{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:39:03Z","timestamp":1792874343341,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Frailty &amp; Aging"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tjfa.2026.100195","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:36:36Z","timestamp":1788471396000},"page":"100195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Higher cystatin C, but not creatinine, predicts frailty risk in individuals with normal kidney function"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-0526","authenticated-orcid":false,"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjfa.2026.100195_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanhl.2024.100666","article-title":"Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice","volume":"6","author":"Borda","year":"2025","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.tjfa.2026.100195_bib0002","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.tjfa.2026.100195_bib0003","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"10.1016\/j.tjfa.2026.100195_bib0004","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1016\/S2589-7500(23)00066-3","article-title":"Steps in the right direction for physical frailty research","volume":"5","author":"Cox","year":"2023","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.tjfa.2026.100195_bib0005","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1056\/NEJMra054415","article-title":"Assessing kidney function\u2013measured and estimated glomerular filtration rate","volume":"354","author":"Stevens","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0006","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1056\/NEJMoa1214234","article-title":"Cystatin C versus creatinine in determining risk based on kidney function","volume":"369","author":"Shlipak","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0007","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0008","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C","volume":"367","author":"Inker","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0009","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/aje\/kwp354","article-title":"Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study","volume":"171","author":"Meinhold","year":"2010","journal-title":"Am j epidemiol"},{"key":"10.1016\/j.tjfa.2026.100195_bib0010","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.ajkd.2013.03.027","article-title":"Update on cystatin C: incorporation into clinical practice","volume":"62","author":"Shlipak","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.tjfa.2026.100195_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009077","article-title":"Cystatin C for risk stratification in patients after an acute coronary syndrome","volume":"7","author":"Correa","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.tjfa.2026.100195_bib0012","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40256-024-00629-5","article-title":"Serum cystatin C as a risk factor for supratherapeutic digoxin concentration in elderly patients with heart failure and chronic kidney disease","volume":"24","author":"Lu","year":"2024","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.tjfa.2026.100195_bib0013","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-142-7-200504050-00008","article-title":"Cystatin C concentration as a risk factor for heart failure in older adults","volume":"142","author":"Sarnak","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0014","article-title":"2024 Clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.tjfa.2026.100195_bib0015","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1","article-title":"Strengthening the reporting of Observational studies in epidemiology (STROBE): explanation and elaboration","volume":"147","author":"Vandenbroucke","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0016","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ije\/dyu067","article-title":"Cohort profile: the Health and Retirement Study (HRS)","volume":"43","author":"Sonnega","year":"2014","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.tjfa.2026.100195_bib0017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ije\/dys203","article-title":"Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS)","volume":"43","author":"Zhao","year":"2014","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.tjfa.2026.100195_bib0018","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afad221","article-title":"How to construct a frailty index from an existing dataset in 10 steps","volume":"52","author":"Theou","year":"2023","journal-title":"Age Ageing"},{"key":"10.1016\/j.tjfa.2026.100195_bib0019","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jcsm.13169","article-title":"Associations of metabolic heterogeneity of obesity with frailty progression: results from two prospective cohorts","volume":"14","author":"He","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tjfa.2026.100195_bib0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/s12877-022-03219-9","article-title":"Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations","volume":"22","author":"Sun","year":"2022","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.tjfa.2026.100195_bib0021","doi-asserted-by":"crossref","first-page":"e650","DOI":"10.1016\/S2468-2667(20)30113-4","article-title":"Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study","volume":"5","author":"Fan","year":"2020","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.tjfa.2026.100195_bib0022","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12992-024-01056-6","article-title":"Internet use and frailty in middle-aged and older adults: findings from developed and developing countries","volume":"20","author":"Li","year":"2024","journal-title":"Glob Health"},{"key":"10.1016\/j.tjfa.2026.100195_bib0023","first-page":"1","article-title":"e: 2018 Chinese guidelines for the management of hypertension","volume":"24","author":"Liu","year":"2019","journal-title":"Chin J Cardiovasc Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0024","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2337\/dc22-S002","article-title":"2 Classification and diagnosis of diabetes: standards of medical care in diabetes-2022","volume":"45","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tjfa.2026.100195_bib0025","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.16591","article-title":"Association of depressive symptoms with incident cardiovascular diseases in middle-aged and older Chinese adults","volume":"2","author":"Li","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.tjfa.2026.100195_bib0026","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jclinepi.2006.01.014","article-title":"Review: a gentle introduction to imputation of missing values","volume":"59","author":"Donders","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.tjfa.2026.100195_bib0027","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.tjfa.2026.100195_bib0028","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0029","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/joim.12051","article-title":"High levels of cystatin C predict the metabolic syndrome: the prospective Malm\u00f6 Diet and Cancer Study","volume":"274","author":"Magnusson","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100531","article-title":"Estimated GFR, albuminuria, and physical function: the brain in Kidney disease (BRINK) cohort study","volume":"4","author":"Mello","year":"2022","journal-title":"Kidney Med"},{"key":"10.1016\/j.tjfa.2026.100195_bib0031","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.ajkd.2023.03.005","article-title":"The difference between cystatin C- and creatinine-based estimated GFR in heart failure with reduced ejection fraction: insights from PARADIGM-HF","volume":"82","author":"Pinsino","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.tjfa.2026.100195_bib0032","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/s12877-020-01862-8","article-title":"Renal dysfunction is associated with decline of cognitive function in community-dwelling older adults: korean frailty and aging cohort study","volume":"20","author":"Kong","year":"2020","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.tjfa.2026.100195_bib0033","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/ndt\/gft509","article-title":"Glomerular filtration rate estimation using cystatin C alone or combined with creatinine as a confirmatory test","volume":"29","author":"Fan","year":"2014","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.tjfa.2026.100195_bib0034","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12966-025-01722-x","article-title":"Is meeting 24-hour movement guidelines associated with a lower risk of frailty among adults?","volume":"22","author":"Liu","year":"2025","journal-title":"Int J Behav Nutr Phys Act"}],"container-title":["The Journal of Frailty &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2260134126000642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2260134126000642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:29:32Z","timestamp":1792873772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2260134126000642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2260134126000642"],"URL":"https:\/\/doi.org\/10.1016\/j.tjfa.2026.100195","relation":{},"ISSN":["2260-1341"],"issn-type":[{"value":"2260-1341","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher cystatin C, but not creatinine, predicts frailty risk in individuals with normal kidney function","name":"articletitle","label":"Article Title"},{"value":"The Journal of Frailty & Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjfa.2026.100195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100195"}}