{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:18:50Z","timestamp":1785583130484,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013062","name":"G\u00e9nome Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008638","name":"Environment and Climate Change Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tiv.2025.106129","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:30:35Z","timestamp":1755239435000},"page":"106129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Transcriptomic points of departure for 6PPD-Quinone derived from human Caco-2 and HepG2 cells"],"prefix":"10.1016","volume":"109","author":[{"given":"Ke","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krittika","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niladri","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.tiv.2025.106129_bb0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/acs.estlett.4c00342","article-title":"Biotransformation of 6PPD-quinone in vitro using RTL-W1 cell line","volume":"11","author":"Ankley","year":"2024","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tiv.2025.106129_bb0015","series-title":"Standard Methods for Development of EPA Transcriptomic Assessment Products (ETAPs). (360671). Washington, DC","author":"Brennan","year":"2024"},{"issue":"4","key":"10.1016\/j.tiv.2025.106129_bb0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1021\/acs.estlett.2c00050","article-title":"Acute toxicity of the Tire rubber-derived chemical 6PPD-quinone to four fishes of commercial, cultural, and ecological importance","volume":"9","author":"Brinkmann","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tiv.2025.106129_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131245","article-title":"Analysis, environmental occurrence, fate and potential toxicity of tire wear compounds 6PPD and 6PPD-quinone","volume":"452","author":"Chen","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"12","key":"10.1016\/j.tiv.2025.106129_bb0035","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.estlett.2c00821","article-title":"First report on the occurrence of N-(1, 3-dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from South China","volume":"9","author":"Du","year":"2022","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tiv.2025.106129_bb0040","series-title":"Comptox Chemicals Dashboard","article-title":"6ppd quinone","author":"EPA","year":"2024"},{"key":"10.1016\/j.tiv.2025.106129_bb0045","series-title":"Acute Aquatic Life Screening Value for 6PPD-Quinone in Freshwater. Washington, DC","author":"EPA","year":"2024"},{"issue":"7","key":"10.1016\/j.tiv.2025.106129_bb0050","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/bioinformatics\/btaa700","article-title":"FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data","volume":"37","author":"Ewald","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.tiv.2025.106129_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133312","article-title":"6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by \u03b1-synuclein preformed fibrils seeding","volume":"465","author":"Fang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.tiv.2025.106129_bb0060","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1021\/envhealth.3c00205","article-title":"Unexpected exposure risks to emerging aromatic amine antioxidants and p-phenylenediamine quinones to residents: evidence from external and internal exposure as well as hepatotoxicity evaluation","volume":"2","author":"Guo","year":"2024","journal-title":"Environment & Health"},{"key":"10.1016\/j.tiv.2025.106129_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.105020","article-title":"Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology","volume":"125","author":"Harrill","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2025.106129_bb0070","first-page":"5954","article-title":"The DIKW of transcriptomics in ecotoxicology: extracting information, knowledge, and wisdom from big data","author":"Head","year":"2024","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tiv.2025.106129_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108677","article-title":"Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone","volume":"187","author":"Jiang","year":"2024","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.tiv.2025.106129_bb0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/toxsci\/kfac097","article-title":"A transformative vision for an omics-based regulatory chemical testing paradigm","volume":"190","author":"Johnson","year":"2022","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.tiv.2025.106129_bb0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.scib.2023.12.045","article-title":"Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout","volume":"69","author":"Liao","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.tiv.2025.106129_bb0090","author":"Liu"},{"issue":"9","key":"10.1016\/j.tiv.2025.106129_bb0030","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/acs.estlett.2c00431","article-title":"Exposure to the tire rubber-derived contaminant 6PPD-quinone causes mitochondrial dysfunction in vitro","volume":"9","author":"Mahoney","year":"2022","journal-title":"Environmental Science & Technology Letters"},{"key":"10.1016\/j.tiv.2025.106129_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.106001","article-title":"TPD-seq: A high throughput RNA-seq method to derive transcriptomic points of departure from cell lines","volume":"104","author":"Mittal","year":"2025","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2025.106129_bb0135","series-title":"RNA-Seq Alignment and Differential Expression Software Comparison","author":"Munster","year":"2023"},{"issue":"23","key":"10.1016\/j.tiv.2025.106129_bb0100","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2025.106129_bb0105","series-title":"Test No. 249: Fish Cell Line Acute Toxicity - The RTgill-W1 cell line assay","author":"OECD","year":"2021"},{"issue":"6","key":"10.1016\/j.tiv.2025.106129_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12060389","article-title":"Effects of 6PPD-Quinone on human liver cell lines as revealed with cell viability assay and metabolomics analysis","volume":"12","author":"Qi","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.tiv.2025.106129_bb0115","doi-asserted-by":"crossref","first-page":"1194895","DOI":"10.3389\/ftox.2023.1194895","article-title":"From vision toward best practices: evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow","volume":"5","author":"Reardon","year":"2023","journal-title":"Front Toxicol"},{"key":"10.1016\/j.tiv.2025.106129_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-005-0085-6","article-title":"The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics","volume":"21","author":"Sambuy","year":"2005","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.tiv.2025.106129_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108082","article-title":"New approach methodologies in human regulatory toxicology\u2013not if, but how and when!","volume":"178","author":"Schmeisser","year":"2023","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.tiv.2025.106129_bib166","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.toxlet.2009.09.002","article-title":"CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells","volume":"191","author":"Sergent","year":"2009","journal-title":"Toxicol. Lett."},{"issue":"6525","key":"10.1016\/j.tiv.2025.106129_bb0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.abd6951","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.tiv.2025.106129_bb0140","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1007\/s00204-022-03365-4","article-title":"A framework for establishing scientific confidence in new approach methodologies","volume":"96","author":"Van der Zalm","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.tiv.2025.106129_bb0145","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1124\/dmd.31.8.1035","article-title":"Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties","volume":"31","author":"Wilkening","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tiv.2025.106129_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161373","article-title":"A new toxicity mechanism of N-(1,3-Dimethylbutyl)-N\u2032-phenyl-p-phenylenediamine quinone: formation of DNA adducts in mammalian cells and aqueous organisms","volume":"866","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2025.106129_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113501","article-title":"Transcriptomic points of departure calculated from human intestinal cells exposed to dietary nanoparticles","volume":"170","author":"Xu","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2025.106129_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123514","article-title":"In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: kinetics, pathways, and mechanism","volume":"345","author":"Zhang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tiv.2025.106129_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171393","article-title":"A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China","volume":"922","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325001237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325001237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:20:35Z","timestamp":1756880435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233325001237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"alternative-id":["S0887233325001237"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106129","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic points of departure for 6PPD-Quinone derived from human Caco-2 and HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106129"}}