{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:09:57Z","timestamp":1785906597251,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012228","name":"Development and Reform Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["XMHT20220104055"],"award-info":[{"award-number":["XMHT20220104055"]}],"id":[{"id":"10.13039\/501100012228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["JSGG20201103153807021"],"award-info":[{"award-number":["JSGG20201103153807021"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425052"],"award-info":[{"award-number":["82425052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009600"],"award-info":[{"award-number":["2022YFC2009600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500601"],"award-info":[{"award-number":["2021YFC2500601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009601"],"award-info":[{"award-number":["2022YFC2009601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A04J6609"],"award-info":[{"award-number":["2024A04J6609"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["KJZD20230923114408018"],"award-info":[{"award-number":["KJZD20230923114408018"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.tjnut.2025.08.010","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T23:19:08Z","timestamp":1755040748000},"page":"3506-3516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patterns and Correlates of Concurrent Serum Vitamin D, Folate, and Vitamin B12 Status in a Rural Chinese Population"],"prefix":"10.1016","volume":"155","author":[{"given":"Jiafeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia'ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changrui","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-6215","authenticated-orcid":false,"given":"Chen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2025.08.010_bib1","article-title":"Secular trends in the prevalence of and disability-adjusted life years due to common micronutrient deficiencies in China from 1990 to 2019: an age-period-cohort study and joinpoint analysis","volume":"9","author":"Chen","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.tjnut.2025.08.010_bib2","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(24)00276-6","article-title":"Global estimation of dietary micronutrient inadequacies: a modelling analysis","volume":"12","author":"Passarelli","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.tjnut.2025.08.010_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mam.2016.11.007","article-title":"One-carbon metabolism and epigenetics","volume":"54","author":"Friso","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.tjnut.2025.08.010_bib4","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.3390\/molecules26123731","article-title":"The concept of folic acid in health and disease","volume":"26","author":"Shulpekova","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.tjnut.2025.08.010_bib5","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3390\/nu12092867","article-title":"B vitamins and one-carbon metabolism: implications in human health and disease","volume":"12","author":"Lyon","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tjnut.2025.08.010_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/10408363.2021.1885339","article-title":"Vitamin B12 status in health and disease: a critical review, diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls","volume":"58","author":"Sobczy\u0144ska-Malefora","year":"2021","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.tjnut.2025.08.010_bib7","doi-asserted-by":"crossref","first-page":"17531","DOI":"10.1073\/pnas.1907077116","article-title":"Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha","volume":"116","author":"Alam","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.tjnut.2025.08.010_bib8","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/jbmr.493","article-title":"1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine \u03b2-synthase","volume":"26","author":"Kriebitzsch","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tjnut.2025.08.010_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1139124","article-title":"Regional distribution of the MTHFR C677T polymorphism in Chinese females","volume":"14","author":"Lin","year":"2023","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.tjnut.2025.08.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2014.10.004","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases","volume":"58","author":"Liew","year":"2015","journal-title":"Eur. J. Med. Genet."},{"issue":"11","key":"10.1016\/j.tjnut.2025.08.010_bib11","doi-asserted-by":"crossref","first-page":"e1126","DOI":"10.1212\/WNL.0000000000008932","article-title":"Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke","volume":"94","author":"Qin","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tjnut.2025.08.010_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1089\/ars.2005.7.547","article-title":"Homocysteine and redox signaling","volume":"7","author":"Zou","year":"2005","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.tjnut.2025.08.010_bib13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00198-018-4784-2","article-title":"Multiple vitamin deficiencies additively increase the risk of incident fractures in Japanese postmenopausal women","volume":"30","author":"Kuroda","year":"2019","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.tjnut.2025.08.010_bib14","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1186\/s12877-023-04391-2","article-title":"Folate, vitamin B12 and vitamin D status in healthy and active home-dwelling people over 70 years","volume":"23","author":"Kerlikowsky","year":"2023","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.tjnut.2025.08.010_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.707036","article-title":"Burden of vitamin D, vitamin B12 and folic acid deficiencies in an aging, rural Indian community","volume":"9","author":"Sundarakumar","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.tjnut.2025.08.010_bib16","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.3390\/nu15204476","article-title":"Vitamin D status and associated factors of older adults in the cross-sectional 2015-2017 