Humphrey","year":"2018","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0155","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cell.2015.06.043","article-title":"The BioPlex network: a systematic exploration of the human Interactome","volume":"162","author":"Huttlin","year":"2015","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF01799435","article-title":"3-phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesis","volume":"19","author":"Jaeken","year":"1996","journal-title":"J. Inherit. Metab. Dis."},{"issue":"4\u20135","key":"10.1016\/j.tiv.2025.106058_bb0165","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuint.2007.10.003","article-title":"The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells","volume":"52","author":"Jantas","year":"2008","journal-title":"Neurochem. Int."},{"issue":"24","key":"10.1016\/j.tiv.2025.106058_bb0170","doi-asserted-by":"crossref","first-page":"19786","DOI":"10.1074\/jbc.R112.357194","article-title":"Resurgence of serine: an often neglected but indispensable amino acid","volume":"287","author":"Kalhan","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.tiv.2025.106058_bb0175","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1007\/s10661-014-3710-0","article-title":"Cyanotoxin management and human health risk mitigation in recreational waters","volume":"186","author":"Koreivien\u0117","year":"2014","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.tiv.2025.106058_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fncel.2015.00091","article-title":"Researching glutamate\u2013induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study","volume":"9","author":"Kritis","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0185","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10517-007-0390-6","article-title":"Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced differentiation","volume":"144","author":"Kulikov","year":"2007","journal-title":"Bull. Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.tiv.2025.106058_bb0190","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1212\/WNL.4.6.438","article-title":"Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution and special reference to the Mariana Islands, including clinical and pathologic observations","volume":"4","author":"Kurland","year":"1954","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0195","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuron.2014.07.001","article-title":"A computational model of motor neuron degeneration","volume":"83","author":"Le Masson","year":"2014","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0200","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0205","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nbd.2006.10.002","article-title":"\u03b2-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms","volume":"25","author":"Lobner","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0210","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12640-017-9763-4","article-title":"Assessing the combined toxicity of BMAA and its isomers 2,4-DAB and AEG in vitro using human neuroblastoma cells","volume":"33","author":"Main","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tiv.2025.106058_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2015.11.003","article-title":"The use of l-serine to prevent \u03b2-methylamino-l-alanine (BMAA)-induced proteotoxic stress in vitro","volume":"109","author":"Main","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.tiv.2025.106058_bb0220","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2019.04.013","article-title":"Mixture designs to investigate adverse effects upon co-exposure to environmental cyanotoxins","volume":"421","author":"Martin","year":"2019","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12640-021-00465-4","article-title":"The cyanotoxin 2,4-DAB reduces viability and causes behavioral and molecular dysfunctions associated with neurodegeneration in larval zebrafish","volume":"40","author":"Martin","year":"2022","journal-title":"Neurotox. Res."},{"issue":"17","key":"10.1016\/j.tiv.2025.106058_bb0230","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/ac301572t","article-title":"Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses","volume":"84","author":"McAlister","year":"2012","journal-title":"Anal. Chem."},{"issue":"14","key":"10.1016\/j.tiv.2025.106058_bb0235","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"J. Anal. Chem."},{"issue":"7844","key":"10.1016\/j.tiv.2025.106058_bb0240","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0140-6736(73)92735-9","article-title":"Motoneurone disease and ageing","volume":"2","author":"McComas","year":"1973","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0245","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12640-017-9814-x","article-title":"L-serine: a naturally-occurring amino acid with therapeutic potential","volume":"33","author":"Metcalf","year":"2018","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0250","doi-asserted-by":"crossref","first-page":"12685","DOI":"10.1038\/s41598-017-12858-7","article-title":"Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes","volume":"7","author":"Mirzaei","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2025.106058_bb0255","series-title":"Proteome Bioinformatics","first-page":"45","article-title":"TMT one-stop shop: From reliable sample preparation to computational analysis platform","author":"Mirzaei","year":"2017"},{"issue":"7","key":"10.1016\/j.tiv.2025.106058_bb0260","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41591-021-01346-1","article-title":"Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis","volume":"27","author":"Mohassel","year":"2021","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.tiv.2025.106058_bb0265","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1073\/pnas.1521548113","article-title":"Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers","volume":"113","author":"Mullarky","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0270","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/toxsci\/kfs291","article-title":"L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low Nonexcitotoxic concentrations","volume":"131","author":"Okle","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0275","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1042\/bj1060699","article-title":"The \u2018neurotoxicity\u2019 of L-2,4-diaminobutyric acid","volume":"106","author":"O\u2019Neal","year":"1968","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.tiv.2025.106058_bb0280","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nchembio.2070","article-title":"A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate","volume":"12","author":"Pacold","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tiv.2025.106058_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1137893","article-title":"Sphingolipids in neurodegenerative diseases","volume":"17","author":"Pan","year":"2023","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.tiv.2025.106058_bb0290","first-page":"1473","article-title":"Distribution and toxicity of alpha-amino-beta-methylaminopropionic acid","volume":"31","author":"Polsky","year":"1972","journal-title":"Fed. Proc."