{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:02:06Z","timestamp":1791540126046,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"USDA Agricultural Research Service","doi-asserted-by":"publisher","award":["58-8050-3-003"],"award-info":[{"award-number":["58-8050-3-003"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051641"],"award-info":[{"award-number":["R01AG051641"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG085483"],"award-info":[{"award-number":["R01AG085483"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.tjnut.2026.101428","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:01:14Z","timestamp":1771488074000},"page":"101428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-5582","authenticated-orcid":false,"given":"M Kyla","family":"Shea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L","family":"Rutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bess","family":"Dawson-Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tjnut.2026.101428_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-nutr-013125-030429","article-title":"Dietary patterns and brain aging: enthusiasm before evidence?","volume":"45","author":"Booth","year":"2025","journal-title":"Annu. Rev. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/01.ede.0000135178.36362.ef","article-title":"On the importance of using multiple methods of dietary assessment","volume":"15","author":"Natarajan","year":"2004","journal-title":"Epidemiology"},{"key":"10.1016\/j.tjnut.2026.101428_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104893","article-title":"Vitamin D exerts neuroprotection via SIRT1\/nrf-2\/NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice","volume":"142","author":"Ali","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.tjnut.2026.101428_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2020.10.007","article-title":"Vitamin D deficiency exacerbates Alzheimer-like pathologies by reducing antioxidant capacity","volume":"161","author":"Fan","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101428_bib5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s11011-022-01152-9","article-title":"Vitamin D3 improves spatial memory and modulates cytokine levels in aged rats","volume":"38","author":"Bellettini-Santos","year":"2023","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101428_bib6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.tjnut.2025.01.023","article-title":"Low vitamin K intake impairs cognition, neurogenesis, and elevates neuroinflammation in C57BL\/6 mice","volume":"155","author":"Zheng","year":"2025","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib7","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/alz.12836","article-title":"Brain vitamin D forms, cognitive decline, and neuropathology in community-dwelling older adults","volume":"19","author":"Shea","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101428_bib8","article-title":"Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons","volume":"8","author":"Booth","year":"2022","journal-title":"Alzheimers Dement (N Y)."},{"key":"10.1016\/j.tjnut.2026.101428_bib9","series-title":"Dietary reference intakes for calcium and vitamin D","author":"Ross","year":"2011"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101428_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/nu8010008","article-title":"Concepts and controversies in evaluating vitamin K status in population-based studies","volume":"8","author":"Shea","year":"2016","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib11","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/156720512801322663","article-title":"Overview and findings from the rush Memory and Aging Project","volume":"9","author":"Bennett","year":"2012","journal-title":"Curr. Alzheimer Res. 2012"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101428_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000087446","article-title":"The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort","volume":"25","author":"Bennett","year":"2005","journal-title":"Neuroepidemiology"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101428_bib13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jalz.2015.04.011","article-title":"MIND diet slows cognitive decline with aging","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101428_bib14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/aje\/kwg290","article-title":"Validity and reproducibility of a food frequency questionnaire by cognition in an older biracial sample","volume":"158","author":"Morris","year":"2003","journal-title":"Am. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101428_bib15","doi-asserted-by":"crossref","first-page":"e694","DOI":"10.1212\/WNL.0000000000201541","article-title":"Association of dietary intake of flavonols with changes in global cognition and several cognitive abilities","volume":"100","author":"Holland","year":"2023","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101428_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ypmed.2006.12.009","article-title":"Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore","volume":"44","author":"Panagiotakos","year":"2007","journal-title":"Prev. Med."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101428_bib17","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.jand.2012.07.007","article-title":"Determinants and consequences of adherence to the dietary approaches to stop hypertension diet in African-American and White adults with high blood pressure: results from the ENCORE trial","volume":"112","author":"Epstein","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101428_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzz074","article-title":"Determination of vitamin D and its metabolites in human brain using an ultra-pressure LC-tandem mass spectra method","volume":"3","author":"Fu","year":"2019","journal-title":"Curr. Dev. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101428_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/jn\/nxaa336","article-title":"Vitamin D and vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project","volume":"151","author":"Fu","year":"2021","journal-title":"J. Nutr."},{"issue":"24","key":"10.1016\/j.tjnut.2026.101428_bib20","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1212\/WNL.0000000000005677","article-title":"APOE \u03b52\u03b54 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults","volume":"90","author":"Oveisgharan","year":"2018","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.tjnut.2026.101428_bib21","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1016\/j.tjnut.2025.04.035","article-title":"Warfarin treatment is associated with lower postmortem brain vitamin K concentrations in older adults","volume":"155","author":"Shea","year":"2025","journal-title":"J. Nutr."},{"issue":"14","key":"10.1016\/j.tjnut.2026.101428_bib22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.2016.14403","article-title":"Trends in dietary supplement use among US adults from 1999-2012","volume":"316","author":"Kantor","year":"2016","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.tjnut.2026.101428_bib23","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1017\/S0007114513001013","article-title":"The role of menaquinones (vitamin K2) in human health","volume":"110","author":"Beulens","year":"2013","journal-title":"Br. J. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib24","doi-asserted-by":"crossref","DOI":"10.3945\/cdn.117.000638","article-title":"Multiple vitamin K forms exist in dairy foods","volume":"1","author":"Fu","year":"2017","journal-title":"Curr. Dev. Nutr."},{"issue":"22","key":"10.1016\/j.tjnut.2026.101428_bib25","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1021\/acs.jafc.6b00938","article-title":"Measurement of multiple vitamin K forms in processed and fresh-cut pork products in the U.S. Food supply","volume":"64","author":"Fu","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib26","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/ajcn\/nqaa082","article-title":"Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts","volume":"111","author":"Shea","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/jn\/132.6.1329","article-title":"Dietary and nondietary determinants of vitamin K biochemical measures in men and women","volume":"132","author":"McKeown","year":"2002","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101428_bib28","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1160\/TH14-08-0675","article-title":"Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial","volume":"113","author":"Knapen","year":"2015","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101428_bib29","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3945\/jn.111.139634","article-title":"Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults","volume":"141","author":"Shea","year":"2011","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101428_bib30","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/advances\/nmab004","article-title":"Perspective: evidence before enthusiasm-A critical review of the potential cardiovascular benefits of vitamin K","volume":"12","author":"Shea","year":"2021","journal-title":"Adv. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101428_bib31","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/jn\/nxab332","article-title":"Multiple dietary vitamin K forms are converted to tissue Menaquinone-4 in mice","volume":"152","author":"Ellis","year":"2022","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101428_bib32","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3945\/jn.111.155804","article-title":"Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats","volume":"142","author":"Al Rajabi","year":"2012","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101428_bib33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1471-4159.2007.04773.x","article-title":"Vitamin transport and homeostasis in mammalian brain: focus on vitamins B and E","volume":"103","author":"Spector","year":"2007","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101428_bib34","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2026.101428_bib35","series-title":"United States vitamin D supplements market size and share analysis \u2013 growth trends and forecast (2026-2031)","year":"2025"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626000775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626000775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:44:51Z","timestamp":1790279091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626000775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0022316626000775"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101428","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101428"}}