{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:12:06Z","timestamp":1788487926166,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/3\/8\/43\/2020-ITR"],"award-info":[{"award-number":["5\/3\/8\/43\/2020-ITR"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology in Vitro"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tiv.2026.106268","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:11:53Z","timestamp":1781223113000},"page":"106268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In vitro exposure to polystyrene microplastic induces oxidative stress mediated \u03b2-cell dysfunction"],"prefix":"10.1016","volume":"116","author":[{"given":"Pratibha","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariya","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalaj","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samradhi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girijesh Kumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tiv.2026.106268_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/endocrines6020023","article-title":"Endocrine toxicity of micro- and nanoplastics, and advances in detection techniques for human tissues: a comprehensive review","volume":"6","author":"Bossio","year":"2025","journal-title":"Endocrines"},{"key":"10.1016\/j.tiv.2026.106268_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123308","article-title":"In vitro chemical and physical toxicities of polystyrene microfragments in human-derived cells","volume":"400","author":"Choi","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"17","key":"10.1016\/j.tiv.2026.106268_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/nano14171435","article-title":"Size-dependent internalization of microplastics and nanoplastics using in vitro model of the human intestine\u2014contribution of each cell in the tri-culture models","volume":"14","author":"Choi","year":"2024","journal-title":"Nanomaterials"},{"key":"10.1016\/j.tiv.2026.106268_bb0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s40726-020-00171-3","article-title":"A review of microplastics in aquatic sediments: occurrence, fate, transport, and ecological impact","volume":"7","author":"Darabi","year":"2021","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.tiv.2026.106268_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121575","article-title":"Polystyrene microplastic particles: in vitro pulmonary toxicity assessment","volume":"385","author":"Dong","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11010-018-3361-5","article-title":"The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes","volume":"449","author":"Dos Santos","year":"2018","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-024-00578-6","article-title":"Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage\u2013hepatocyte crosstalk","volume":"21","author":"Fan","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"31","key":"10.1016\/j.tiv.2026.106268_bb0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2104610118","article-title":"Microplastics destabilize lipid membranes by mechanical stretching","volume":"118","author":"Fleury","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"38","key":"10.1016\/j.tiv.2026.106268_bb0050","doi-asserted-by":"crossref","first-page":"34136","DOI":"10.1021\/acsomega.2c03453","article-title":"Effects of polystyrene microplastics on human kidney and liver cell morphology, cellular proliferation, and metabolism","volume":"7","author":"Goodman","year":"2022","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40104-024-01077-6","article-title":"Polystyrene nanoplastic exposure activates ferroptosis by oxidative stress-induced lipid peroxidation in porcine oocytes during maturation","volume":"15","author":"He","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"3","key":"10.1016\/j.tiv.2026.106268_bb0060","doi-asserted-by":"crossref","DOI":"10.12998\/wjcc.v13.i3.98110","article-title":"Microplastic and nanoplastic exposure and risk of diabetes mellitus","volume":"13","author":"Hsiao","year":"2025","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.tiv.2026.106268_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155937","article-title":"Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation","volume":"838","author":"Huang","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12989-023-00556-4","article-title":"Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK\/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo","volume":"20","author":"Huang","year":"2023","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.tiv.2026.106268_bb0075","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.scitotenv.2019.05.071","article-title":"An assessment of the toxicity of polypropylene microplastics in human-derived cells","volume":"684","author":"Hwang","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.tiv.2026.106268_bb0080","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s40200-022-01081-5","article-title":"Role of butyrogenic Firmicutes in type-2 diabetes","volume":"21","author":"James","year":"2022","journal-title":"J. Diabetes Metab. Disord."},{"issue":"20","key":"10.1016\/j.tiv.2026.106268_bb0085","first-page":"546","article-title":"Microplastics: state of the evidence on health effects and public perception","volume":"122","author":"Janzik","year":"2025","journal-title":"Dtsch. Arztebl. Int."