{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:02:37Z","timestamp":1780531357829,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tiv.2026.106242","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:27:52Z","timestamp":1776443272000},"page":"106242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells"],"prefix":"10.1016","volume":"115","author":[{"given":"Berta","family":"Fal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Matysiak-Kucharek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Sawicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Horecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Kapka-Skrzypczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"28","key":"10.1016\/j.tiv.2026.106242_bb0005","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1703151114","article-title":"Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins","volume":"114","author":"Ali","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tiv.2026.106242_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122899","article-title":"Nanoparticles in cancer theragnostic and drug delivery: a comprehensive review","volume":"352","author":"Al-Thani","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.tiv.2026.106242_bb0015","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/ijms26030904","article-title":"Integrins as key mediators of metastasis","volume":"26","author":"C\u00e1ceres-Calle","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2026.106242_bb0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jcis.2016.09.024","article-title":"Effects of surface modification of quantum dots on viability and migration of triple-negative breast cancer cells","volume":"485","author":"Chen","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.tiv.2026.106242_bb0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.toxlet.2014.02.004","article-title":"Epithelial\u2013mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta\/Smad signaling pathway","volume":"226","author":"Chen","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.tiv.2026.106242_bb0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/sj.neo.7900224","article-title":"The role of alpha(v)beta(3) in prostate cancer progression","volume":"4","author":"Cooper","year":"2002","journal-title":"Neoplasia"},{"key":"10.1016\/j.tiv.2026.106242_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104337","article-title":"Peptide-mediated targeting of quantum dots in a 3D model of head and neck cancer","volume":"49","author":"Dirheimer","year":"2024","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.tiv.2026.106242_bb0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2024.04.003","article-title":"Integrating integrins with the hallmarks of cancer","volume":"130","author":"Haake","year":"2024","journal-title":"Matrix Biol."},{"key":"10.1016\/j.tiv.2026.106242_bb0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"21","key":"10.1016\/j.tiv.2026.106242_bb0050","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.3748\/wjg.v22.i21.5012","article-title":"CdSe\/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells","volume":"22","author":"He","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.tiv.2026.106242_bb0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/jnt1010003","article-title":"The future of anticancer drugs: a cytotoxicity assessment study of CdSe\/ZnS quantum dots","volume":"1","author":"Hens","year":"2020","journal-title":"J. Nanotheranost."},{"key":"10.1016\/j.tiv.2026.106242_bib206","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.2147\/OTT.S273803","article-title":"The roles of integrin \u03b15\u03b21 in human cancer","volume":"13","author":"Hou","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.tiv.2026.106242_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111609","article-title":"Toxicity evaluation of cadmium-containing quantum dots: a review of optimizing physicochemical properties to diminish toxicity","volume":"200","author":"Hu","year":"2021","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.tiv.2026.106242_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6800","article-title":"RGD peptide in cancer targeting: benefits, challenges, solutions, and possible integrin\u2013RGD interactions","volume":"13","author":"Javid","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.tiv.2026.106242_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154536","article-title":"PHB promotes bladder cancer cell epithelial-mesenchymal transition via the wnt\/\u03b2-catenin signaling pathway","volume":"247","author":"Jiang","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.tiv.2026.106242_bb0075","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.2147\/IJN.S301892","article-title":"Layer-number-dependent effects of graphene oxide on the pluripotency of mouse embryonic stem cells through the regulation of the interaction between the extracellular matrix and integrins","volume":"16","author":"Jing","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2026.106242_bb0080","series-title":"Madame Curie Bioscience Database [Internet]","article-title":"Integrins in Cancer cell invasion","author":"Koistinen","year":"2000"},{"issue":"12","key":"10.1016\/j.tiv.2026.106242_bb0085","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s10439-013-0860-0","article-title":"Cellular function and adhesion mechanisms of human bone marrow mesenchymal stem cells on multi-walled carbon nanotubes","volume":"41","author":"Kroustalli","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.tiv.2026.106242_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110396","article-title":"Quantum dots are time bomb: multiscale toxicological study","volume":"374","author":"Kuznetsov","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tiv.2026.106242_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108458","article-title":"Integrins in cancer: emerging mechanisms and therapeutic opportunities","volume":"247","author":"Liu","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"26","key":"10.1016\/j.tiv.2026.106242_bb0100","doi-asserted-by":"crossref","first-page":"10666","DOI":"10.1073\/pnas.0903035106","article-title":"Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain","volume":"106","author":"Lorger","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tiv.2026.106242_bb0105","article-title":"Silver nanoparticles alter epithelial basement membrane