{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:55:03Z","timestamp":1764557703807,"version":"3.40.3"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009648","name":"New Zealand Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007879","name":"New Zealand Tertiary Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.tjnut.2024.02.027","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:12:22Z","timestamp":1709287942000},"page":"1461-1471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of a Combined In Vivo\/In Vitro Ileal Fermentation Assay in the Growing Pig to be Used as a Model for Adult Humans"],"prefix":"10.1016","volume":"154","author":[{"given":"Anna ME","family":"Hoogeveen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J","family":"Moughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha","family":"Stroebinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren C","family":"McNabb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.tjnut.2024.02.027_bib1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/ismej.2011.212","article-title":"The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates","volume":"6","author":"Zoetendal","year":"2012","journal-title":"ISME J"},{"issue":"20","key":"10.1016\/j.tjnut.2024.02.027_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000455","article-title":"Fermentation kinetics of selected dietary fibers by human small intestinal microbiota depend on the type of fiber and subject","volume":"64","author":"van Trijp","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"issue":"6","key":"10.1016\/j.tjnut.2024.02.027_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1017\/S0007114520001385","article-title":"Ileal and hindgut fermentation in the growing pig fed a human-type diet","volume":"124","author":"Hoogeveen","year":"2020","journal-title":"Br. J. Nutr."},{"issue":"10","key":"10.1016\/j.tjnut.2024.02.027_bib4","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1093\/jn\/nxab228","article-title":"Type of dietary fiber is associated with changes in ileal and hindgut microbial communities in growing pigs and influences in vitro ileal and hindgut fermentation","volume":"151","author":"Hoogeveen","year":"2021","journal-title":"J.\u00a0Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2024.02.027_bib5","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.tjnut.2024.02.027_bib6","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1111\/j.1462-2920.2010.02294.x","article-title":"High temporal and inter-individual variation detected in the human ileal microbiota","volume":"12","author":"Booijink","year":"2010","journal-title":"Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.anifeedsci.2008.03.009","article-title":"Changes in bacterial populations in the ileum of pigs fed low-phosphorus diets supplemented with different sources of fermentable carbohydrates","volume":"148","author":"Metzler","year":"2009","journal-title":"Anim. Feed Sci. Technol."},{"issue":"23","key":"10.1016\/j.tjnut.2024.02.027_bib8","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1128\/AEM.02691-13","article-title":"Changing dietary calcium-phosphorus level and cereal source selectively alters abundance of bacteria and metabolites in the upper gastrointestinal tracts of weaned pigs","volume":"79","author":"Metzler-Zebeli","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"issue":"Suppl 2","key":"10.1016\/j.tjnut.2024.02.027_bib9","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1017\/S0007114512002346","article-title":"Animal models for determining amino acid digestibility in humans - a review","volume":"108","author":"Deglaire","year":"2012","journal-title":"Br. J Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jn\/nxx038","article-title":"Development of an in vivo and in vitro ileal fermentation method in a growing pig model","volume":"148","author":"Montoya","year":"2018","journal-title":"J.\u00a0Nutr."},{"issue":"9","key":"10.1016\/j.tjnut.2024.02.027_bib11","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1017\/S0007114520003542","article-title":"In vitro ileal and caecal fermentation of fibre substrates in the growing pig given a human-type diet","volume":"125","author":"Montoya","year":"2021","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2024.02.027_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdnut.2023.100076","article-title":"In vitro ileal fermentation is affected more by the fiber source fermented than the ileal microbial composition in growing pigs","volume":"7","author":"Hoogeveen","year":"2023","journal-title":"Curr. Dev. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.foodchem.2012.08.045","article-title":"Optimisation of inoculum concentration and incubation duration for an in vitro hindgut dry matter digestibility assay","volume":"136","author":"Coles","year":"2013","journal-title":"Food Chem"},{"issue":"11","key":"10.1016\/j.tjnut.2024.02.027_bib14","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/jsfa.6108","article-title":"Validation of a dual in vivo-in vitro assay for predicting the digestibility of nutrients in humans","volume":"93","author":"Coles","year":"2013","journal-title":"J.\u00a0Sci. Food Agric."},{"issue":"8","key":"10.1016\/j.tjnut.2024.02.027_bib15","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1017\/S0007114515002883","article-title":"Kiwifruit fibre level influences the predicted production and absorption of SCFA in the hindgut of growing pigs using a combined in vivo-in vitro digestion methodology","volume":"115","author":"Montoya","year":"2016","journal-title":"Br. J. Nutr."