{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:27:25Z","timestamp":1785032845989,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.tjnut.2025.05.022","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:44:02Z","timestamp":1747968242000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between Human Milk Fatty Acid Esters of Hydroxy Fatty Acids and Maternal Body Mass Index and Early Infant Growth: A Longitudinal Study"],"prefix":"10.1016","volume":"155","author":[{"given":"Ping","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-yong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-mei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000496471","article-title":"Nutrition during pregnancy, lactation and early childhood and its implications for maternal and long-term child health: the early nutrition project recommendations","volume":"74","author":"Koletzko","year":"2019","journal-title":"Ann. Nutr. Metab."},{"issue":"Suppl. 2","key":"10.1016\/j.tjnut.2025.05.022_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000452819","article-title":"Human milk lipids","volume":"69","author":"Koletzko","year":"2016","journal-title":"Ann. Nutr. Metab."},{"issue":"Suppl","key":"10.1016\/j.tjnut.2025.05.022_bib3","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.jpeds.2016.02.077","article-title":"Clinical benefits of milk fat globule membranes for infants and children","volume":"173","author":"Hernell","year":"2016","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2014.09.035","article-title":"Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects","volume":"159","author":"Yore","year":"2014","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.tjnut.2025.05.022_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/metabo10120512","article-title":"Fatty acyl esters of hydroxy fatty acid (FAHFA) lipid families","volume":"10","author":"Wood","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.tjnut.2025.05.022_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2020.101053","article-title":"Understanding FAHFAs: from structure to metabolic regulation","volume":"79","author":"Brejchova","year":"2020","journal-title":"Prog. Lipid Res."},{"issue":"9","key":"10.1016\/j.tjnut.2025.05.022_bib7","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.2337\/db16-0385","article-title":"Docosahexaenoic acid-derived fatty acid esters of hydroxy fatty acids (FAHFAs) with anti-inflammatory properties","volume":"65","author":"Kuda","year":"2016","journal-title":"Diabetes"},{"issue":"38","key":"10.1016\/j.tjnut.2025.05.022_bib8","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1039\/C6OB01597B","article-title":"Regiocontrolled syntheses of FAHFAs and LC-MS\/MS differentiation of regioisomers","volume":"14","author":"Balas","year":"2016","journal-title":"Org. Biomol. Chem."},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2018.01.001","article-title":"Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial effects on glucose homeostasis","volume":"27","author":"Syed","year":"2018","journal-title":"Cell Metab."},{"issue":"18","key":"10.1016\/j.tjnut.2025.05.022_bib10","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1039\/C8LC00624E","article-title":"Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid","volume":"18","author":"Bandak","year":"2018","journal-title":"Lab. Chip."},{"issue":"10","key":"10.1016\/j.tjnut.2025.05.022_bib11","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1172\/JCI127092","article-title":"PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms","volume":"129","author":"Zhou","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"42","key":"10.1016\/j.tjnut.2025.05.022_bib12","doi-asserted-by":"crossref","first-page":"22207","DOI":"10.1074\/jbc.M115.703835","article-title":"Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses","volume":"291","author":"Lee","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2025.05.022_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108361","article-title":"Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice","volume":"79","author":"Benlebna","year":"2020","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.tjnut.2025.05.022_bib14","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00394-020-02391-1","article-title":"Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice","volume":"60","author":"Benlebna","year":"2021","journal-title":"Eur. J. Nutr."},{"issue":"27","key":"10.1016\/j.tjnut.2025.05.022_bib15","doi-asserted-by":"crossref","first-page":"10698","DOI":"10.1074\/jbc.RA118.006956","article-title":"Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals","volume":"294","author":"Kolar","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbalip.2017.11.004","article-title":"Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers","volume":"1863","author":"Brezinova","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids."},{"issue":"7","key":"10.1016\/j.tjnut.2025.05.022_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/ejlt.202100224","article-title":"Compositional differences between preterm milk of different gestational ages with the term milk: a comparative lipidomic study by LC-MS\/MS","volume":"124","author":"Zhao","year":"2022","journal-title":"Eur. J. Lipid. Sci. Technol."},{"issue":"7","key":"10.1016\/j.tjnut.2025.05.022_bib18","doi-asserted-by":"crossref","first-page":"E838","DOI":"10.1152\/ajpendo.00605.2013","article-title":"De novo synthesis of milk triglycerides in humans","volume":"306","author":"Mohammad","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.tjnut.2025.05.022_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10911-009-9142-8","article-title":"Mechanism of chain length determination in biosynthesis of milk fatty acids. 1980, J. Mammary Gland","volume":"14","author":"Smith","year":"2009","journal-title":"Biol. Neoplasia."},{"issue":"4","key":"10.1016\/j.tjnut.2025.05.022_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nprot.2016.040","article-title":"A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids","volume":"11","author":"Zhang","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tjnut.2025.05.022_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132983","article-title":"Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase","volume":"388","author":"Brejchova","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.tjnut.2025.05.022_bib22","series-title":"WHO Anthro (version 3.2.2, January 2011) and macros","year":"2011"},{"issue":"13","key":"10.1016\/j.tjnut.2025.05.022_bib23","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/(SICI)1097-0258(19990715)18:13<1707::AID-SIM138>3.0.CO;2-H","article-title":"Longitudinal data analysis (repeated measures) in clinical trials","volume":"18","author":"Albert","year":"1999","journal-title":"Stat. Med."