integrity, cell adhesion molecule expression, and TGF-\u03b21 secretion","volume":"21","author":"Martin","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.tiv.2026.106242_bb0110","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3390\/ijms26062777","article-title":"Prometastatic potential of non-functionalized multiwalled carbon nanotubes in the MDA-MB-436 breast cancer cell line model","volume":"26","author":"Matysiak-Kucharek","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.tiv.2026.106242_bb0115","article-title":"Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces, cell stiffness, and motility in a microenvironment stiffness-dependent manner","volume":"19","author":"Molter","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.tiv.2026.106242_bb0120","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s12551-020-00653-0","article-title":"Revisiting the cytotoxicity of quantum dots: an in-depth overview","volume":"12","author":"Nikazar","year":"2020","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.tiv.2026.106242_bb0125","doi-asserted-by":"crossref","first-page":"9203","DOI":"10.3390\/ijms22179203","article-title":"Silver nanoparticles modulate the epithelial-to-mesenchymal transition in Estrogen-dependent breast cancer cells in vitro","volume":"22","author":"Rakowski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2026.106242_bb0130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2147\/IJN.S152237","article-title":"Adhesion, proliferation, and apoptosis in different molecular portraits of breast cancer treated with silver nanoparticles and its pathway-network analysis","volume":"13","author":"Rodr\u00edguez-Raz\u00f3n","year":"2018","journal-title":"Int. J. Nanomedicine"},{"issue":"7","key":"10.1016\/j.tiv.2026.106242_bb0135","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1002\/jcp.30202","article-title":"Integrin \u03b12\u03b21 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial-mesenchymal transition","volume":"236","author":"Salemi","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.tiv.2026.106242_bb0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2310\/7290.2008.00019A","article-title":"Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells","volume":"7","author":"Sameni","year":"2008","journal-title":"Mol. Imaging"},{"issue":"18","key":"10.1016\/j.tiv.2026.106242_bb0145","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1128\/MCB.00694-14","article-title":"Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition","volume":"34","author":"Schaeffer","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tiv.2026.106242_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201800922","article-title":"Nano-TiO2 drives epithelial\u2013mesenchymal transition in intestinal epithelial cancer cells","volume":"14","author":"Setyawati","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.tiv.2026.106242_bb0155","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1016\/j.biomaterials.2012.04.045","article-title":"ROS-mediated apoptotic cell death in prostate cancer LNCaP cells induced by biosurfactant stabilized CdS quantum dots","volume":"33","author":"Singh","year":"2012","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.tiv.2026.106242_bb0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/14686996.2018.1444318","article-title":"PEGylated TiO2 nanoparticles mediated inhibition of cell migration via integrin beta 1","volume":"19","author":"Sun","year":"2018","journal-title":"Sci. Technol. Adv. Mater."},{"key":"10.1016\/j.tiv.2026.106242_bb0165","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.2147\/OTT.S258252","article-title":"Role of \u03b1V\u03b23 in prostate cancer: metastasis initiator and important therapeutic target","volume":"13","author":"Tang","year":"2020","journal-title":"Onco. Targets Ther."},{"issue":"1","key":"10.1016\/j.tiv.2026.106242_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69670-z","article-title":"NHF-derived carbon dots: prevalidation approach in breast cancer treatment","volume":"10","author":"Tiron","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2026.106242_bb0175","article-title":"Metallic nanoparticles reduce the migration of human fibroblasts in vitro","volume":"1","author":"Vieira","year":"2017","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.tiv.2026.106242_bb0180","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.2147\/IJN.S449887","article-title":"Anti-Cancer potency of copper-doped carbon quantum dots against breast cancer progression","volume":"19","author":"Wang","year":"2024","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.tiv.2026.106242_bb0185","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11033-023-08920-5","article-title":"Adhesion, metastasis, and inhibition of cancer cells: a comprehensive review","volume":"51","author":"Yayan","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.tiv.2026.106242_bb0190","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2147\/NSA.S540050","article-title":"Diamond nanoparticles suppress migration of T98G glioblastoma cells by targeting ECM-integrin interactions and intracellular signaling, leading to extensive proteome alterations","volume":"18","author":"Zawadzka","year":"2025","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.tiv.2026.106242_bb0195","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1080\/17435390.2022.2030822","article-title":"MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells","volume":"15","author":"Zhang","year":"2021","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.tiv.2026.106242_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113714","article-title":"Current progress of nanomedicine for prostate cancer diagnosis and treatment","volume":"155","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tiv.2026.106242_bb0205","article-title":"Targeting integrin \u03b15\u03b21 in urological tumors: opportunities and challenges","volume":"13","author":"Zhou","year":"2023","journal-title":"Front. Oncol."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:21:50Z","timestamp":1780528910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233326000500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":42,"alternative-id":["S0887233326000500"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106242","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106242","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106242"}}