{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:46:34Z","timestamp":1777625194091,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["S10RR027047"],"award-info":[{"award-number":["S10RR027047"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.tjnut.2025.101350","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:03:48Z","timestamp":1767859428000},"page":"101350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Dynamics in Splanchnic Amino Acid Extraction During Early Sepsis Recovery in Pigs: Whole Body Compared with Interorgan Balance Assessments"],"prefix":"10.1016","volume":"156","author":[{"given":"Gabriella AM","family":"ten Have","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"Thaden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00eblle PKJ","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas EP","family":"Deutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2025.101350_bib1","first-page":"89","article-title":"Optimizing protein intake in aging","volume":"8","author":"Walrand","year":"2005","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"7","key":"10.1016\/j.tjnut.2025.101350_bib2","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/jn\/131.7.1965","article-title":"Whole-body nitrogen and splanchnic AA metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture","volume":"131","author":"Daenzer","year":"2001","journal-title":"J, Nutr."},{"issue":"11","key":"10.1016\/j.tjnut.2025.101350_bib3","first-page":"148","article-title":"Dietary bioactive components: interorgan \u03b2-Hydroxy-\u03b2-methylbutyric acid (HMB) and branched chain keto acids (BCKA) transport in the healthy pig (P08-111)","volume":"2","author":"Ten Have","year":"2018","journal-title":"Curr. Dev. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2025.101350_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130638","article-title":"Enhanced lacto-tri-peptide bio-availability by co-ingestion of macronutrients","volume":"10","author":"Ten Have","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tjnut.2025.101350_bib5","series-title":"book Encyclopedia of Human Biology","article-title":"Protein Digestion, Absorption, and Metabolism","author":"Savary-Auzeloux","year":"2013"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101350_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1172\/JCI106788","article-title":"Protein synthesis in intestinal mucosa: the effect of route of administration of precursor amino acids","volume":"51","author":"Alpers","year":"1972","journal-title":"J. Clin. Invest."},{"issue":"1 Pt 1","key":"10.1016\/j.tjnut.2025.101350_bib7","first-page":"E36","article-title":"Quantitative role of splanchnic region in leucine metabolism: L-[1-13C,15N]leucine and substrate balance studies","volume":"259","author":"Yu","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib8","series-title":"Isotope tracers in metabolic research: principles and practice of kinetic analysis","first-page":"274","author":"Wolfe","year":"2005"},{"issue":"9","key":"10.1016\/j.tjnut.2025.101350_bib9","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s12276-022-00817-w","article-title":"Tracing metabolic flux to assess optimal dietary protein and amino acid consumption","volume":"54","author":"Wolfe","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.tjnut.2025.101350_bib10","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/48.4.998","article-title":"Leucine kinetics at graded intakes in young men: quantitative fate of dietary leucine","volume":"48","author":"Cortiella","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib11","doi-asserted-by":"crossref","first-page":"E455","DOI":"10.1152\/ajpendo.1992.262.4.E455","article-title":"Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach","volume":"262","author":"Biolo","year":"1992","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/ajcn\/65.2.489","article-title":"Splanchnic and whole-body leucine kinetics in young and elderly men","volume":"65","author":"Boirie","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib13","doi-asserted-by":"crossref","first-page":"E513","DOI":"10.1152\/ajpendo.1999.277.3.E513","article-title":"Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction","volume":"277","author":"Volpi","year":"1999","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib14","doi-asserted-by":"crossref","first-page":"E109","DOI":"10.1152\/ajpendo.1993.264.1.E109","article-title":"Splanchnic bed utilization of leucine and phenylalanine in humans","volume":"264","author":"Matthews","year":"1993","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib15","doi-asserted-by":"crossref","first-page":"E567","DOI":"10.1152\/ajpendo.1993.264.4.E567","article-title":"Effects of protein restriction and acute refeeding on leucine and lysine kinetics in young men","volume":"264","author":"Hoerr","year":"1993","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib16","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.3168\/jds.2009-2317","article-title":"The production of intrinsically labeled milk protein provides a functional tool for human nutrition research","volume":"92","author":"Van