},{"issue":"16","key":"10.1016\/j.tiv.2026.106268_bb0090","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1021\/acs.est.6b01441","article-title":"Microplastic size-dependent toxicity, oxidative stress induction, and p-JNK and p-P38 activation in the monogonont rotifer (Brachionus koreanus)","volume":"50","author":"Jeong","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0095","doi-asserted-by":"crossref","first-page":"16329","DOI":"10.1038\/s41598-024-67289-y","article-title":"Polystyrene nanoplastics of different particle sizes regulate the polarization of pro-inflammatory macrophages","volume":"14","author":"Jiang","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0100","doi-asserted-by":"crossref","first-page":"41120","DOI":"10.1038\/s41598-025-24887-8","article-title":"Polyethylene microplastics disrupt renal function, mitochondrial bioenergetics, redox homeostasis, and histoarchitecture in Wistar rats","volume":"15","author":"Kehinde","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2026.106268_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2025.100549","article-title":"Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae","volume":"37","author":"Kim","year":"2025","journal-title":"NanoImpact"},{"issue":"15","key":"10.1016\/j.tiv.2026.106268_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/s22155589","article-title":"Ti2C-TiO2 MXene nanocomposite-based high-efficiency non-enzymatic glucose sensing platform for diabetes monitoring","volume":"22","author":"Kumar","year":"2022","journal-title":"Sensors"},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0115","doi-asserted-by":"crossref","DOI":"10.2174\/1573399819666230413094200","article-title":"Prevalence of diabetes in India: a review of IDF diabetes atlas 10th edition","volume":"20","author":"Kumar","year":"2024","journal-title":"Curr. Diabetes Rev."},{"issue":"35","key":"10.1016\/j.tiv.2026.106268_bb0120","doi-asserted-by":"crossref","first-page":"23602","DOI":"10.1074\/jbc.M109.024323","article-title":"Transient oxidative stress damages mitochondrial machinery inducing persistent \u03b2-cell dysfunction","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tiv.2026.106268_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125492","article-title":"Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2026.106268_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127094","article-title":"Microplastics as an aquatic pollutant affect gut microbiota within aquatic animals","volume":"423","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"10.1016\/j.tiv.2026.106268_bb0135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/envhealth.3c00052","article-title":"Potential health impact of microplastics: a review of environmental distribution, human exposure, and toxic effects","volume":"1","author":"Li","year":"2023","journal-title":"Environ. Health"},{"issue":"Suppl. 1","key":"10.1016\/j.tiv.2026.106268_bb0140","first-page":"2884","article-title":"Assessment of microplastic concentrations in human stool: final results of a prospective study","volume":"6","author":"Liebmann","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.tiv.2026.106268_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146523","article-title":"Cellular internalization and release of polystyrene microplastics and nanoplastics","volume":"779","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tiv.2026.106268_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113520","article-title":"Polystyrene microplastics induce mitochondrial damage in mouse GC-2 cells","volume":"237","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"21","key":"10.1016\/j.tiv.2026.106268_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells13211788","article-title":"Molecular and cellular effects of microplastics and nanoplastics: focus on inflammation and senescence","volume":"13","author":"Mahmud","year":"2024","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.tiv.2026.106268_bb0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/nano15040267","article-title":"Exposure of polystyrene nano- and microplastics in increasingly complex in vitro intestinal cell models","volume":"15","author":"Marcellus","year":"2025","journal-title":"Nanomaterials"},{"issue":"10","key":"10.1016\/j.tiv.2026.106268_bb0165","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa2309822","article-title":"Microplastics and nanoplastics in atheromas and cardiovascular events","volume":"390","author":"Marfella","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-025-11760-1","article-title":"Oral exposure to PET microplastics induces the pancreatic immune response and oxidative stress in immature pigs","volume":"26","author":"Mierzejewski","year":"2025","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tiv.2026.106268_bb0175","first-page":"51","article-title":"Endocytosis and exocytosis of nanoparticles in mammalian cells","volume":"9","author":"Oh","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tiv.2026.106268_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122550","article-title":"Cellular and bioenergetic effects of polystyrene microplastic in function of cell type, differentiation status and post-exposure time","volume":"337","author":"Peng","year":"2023","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.tiv.2026.106268_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cells13090768","article-title":"Important factors affecting induction of cell death, oxidative stress and DNA damage by nano- and microplastic particles in vitro","volume":"13","author":"P\u0142uciennik","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.tiv.2026.106268_bb0190","first-page":"1299","article-title":"In vitro genotoxicity of polystyrene nanoparticles on the human fibroblast Hs27 cell line","volume":"2","author":"Poma","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.tiv.2026.106268_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137647","article-title":"Cellular internalization pathways of environmentally exposed microplastic particles: phagocytosis or macropinocytosis?","volume":"489","author":"Ramsperger","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tiv.2026.106268_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1354199","article-title":"Mitochondrial bioenergetics, metabolism, and beyond in pancreatic \u03b2-cells and diabetes","volume":"11","author":"Rivera Nieves","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.tiv.2026.106268_bb0205","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.envres.2017.08.043","article-title":"Cytotoxic effects of commonly used nanomaterials and microplastics on cerebral and epithelial human cells","volume":"159","author":"Schirinzi","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.tiv.2026.106268_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107273","article-title":"Disturbed gut\u2013liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance","volume":"164","author":"Shi","year":"2022","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.tiv.2026.106268_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2023.151329","article-title":"Recent trends and advances in type 1 diabetes therapeutics: a comprehensive review","volume":"102","author":"Singh","year":"2023","journal-title":"Eur. J. Cell Biol."