{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:35:19Z","timestamp":1792697719311,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.tiv.2025.106168","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:47:05Z","timestamp":1760503625000},"page":"106168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Assessment of ocular irritation potential of moisturizing and sunscreen cosmetic creams marketed in Algeria using the HET-CAM test"],"prefix":"10.1016","volume":"111","author":[{"given":"Mecheri","family":"Imane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djafer","family":"Rachid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belmahi Mohamed","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2025.106168_bb0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.addr.2017.12.017","article-title":"Ophthalmic gels: past, present and future","volume":"126","author":"Al-Kinani","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.tiv.2025.106168_bb0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/jid.1952.52","article-title":"Factors which influence the water content of the stratum corneum","volume":"18","author":"Blank","year":"1952","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.tiv.2025.106168_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.yrtph.2014.02.003","article-title":"Toxic metals contained in cosmetics: a status report","volume":"68","author":"Bocca","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tiv.2025.106168_bb0020","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114517002227","article-title":"The 3Rs in research: a contemporary approach to replacement, reduction and refinement","volume":"120","author":"Clark","year":"2018","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.tiv.2025.106168_bb0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tiv.2010.12.003","article-title":"Survey of ocular irritation predictive capacity using Chorioallantoic membrane vascular assay (CAMVA) and bovine corneal opacity and permeability (BCOP) test historical data for 319 personal care products over fourteen years","volume":"25","author":"Donahue","year":"2011","journal-title":"Toxicol. in Vitro"},{"issue":"1","key":"10.1016\/j.tiv.2025.106168_bb0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1365-4362.2001.00113.x","article-title":"So moisturizers may cause trouble!","volume":"40","author":"Held","year":"2001","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.tiv.2025.106168_bb0035","author":"L\u00e9gifrance"},{"issue":"6","key":"10.1016\/j.tiv.2025.106168_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0278-6915(86)90099-2","article-title":"The HET-CAM test: an alternative to the Draize eye test","volume":"24","author":"Luepke","year":"1986","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2025.106168_bb0045","first-page":"5","article-title":"Executive Decree No. 10\u2013114 of 18 April 2010 amending and supplementing Executive Decree No. 97\u201337 of 14 January 1997 [in French]","volume":"26","author":"Minist\u00e8re du Commerce, Alg\u00e9rie","year":"2010","journal-title":"J. Off. R\u00e9pub. Alg\u00e9r."},{"key":"10.1016\/j.tiv.2025.106168_bb0050","series-title":"Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants [Internet]","author":"OECD","year":"2012"},{"key":"10.1016\/j.tiv.2025.106168_bb0055","series-title":"Test No. 405: Acute Eye Irritation\/Corrosion [Internet]","author":"OECD","year":"2021"},{"key":"10.1016\/j.tiv.2025.106168_bb0060","series-title":"Test No. 492: Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage [Internet]","author":"OECD","year":"2022"},{"key":"10.1016\/j.tiv.2025.106168_bb0065","series-title":"Test No. 437: Bovine Corneal Opacity and Permeability (BCOP) Test Method for Identifying (I) Chemicals Inducing Serious Eye Damage and (II) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage [Internet]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2025.106168_bb0070","series-title":"Test No. 438: Isolated Chicken Eye (ICE) Test Method for Identifying (I) Chemicals Inducing Serious Eye Damage and (II) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage [Internet]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2025.106168_bb0075","first-page":"21","article-title":"\u201cMoisturizers\u201d (Hydratants) & Cosm\u00e9tique - Entre mythe, r\u00e9alit\u00e9 et controverse","volume":"5","author":"Pott","year":"2006","journal-title":"MiDiFABs"},{"key":"10.1016\/j.tiv.2025.106168_bb0080","series-title":"SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation 12th revision, 15 May 2023, Corrigendum 1 on 26 October 2023, Corrigendum 2 on 21 December 2023, SCCS\/1647\/22","author":"Scientific Committee on Consumer Safety (SCCS)","year":"2025"},{"issue":"2","key":"10.1016\/j.tiv.2025.106168_bb0085","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0887-2333(98)00091-5","article-title":"The HET-CAM, a useful in vitro assay for assessing the eye irritation properties of cosmetic formulations and ingredients","volume":"13","author":"Steiling","year":"1999","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.tiv.2025.106168_bb0090","first-page":"36","article-title":"Photoprotection solaire interne et externe","volume":"14","author":"Talvas","year":"2018","journal-title":"Prat. Nutr. Sant\u00e9 Alim."},{"issue":"2","key":"10.1016\/j.tiv.2025.106168_bb0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1011-1344(98)00137-7","article-title":"Efficacy of micronized titanium dioxide-containing compounds in protection against UVB-induced immunosuppression in humans in vivo","volume":"44","author":"Van Der Molen","year":"1998","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.tiv.2025.106168_bb0100","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1039\/C6RA25267B","article-title":"In silico prediction of serious eye irritation or corrosion potential of chemicals","volume":"7","author":"Wang","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.tiv.2025.106168_bb0105","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2014.11.003","article-title":"An overview of current techniques for ocular toxicity testing","volume":"327","author":"Wilson","year":"2015","journal-title":"Toxicology"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325001626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233325001626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:31:57Z","timestamp":1764937917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233325001626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":21,"alternative-id":["S0887233325001626"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106168","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of ocular irritation potential of moisturizing and sunscreen cosmetic creams marketed in Algeria using the HET-CAM test","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2025.106168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106168"}}