{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T22:40:07Z","timestamp":1750718407714,"version":"3.41.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002742","name":"Banaras Hindu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018784","name":"Indian Institute of Technology (BHU) Varanasi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tiv.2025.106079","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:42:27Z","timestamp":1747136547000},"page":"106079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cadmium sulfide nanoparticles (CdSNPs) modulate key oncogenic pathways in PA1 ovarian cancer cells: Insights from transcriptomic analysis"],"prefix":"10.1016","volume":"107","author":[{"given":"Aditi","family":"Bhatnagar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay Dev","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abha","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2025.106079_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-45144-w","article-title":"Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations","volume":"13","author":"Abbas","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2025.106079_bb0010","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2147\/IJN.S355408","article-title":"Transcriptomics-based investigation of molecular mechanisms underlying apoptosis induced by ZnO nanoparticles in human diffuse large B-cell lymphoma","volume":"17","author":"Alsagaby","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2025.106079_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118914","article-title":"Nanotechnology in ovarian cancer: diagnosis and treatment","volume":"266","author":"Barani","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0020","first-page":"C255","article-title":"Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer","volume":"301","author":"Becchetti","year":"2011","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.tiv.2025.106079_bb0025","article-title":"Development of Daruharidra (Berberis aristata) based biogenic cadmium sulfide nanoparticles: their implementation as antibacterial and novel therapeutic agents against human breast and ovarian cancer","volume":"25","author":"Bhatnagar","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.tiv.2025.106079_bb0030","series-title":"From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology","first-page":"39","article-title":"Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression","author":"Boedtkjer","year":"2022"},{"key":"10.1016\/j.tiv.2025.106079_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-9-686","article-title":"Biosynthesis of luminescent CdS quantum dots using plant hairy root culture","volume":"9","author":"Borovaya","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.tiv.2025.106079_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.13207","article-title":"B vitamins in the nervous system: current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin","volume":"26","author":"Calder\u00f3n-Ospina","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tiv.2025.106079_bb0045","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biomaterials.2011.10.070","article-title":"The cytotoxicity of cadmium-based quantum dots","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.tiv.2025.106079_bb0050","first-page":"1","article-title":"Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.tiv.2025.106079_bb0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12906-022-03579-0","article-title":"Parthenolide leads to proteomic differences in thyroid cancer cells and promotes apoptosis","volume":"22","author":"Cui","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.tiv.2025.106079_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-020-01684-z","article-title":"miR-335-5p suppresses gastric cancer progression by targeting MAPK10","volume":"21","author":"Gao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.tiv.2025.106079_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-019-0953-4","article-title":"Effect of hyperoside on cervical cancer cells and transcriptome analysis of differentially expressed genes","volume":"19","author":"Guo","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.tiv.2025.106079_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100184","article-title":"Berberis aristata and its secondary metabolites: insights into nutraceutical and therapeutical applications","volume":"5","author":"Jahan","year":"2022","journal-title":"Pharmacol. Res. Modern Chin. Med."},{"key":"10.1016\/j.tiv.2025.106079_bb0075","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1210\/er.2003-0008","article-title":"Regulation of cell cycle progression by calcium\/calmodulin-dependent pathways","volume":"24","author":"Kahl","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tiv.2025.106079_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/jmbi.1999.3007","article-title":"Zinc finger peptides for the regulation of gene expression","volume":"293","author":"Klug","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tiv.2025.106079_bb0085","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature22965","article-title":"PTEN counteracts FBXL2 to promote IP3R3-and Ca2+\u2212mediated apoptosis limiting tumour growth","volume":"546","author":"Kuchay","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tiv.2025.106079_bb0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0959-440X(00)00167-6","article-title":"Zinc finger proteins: new insights into structural and functional diversity","volume":"11","author":"Laity","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.tiv.2025.106079_bb0095","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s13402-021-00651-8","article-title":"IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt\/\u03b2-catenin signaling","volume":"44","author":"Li","year":"2021","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.tiv.2025.106079_bb0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemistry, metabolism and clinical benefits of thiamin (e) and its derivatives","volume":"3","author":"Lonsdale","year":"2006","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.tiv.2025.106079_bb0105","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1073\/pnas.96.20.11364","article-title":"RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination","volume":"96","author":"Lorick","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2021.100433","article-title":"Recent advances on Berberis aristata emphasizing berberine alkaloid including phytochemistry, pharmacology and drug delivery system","volume":"27","author":"Malhotra","year":"2021","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.tiv.2025.106079_bb0115","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.cell.2020.07.017","article-title":"Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing","volume":"182","author":"Maynard","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.tiv.2025.106079_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119935","article-title":"HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis","volume":"284","author":"Meng","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0125","article-title":"Nanoparticle delivery systems to combat drug resistance in ovarian cancer","volume":"31","author":"Miller","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.tiv.2025.106079_bb0130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrc.2017.18","article-title":"The calcium\u2013cancer signalling nexus","volume":"17","author":"Monteith","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tiv.2025.106079_bb0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0303-2647(98)00017-3","article-title":"Computation with the KEGG pathway database","volume":"47","author":"Ogata","year":"1998","journal-title":"BioSystems"},{"key":"10.1016\/j.tiv.2025.106079_bb0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bdq.2018.02.001","article-title":"A PCR-based quantitative assay for the evaluation of mRNA integrity in rat samples","volume":"15","author":"Padhi","year":"2018","journal-title":"Biomol. Detect. Quantif."