},{"issue":"8","key":"10.1016\/j.tjnut.2025.05.022_bib24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0006-3223(02)01867-X","article-title":"Assessing and interpreting treatment effects in longitudinal clinical trials with missing data","volume":"53","author":"Mallinckrodt","year":"2003","journal-title":"Biol. Psychiatry."},{"issue":"11","key":"10.1016\/j.tjnut.2025.05.022_bib25","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/ibd.20511","article-title":"Longitudinal study of quality of life and psychological functioning for active, fluctuating, and inactive disease patterns in inflammatory bowel disease","volume":"14","author":"Lix","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.tjnut.2025.05.022_bib26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1037\/a0017737","article-title":"Testing multiple outcomes in repeated measures designs","volume":"15","author":"Lix","year":"2010","journal-title":"Psychol. Methods"},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib27","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"issue":"5","key":"10.1016\/j.tjnut.2025.05.022_bib28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2105\/AJPH.86.5.726","article-title":"Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods","volume":"86","author":"Aickin","year":"1996","journal-title":"Am. J. Public Health."},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1017\/S2040174412000657","article-title":"Infant body composition in the PEA POD\u00ae era: what have we learned and where do we go from here?","volume":"4","author":"Li","year":"2013","journal-title":"J. Dev. Orig. Health Dis"},{"issue":"1","key":"10.1016\/j.tjnut.2025.05.022_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/nu13010019","article-title":"Impact of maternal obesity on the metabolism and bioavailability of polyunsaturated fatty acids during pregnancy and breastfeeding","volume":"13","author":"Alvarez","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.tjnut.2025.05.022_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.clnu.2023.11.028","article-title":"The association between human milk fatty acid composition in mothers with an elevated body mass index and infant growth changes","volume":"43","author":"Hua","year":"2024","journal-title":"Clin. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2025.05.022_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1215","article-title":"Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics","volume":"13","author":"J\u00f6nsson","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"6","key":"10.1016\/j.tjnut.2025.05.022_bib33","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.3390\/nu13061903","article-title":"Do lifestyle interventions in pregnant women with overweight or obesity have an effect on neonatal adiposity? A systematic review with meta-analysis","volume":"13","author":"Baroni","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.tjnut.2025.05.022_bib34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2016.07.002","article-title":"Maternal obesity and prenatal programming","volume":"435","author":"Elshenawy","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"issue":"8","key":"10.1016\/j.tjnut.2025.05.022_bib35","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Phys."},{"issue":"11","key":"10.1016\/j.tjnut.2025.05.022_bib36","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10654-015-0106-6","article-title":"Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study","volume":"30","author":"Vidakovic","year":"2015","journal-title":"Eur. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.tjnut.2025.05.022_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1469-7580.2005.00417.x","article-title":"Anatomy of the lactating human breast redefined with ultrasound imaging","volume":"206","author":"Ramsay","year":"2005","journal-title":"J. Anat."},{"issue":"2","key":"10.1016\/j.tjnut.2025.05.022_bib38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00006534-199702000-00012","article-title":"Evaluation of fat in breast tissue removed by vertical mammaplasty","volume":"99","author":"Lejour","year":"1997","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.tjnut.2025.05.022_bib39","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1038\/nutd.2013.25","article-title":"Changes in adipose tissue distribution during pregnancy in overweight and obese compared with normal weight women","volume":"3","author":"Straughen","year":"2013","journal-title":"Nutr Diabetes"},{"issue":"6","key":"10.1016\/j.tjnut.2025.05.022_bib40","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/ajcn\/nqz229","article-title":"Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study","volume":"110","author":"Miliku","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"issue":"18","key":"10.1016\/j.tjnut.2025.05.022_bib41","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.3390\/nu14183858","article-title":"Predictors of human milk fatty acids and associations with infant growth in a Norwegian birth cohort","volume":"14","author":"Criswell","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.tjnut.2025.05.022_bib42","first-page":"247","article-title":"Role of nutrition in preventing insulin resistance in children","volume":"29","author":"Blasetti","year":"2016","journal-title":"J. Pediatr. Endocr. Met."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625003049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625003049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:01:48Z","timestamp":1760007708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316625003049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022316625003049"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.05.022","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between Human Milk Fatty Acid Esters of Hydroxy Fatty Acids and Maternal Body Mass Index and Early Infant Growth: A Longitudinal Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}]}}