{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:26:36Z","timestamp":1782397596975,"version":"3.54.5"},"reference-count":74,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802303"],"award-info":[{"award-number":["31802303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273142"],"award-info":[{"award-number":["32273142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2400601"],"award-info":[{"award-number":["2023YFD2400601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024C02006"],"award-info":[{"award-number":["2024C02006"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020738","name":"K C Wong Magna Fund in Ningbo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tjnut.2025.101258","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:00:01Z","timestamp":1765209601000},"page":"101258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leucine Alleviates Endoplasmic Reticulum\u2013Stress Mediated Lipotoxic Injury Induced by High-Fat Diet Via Sar1b\/Sestrin2\/Ampk\u03b11 Pathways in Acanthopagrus Schlegelii"],"prefix":"10.1016","volume":"156","author":[{"given":"Wenli","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuedong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangguang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Monroig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Shichao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R","family":"Tocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qicun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tjnut.2025.101258_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s13679-018-0317-8","article-title":"Epidemiology of obesity in adults: latest trends","volume":"7","author":"Inoue","year":"2018","journal-title":"Curr. Obes. Rep."},{"issue":"Suppl","key":"10.1016\/j.tjnut.2025.101258_bib2","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.3350\/cmh.2022.0367","article-title":"MAFLD: How is it different from NAFLD?","volume":"29","author":"Gofton","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.tjnut.2025.101258_bib3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature09968","article-title":"Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity","volume":"473","author":"Suneng","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tjnut.2025.101258_bib4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s11010-023-04780-6","article-title":"IRE1\u03b1: from the function to the potential therapeutic target in atherosclerosis","volume":"479","author":"Zheng","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tjnut.2025.101258_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MOL.0b013e3283395e5c","article-title":"Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis","volume":"21","author":"Flamment","year":"2010","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.tjnut.2025.101258_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13578-023-01062-y","article-title":"ER Ca2+ overload activates the IRE1\u03b1 signaling and promotes cell survival","volume":"13","author":"Song","year":"2023","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.tjnut.2025.101258_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41419-019-2128-6","article-title":"eIF2\u03b1-CHOP-BCl-2\/JNK and IRE1\u03b1-XBP1\/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus","volume":"10","author":"Yan","year":"2019","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.tjnut.2025.101258_bib8","doi-asserted-by":"crossref","first-page":"15692","DOI":"10.1074\/jbc.REV120.010218","article-title":"Small molecule strategies to harness the unfolded protein response: where do we go from here?","volume":"295","author":"Grandjean","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1868-7083-6-27","article-title":"Leucine alters hepatic glucose\/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway - potential implications for nonalcoholic fatty liver disease","volume":"6","author":"Zarfeshani","year":"2014","journal-title":"Clin. Epigenetics"},{"issue":"6","key":"10.1016\/j.tjnut.2025.101258_bib10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2337\/db07-0123","article-title":"Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms","volume":"56","author":"Zhang","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.tjnut.2025.101258_bib11","doi-asserted-by":"crossref","DOI":"10.3402\/fnr.v60.31304","article-title":"Chronic leucine supplementation improves lipid metabolism in C57BL\/6J mice fed with a high-fat\/cholesterol diet","volume":"60","author":"Jiao","year":"2016","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.tjnut.2025.101258_bib12","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s13105-016-0516-2","article-title":"Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats","volume":"72","author":"Baum","year":"2016","journal-title":"J. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.tjnut.2025.101258_bib13","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/nu6041364","article-title":"L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation","volume":"6","author":"Zampieri","year":"2014","journal-title":"Nutrients"},{"issue":"160","key":"10.1016\/j.tjnut.2025.101258_bib14","article-title":"Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases","volume":"14","author":"Lu","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"6268","key":"10.1016\/j.tjnut.2025.101258_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncb2390","article-title":"COPII and the regulation of protein sorting in mammals","volume":"14","author":"Zanetti","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"7871","key":"10.1016\/j.tjnut.2025.101258_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-021-03768-w","article-title":"SAR1B senses leucine levels to regulate mTORC1 signalling","volume":"596","author":"Chen","year":"2021","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.tjnut.2025.101258_bib18","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1159\/000362960","article-title":"Tissue distribution and regulation of the small Sar1b GTPase in mice","volume":"33","author":"Marcil","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jphs.2020.11.012","article-title":"Sestrin2 protects against bavachin induced ER stress through AMPK\/mTORC1 signaling pathway in HepG2 cells","volume":"145","author":"Yang","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.tjnut.2025.101258_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12944-019-1136-y","article-title":"Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating Ampk\/SREBP-1c signaling","volume":"18","author":"Meng","year":"2019","journal-title":"Lipids Health Dis"},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1039\/D0FO02501A","article-title":"Berbamine induced activation of the SIRT1\/LKB1\/Ampk signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats","volume":"12","author":"Sharma","year":"2021","journal-title":"Food Funct"},{"issue":"6","key":"10.1016\/j.tjnut.2025.101258_bib22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1389203717666160627071125","article-title":"AMPK regulation of glucose, lipid and protein metabolism: mechanisms and nutritional significance","volume":"18","author":"He","year":"2017","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13254","article-title":"A systems study reveals concurrent activation of AMPK and mTOR by amino acids","volume":"7","author":"Dalle Pezze","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tjnut.2025.101258_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12964-021-00706-1","article-title":"Interactions among mTORC, Ampk and SIRT: a computational model for cell energy balance and metabolism","volume":"19","author":"Sadria","year":"2021","journal-title":"J. Cell Commun. Signal."},{"issue":"4","key":"10.1016\/j.tjnut.2025.101258_bib25","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long-standing partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101258_bib26","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.tjnut.2025.101258_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2020.10.002","article-title":"Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK\/Sirt-1\/PGC-1\u03b1 signaling axis","volume":"91","author":"Silva","year":"2021","journal-title":"Alcohol"},{"key":"10.1016\/j.tjnut.2025.101258_bib28","first-page":"1628","article-title":"Causes of fatty liver in farmed fish: a review and new perspectives","volume":"38","author":"Du","year":"2014","journal-title":"J. Fish. Sci. China"},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib29","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/jpn.13759","article-title":"The risk assessment of high-fat diet in farmed fish and its mitigation approaches: a review","volume":"107","author":"Naiel","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.tjnut.2025.101258_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740306","article-title":"The ameliorative role of methionine in hepatic steatosis and stress response in juvenile black seabream (Acanthopagrus schlegelii) fed with a high-fat diet","volume":"580","author":"Yang","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.tjnut.2025.101258_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738532","article-title":"Differential regulatory effects of optimal or excessive dietary lipid levels on growth, lipid metabolism and physiological response in black seabream (Acanthopagrus schlegelii)","volume":"560","author":"Shen","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.tjnut.2025.101258_bib32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10695-022-01095-z","article-title":"Lipid metabolic disorders and physiological stress caused by a high-fat diet have lipid source-dependent effects in juvenile black seabream Acanthopagrus schlegelii","volume":"48","author":"Shen","year":"2022","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.tjnut.2025.101258_bib33","article-title":"High dietary arachidonic acid produces excess eicosanoids, and induces hepatic inflammatory responses, oxidative stress and apoptosis in juvenile Acanthopagrus schlegelii","volume":"29","author":"Bao","year":"2023","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.tjnut.2025.101258_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7570\/jomes21062","article-title":"Hepatic fibrosis and steatosis in metabolic syndrome","volume":"31","author":"Gangireddy","year":"2022","journal-title":"J. Obes. Metab. Syndr."