},{"issue":"10","key":"10.1016\/j.tjnut.2024.02.027_bib16","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1093\/jn\/nxaa210","article-title":"Determination of true ileal amino acid digestibility in the growing pig for calculation of digestible indispensable amino acid score (DIAAS)","volume":"150","author":"Hodgkinson","year":"2020","journal-title":"J.\u00a0Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2024.02.027_bib17","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3945\/ajcn.113.074724","article-title":"Similar metabolic responses in pigs and humans to breads with different contents and compositions of dietary fibers: A metabolomics study","volume":"99","author":"Nielsen","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2024.02.027_bib18","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/jsfa.6316","article-title":"Comparative digestibility of energy and nutrients and fermentability of dietary fiber in eight cereal grains fed to pigs","volume":"94","author":"Cervantes-Pahm","year":"2014","journal-title":"J.\u00a0Sci. Food Agric."},{"issue":"7285","key":"10.1016\/j.tjnut.2024.02.027_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A\u00a0human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.tjnut.2024.02.027_bib20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/1574-6976.12075","article-title":"The first 1000 cultured species of the human gastrointestinal microbiota","volume":"38","author":"Rajili\u0107-Stojanovi\u0107","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.tjnut.2024.02.027_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vetmic.2011.05.021","article-title":"Longitudinal investigation of the age-related bacterial diversity in the feces of commercial pigs","volume":"153","author":"Kim","year":"2011","journal-title":"Vet. Microbiol."},{"issue":"6032","key":"10.1016\/j.tjnut.2024.02.027_bib22","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1198719","article-title":"Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans","volume":"332","author":"Muegge","year":"2011","journal-title":"Science"},{"issue":"6052","key":"10.1016\/j.tjnut.2024.02.027_bib23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S000711450720580X","article-title":"Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning","volume":"97","author":"Montagne","year":"2007","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S0954422413000152","article-title":"Use of pigs as a potential model for research into dietary modulation of the human gut microbiota","volume":"26","author":"Heinritz","year":"2013","journal-title":"Nutr. Res. Rev."},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/ismej.2007.23","article-title":"Inter-species transplantation of gut microbiota from human to pigs","volume":"1","author":"Pang","year":"2007","journal-title":"ISME J"},{"issue":"7","key":"10.1016\/j.tjnut.2024.02.027_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040758","article-title":"Comprehensive postmortem analyses of intestinal microbiota changes and bacterial translocation in human flora associated mice","volume":"7","author":"Heimesaat","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tjnut.2024.02.027_bib28","series-title":"The Gestating and Lactating Sow","first-page":"115","article-title":"Composition of sow colostrum and milk","author":"Hurley","year":"2015"},{"issue":"7","key":"10.1016\/j.tjnut.2024.02.027_bib29","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3168\/jds.S0022-0302(06)72313-X","article-title":"True ileal amino acid digestibility of goat and cow milk Infant Formulas","volume":"89","author":"Rutherfurd","year":"2006","journal-title":"J.\u00a0Dairy Sci."},{"issue":"4","key":"10.1016\/j.tjnut.2024.02.027_bib30","first-page":"387","article-title":"The three-week-old piglet as a model animal for studying protein digestion in human infants","volume":"21","author":"Darragh","year":"1995","journal-title":"J.\u00a0Pediatr. Gastroenterol. Nutr."},{"year":"2012","series-title":"Nutrient Requirements of Swine","key":"10.1016\/j.tjnut.2024.02.027_bib31"},{"issue":"15","key":"10.1016\/j.tjnut.2024.02.027_bib32","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/jsfa.1258","article-title":"The diurnal pattern of ileal dry matter and endogenous ileal nitrogen flows in the growing pig","volume":"82","author":"Hodgkinson","year":"2002","journal-title":"J.\u00a0Sci. Food Agric."},{"issue":"1\u20132","key":"10.1016\/j.tjnut.2024.02.027_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0377-8401(94)90080-9","article-title":"Comparison of the slaughter method and simple T-piece cannulation of the terminal ileum for determining ileal amino acid digestibility in meat and bone meal for the growing pig","volume":"49","author":"Donkoh","year":"1994","journal-title":"Anim. Feed Sci. Technol."},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1079\/BJN19910078","article-title":"Digestive development of the early-weaned pig. 1. Effect of continuous nutrient supply on the development of the digestive tract and on changes in digestive enzyme activity during the first week post-weaning","volume":"65","author":"Kelly","year":"1991","journal-title":"Br. J. Nutr."},{"year":"2012","series-title":"AOAC Official Method of Analysis","key":"10.1016\/j.tjnut.2024.02.027_bib35"},{"issue":"4","key":"10.1016\/j.tjnut.2024.02.027_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0377-8401(95)00916-7","article-title":"Determination of titanium dioxide added as an inert marker in chicken digestibility studies","volume":"59","author":"Short","year":"1996","journal-title":"Anim. Feed Sci. Technol."