{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:46:17Z","timestamp":1792791977175,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008796","name":"Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000203","name":"Canadian Foundation for Dietetic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.tjnut.2024.06.013","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T02:32:29Z","timestamp":1719369149000},"page":"2680-2687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin B12 Is Associated with Higher Serum Testosterone Concentrations and Improved Androgenic Profiles Among Men with Infertility"],"prefix":"10.1016","volume":"154","author":[{"given":"Matineh","family":"Rastegar Panah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Jarvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-6414","authenticated-orcid":false,"given":"Ahmed","family":"El-Sohemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tjnut.2024.06.013_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1210\/jc.2006-1375","article-title":"A\u00a0population-level decline in serum testosterone levels in American men","volume":"92","author":"Travison","year":"2007","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.tjnut.2024.06.013_bib3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/humupd\/dmx022","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis","volume":"23","author":"Levine","year":"2017","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib4","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.euf.2020.02.006","article-title":"Decline in serum testosterone levels among adolescent and young adult men in the USA","volume":"7","author":"Lokeshwar","year":"2021","journal-title":"Eur. Urol. Focus"},{"issue":"1","key":"10.1016\/j.tjnut.2024.06.013_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0094-0143(02)00117-9","article-title":"Endocrine causes of male infertility","volume":"30","author":"Jarow","year":"2003","journal-title":"Urol. Clin. North Am."},{"issue":"2","key":"10.1016\/j.tjnut.2024.06.013_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/00325481.1987.11699712","article-title":"Male infertility. 3. Endocrine causes","volume":"81","author":"McNally","year":"1987","journal-title":"Postgrad. Med."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/01485010701271786","article-title":"Genetic risk factors in male infertility","volume":"53","author":"Krausz","year":"2007","journal-title":"Arch. Androl."},{"key":"10.1016\/j.tjnut.2024.06.013_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.smrv.2018.07.006","article-title":"Linking sleep disturbance to idiopathic male infertility","volume":"42","author":"Palnitkar","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.tjnut.2024.06.013_bib9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3389\/fphys.2019.01356","article-title":"Relationship between smoking habit and sperm parameters among patients attending an infertility clinic","volume":"10","author":"Rehman","year":"2019","journal-title":"Front. Physiol."},{"issue":"3\u20134","key":"10.1016\/j.tjnut.2024.06.013_bib10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/10937400701873472","article-title":"Human exposure to endocrine disrupters and semen quality","volume":"11","author":"Phillips","year":"2008","journal-title":"J.\u00a0Toxicol. Environ. Health B Crit. Rev."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/tau.2018.05.17","article-title":"Endocrine disrupting chemicals and impact on male reproductive health","volume":"7","author":"Rehman","year":"2018","journal-title":"Transl. Androl. Urol."},{"issue":"7","key":"10.1016\/j.tjnut.2024.06.013_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11934-018-0805-0","article-title":"The role of lifestyle in male infertility: diet, physical activity, and body habitus","volume":"19","author":"Hayden","year":"2018","journal-title":"Curr. Urol. Rep."},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib13","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1530\/REP-17-0161","article-title":"Obesity, a serious etiologic factor for male subfertility in modern society","volume":"154","author":"Liu","year":"2017","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.tjnut.2024.06.013_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MOU.0000000000000417","article-title":"Obesity and male infertility","volume":"27","author":"Kahn","year":"2017","journal-title":"Curr. Opin. Urol."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/1008-682X.148076","article-title":"Male obesity and subfertility, is it really about increased adiposity?","volume":"17","author":"McPherson","year":"2015","journal-title":"Asian J. Androl."},{"issue":"11","key":"10.1016\/j.tjnut.2024.06.013_bib16","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1093\/humrep\/des311","article-title":"Intake of food groups and idiopathic asthenozoospermia: a case-control study","volume":"27","author":"Eslamian","year":"2012","journal-title":"Hum. Reprod."},{"issue":"10","key":"10.1016\/j.tjnut.2024.06.013_bib17","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/humrep\/des298","article-title":"Dietary patterns and semen quality in young men","volume":"27","author":"Gaskins","year":"2012","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.tjnut.2024.06.013_bib18","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/humrep\/dep024","article-title":"Associations between dietary patterns and semen quality in men undergoing IVF\/ICSI treatment","volume":"24","author":"Vujkovic","year":"2009","journal-title":"Hum. Reprod."