},{"key":"10.1016\/j.tjnut.2025.101258_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741102","article-title":"Lipid-induced lipotoxic damage in liver and hepatocytes of black seabream Acanthopagrus schlegelii is mediated by endoplasmic reticulum stress","volume":"590","author":"Zhao","year":"2024","journal-title":"Aquaculture"},{"issue":"5","key":"10.1016\/j.tjnut.2025.101258_bib36","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1096\/fj.10-173492","article-title":"Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver","volume":"25","author":"Li","year":"2011","journal-title":"The FASEB J"},{"key":"10.1016\/j.tjnut.2025.101258_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2024.152134","article-title":"SIRT1 regulates endoplasmic reticulum stress-related organ damage","volume":"126","author":"Hu","year":"2024","journal-title":"Acta Histochem"},{"key":"10.1016\/j.tjnut.2025.101258_bib38","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.tjnut.2025.101258_bib39","doi-asserted-by":"crossref","first-page":"D458","DOI":"10.1093\/nar\/gkaa937","article-title":"SMART: recent updates, new developments and status in 2020, Nucleic","volume":"49","author":"Letunic","year":"2021","journal-title":"Acids Res."},{"key":"10.1016\/j.tjnut.2025.101258_bib40","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tjnut.2025.101258_bib41","article-title":"Establishment and characterization of a liver cell line from black porgy, Acanthopagrus schlegelii","volume":"25","author":"Pan","year":"2022","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.tjnut.2025.101258_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109212","article-title":"High-fat-diet induced inflammation and apoptosis via activation of Ire1\u03b1 in liver and hepatocytes of black seabream (Acanthopagrus schlegelii)","volume":"143","author":"Shen","year":"2023","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.tjnut.2025.101258_bib43","series-title":"Official Methods of Analysis","year":"2006"},{"key":"10.1016\/j.tjnut.2025.101258_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111379","article-title":"Sestrin family-the stem controlling healthy ageing","volume":"192","author":"Haidurov","year":"2020","journal-title":"Mech. Ageing Dev."},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib45","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jcmgh.2021.04.015","article-title":"Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-Terminal kinases","volume":"12","author":"Fang","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tjnut.2025.101258_bib46","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1182228","article-title":"Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies","volume":"327","author":"Lee","year":"2010","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib47","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11011-023-01323-2","article-title":"Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK\/mTORC1 signaling pathway","volume":"39","author":"Zhou","year":"2024","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113614","article-title":"AMP-activated protein kinase: an energy sensor and survival mechanism in the reinstatement of metabolic homeostasis","volume":"428","author":"Sharma","year":"2023","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.tjnut.2025.101258_bib49","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tips.2016.05.004","article-title":"Leucine in obesity: therapeutic prospects","volume":"37","author":"Yao","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"10","key":"10.1016\/j.tjnut.2025.101258_bib50","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1194\/jlr.RA119000119","article-title":"SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation [S]","volume":"60","author":"San\u00e9","year":"2019","journal-title":"J. Lipid. Res."},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3727\/105221619X15553433838609","article-title":"Nonalcoholic fatty liver disease: an update on the diagnosis","volume":"19","author":"Zhang","year":"2019","journal-title":"Gene Expr"},{"key":"10.1016\/j.tjnut.2025.101258_bib52","first-page":"75","article-title":"Regulation of liver glucose metabolism by the metabolic sensing of leucine in the hypothalamus","author":"Guti\u00e9rrez-Ju\u00e1rez","year":"2015","journal-title":"BCAAs"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2337\/db11-0857","article-title":"Hypothalamic leucine metabolism regulates liver glucose production","volume":"61","author":"Su","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.tjnut.2025.101258_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109321","article-title":"Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism","volume":"117","author":"Mo","year":"2023","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib55","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"issue":"5775","key":"10.1016\/j.tjnut.2025.101258_bib56","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/cells9020327","article-title":"Leucine improved growth performance, muscle Growth, and muscle protein deposition through AKT\/TOR and AKT\/FOXO3a signaling pathways in hybrid catfish Pelteobagrus vachelli \u00d7 Leiocassis longirostris","volume":"9","author":"Zhao","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib58","article-title":"Dietary leucine supplementation improves muscle fiber growth and development by activating AMPK\/Sirt1 pathway in blunt snout bream (Megalobrama amblycephala)","volume":"2022","author":"Wang","year":"2022","journal-title":"Aquac. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2025.101258_bib59","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1111\/are.13682","article-title":"Effects of dietary leucine levels on growth, tissue protein content and relative expression of genes related to protein synthesis in juvenile gibel carp (Carassius auratus gibelio var. CAS III)","volume":"49","author":"Zou","year":"2018","journal-title":"Aquac. Res."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/raq.12604","article-title":"Are we actually measuring growth?\u2014An appeal to use a more comprehensive growth index system for advancing aquaculture research","volume":"14","author":"Du","year":"2022","journal-title":"Rev. Aquac."},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib61","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1039\/C9FO03084K","article-title":"Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice","volume":"11","author":"Ma","year":"2020","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101258_bib62","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10695-022-01126-9","article-title":"Dietary leucine supplementation improves growth performance, metabolic responses of liver via GCN2\/ATF4, and insulin signaling pathways in largemouth bass (Micropterus salmoides)","volume":"50","author":"Shao","year":"2024","journal-title":"Fish Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.tjnut.2025.101258_bib63","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.bbrc.2020.03.032","article-title":"Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2\/HO-1 pathway","volume":"525","author":"Han","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib64","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/ars.2018.7559","article-title":"Inhibitory effect of Sestrin 2 on hepatic stellate cell activation and liver fibrosis","volume":"31","author":"Yang","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.tjnut.2025.101258_bib65","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.bbadis.2017.02.018","article-title":"Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism","volume":"1863","author":"Hwang","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib66","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101258_bib67","first-page":"1061","article-title":"Trehalose-induced SIRT1\/AMPK activation regulates SREBP-1c\/PPAR-\u03b1 to alleviate lipid accumulation in aged liver, Naunyn Schmiedeberg's Arch","volume":"397","author":"Naiini","year":"2024","journal-title":"Pharmacol"},{"key":"10.1016\/j.tjnut.2025.101258_bib68","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3389\/fphys.2018.01258","article-title":"Resveratrol improves the energy sensing and glycolipid metabolism of blunt snout bream megalobrama amblycephala fed high-carbohydrate diets by activating the AMPK-SIRT1-PGC-1\u03b1 network","volume":"9","author":"Shi","year":"2018","journal-title":"Front. Physiol."},{"issue":"31","key":"10.1016\/j.tjnut.2025.101258_bib69","doi-asserted-by":"crossref","first-page":"12861","DOI":"10.1073\/pnas.0702509104","article-title":"Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1","volume":"104","author":"Rodgers","year":"2007","journal-title":"Proc. Nat. Acad. Sci. the U S A"},{"issue":"5","key":"10.1016\/j.tjnut.2025.101258_bib70","doi-asserted-by":"crossref","first-page":"E1179","DOI":"10.1152\/ajpendo.90997.2008","article-title":"Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice","volume":"297","author":"Yamazaki","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.tjnut.2025.101258_bib71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fcell.2017.00075","article-title":"Regulation of the Sar1 GTPase cycle is necessary for large cargo secretion from the endoplasmic reticulum","volume":"5","author":"Saito","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tjnut.2025.101258_bib72","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/cancers11091378","article-title":"CYP17A1 maintains the survival of glioblastomas by regulating SAR1-mediated endoplasmic reticulum health and redox homeostasis","volume":"11","author":"Lin","year":"2019","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.tjnut.2025.101258_bib73","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1159\/000443039","article-title":"IRE1\u03b1 signaling pathways involved in mammalian cell fate determination","volume":"38","author":"Wu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tjnut.2025.101258_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110601","article-title":"SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage","volume":"130","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625007643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625007643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:27:53Z","timestamp":1781234873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316625007643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0022316625007643"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.101258","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leucine Alleviates Endoplasmic Reticulum\u2013Stress Mediated Lipotoxic Injury Induced by High-Fat Diet Via Sar1b\/Sestrin2\/Ampk\u03b11 Pathways in Acanthopagrus Schlegelii","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.101258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101258"}}