{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:00:47Z","timestamp":1775214047583,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016156","name":"US Army Medical Research and Development Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.tjnut.2026.101380","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:23:03Z","timestamp":1769530983000},"page":"101380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated miR-194-5p Expression during Short-Term Energy Deficit Attenuates Postexercise Muscle Protein Synthesis by Inhibiting Anabolic Signaling"],"prefix":"10.1016","volume":"156","author":[{"given":"Jess A","family":"Gwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian T","family":"Robillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T","family":"Carrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marques A","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa N","family":"Varanoske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D","family":"Church","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arny A","family":"Ferrando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan M","family":"Pasiakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee M","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2026.101380_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fnut.2020.00142","article-title":"Energy deficiency in soldiers: the risk of the athlete triad and relative energy deficiency in sport syndromes in the military","volume":"7","author":"O'Leary","year":"2020","journal-title":"Front. Nutr."},{"issue":"17","key":"10.1016\/j.tjnut.2026.101380_bib2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/bjsports-2023-106994","article-title":"2023 International Olympic Committee\u2019s (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs)","volume":"57","author":"Mountjoy","year":"2023","journal-title":"Br. J. Sports Med."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101380_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40279-024-02130-0","article-title":"Low energy availability and relative energy deficiency in sport: a systematic review and meta-analysis","volume":"55","author":"Gallant","year":"2025","journal-title":"Sports Med"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101380_bib4","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s40279-018-0945-x","article-title":"Threshold of energy deficit and lower-body performance declines in military personnel: a meta-regression","volume":"48","author":"Murphy","year":"2018","journal-title":"Sports Med"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101380_bib5","doi-asserted-by":"crossref","first-page":"C1061","DOI":"10.1152\/ajpcell.00209.2019","article-title":"Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance","volume":"317","author":"Hodson","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101380_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1249\/MSS.0000000000003541","article-title":"Consuming whey protein with added essential amino acids, not carbohydrate, maintains postexercise anabolism while underfed","volume":"57","author":"Gwin","year":"2025","journal-title":"Med. Sci. Sports Exerc."},{"issue":"Pt 20","key":"10.1016\/j.tjnut.2026.101380_bib7","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1113\/jphysiol.2010.198218","article-title":"MicroRNAs and exercise-induced skeletal muscle adaptations","volume":"588","author":"Drummond","year":"2010","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101380_bib8","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1038\/s41467-021-26095-0","article-title":"Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism","volume":"12","author":"Massart","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101380_bib9","doi-asserted-by":"crossref","first-page":"C977","DOI":"10.1152\/ajpcell.00190.2021","article-title":"miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition","volume":"321","author":"Rivas","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101380_bib10","article-title":"Acute resistance exercise modulates microRNA expression profiles: Combined tissue and circulatory targeted analyses","volume":"12","author":"D'Souza","year":"2017","journal-title":"PLOS One"},{"issue":"8","key":"10.1016\/j.tjnut.2026.101380_bib11","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1249\/MSS.0000000000002632","article-title":"Time course of skeletal muscle miRNA expression after resistance, high-intensity interval, and concurrent exercise","volume":"53","author":"Telles","year":"2021","journal-title":"Med. Sci. Sports Exerc."},{"issue":"18","key":"10.1016\/j.tjnut.2026.101380_bib12","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1113\/jphysiol.2013.255695","article-title":"Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training","volume":"591","author":"Russell","year":"2013","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101380_bib13","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1096\/fj.14-254490","article-title":"Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling","volume":"28","author":"Rivas","year":"2014","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101380_bib14","doi-asserted-by":"crossref","first-page":"E1333","DOI":"10.1152\/ajpendo.90562.2008","article-title":"Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids","volume":"295","author":"Drummond","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101380_bib15","doi-asserted-by":"crossref","first-page":"E435","DOI":"10.1152\/ajpendo.00110.2022","article-title":"Carbohydrate intake in recovery from aerobic exercise differentiates skeletal muscle microRNA expression","volume":"323","author":"Margolis","year":"2022","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2026.101380_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fphys.2017.00182","article-title":"Skeletal muscle myomiR are differentially expressed by endurance exercise mode and combined essential amino acid and carbohydrate supplementation","volume":"8","author":"Margolis","year":"2017","journal-title":"Front. Physiol."},{"issue":"23","key":"10.1016\/j.tjnut.2026.101380_bib17","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13931","article-title":"PI3K-AKT-FOXO1 pathway targeted by skeletal muscle microRNA to suppress proteolytic gene expression in response to carbohydrate intake during aerobic exercise","volume":"6","author":"Margolis","year":"2018","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.tjnut.2026.101380_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnut.2019.00091","article-title":"Whey protein supplementation post resistance exercise in elderly men induces changes in muscle miRNA\u2019s compared with resistance exercise alone","volume":"6","author":"D'Souza","year":"2019","journal-title":"Front Nutr"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101380_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/japplphysiol.00932.2006","article-title":"MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy","volume":"102","author":"McCarthy","year":"2007","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101380_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/japplphysiol.00901.2010","article-title":"High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression","volume":"110","author":"Davidsen","year":"2011","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"44","key":"10.1016\/j.tjnut.2026.101380_bib21","doi-asserted-by":"crossref","first-page":"38456","DOI":"10.1074\/jbc.M111.271270","article-title":"Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy","volume":"286","author":"Wada","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2026.101380_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8361237","article-title":"Serum miRNAs miR-23a, 206, and 499 as potential biomarkers for skeletal muscle atrophy","volume":"2017","author":"Wang","year":"2017","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101380_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1249\/01.MSS.0000155699.51360.2F","article-title":"Failure to repeatedly supercompensate muscle glycogen stores in highly trained men","volume":"37","author":"McInerney","year":"2005","journal-title":"Med. Sci. Sports Exerc."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101380_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101380_bib25","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1152\/japplphysiol.90333.2008","article-title":"Coingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans","volume":"106","author":"Howarth","year":"2009","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"17","key":"10.1016\/j.tjnut.2026.101380_bib26","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1113\/JP283209","article-title":"Circulating and skeletal muscle microRNA profiles are more sensitive to sustained aerobic exercise than energy balance in males","volume":"600","author":"Margolis","year":"2022","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101380_bib27","doi-asserted-by":"crossref","first-page":"R298","DOI":"10.1152\/ajpregu.00054.2017","article-title":"Upregulation of circulating myomiR following short-term energy restriction is inversely associated with whole body protein synthesis","volume":"313","author":"Margolis","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101380_bib28","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/jcp.24604","article-title":"Ribosome biogenesis: emerging evidence for a central role in the regulation of skeletal muscle mass","volume":"229","author":"Chaillou","year":"2014","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101380_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1249\/JES.0000000000000117","article-title":"Skeletal muscle remodeling: interconnections between stem cells and protein turnover","volume":"45","author":"Burd","year":"2017","journal-title":"Exerc. Sport Sci. Rev."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101380_bib30","doi-asserted-by":"crossref","first-page":"E620","DOI":"10.1152\/ajpendo.2000.278.4.E620","article-title":"Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds","volume":"278","author":"Hasten","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626000295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626000295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:29:57Z","timestamp":1775212197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626000295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0022316626000295"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101380","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated miR-194-5p Expression during Short-Term Energy Deficit Attenuates Postexercise Muscle Protein Synthesis by Inhibiting Anabolic Signaling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101380"}}