},{"issue":"7","key":"10.1016\/j.tiv.2026.106268_bb0220","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/biology12071019","article-title":"Peripheral mitochondrial dysfunction: a potential contributor to the development of metabolic disorders and Alzheimer\u2019s disease","volume":"12","author":"Sultana","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.tiv.2026.106268_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113845","article-title":"Immunotoxicity of microplastics and two persistent organic pollutants alone or in combination to a bivalve species","volume":"258","author":"Tang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"13","key":"10.1016\/j.tiv.2026.106268_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136156","article-title":"Micro- and nanoplastics as disruptors of the endocrine system\u2014a review of the threats and consequences associated with plastic exposure","volume":"26","author":"Tyc","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tiv.2026.106268_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1084236","article-title":"A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals","volume":"13","author":"Ullah","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.tiv.2026.106268_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136591","article-title":"Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice","volume":"308","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2026.106268_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128323","article-title":"Effects of polyethylene microplastics on cell membranes: a combined study of experiments and molecular dynamics simulations","volume":"429","author":"Wang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.tiv.2026.106268_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113642","article-title":"The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes","volume":"173","author":"Wang","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0255","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41467-024-45281-4","article-title":"Nominally identical microplastic models differ greatly in their particle\u2013cell interactions","volume":"15","author":"Wieland","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.tiv.2026.106268_bb0260","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tiv.2026.106268_bb0265","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.chemosphere.2019.01.056","article-title":"Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells","volume":"221","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.tiv.2026.106268_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169260","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress","volume":"912","author":"Wu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.tiv.2026.106268_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/metabo14090504","article-title":"Impact of microplastic exposure on blood glucose levels and gut microbiota: differential effects under normal or high-fat diet conditions","volume":"14","author":"Xu","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.tiv.2026.106268_bb0280","doi-asserted-by":"crossref","first-page":"8609213","DOI":"10.1155\/2020\/8609213","article-title":"Molecular mechanisms linking oxidative stress and diabetes mellitus","volume":"2020","author":"Yaribeygi","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0285","doi-asserted-by":"crossref","first-page":"10752","DOI":"10.1038\/s41598-025-94902-5","article-title":"Synergistic endocrine disruption and cellular toxicity of polyethylene microplastics and bisphenol a in MLTC-1 cells and zebrafish","volume":"15","author":"Ye","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.tiv.2026.106268_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/nano11020496","article-title":"Impact of microplastics and nanoplastics on human health","volume":"11","author":"Yee","year":"2021","journal-title":"Nanomaterials"},{"issue":"10","key":"10.1016\/j.tiv.2026.106268_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/fishes10100474","article-title":"Polystyrene microplastics induce insulin resistance and glucose metabolism disorders in grass carp (Ctenopharyngodon idellus) via the gut microbiome\u2013metabolism axis","volume":"10","author":"Zhang","year":"2025","journal-title":"Fishes"},{"issue":"1","key":"10.1016\/j.tiv.2026.106268_bb0300","doi-asserted-by":"crossref","first-page":"26616","DOI":"10.1038\/s41598-025-11577-8","article-title":"Large-sized polystyrene microplastics induce oxidative stress in AML12 cells","volume":"15","author":"Zhao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tiv.2026.106268_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.111669","article-title":"The effects of microplastics on ionoregulatory processes in the gills of freshwater fish and invertebrates: a prospective review","volume":"295","author":"Zink","year":"2024","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"8","key":"10.1016\/j.tiv.2026.106268_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087382","article-title":"Polystyrene microplastics induce oxidative stress in mouse hepatocytes in relation to their size","volume":"24","author":"Zou","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Toxicology in Vitro"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887233326000767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:13:57Z","timestamp":1788484437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887233326000767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":61,"alternative-id":["S0887233326000767"],"URL":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106268","relation":{},"ISSN":["0887-2333"],"issn-type":[{"value":"0887-2333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro exposure to polystyrene microplastic induces oxidative stress mediated \u03b2-cell dysfunction","name":"articletitle","label":"Article Title"},{"value":"Toxicology in Vitro","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tiv.2026.106268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106268"}}