{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:10:56Z","timestamp":1785514256894,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["24K09793"],"award-info":[{"award-number":["24K09793"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["24H00749"],"award-info":[{"award-number":["24H00749"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["24K21304"],"award-info":[{"award-number":["24K21304"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["22K05345"],"award-info":[{"award-number":["22K05345"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001331","name":"Arts and Culture Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004322","name":"Agilent Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002709","name":"Agilent Technologies Japan Ltd","doi-asserted-by":"publisher","award":["4366"],"award-info":[{"award-number":["4366"]}],"id":[{"id":"10.13039\/501100002709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002709","name":"Agilent Technologies Japan Ltd","doi-asserted-by":"publisher","award":["4489"],"award-info":[{"award-number":["4489"]}],"id":[{"id":"10.13039\/501100002709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tjnut.2025.11.024","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:56:48Z","timestamp":1764403008000},"page":"101255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein-Conjugated 1\u03b2-Seleno-N-Acetyl-D-Galactosamine Plays Key Roles in Selenium Transport and Storage in Rats and Mammalian Cultured Cells"],"prefix":"10.1016","volume":"156","author":[{"given":"Noriyuki","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3126-8970","authenticated-orcid":false,"given":"Yasunori","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Yomogita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-1828","authenticated-orcid":false,"given":"Yasumitsu","family":"Ogra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2025.11.024_bib1","series-title":"Vitamin and mineral requirements in human nutrition","year":"2004"},{"issue":"1","key":"10.1016\/j.tjnut.2025.11.024_bib2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0003-9861(69)90070-8","article-title":"Trimethyl selenide. A urinary metabolite of selenite","volume":"130","author":"Byard","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"issue":"25","key":"10.1016\/j.tjnut.2025.11.024_bib3","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1073\/pnas.252610699","article-title":"Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1570-0232(01)00581-5","article-title":"Identification of a novel selenium metabolite, Se-methyl-N-acetylselenohexosamine, in rat urine by high-performance liquid chromatography\u2014inductively coupled plasma mass spectrometry and\u2014electrospray ionization tandem mass spectrometry","volume":"767","author":"Ogra","year":"2002","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"10","key":"10.1016\/j.tjnut.2025.11.024_bib5","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1080\/02652030210153578","article-title":"Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se","volume":"19","author":"Suzuki","year":"2002","journal-title":"Food Addit. Contam."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1248\/jhs.51.107","article-title":"Metabolomics of selenium: Se metabolites based on speciation studies","volume":"51","author":"Suzuki","year":"2005","journal-title":"J. Health Sci."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.taap.2006.02.011","article-title":"Metabolic transformation of methylseleninic acid through key selenium intermediate selenide","volume":"215","author":"Suzuki","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.tjnut.2025.11.024_bib8","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1021\/acs.chemrestox.0c00254","article-title":"Production of a urinary selenium metabolite, trimethylselenonium, by thiopurine S-methyltransferase and Indolethylamine N-methyltransferase","volume":"33","author":"Fukumoto","year":"2020","journal-title":"Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105599","article-title":"Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion","volume":"300","author":"Fukumoto","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.tjnut.2025.11.024_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.tjnut.2025.11.024_bib11","doi-asserted-by":"crossref","first-page":"F1244","DOI":"10.1152\/ajprenal.00662.2009","article-title":"Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells","volume":"298","author":"Olson","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"10","key":"10.1016\/j.tjnut.2025.11.024_bib12","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1093\/jn\/124.10.1891","article-title":"A selenium-rich extracellular glycoprotein","volume":"124","author":"Burk","year":"1994","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2025.11.024_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.nutr.24.012003.132120","article-title":"Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis","volume":"25","author":"Burk","year":"2005","journal-title":"Annu. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2025.11.024_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-4165(82)90318-X","article-title":"A selenocysteine-containing selenium-transport protein in rat plasma","volume":"719","author":"Motsenbocker","year":"1982","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.tjnut.2025.11.024_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jtemb.2018.05.007","article-title":"Effect of administration route and dose on metabolism of nine bioselenocompounds","volume":"49","author":"Takahashi","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.tjnut.2025.11.024_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126537","article-title":"Effect of gut microflora on nutritional availability of selenium","volume":"319","author":"Takahashi","year":"2020","journal-title":"Food Chem"},{"issue":"3","key":"10.1016\/j.tjnut.2025.11.024_bib17","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/ijms18030506","article-title":"Bioavailability comparison of nine bioselenocompounds in vitro and in vivo","volume":"18","author":"Takahashi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.tjnut.2025.11.024_bib18","first-page":"2882","article-title":"In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention","volume":"60","author":"Ip","year":"2000","journal-title":"Cancer Res."