},{"issue":"9","key":"10.1016\/j.tiv.2025.106058_bb0295","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00726-021-03049-w","article-title":"\u03b2-Methylamino-L-alanine-induced protein aggregation in vitro and protection by L-serine","volume":"53","author":"Quinn","year":"2021","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.tiv.2025.106058_bb0300","doi-asserted-by":"crossref","first-page":"12347","DOI":"10.3390\/s120912347","article-title":"Multiple applications of Alamar blue as an indicator of metabolic function and cellular health in cell viability bioassays","volume":"12","author":"Rampersad","year":"2012","journal-title":"Sensors"},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0305","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/oxfordjournals.aje.a120570","article-title":"The amyotrophic lateral sclerosis\/parkinsonism-dementia complex: a ten-year follow-up on Guam. I. Epidemiologic studies","volume":"83","author":"Reed","year":"1966","journal-title":"Am. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0310","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1038\/s41467-018-07868-6","article-title":"Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism","volume":"9","author":"Reid","year":"2018","journal-title":"Nat. Commun."},{"issue":"3473","key":"10.1016\/j.tiv.2025.106058_bb0315","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.134.3473.188","article-title":"Isolation and identification of a neuroactive factor from Lathyrus latifolius","volume":"134","author":"Ressler","year":"1961","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0320","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12640-017-9757-2","article-title":"Cyanobacterial neurotoxins: their occurrence and mechanisms of toxicity","volume":"33","author":"Rodgers","year":"2018","journal-title":"Neurotox. Res."},{"issue":"10","key":"10.1016\/j.tiv.2025.106058_bb0325","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/cdd.2012.33","article-title":"Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration","volume":"19","author":"Rodriguez-Rodriguez","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tiv.2025.106058_bb0330","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.toxicon.2020.06.014","article-title":"Neurotoxicity of isomers of the environmental toxin L-BMAA","volume":"184","author":"Schneider","year":"2020","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.tiv.2025.106058_bb0335","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/j.1471-4159.1987.tb01039.x","article-title":"Kinetics of neutral amino acid transport across the blood-brain barrier","volume":"49","author":"Smith","year":"1987","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0340","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.femsec.2004.12.007","article-title":"The distribution of cyanobacteria across physical and chemical gradients in hot springs in northern Thailand","volume":"52","author":"Sompong","year":"2005","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.tiv.2025.106058_bb0345","first-page":"221","article-title":"Discovery and partial characterization of primate motor-system toxins","volume":"126","author":"Spencer","year":"1987","journal-title":"CIBA Found. Symp."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0350","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/brv.12140","article-title":"The return of metabolism: biochemistry and physiology of the pentose phosphate pathway","volume":"90","author":"Stincone","year":"2015","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0355","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ymgme.2009.10.012","article-title":"L-serine synthesis in the central nervous system: a review on serine deficiency disorders","volume":"99","author":"Tabatabaie","year":"2010","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.tiv.2025.106058_bb0360","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1574-6941.2006.00110.x","article-title":"Biogeographical distribution and ecological ranges of benthic cyanobacteria in East Antarctic lakes","volume":"57","author":"Taton","year":"2006","journal-title":"FEMS Microbiol. Ecol."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0365","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00401-018-1835-x","article-title":"Energy metabolism in ALS: an underappreciated opportunity?","volume":"135","author":"Vandoorne","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.tiv.2025.106058_bb0370","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ecoenv.2019.01.046","article-title":"Prevalence of \u03b2-methylamino-L-alanine (BMAA) and its isomers in freshwater cyanobacteria isolated from eastern Australia","volume":"172","author":"Violi","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.tiv.2025.106058_bb0375","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15110647","article-title":"Effects of the toxic non-protein amino acid beta-Methylamino-L-Alanine (BMAA) on intracellular amino acid levels in neuroblastoma cells","volume":"vol. 15","author":"Violi","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.tiv.2025.106058_bb0380","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0896-6273(89)90256-0","article-title":"Bicarbonate dependence of glutamate receptor activation by \u03b2-N-methylamino-l-alanine: channel recording and study with related compounds","volume":"3","author":"Weiss","year":"1989","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.tiv.2025.106058_bb0385","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","article-title":"A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids","volume":"138","author":"Wessel","year":"1984","journal-title":"J. Anal. Biochem."},{"issue":"4","key":"10.1016\/j.tiv.2025.106058_bb0390","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF02860136","article-title":"Toxicity of cycads","volume":"17","author":"Whiting","year":"1963","journal-title":"Econ. Bot."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325000529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325000529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T22:37:14Z","timestamp":1744411034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233325000529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":78,"alternative-id":["S0887233325000529"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106058","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cyanobacterial toxins BMAA and 2,4-DAB perturb the l-serine biosynthesis pathway and induce systemic changes in energy metabolism in human neuroblastoma cells: A proteomic study","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106058"}}