{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:02:36Z","timestamp":1780531356333,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["0\/23\/026\/K (EHaP"],"award-info":[{"award-number":["0\/23\/026\/K (EHaP"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tiv.2026.106243","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:13:35Z","timestamp":1776294815000},"page":"106243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparison of two human cell-based in vitro eye hazard assessment methods: the cytotoxicity test for evaluation of eye irritation (CEI) and the OECD 492B method"],"prefix":"10.1016","volume":"115","author":[{"given":"Daniel","family":"Krakowian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"\u017bem\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"G\u0105darowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Mrzyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tiv.2026.106243_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104960","article-title":"Development of the SkinEthic HCE Time-to-Toxicity test method for identifying liquid chemicals not requiring classification and labelling and liquids inducing serious eye damage and eye irritation","volume":"69","author":"Al\u00e9p\u00e9e","year":"2020","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2026.106243_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105203","article-title":"SkinEthic HCE time-to-toxicity on solids: a test method for distinguishing chemicals inducing serious eye damage, eye irritation and not requiring classification and labelling","volume":"75","author":"Al\u00e9p\u00e9e","year":"2021","journal-title":"Toxicol. in Vitro"},{"issue":"2","key":"10.1016\/j.tiv.2026.106243_bb0015","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00204-016-1679-x","volume":"91","author":"Barroso","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.tiv.2026.106243_bb0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.toxlet.2012.05.004","article-title":"A new cell-based method for assessing the eye irritation potential of chemicals: an alternative to the Draize test","volume":"212","author":"Cho","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.tiv.2026.106243_bb0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tiv.2010.10.008","article-title":"A potential in vitro epidermal equivalent assay to determine sensitizer potency","volume":"25","author":"dos Santos","year":"2011","journal-title":"Toxicol. in Vitro"},{"issue":"3","key":"10.1016\/j.tiv.2026.106243_bb0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-3565(25)08751-8","article-title":"Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes","volume":"82","author":"Draize","year":"1944","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tiv.2026.106243_bb0035","author":"ECHA"},{"key":"10.1016\/j.tiv.2026.106243_bb0040","author":"EU"},{"issue":"23","key":"10.1016\/j.tiv.2026.106243_bb0045","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15287394.2021.1956661","article-title":"In silico prediction of the full United Nations Globally Harmonized System eye irritation categories of liquid chemicals by IATA-like bottom-up approach of random forest method","volume":"84","author":"Kang","year":"2021","journal-title":"J. Toxicol. Environ. Health A."},{"issue":"S1","key":"10.1016\/j.tiv.2026.106243_bb0050","first-page":"148","article-title":"P06-035 Problem with incorrect classification of substances in terms of irritation or serious eye damage using Short Time Exposure test method","volume":"314","author":"Krakowian","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2026.106243_bb0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2020.12.003","article-title":"A proposal for a new in vitro method for direct classification of eye irritants by cytotoxicity test \u2013 Preliminary study","volume":"338","author":"Krakowian","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2026.106243_bb0060","doi-asserted-by":"crossref","first-page":"105343","DOI":"10.1016\/j.tiv.2022.105343","article-title":"Cytotoxicity assay to assess eye irritation \u2013 a comparison with other methods and possible strategies for use","volume":"81","author":"Krakowian","year":"2022","journal-title":"Toxicol. in Vitro"},{"issue":"S2","key":"10.1016\/j.tiv.2026.106243_bb0065","doi-asserted-by":"crossref","first-page":"S354","DOI":"10.1016\/j.toxlet.2024.07.843","article-title":"P25-05 Applicability of the Cytotoxicity Eye Irritation (CEI) test for classification of mixtures for eye hazard identification","volume":"399","author":"Krakowian","year":"2024","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tiv.2026.106243_bb0070","article-title":"Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests [WWW document]","author":"OECD","year":"2010"},{"key":"10.1016\/j.tiv.2026.106243_bb0075","article-title":"Guidance Document on Good in Vitro Method Practices (GIVIMP) [WWW Document]","author":"OECD","year":"2018"},{"key":"10.1016\/j.tiv.2026.106243_bb0080","article-title":"Test No. 405: Acute Eye Irritation\/Corrosion [WWW Document]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2026.106243_bb0085","doi-asserted-by":"crossref","DOI":"10.1787\/9789264185401-en","article-title":"Test no. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants [WWW Document]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2026.106243_bb0090","doi-asserted-by":"crossref","DOI":"10.1787\/9789264203860-en","article-title":"Test no. 438: (Isolated Chicken Eye Test Method for Identifying i) (Chemicals Inducing Serious Eye Damage and ii) Chemicals not Requiring Classification for Eye Irritation or Serious Eye Damage [WWW Document]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2026.106243_bb0095","series-title":"Test no. 491: (Short Time Exposure in Vitro Test Method for Identifying i) (Chemicals Inducing Serious Eye Damage and ii) Chemicals not Requiring Classification for Eye Irritation or Serious Eye Damage [WWW Document]","author":"OECD","year":"2023"},{"key":"10.1016\/j.tiv.2026.106243_bb0100","article-title":"Guidance Document on Integrated Approaches to Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation, Third Edition [WWW Document]","author":"OECD","year":"2024"},{"key":"10.1016\/j.tiv.2026.106243_bb0105","article-title":"Test No. 492: Reconstructed Human Cornea-Like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage [WWW Document]","author":"OECD","year":"2024"},{"key":"10.1016\/j.tiv.2026.106243_bb0110","article-title":"Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation [WWW Document]","author":"OECD","year":"2024"},{"key":"10.1016\/j.tiv.2026.106243_bb0115","doi-asserted-by":"crossref","DOI":"10.1787\/0d603916-en","article-title":"Test No. 492B: Reconstructed Human Cornea-Like Epithelium (RHCE) Test Method for Eye Hazard Identification [WWW Document]","author":"OECD","year":"2024"},{"key":"10.1016\/j.tiv.2026.106243_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tiv.2009.05.019","article-title":"A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom\u2013Up and Top\u2013Down approaches","volume":"24","author":"Scott","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2026.106243_bb0125","doi-asserted-by":"crossref","DOI":"10.1186\/1747-5341-4-2","article-title":"Are animal models predictive for humans?","volume":"4","author":"Shanks","year":"2009","journal-title":"Philos. Ethics Humanit. Med."},{"issue":"7","key":"10.1016\/j.tiv.2026.106243_bb0130","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.tiv.2011.04.012","article-title":"The Short Time Exposure (STE) test for predicting eye irritation potential: Intra-laboratory reproducibility and correspondence to globally harmonized system (GHS) and EU eye irritation classification for 109 chemicals","volume":"25","author":"Takahashi","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.tiv.2026.106243_bb0135","series-title":"Globally Harmonized System of Classification and Labelling of Chemicals (GHS)","author":"UN","year":"2023"}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:21:44Z","timestamp":1780528904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233326000512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":27,"alternative-id":["S0887233326000512"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106243","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of two human cell-based in vitro eye hazard assessment methods: the cytotoxicity test for evaluation of eye irritation (CEI) and the OECD 492B method","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106243"}}