},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1472-765X.1989.tb00278.x","article-title":"Simultaneous determination of volatile and non-volatile acidic fermentation products of anaerobes by capillary gas chromatography","volume":"9","author":"Richardson","year":"1989","journal-title":"Lett. Appl. Microbiol."},{"issue":"3","key":"10.1016\/j.tjnut.2024.02.027_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-3083.2008.02211.x","article-title":"Effects of human fecal flora on intestinal morphology and mucosal immunity in human flora-associated piglet","volume":"69","author":"Che","year":"2009","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mimet.2005.10.014","article-title":"Comparison of methods and animal models commonly used for investigation of fecal microbiota: effects of time, host and gender","volume":"66","author":"Bernbom","year":"2006","journal-title":"J.\u00a0Microbiol. Methods."},{"issue":"W1","key":"10.1016\/j.tjnut.2024.02.027_bib40","doi-asserted-by":"crossref","first-page":"W180","DOI":"10.1093\/nar\/gkx295","article-title":"MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data","volume":"45","author":"Dhariwal","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.tjnut.2024.02.027_bib41","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41596-019-0264-1","article-title":"Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data","volume":"15","author":"Chong","year":"2020","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib42","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s42003-020-01477-0","article-title":"Differential longitudinal establishment of human fecal bacterial communities in germ-free porcine and murine models","volume":"3","author":"Aluthge","year":"2020","journal-title":"Commun. Biol."},{"issue":"7","key":"10.1016\/j.tjnut.2024.02.027_bib43","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/2050640619852255","article-title":"Composition of the mucosa-associated microbiota along the entire gastrointestinal tract of human individuals","volume":"7","author":"Vuik","year":"2019","journal-title":"United European Gastroenterol. J."},{"issue":"8","key":"10.1016\/j.tjnut.2024.02.027_bib44","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1093\/ecco-jcc\/jjab020","article-title":"The composition and metabolic potential of the human small intestinal microbiota within the context of inflammatory bowel disease","volume":"15","author":"Ruigrok","year":"2021","journal-title":"J.\u00a0Crohns Colitis."},{"issue":"7","key":"10.1016\/j.tjnut.2024.02.027_bib45","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1111\/1462-2920.13248","article-title":"Transition from infant- to adult-like gut microbiota","volume":"18","author":"Avershina","year":"2016","journal-title":"Environ. Microbiol."},{"issue":"Suppl 1","key":"10.1016\/j.tjnut.2024.02.027_bib46","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1000081107","article-title":"Succession of microbial consortia in the developing infant gut microbiome","volume":"108","author":"Koenig","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.tjnut.2024.02.027_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4161\/gmic.23867","article-title":"A\u00a0pig model of the human gastrointestinal tract","volume":"4","author":"Zhang","year":"2013","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.tjnut.2024.02.027_bib48","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1128\/AEM.68.2.673-690.2002","article-title":"Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited","volume":"68","author":"Leser","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tjnut.2024.02.027_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137382","article-title":"Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiota","volume":"719","author":"Huang","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.tjnut.2024.02.027_bib50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s40168-021-01175-x","article-title":"Xylan alleviates dietary fiber deprivation-induced dysbiosis by selectively promoting Bifidobacterium pseudocatenulatum in pigs","volume":"9","author":"Wang","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.tjnut.2024.02.027_bib51","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3389\/fmicb.2019.00797","article-title":"Characterization of the early life microbiota development and predominant Lactobacillus species at distinct gut segments of low- and normal-birth-weight piglets","volume":"10","author":"Li","year":"2019","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.tjnut.2024.02.027_bib52","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2527\/2006.844843x","article-title":"Effects of guar gum and cellulose on digesta passage rate, ileal microbial populations, energy and protein digestibility, and performance of grower pigs","volume":"84","author":"Owusu-Asiedu","year":"2006","journal-title":"J.\u00a0Anim. Sci."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316624001159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316624001159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T03:12:04Z","timestamp":1743909124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316624001159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0022316624001159"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2024.02.027","relation":{},"ISSN":["0022-3166"],"issn-type":[{"type":"print","value":"0022-3166"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of a Combined In Vivo\/In Vitro Ileal Fermentation Assay in the Growing Pig to be Used as a Model for Adult Humans","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2024.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}