{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:03:26Z","timestamp":1790280206318,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58-8050-3-003"],"award-info":[{"award-number":["58-8050-3-003"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051641"],"award-info":[{"award-number":["R01AG051641"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG072559"],"award-info":[{"award-number":["R01AG072559"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.tjnut.2025.04.035","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T19:06:37Z","timestamp":1746558397000},"page":"2711-2716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults"],"prefix":"10.1016","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-5582","authenticated-orcid":false,"given":"M Kyla","family":"Shea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2025.04.035_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fneur.2019.00239","article-title":"The relationships between vitamin K and cognition: a review of current evidence","volume":"10","author":"Alisi","year":"2019","journal-title":"Front. Neurol."},{"issue":"10","key":"10.1016\/j.tjnut.2025.04.035_bib2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3390\/cells13100873","article-title":"Modification of Gas6 protein in the brain by a functional endogenous tissue vitamin K cycle","volume":"13","author":"Aydin","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229769","article-title":"Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia\/reperfusion injury in rat","volume":"15","author":"Farhadi Moghadam","year":"2020","journal-title":"PLOS One"},{"issue":"13","key":"10.1016\/j.tjnut.2025.04.035_bib4","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1523\/JNEUROSCI.23-13-05816.2003","article-title":"Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tjnut.2025.04.035_bib5","article-title":"Association of vitamin K insufficiency with cognitive dysfunction in community-dwelling older adults","volume":"8","author":"Azuma","year":"2021","journal-title":"Front. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib6","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1212\/WNL.0000000000004815","article-title":"Nutrients and bioactives in green leafy vegetables and cognitive decline: prospective study","volume":"90","author":"Morris","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.tjnut.2025.04.035_bib7","article-title":"Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population, Age","volume":"51","author":"Camacho-Barcia","year":"2022","journal-title":"Ageing"},{"issue":"8","key":"10.1016\/j.tjnut.2025.04.035_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/1028415X.2018.1536411","article-title":"Vitamin K status and inflammation are associated with cognition in older Irish adults","volume":"23","author":"Kiely","year":"2020","journal-title":"Nutr. Neurosci."},{"issue":"4","key":"10.1016\/j.tjnut.2025.04.035_bib9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3945\/an.113.003855","article-title":"Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements","volume":"4","author":"Walther","year":"2013","journal-title":"Adv. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2025.04.035_bib10","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/jn\/nxab332","article-title":"Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice","volume":"152","author":"Ellis","year":"2022","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2025.04.035_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/jn\/126.2.537","article-title":"Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations","volume":"126","author":"Thijssen","year":"1996","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2025.04.035_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3945\/jn.111.155804","article-title":"Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats","volume":"142","author":"Al Rajabi","year":"2012","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2025.04.035_bib13","article-title":"Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons","volume":"8","author":"Booth","year":"2022","journal-title":"Alzheimers. Dement (N Y)."},{"issue":"12","key":"10.1016\/j.tjnut.2025.04.035_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.tjnut.2025.04.035_bib15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3945\/ajcn.2009.27930","article-title":"Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?","volume":"90","author":"McCann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.04.035_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnagi.2018.00213","article-title":"Vitamin K deficiency induced by warfarin is associated with cognitive and behavioral perturbations, and alterations in brain sphingolipids in rats","volume":"10","author":"Tamadon-Nejad","year":"2018","journal-title":"Front. Aging. Neurosci."},{"issue":"4","key":"10.1016\/j.tjnut.2025.04.035_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000087446","article-title":"The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort","volume":"25","author":"Bennett","year":"2005","journal-title":"Neuroepidemiology"},{"issue":"1","key":"10.1016\/j.tjnut.2025.04.035_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/jn\/nxaa336","article-title":"Vitamin D and vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project","volume":"151","author":"Fu","year":"2021","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000096129","article-title":"Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study","volume":"27","author":"Bennett","year":"2006","journal-title":"Neuroepidemiology"},{"issue":"24","key":"10.1016\/j.tjnut.2025.04.035_bib20","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"issue":"24","key":"10.1016\/j.tjnut.2025.04.035_bib21","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1212\/WNL.0000000000005677","article-title":"APOE