},{"issue":"23","key":"10.1016\/j.tjnut.2025.11.024_bib19","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.1021\/acs.iecr.0c01147","article-title":"Kilogram-scale production of selenized glucose","volume":"59","author":"Zhou","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"issue":"7","key":"10.1016\/j.tjnut.2025.11.024_bib20","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies","volume":"107","year":"1977","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2025.11.024_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/jn\/126.1.138","article-title":"Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects","volume":"126","author":"Hill","year":"1996","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2025.11.024_bib22","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3390\/nu7042209","article-title":"Biomarkers of selenium status","volume":"7","author":"Combs","year":"2015","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.tjnut.2025.11.024_bib23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0003-9861(80)90091-0","article-title":"The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine","volume":"205","author":"Hoffman","year":"1980","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0003-9861(87)90134-2","article-title":"Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite","volume":"254","author":"Hoffman","year":"1987","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.tjnut.2025.11.024_bib25","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.bbagen.2007.03.007","article-title":"Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide","volume":"1770","author":"Suzuki","year":"2007","journal-title":"Biochim. Biophys. Acta."},{"issue":"9","key":"10.1016\/j.tjnut.2025.11.024_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/antiox8090357","article-title":"Selenocysteine beta-Lyase: biochemistry, regulation and physiological role of the selenocysteine decomposition enzyme","volume":"8","author":"Seale","year":"2019","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.tjnut.2025.11.024_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/bi00570a003","article-title":"Catalytic action of L-methionine gamma-lyase on selenomethionine and selenols","volume":"18","author":"Esaki","year":"1979","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.tjnut.2025.11.024_bib28","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1016\/S0021-9258(18)34734-3","article-title":"Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine. Mammalian distribution and purification and properties of pig liver enzyme","volume":"257","author":"Esaki","year":"1982","journal-title":"J. Biol. Chem."},{"issue":"1\u20133","key":"10.1016\/j.tjnut.2025.11.024_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1385\/BTER:108:1-3:245","article-title":"Identification of mouse selenomethionine alpha, gamma-elimination enzyme: cystathionine gamma-lyase catalyzes its reaction to generate methylselenol","volume":"108","author":"Okuno","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1385\/BTER:109:2:155","article-title":"Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver","volume":"109","author":"Okuno","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"issue":"7930","key":"10.1016\/j.tjnut.2025.11.024_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-022-05174-2","article-title":"Biosynthesis of selenium-containing small molecules in diverse microorganisms","volume":"610","author":"Kayrouz","year":"2022","journal-title":"Nature"},{"issue":"4073","key":"10.1016\/j.tjnut.2025.11.024_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.tjnut.2025.11.024_bib33","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1182\/blood.V68.3.640.640","article-title":"Selenium-dependent glutathione peroxidase protein and activity: immunological investigations on cellular and plasma enzymes","volume":"68","author":"Takahashi","year":"1986","journal-title":"Blood"},{"issue":"2 Pt 1","key":"10.1016\/j.tjnut.2025.11.024_bib34","doi-asserted-by":"crossref","first-page":"C367","DOI":"10.1152\/ajpcell.1994.266.2.C367","article-title":"Human kidney proximal tubules are the main source of plasma glutathione peroxidase","volume":"266","author":"Avissar","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.tjnut.2025.11.024_bib35","doi-asserted-by":"crossref","first-page":"F20","DOI":"10.1152\/ajprenal.00014.2001","article-title":"Extracellular glutathione peroxidase is secreted basolaterally by human renal proximal tubule cells","volume":"283","author":"Whitin","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"5","key":"10.1016\/j.tjnut.2025.11.024_bib36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1039\/d0mt90015j","article-title":"Correction: identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver","volume":"12","author":"Bierla","year":"2020","journal-title":"Metallomics"},{"issue":"11","key":"10.1016\/j.tjnut.2025.11.024_bib37","article-title":"Effect of graded levels of selenium supplementation as selenite on expression of selenosugars, selenocysteine, and other selenometabolites in rat liver","volume":"15","author":"Bierla","year":"2023","journal-title":"Metallomics"},{"issue":"11","key":"10.1016\/j.tjnut.2025.11.024_bib38","article-title":"Selenomethionine supplementation and expression of selenosugars, selenocysteine, and other selenometabolites in rat liver","volume":"15","author":"Bierla","year":"2023","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfaf002","article-title":"Use of laser-ablation inductively-coupled plasma mass spectrometry for analysis of selenosugars bound to proteins","volume":"17","author":"Bierla","year":"2025","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.tjnut.2025.11.024_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10654-023-01091-4","article-title":"Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults","volume":"39","author":"Schottker","year":"2024","journal-title":"Eur. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.tjnut.2025.11.024_bib41","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3390\/nu12041067","article-title":"Selenoprotein P as biomarker of selenium status in clinical trials with therapeutic dosages of selenite","volume":"12","author":"Brodin","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.tjnut.2025.11.024_bib42","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ijheh.2018.02.006","article-title":"Biomonitoring of selenoprotein P in human serum by fast affinity chromatography coupled to ICP-MS","volume":"221","author":"Heitland","year":"2018","journal-title":"Int. J. Hyg. Environ. Health."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662500759X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662500759X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:28:36Z","timestamp":1781234916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662500759X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S002231662500759X"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.11.024","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein-Conjugated 1\u03b2-Seleno-N-Acetyl-D-Galactosamine Plays Key Roles in Selenium Transport and Storage in Rats and Mammalian Cultured Cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2025.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101255"}}