Loon","year":"2009","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.tjnut.2025.101350_bib17","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3945\/jn.109.109173","article-title":"Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men","volume":"139","author":"Koopman","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/japplphysiol.01230.2012","article-title":"Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats","volume":"115","author":"Jourdan","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib19","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1210\/jc.2013-3970","article-title":"Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion","volume":"99","author":"Gorissen","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib20","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/jn\/nxaa024","article-title":"Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans","volume":"150","author":"Gorissen","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1391750","article-title":"Quantification and interpretation of postprandial whole-body protein metabolism using stable isotope methodology: a narrative review","volume":"11","author":"Trommelen","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.clnu.2011.09.008","article-title":"Absence of post-prandial gut anabolism after intake of a low quality protein meal","volume":"31","author":"Ten Have","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib23","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1123\/ijsnem.17.s1.s23","article-title":"Absorption kinetics of amino acids, peptides, and intact proteins","volume":"17","author":"Have","year":"2007","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/CS20171068","article-title":"A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults","volume":"132","author":"Jonker","year":"2018","journal-title":"Clin. Sci. (Lond)."},{"key":"10.1016\/j.tjnut.2025.101350_bib25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.clnu.2015.12.011","article-title":"Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men","volume":"36","author":"Gorissen","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.meatsci.2015.05.009","article-title":"The muscle protein synthetic response to food ingestion","volume":"109","author":"Gorissen","year":"2015","journal-title":"Meat Sci"},{"issue":"1","key":"10.1016\/j.tjnut.2025.101350_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jim-2019-001108","article-title":"Advances in stable isotope tracer methodology part 2: new thoughts about an \"old\" method-measurement of whole body protein synthesis and breakdown in the fed state","volume":"68","author":"Wolfe","year":"2020","journal-title":"J. Investig Med."},{"key":"10.1016\/j.tjnut.2025.101350_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.nutos.2021.02.006","article-title":"Whole-body protein kinetic models to quantify the anabolic response to dietary protein consumption","volume":"36","author":"Wolfe","year":"2021","journal-title":"Clin. Nutr. Open Sci."},{"key":"10.1016\/j.tjnut.2025.101350_bib29","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1152\/ajpendo.00155.2019","article-title":"The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation","volume":"317","author":"Trommelen","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib30","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00186.2019","article-title":"Reply to letter to the editor: \"The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation\"","volume":"317","author":"Wolfe","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nutos.2020.12.006","article-title":"Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism","volume":"36","author":"Trommelen","year":"2021","journal-title":"Clin. Nutr. Open Sci."},{"issue":"6","key":"10.1016\/j.tjnut.2025.101350_bib32","doi-asserted-by":"crossref","first-page":"E519","DOI":"10.1152\/ajpendo.00351.2016","article-title":"Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig","volume":"312","author":"Ten Have","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.clnu.2012.04.006","article-title":"Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids","volume":"31","author":"Engelen","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.metabol.2016.12.010","article-title":"Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults","volume":"69","author":"Jonker","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.tjnut.2025.101350_bib35","doi-asserted-by":"crossref","first-page":"2068S","DOI":"10.1093\/jn\/133.6.2068S","article-title":"Interorgan amino acid transport and its regulation","volume":"133","author":"Brosnan","year":"2003","journal-title":"J. Nutr."