},{"key":"10.1016\/j.tiv.2025.106079_bb0145","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.fitote.2012.04.012","article-title":"Phyto-chemical and pharmacological applications of Berberis aristata","volume":"83","author":"Potdar","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.tiv.2025.106079_bb0150","doi-asserted-by":"crossref","first-page":"20130097","DOI":"10.1098\/rstb.2013.0097","article-title":"Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?","volume":"369","author":"Prevarskaya","year":"2014","journal-title":"Philos. Trans. R. Soc. B"},{"key":"10.1016\/j.tiv.2025.106079_bb0155","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3390\/genes11101190","article-title":"Low RIN value for RNA-seq library construction from long-term stored seeds: a case study of barley seeds","volume":"11","author":"Puchta","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.tiv.2025.106079_bb0160","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11427-013-4561-6","article-title":"Potential antitumor mechanisms of phenothiazine drugs","volume":"56","author":"Qi","year":"2013","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0165","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s43032-019-00047-y","article-title":"miR-205-3p functions as a tumor suppressor in ovarian carcinoma","volume":"27","author":"Qiao","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0170","first-page":"194","article-title":"Multi-perspective quality control of Illumina RNA sequencing data analysis","volume":"16","author":"Sheng","year":"2017","journal-title":"Brief. Funct. Genomics"},{"key":"10.1016\/j.tiv.2025.106079_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bbrc.2017.05.070","article-title":"Alpha B-crystallin promotes the invasion and metastasis of colorectal cancer via epithelial-mesenchymal transition","volume":"489","author":"Shi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tiv.2025.106079_bb0180","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/acsanm.8b00147","article-title":"Green-synthesis-derived CdS quantum dots using tea leaf extract: antimicrobial, bioimaging, and therapeutic applications in lung Cancer cells","volume":"1","author":"Shivaji","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.tiv.2025.106079_bb0185","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.apsusc.2019.05.050","article-title":"Utilization of waste tea leaves as bio-surfactant in CdS quantum dots synthesis and their cytotoxicity effect in breast cancer cells","volume":"487","author":"Shivaji","year":"2019","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ygeno.2021.11.031","article-title":"Gene expression profiles and pathway enrichment analysis to identification of differentially expressed gene and signaling pathways in epithelial ovarian cancer based on high-throughput RNA-seq data","volume":"114","author":"Siavoshi","year":"2022","journal-title":"Genomics"},{"key":"10.1016\/j.tiv.2025.106079_bb0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ygeno.2021.11.031","article-title":"Gene expression profiles and pathway enrichment analysis to identification of differentially expressed gene and signaling pathways in epithelial ovarian cancer based on high-throughput RNA-seq data","volume":"114","author":"Siavoshi","year":"2022","journal-title":"Genomics"},{"key":"10.1016\/j.tiv.2025.106079_bb0200","doi-asserted-by":"crossref","first-page":"14394","DOI":"10.1038\/s41598-019-50840-7","article-title":"Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment","volume":"9","author":"Sojka","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2025.106079_bb0205","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1080\/09553002.2019.1665213","article-title":"Radiotherapy in combination with hyperthermia suppresses lung cancer progression via increased NR4A3 and KLF11 expression","volume":"95","author":"Son","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.tiv.2025.106079_bb0210","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.7150\/thno.35861","article-title":"19q13 KRAB zinc-finger protein ZNF471 activates MAPK10\/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.tiv.2025.106079_bb0215","article-title":"Nanoparticles as an emerging tool to alter the gene expression: preparation and conjugation methods","volume":"17","author":"Thakur","year":"2020","journal-title":"Mater. Today Chem."},{"key":"10.1016\/j.tiv.2025.106079_bb0220","article-title":"Glypican1: a potential cancer biomarker for nanotargeted therapy","volume":"103660","author":"Tripathi","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.tiv.2025.106079_bb0225","first-page":"2659","article-title":"Prediction of candidate RNA signatures for recurrent ovarian cancer prognosis by the construction of an integrated competing endogenous RNA network","volume":"40","author":"Wang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.tiv.2025.106079_bb0230","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.chemosphere.2019.05.129","article-title":"A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol a in rats","volume":"231","author":"Yang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2025.106079_bb0235","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1349-7006.2004.tb03220.x","article-title":"Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications","volume":"95","author":"Yasui","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.tiv.2025.106079_bb0240","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.tiv.2025.106079_bb0245","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13046-017-0599-9","article-title":"The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin\/NFAT1 axis","volume":"36","author":"Zhou","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.tiv.2025.106079_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-019-1090-3","article-title":"AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325000736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325000736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T22:26:40Z","timestamp":1750717600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233325000736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"alternative-id":["S0887233325000736"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106079","relation":{},"ISSN":["0887-2333"],"issn-type":[{"type":"print","value":"0887-2333"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium sulfide nanoparticles (CdSNPs) modulate key oncogenic pathways in PA1 ovarian cancer cells: Insights from transcriptomic analysis","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106079"}}