{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:02:49Z","timestamp":1780531369864,"version":"3.54.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56 AR070181"],"award-info":[{"award-number":["R56 AR070181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tiv.2026.106230","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:59:32Z","timestamp":1775026772000},"page":"106230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In-vitro study and in-vivo zebrafish model to minimize the toxic effects of implant (CoCrMo particles) by antioxidants"],"prefix":"10.1016","volume":"115","author":[{"given":"Sowmya Gurusamy","family":"Kamaraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha","family":"Kanniyappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Thayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puranjay","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareeswari","family":"Paramasivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Oral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Min","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew T.","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2026.106230_bb0005","article-title":"Beyond tissue replacement: the emerging role of smart implants in healthcare","volume":"22","author":"Abyzova","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.tiv.2026.106230_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e14557","article-title":"Effectiveness of zebrafish models in understanding human diseases-a review of models","volume":"9","author":"Adhish","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.tiv.2026.106230_bb0015","article-title":"Recent advances in the pharmacological properties and molecular mechanisms of carvacrol","volume":"34","author":"Ali","year":"2023","journal-title":"Rev. Bras"},{"key":"10.1016\/j.tiv.2026.106230_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/polym15122601","article-title":"Biomaterials as implants in the orthopedic field for regenerative medicine: metal versus synthetic polymers","volume":"15","author":"Al-Shalawi","year":"2023","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.tiv.2026.106230_bb0025","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/bs.ctdb.2016.10.007","article-title":"Zebrafish in toxicology and environmental health","volume":"124","author":"Bambino","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.tiv.2026.106230_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3957262","article-title":"An overview on the anti-inflammatory potential and antioxidant profile of eugenol","volume":"2018","author":"Barboza","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tiv.2026.106230_bb0035","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.nano.2018.01.001","article-title":"Systemic and local toxicity of metal debris released from hip prostheses: a review of experimental approaches","volume":"14","author":"Bijukumar","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.tiv.2026.106230_bb0040","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.nano.2018.01.001","article-title":"Systemic and local toxicity of metal debris released from hip prostheses: a review of experimental approaches","volume":"14","author":"Bijukumar","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.tiv.2026.106230_bb0045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12011-012-9506-6","article-title":"The effects of cobalt on the development, oxidative stress, and apoptosis in zebrafish embryos","volume":"150","author":"Cai","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tiv.2026.106230_bb0050","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/jor.22411","article-title":"Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms","volume":"31","author":"Caicedo","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tiv.2026.106230_bb0055","series-title":"Local and Systemic Consequences of Metal-on-Metal Hip Resurfacing Implants","first-page":"5","volume":"2019","author":"Campbell","year":"2019"},{"key":"10.1016\/j.tiv.2026.106230_bb0060","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s10439-023-03330-x","article-title":"Survivability of titanium implant materials: in vitro simulated inflammatory and infectious environment","volume":"51","author":"Cheng","year":"2023","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.tiv.2026.106230_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70241","article-title":"Heavy metals toxicity: mechanism, health effects, and therapeutic interventions","volume":"6","author":"Cheng","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.tiv.2026.106230_bb0070","article-title":"A comprehensive review of total hip arthroplasty outcomes in post-traumatic hip arthritis: insights and perspectives","volume":"16","author":"Choudhary","year":"2026","journal-title":"Cureus"},{"key":"10.1016\/j.tiv.2026.106230_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123400","article-title":"Zebrafish neuromast sensory system: is it an emerging target to assess environmental pollution impacts?","volume":"344","author":"Cirqueira","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tiv.2026.106230_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/zeb.2008.0562","article-title":"Zebrafish development and genetics: introducing undergraduates to developmental biology and genetics in a large introductory laboratory class","volume":"6","author":"D\u2019Costa","year":"2009","journal-title":"Zebrafish"},{"key":"10.1016\/j.tiv.2026.106230_bb0090","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2532120","article-title":"Research progress on nanotoxicity and detoxification of cobalt in metal-based implants","volume":"57","author":"Fan","year":"2025","journal-title":"Ann. Med."