},{"issue":"Suppl","key":"10.1016\/j.tjnut.2025.101350_bib36","doi-asserted-by":"crossref","first-page":"E60","DOI":"10.2527\/2006.8413_supplE60x","article-title":"Measuring splanchnic amino acid metabolism in vivo using stable isotopic tracers","volume":"84","author":"Stoll","year":"2006","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.tjnut.2025.101350_bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clnesp.2022.09.044","article-title":"Mainly muscle, jejunum, and lung fractional protein synthesis rates are related to whole-body protein synthesis in the pig","volume":"54","author":"Have","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.tjnut.2025.101350_bib38","doi-asserted-by":"crossref","first-page":"G755","DOI":"10.1152\/ajpgi.00407.2018","article-title":"Inhibition of jejunal protein synthesis and breakdown in pseudomonas aeruginosa-induced sepsis pig model","volume":"316","author":"Ten Have","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.clnesp.2022.09.117","article-title":"Enhanced splanchnic extraction of nutritional arginine and lower citrulline production play a role in the reduced systemic availability of arginine in the early recovery phase of sepsis in the pig","volume":"54","author":"Rice","year":"2023","journal-title":"Clin. Nutr. ESPEN."},{"key":"10.1016\/j.tjnut.2025.101350_bib40","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.70129","article-title":"The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs","volume":"13","author":"Morse","year":"2025","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.tjnut.2025.101350_bib41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.clnesp.2020.09.155","article-title":"Excessive nitrogen uptake by the liver limits the anabolic response to enteral amino acids intervention during early sepsis-recovery","volume":"40","author":"Have","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.tjnut.2025.101350_bib42","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/cdn\/nzaa055_032","article-title":"Compromised glutamine-glutamate metabolism in a Pseudomonas aeruginosa induced hyperdynamic sepsis-recovery pig model during an anabolic nutritional intervention","volume":"4","author":"Have","year":"2020","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib43","doi-asserted-by":"crossref","first-page":"E1831","DOI":"10.1210\/jc.2011-1262","article-title":"A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men","volume":"96","author":"Sheffield-Moore","year":"2011","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.tjnut.2025.101350_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1258\/002367796780739862","article-title":"Simultaneous measurement of metabolic flux in portally-drained viscera, liver, spleen, kidney and hindquarter in the conscious pig","volume":"30","author":"ten Have","year":"1996","journal-title":"Lab. Anim."},{"key":"10.1016\/j.tjnut.2025.101350_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/0023677217718003","article-title":"Characteristics of a Pseudomonas aeruginosa-induced porcine sepsis model for multi-organ metabolic flux measurements","volume":"52","author":"ten Have","year":"2018","journal-title":"Lab. Anim."},{"key":"10.1016\/j.tjnut.2025.101350_bib46","doi-asserted-by":"crossref","first-page":"E629","DOI":"10.1152\/ajpendo.00384.2020","article-title":"Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and \u03b2-hydroxy \u03b2-methylbutyric acid across multiple organs in the pig","volume":"320","author":"ten Have","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101350_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2527\/1998.762513x","article-title":"Essential and nonessential amino acid composition of pigs from birth to 145 kilograms of body weight, and comparison to other studies","volume":"76","author":"Mahan","year":"1998","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.tjnut.2025.101350_bib48","doi-asserted-by":"crossref","first-page":"E256","DOI":"10.1152\/ajpendo.00503.2014","article-title":"Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism","volume":"309","author":"Schooneman","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.tjnut.2025.101350_bib49","doi-asserted-by":"crossref","first-page":"F236","DOI":"10.1152\/ajprenal.00336.2001","article-title":"Rapid microplate method for PAH estimation","volume":"283","author":"Agarwal","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib50","doi-asserted-by":"crossref","first-page":"G673","DOI":"10.1152\/ajpgi.00257.2023","article-title":"Muscle protein catabolism and splanchnic arginine consumption drive arginine dysregulation during Pseudomonas aeruginosa-induced early acute sepsis in swine","volume":"327","author":"Rice","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib51","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3945\/ajcn.115.129924","article-title":"Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial","volume":"105","author":"Gorissen","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib52","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1152\/ajpendo.00362.2016","article-title":"A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans","volume":"313","author":"Mason","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib53","doi-asserted-by":"crossref","first-page":"E74","DOI":"10.1152\/ajpendo.00294.2018","article-title":"Quaifying the contribution of dietary protein to whole body protein kinetics: examination of the intrinsically-labeled proteins method","volume":"317","author":"Wolfe","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2025.101350_bib54","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.clnesp.2023.09.782","article-title":"Meal anabolic capacity, measured by either non- or