Survey","volume":"15","author":"Hu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tjnut.2025.08.010_bib17","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1093\/jn\/133.11.3630","article-title":"Geographical, seasonal and gender differences in folate status among Chinese adults","volume":"133","author":"Hao","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib18","article-title":"Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: a systematic review","volume":"67","author":"Quinn","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tjnut.2025.08.010_bib19","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1161\/STROKEAHA.119.025449","article-title":"Vitamin D status and risk of stroke: the Rotterdam study","volume":"50","author":"Berghout","year":"2019","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.tjnut.2025.08.010_bib20","article-title":"China precision nutrition and health-KAP real world study (CPN-KAPS): rationale, study design, and protocol","volume":"1","author":"Shi","year":"2021","journal-title":"Precis. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib21","article-title":"China precision nutrition and health-KAP (knowledge, attitude, and practice) real-world study (CPNAS): enrollment progress and baseline characteristics","author":"Jianping","year":"2025","journal-title":"Precision Nutr"},{"key":"10.1016\/j.tjnut.2025.08.010_bib22","doi-asserted-by":"crossref","DOI":"10.7754\/Clin.Lab.2019.190604","article-title":"A rapid quantitative chemiluminescence immunoassay for vitamin B12 in human serum","volume":"66","author":"Chen","year":"2020","journal-title":"Clin. Lab."},{"key":"10.1016\/j.tjnut.2025.08.010_bib23","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.3390\/molecules24152730","article-title":"A rapid chemiluminescence assay for measurement of folate in small volumes of breast milk","volume":"24","author":"Guignard","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.tjnut.2025.08.010_bib24","article-title":"Simultaneous determination of vitamins A, D, E, K in human plasma","volume":"3","author":"Chen","year":"2024","journal-title":"Precis. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib25","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.tjnut.2025.08.010_bib26","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.2105\/AJPH.2015.302902","article-title":"Global birth prevalence of spina bifida by folic acid fortification status: a systematic review and meta-analysis","volume":"106","author":"Atta","year":"2016","journal-title":"Am. J. Public Health."},{"key":"10.1016\/j.tjnut.2025.08.010_bib27","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1016\/j.clnu.2021.01.025","article-title":"Relationship of several serum folate forms with the risk of mortality: a prospective cohort study","volume":"40","author":"Liu","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib28","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2025.08.010_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jcma.2016.07.005","article-title":"Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China","volume":"80","author":"Ni","year":"2017","journal-title":"J. Chin. Med. Assoc."},{"issue":"11","key":"10.1016\/j.tjnut.2025.08.010_bib30","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/sj.ejcn.1602002","article-title":"Effects of moderate alcohol consumption on folate and vitamin B12 status in postmenopausal women","volume":"58","author":"Laufer","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2025.08.010_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1617-9625-4-8","article-title":"Smoking status in relation to serum folate and dietary vitamin intake","volume":"4","author":"Vardavas","year":"2008","journal-title":"Tob. Induc. Dis."},{"issue":"10","key":"10.1016\/j.tjnut.2025.08.010_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140840","article-title":"The influence of malnutrition and micronutrient status on anemic risk in children under 3 years old in poor areas in China","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tjnut.2025.08.010_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.srhc.2019.100461","article-title":"Alcohol, smoking, folic acid and multivitamin use among women attending maternity care in London: a cross-sectional study","volume":"22","author":"Jawad","year":"2019","journal-title":"Sex Reprod. Healthc."},{"key":"10.1016\/j.tjnut.2025.08.010_bib34","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/jn\/131.7.1952","article-title":"Fruit and vegetable consumption is lower and saturated fat intake is higher among Canadians reporting smoking","volume":"131","author":"Palaniappan","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/ajcn\/88.4.1149","article-title":"Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations","volume":"88","author":"DeVos","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.08.010_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1079\/PHN2003516","article-title":"Determinants of diet quality","volume":"7","author":"Thiele","year":"2004","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.tjnut.2025.08.010_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3945\/jn.114.199117","article-title":"Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations","volume":"145","author":"Bird","year":"2015","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2025.08.010_bib38","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1002\/jsfa.13262","article-title":"An analytical overview of the composition and characteristics of China's food safety standards","volume":"104","author":"Liu","year":"2024","journal-title":"J. Sci. Food Agric."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625004882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625004882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:18:45Z","timestamp":1772831925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316625004882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0022316625004882"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.08.010","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns and Correlates of Concurrent Serum Vitamin D, Folate, and Vitamin B12 Status in a Rural Chinese Population","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}