},{"key":"10.1016\/j.tiv.2026.106230_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112587","article-title":"Neurodevelopmental toxicity of alumina nanoparticles to zebrafish larvae: toxic effects of particle sizes and ions","volume":"157","author":"Fan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tiv.2026.106230_bb0100","series-title":"StatPearls","article-title":"Anatomy, Bony Pelvis and Lower Limb, Hip","author":"Glenister","year":"2024"},{"key":"10.1016\/j.tiv.2026.106230_bb0105","article-title":"Effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles","author":"Gong","year":"2024","journal-title":"Environ. Sci.: Nano"},{"key":"10.1016\/j.tiv.2026.106230_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/nu14142848","article-title":"Anti-inflammatory and antioxidant effects of carvacrol on N-methyl-N-nitro-N-Nitrosoguanidine (MNNG) induced gastric carcinogenesis in Wistar rats","volume":"14","author":"Gunes-Bayir","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tiv.2026.106230_bb0120","series-title":"OrthoInfo","author":"Hip Osteoarthritis","year":"2026"},{"key":"10.1016\/j.tiv.2026.106230_bb0125","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1002\/fsn3.2994","article-title":"Therapeutic application of carvacrol: a comprehensive review","volume":"10","author":"Imran","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.tiv.2026.106230_bb0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxlet.2024.10.009","article-title":"Toxicity risk from hip implant CoCrMo particles: the impact of dynamic flow rate on neuronal cells in microfluidic systems","volume":"402","author":"Jeffers","year":"2024","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2026.106230_bb0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.rdc.2006.12.008","article-title":"Total joint arthroplasties: current concepts of patient outcomes after surgery","volume":"33","author":"Jones","year":"2007","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.tiv.2026.106230_bb0140","first-page":"95","article-title":"Osteoarthritis of the hip: an overview","volume":"117","author":"Jotanovic","year":"2015","journal-title":"Period. Biol."},{"key":"10.1016\/j.tiv.2026.106230_bb0145","first-page":"2070","article-title":"Development of the larval lymphatic system in zebrafish","volume":"144","author":"Jung","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.tiv.2026.106230_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.micromeso.2020.110687","article-title":"Evaluating the inherent osteogenic and angiogenic potential of mesoporous silica nanoparticles to augment vascularized bone tissue formation","volume":"311","author":"Kanniyappan","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.tiv.2026.106230_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106449","article-title":"Investigation of cell-accelerated corrosion (CAC) on the CoCrMo alloy with segregation banding: hip implant applications","volume":"152","author":"Kanniyappan","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.tiv.2026.106230_bb0160","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.tiv.2026.106230_bb0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4103\/bbrj.bbrj_148_24","article-title":"Medical implant heavy metal contents and effect on patients","volume":"8","author":"Latka","year":"2024","journal-title":"Biomed. Biotechnol. Res. J."},{"key":"10.1016\/j.tiv.2026.106230_bb0170","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/srep03169","article-title":"Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells","volume":"3","author":"Lu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2026.106230_bb0175","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/antibiotics12050824","article-title":"Carvacrol-a natural phenolic compound with antimicrobial properties","volume":"12","author":"M\u0105czka","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.tiv.2026.106230_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118368","article-title":"Insights into the combined toxicity of copper and cadmium in zebrafish (Danio rerio) embryos and adults","volume":"299","author":"Majid","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tiv.2026.106230_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2021.104769","article-title":"The role of vitamin e in hip implant-related corrosion and toxicity: initial outcome","volume":"123","author":"Manjunath","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.tiv.2026.106230_bb0190","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1007\/s11999-012-2563-5","article-title":"Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins","volume":"470","author":"Mathew","year":"2012","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"3","key":"10.1016\/j.tiv.2026.106230_bib331","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/ma12030495","article-title":"Materials for hip prostheses: a review of wear and loading considerations","volume":"12","author":"Merola","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.tiv.2026.106230_bb0195","first-page":"1345","article-title":"Zebrafish as a successful animal model for screening toxicity of medicinal plants","volume":"9","author":"Modarresi Chahardehi","year":"2020","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.tiv.2026.106230_bb0200","series-title":"Bioactive Natural Products for Pharmaceutical Applications","article-title":"Carvacrol (Origanum vulgare): therapeutic properties and molecular mechanisms","author":"Mondal","year":"2020"},{"key":"10.1016\/j.tiv.2026.106230_bb0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0967199422000673","article-title":"Effect of carvacrol antioxidant capacity on oocyte maturation and embryo production in cattle","volume":"31","author":"Morais","year":"2023","journal-title":"Zygote"},{"key":"10.1016\/j.tiv.2026.106230_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40496-022-00306-z","article-title":"Insight into corrosion of dental implants: from biochemical mechanisms to designing corrosion-resistant materials","volume":"9","author":"Nagay","year":"2022","journal-title":"Curr. Oral Health Rep."