compartmental analysis after pulse tracer administration, is not different between HMB or LEU added to an essential amino acid mixture in older adults","volume":"58","author":"Knezek","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.tjnut.2025.101350_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1388969","article-title":"Compartmental analysis: a new approach to estimate protein breakdown and meal response in health and critical illness","volume":"11","author":"Deutz","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib56","series-title":"Pig interorgan balance studies in health and disease","first-page":"1","author":"Ten Have","year":"2017"},{"key":"10.1016\/j.tjnut.2025.101350_bib57","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0261-5614(95)80053-0","article-title":"Increased intestinal amino-acid retention from the addition of carbohydrates to a meal","volume":"14","author":"Deutz","year":"1995","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib58","doi-asserted-by":"crossref","unstructured":"M.J. Bruins, K.V.K. Koelfat, P.B. Soeters, Chapter 13 - Amino Acids, Protein, and the Gastrointestinal Tract. In: Dardevet D, editor, The molecular nutrition of amino acids and proteins. Boston: Academic Press. p. 161-179. [Internet] 2016. [cited August 2025]. Available from: https:\/\/doi.org\/10.1016\/B978-0-12-802167-5.00013-X.","DOI":"10.1016\/B978-0-12-802167-5.00013-X"},{"key":"10.1016\/j.tjnut.2025.101350_bib59","first-page":"E168","article-title":"Substrate oxidation by the portal drained viscera of fed piglets","volume":"277","author":"Stoll","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib60","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj2670281","article-title":"Nitrogen metabolism in liver: structural and functional organization and physiological relevance","volume":"267","author":"Ha\u00fcssinger","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.tjnut.2025.101350_bib61","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3945\/jn.108.101675","article-title":"Intestinal inflammation increases gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs","volume":"139","author":"R\u00e9mond","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib62","article-title":"Early versus delayed enteral nutrition in ICU patients with sepsis: a propensity score-matched analysis based on the MIMIC-IV database","volume":"11","author":"Xu","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib63","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.clnu.2023.06.018","article-title":"Controlled enteral nutrition in critical care patients - a randomized clinical trial of a novel management system","volume":"42","author":"Kagan","year":"2023","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib64","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzz044.FS09-03-19","article-title":"Impairments in protein digestion and absorption attenuate the anabolic response to feeding in patients with congestive heart failure (FS09-03-19)","volume":"3","author":"Kirschner","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.tjnut.2025.101350_bib65","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1152\/japplphysiol.00783.2020","article-title":"Walking exercise alters protein digestion, amino acid absorption, and whole body protein kinetics in older adults with and without COPD","volume":"130","author":"Cruthirds","year":"2021","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.tjnut.2025.101350_bib66","first-page":"451","article-title":"Dietary protein splanchnic uptake and digestibility via stable isotope tracers","volume":"27","author":"Cox","year":"2024","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"10.1016\/j.tjnut.2025.101350_bib67","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/s12276-022-00842-9","article-title":"Tracing metabolic flux in vivo: motion pictures differ from snapshots","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tjnut.2025.101350_bib68","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/s12276-022-00803-2","article-title":"Metabolic flux between organs measured by arteriovenous metabolite gradients","volume":"54","author":"Bae","year":"2022","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.tjnut.2025.101350_bib69","doi-asserted-by":"crossref","first-page":"G309","DOI":"10.1152\/ajpgi.00375.2024","article-title":"Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine","volume":"328","author":"Vonderohe","year":"2025","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625008569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316625008569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:55:06Z","timestamp":1777420506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316625008569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0022316625008569"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.101350","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered Dynamics in Splanchnic Amino Acid Extraction During Early Sepsis Recovery in Pigs: Whole Body Compared with Interorgan Balance Assessments","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.101350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101350"}}