epsilon2epsilon4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults","volume":"90","author":"Oveisgharan","year":"2018","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.tjnut.2025.04.035_bib24","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jand.2015.12.023","article-title":"Avoidance of vitamin K-rich foods is common among warfarin users and translates into lower usual vitamin K intakes","volume":"116","author":"Leblanc","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"issue":"8","key":"10.1016\/j.tjnut.2025.04.035_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/nu16081098","article-title":"Mediterranean diet favors vitamin K intake: a descriptive study in a Mediterranean population","volume":"16","author":"Pinto","year":"2024","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.tjnut.2025.04.035_bib26","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1093\/jn\/133.8.2565","article-title":"Dietary phylloquinone depletion and repletion in older women","volume":"133","author":"Booth","year":"2003","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib27","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/advances\/nmab004","article-title":"Perspective: evidence before enthusiasm\u2013a critical review of the potential cardiovascular benefits of vitamin K","volume":"12","author":"Shea","year":"2021","journal-title":"Adv. Nutr."},{"issue":"7320","key":"10.1016\/j.tjnut.2025.04.035_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature09464","article-title":"Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme","volume":"468","author":"Nakagawa","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.tjnut.2025.04.035_bib32","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbrc.2015.03.018","article-title":"YY1 positively regulates human UBIAD1 expression","volume":"460","author":"Funahashi","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.tjnut.2025.04.035_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/jn\/nxz200","article-title":"Concentrations of circulating phylloquinone, but not cerebral menaquinone-4, are positively correlated with a wide range of cognitive measures: exploratory findings in centenarians","volume":"150","author":"Tanprasertsuk","year":"2020","journal-title":"J. Nutr."},{"issue":"5 Pt 1","key":"10.1016\/j.tjnut.2025.04.035_bib34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.7326\/0003-4819-158-5-201303050-00007","article-title":"Cognitive impairment associated with atrial fibrillation: a meta-analysis","volume":"158","author":"Kalantarian","year":"2013","journal-title":"Ann. Intern. Med."},{"issue":"5","key":"10.1016\/j.tjnut.2025.04.035_bib35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCULATIONAHA.121.055018","article-title":"Atrial fibrillation and dementia: a report from the AF-SCREEN International Collaboration","volume":"145","author":"Rivard","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.tjnut.2025.04.035_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jacc.2018.10.077","article-title":"Atrial fibrillation and cognitive function: JACC review topic of the week","volume":"73","author":"Diener","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.tjnut.2025.04.035_bib37","doi-asserted-by":"crossref","first-page":"e1309","DOI":"10.1212\/WNL.0000000000206748","article-title":"Oral anticoagulants and the risk of dementia in patients with nonvalvular atrial fibrillation: a population-based cohort study","volume":"100","author":"Rahman","year":"2023","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.tjnut.2025.04.035_bib38","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.3390\/jcm13082418","article-title":"Exploring the link between anticoagulation, cognitive impairment and dementia in atrial fibrillation: a systematic review","volume":"13","author":"Agarwal","year":"2024","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/20009666.2020.1767270","article-title":"Warfarin therapy in atrial fibrillation: assessment of patient knowledge of risks and benefits","volume":"10","author":"Fitzgerald","year":"2020","journal-title":"J. Community. Hosp. Intern. Med. Perspect."},{"issue":"3","key":"10.1016\/j.tjnut.2025.04.035_bib40","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40256-024-00638-4","article-title":"Trends in oral anticoagulant use and individual expenditures across the United States from 2014 to 2020","volume":"24","author":"Alkhezi","year":"2024","journal-title":"Am. J. Cardiovasc. Drugs."},{"issue":"12","key":"10.1016\/j.tjnut.2025.04.035_bib42","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/jamacardio.2022.3704","article-title":"Association of race and ethnicity with oral anticoagulation and associated outcomes in patients with atrial fibrillation: findings from the Get With The Guidelines-Atrial Fibrillation registry","volume":"7","author":"Essien","year":"2022","journal-title":"JAMA. Cardiol."},{"issue":"10","key":"10.1016\/j.tjnut.2025.04.035_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.015689","article-title":"Sex differences in oral anticoagulation and outcomes of stroke and intracranial bleeding in newly diagnosed atrial fibrillation","volume":"9","author":"Yong","year":"2020","journal-title":"J. Am. Heart. Assoc."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625002810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625002810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:44:47Z","timestamp":1790279087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316625002810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0022316625002810"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.04.035","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}