},{"issue":"7","key":"10.1016\/j.tjnut.2024.06.013_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134224","article-title":"The association between dietary patterns and semen quality in a general Asian population of 7282 males","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib20","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.21037\/tau-20-592","article-title":"Nutrition, genetic variation and male fertility","volume":"10","author":"Vanderhout","year":"2021","journal-title":"Transl. Androl. Urol."},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: a review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"J.\u00a0Hum. Reprod. Sci."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"Suppl 3","key":"10.1016\/j.tjnut.2024.06.013_bib23","doi-asserted-by":"crossref","first-page":"S367","DOI":"10.21037\/tau.2018.03.25","article-title":"Update on male reproductive endocrinology","volume":"7","author":"Clavijo","year":"2018","journal-title":"Transl. Androl. Urol."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib24","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/physrev.00018.2016","article-title":"Estrogens in male physiology","volume":"97","author":"Cooke","year":"2017","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4103\/1008-682X.173932","article-title":"The role of estradiol in male reproductive function","volume":"18","author":"Schulster","year":"2016","journal-title":"Asian J. Androl."},{"issue":"1","key":"10.1016\/j.tjnut.2024.06.013_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aju.2017.10.002","article-title":"Hyperprolactinaemia in male infertility: clinical case scenarios","volume":"16","author":"Dabbous","year":"2017","journal-title":"Arab. J. Urol."},{"issue":"2","key":"10.1016\/j.tjnut.2024.06.013_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/biom7020042","article-title":"Vitamin B12 and semen quality","volume":"7","author":"Banihani","year":"2017","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/humupd\/dml063","article-title":"Impact of folate and homocysteine metabolism on human reproductive health","volume":"13","author":"Forges","year":"2007","journal-title":"Hum. Reprod. Update"},{"issue":"6","key":"10.1016\/j.tjnut.2024.06.013_bib29","doi-asserted-by":"crossref","first-page":"H2649","DOI":"10.1152\/ajpheart.00548.2005","article-title":"Mechanisms of homocysteine-induced oxidative stress","volume":"289","author":"Tyagi","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.tjnut.2024.06.013_bib30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.fertnstert.2008.06.010","article-title":"Low folate in seminal plasma is associated with increased sperm DNA damage","volume":"92","author":"Boxmeer","year":"2009","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.tjnut.2024.06.013_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1933719110385135","article-title":"Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility","volume":"18","author":"Safarinejad","year":"2011","journal-title":"Reprod. Sci."},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib32","first-page":"373","article-title":"Investigation and treatment of the infertile male","volume":"66","author":"Halim","year":"1973","journal-title":"Proc. R. Soc. Med."},{"issue":"7","key":"10.1016\/j.tjnut.2024.06.013_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/gut.23.7.608","article-title":"Male gonadal function in coeliac disease: 1. Sexual dysfunction, infertility, and semen quality","volume":"23","author":"Farthing","year":"1982","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1439-0272.1976.tb01669.x","article-title":"Dietetic habits and quality of semen in Indian subjects","volume":"8","author":"Jathar","year":"1976","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib35","first-page":"581","article-title":"[Clinical experience with methylcobalamin (CH3-B12) for male infertility]","volume":"30","author":"Isoyama","year":"1984","journal-title":"Hinyokika Kiyo"},{"key":"10.1016\/j.tjnut.2024.06.013_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2023.1143579","article-title":"Ascorbic acid is associated with favourable hormonal profiles among infertile males","volume":"5","author":"Rastegar Panah","year":"2023","journal-title":"Front. Reprod. Health."},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/10520295.2021.1962976","article-title":"Vitamin B12 suppresses GADD153, prevents apoptosis and regulates the testicular function in methotrexate treated rat testis","volume":"97","author":"Karabulut","year":"2022","journal-title":"Biotech. Histochem."},{"issue":"4","key":"10.1016\/j.tjnut.2024.06.013_bib38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/molehr\/gal118","article-title":"Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men","volume":"13","author":"Dhillon","year":"2007","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.tjnut.2024.06.013_bib39","first-page":"151","article-title":"[Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia]","volume":"33","author":"Moriyama","year":"1987","journal-title":"Hinyokika Kiyo"},{"key":"10.1016\/j.tjnut.2024.06.013_bib40","series-title":"Vitamin B12 status of Canadians, 2009 to 2011 [Internet]","year":"2012"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316624003523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316624003523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T03:40:02Z","timestamp":1728531602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316624003523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0022316624003523"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2024.06.013","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin B12 Is Associated with Higher Serum Testosterone Concentrations and Improved Androgenic Profiles Among Men with Infertility","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2024.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}]}}