},{"key":"10.1016\/j.tiv.2026.106230_bb0215","series-title":"Osteoarthritis: An Overview of the Disease and Its Treatment Strategies","year":"2026"},{"key":"10.1016\/j.tiv.2026.106230_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162197","article-title":"Zebrafish-based platform for emerging bio-contaminants and virus inactivation research","volume":"872","author":"Patel","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2026.106230_bb0225","article-title":"Evaluation of oxidative stress and antioxidant effects of methylxanthines in adult zebrafish exposed to zinc oxide nanoparticles (ZnO-NPs)","volume":"62","author":"Pavel","year":"2025","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.tiv.2026.106230_bb0230","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tiv.2026.106230_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13050378","article-title":"Toxicological effects of combined exposure of cadmium and enrofloxacin on zebrafish","volume":"13","author":"Ren","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.tiv.2026.106230_bb0250","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/cdn\/nzab033_046","article-title":"Effectiveness of antioxidants on cell viability in beta-amyloid exposed PC12 cells","volume":"5","author":"Rotvold","year":"2021","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.tiv.2026.106230_bb0255","first-page":"34","article-title":"The effects on bone cells of metal ions released from orthopaedic implants. A review","volume":"10","author":"Sansone","year":"2013","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"10.1016\/j.tiv.2026.106230_bb0260","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.chemosphere.2018.05.018","article-title":"Molecular aspect of silver nanoparticles regulated embryonic development in zebrafish (Danio rerio) by oct-4 expression","volume":"206","author":"Sarkar","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2026.106230_bb0265","article-title":"Projections and epidemiology of primary hip and knee arthroplasty in medicare patients to 2040-2060","volume":"8","author":"Shichman","year":"2023","journal-title":"JB JS Open Access"},{"key":"10.1016\/j.tiv.2026.106230_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ma16072923","article-title":"Scratch and wear behaviour of co-Cr-Mo alloy in ringers lactate solution","volume":"16","author":"Silva","year":"2023","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.tiv.2026.106230_bb0275","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1874325001610010241","article-title":"Particle disease: a current review of the biological mechanisms in periprosthetic osteolysis after hip arthroplasty","volume":"10","author":"Sukur","year":"2016","journal-title":"Open Orthop. J."},{"key":"10.1016\/j.tiv.2026.106230_bb0280","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jor.2025.12.064","article-title":"A systematic review and meta-analysis of cases of prosthetic hip-associated cobalt toxicity in patients with prosthetic hip ceramic bearing fractures subsequently revised to metal-on-polyethylene implants","volume":"74","author":"Sweeney","year":"2026","journal-title":"J. Orthop."},{"issue":"4","key":"10.1016\/j.tiv.2026.106230_bb0245","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3390\/cmd4040033","article-title":"Review on corrosion, tribocorrosion and osseointegration of titanium alloys as biomaterials","volume":"4","author":"Takadoum","year":"2023","journal-title":"Corrosion and Materials Degradation"},{"key":"10.1016\/j.tiv.2026.106230_bb0285","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cotox.2020.05.004","article-title":"Translational toxicology in zebrafish","volume":"23\u201324","author":"Tal","year":"2020","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.tiv.2026.106230_bb0290","series-title":"Orthopedic Implant Materials","author":"Tapscott","year":"2020"},{"key":"10.1016\/j.tiv.2026.106230_bb0295","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvag017","article-title":"Role of antioxidant vitamins in mitigating the health risks from environmental toxicant exposures: a narrative review","volume":"10","author":"Thangaraj","year":"2026","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.tiv.2026.106230_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/wdev.160","article-title":"There and back again: development and regeneration of the zebrafish lateral line system","volume":"4","author":"Thomas","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.tiv.2026.106230_bb0305","series-title":"Total Hip Arthroplasty Techniques","author":"Varacallo","year":"2018"},{"key":"10.1016\/j.tiv.2026.106230_bb0310","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1039\/C7TX00300E","article-title":"Mechanistic insight into ROS and neutral lipid alteration induced toxicity in the human model with fins (danio rerio) by industrially synthesized titanium dioxide nanoparticles","volume":"7","author":"Verma","year":"2018","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tiv.2026.106230_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116160","article-title":"The posterity of zebrafish in paradigm of in vivo molecular toxicological profiling","volume":"171","author":"Verma","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tiv.2026.106230_bb0320","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1080\/15548627.2015.1106779","article-title":"Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis","volume":"11","author":"Wang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.tiv.2026.106230_bb0325","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13142","article-title":"CoCrMo-nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway","volume":"54","author":"Xu","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.tiv.2026.106230_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119616","article-title":"Early developmental lead exposure disrupts skeletal development in zebrafish","volume":"309","author":"Ye","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088723332600038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088723332600038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:23:14Z","timestamp":1780528994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088723332600038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"alternative-id":["S088723332600038X"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106230","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In-vitro study and in-vivo zebrafish model to minimize the toxic effects of implant (CoCrMo particles) by antioxidants","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106230"}}