{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:02:28Z","timestamp":1788238948409,"version":"build-2803163510"},"reference-count":85,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007231","name":"Cornell University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023903","name":"Cornell University - Division of Nutritional Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tjnut.2026.101521","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:55:09Z","timestamp":1775436909000},"page":"101521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Ins and Outs of Manganese: ZIP14 Facilitates Manganese Efflux from the Mouse Brain"],"prefix":"10.1016","volume":"156","author":[{"given":"Jiaqi","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trista L","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-4110","authenticated-orcid":false,"given":"Tolunay Beker","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjnut.2026.101521_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914959","article-title":"Consequences of disturbing manganese homeostasis","volume":"24","author":"Baj","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib2","first-page":"273","volume":"29","author":"Smith","year":"2010"},{"key":"10.1016\/j.tjnut.2026.101521_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1752-1947-6-52","article-title":"Manganese toxicity with ephedrone abuse manifesting as parkinsonism: a case report","volume":"6","author":"Iqbal","year":"2012","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.tjnut.2026.101521_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.envres.2017.03.003","article-title":"Manganese exposure and neurotoxic effects in children","volume":"155","author":"Bj\u00f8rklund","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.tjnut.2026.101521_bib5","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/JOM.0b013e318216d01b","article-title":"How does an occupational neurologist assess welders and steelworkers for a manganese-induced movement disorder? An international team\u2019s experiences in Guanxi, China Part II","volume":"54","author":"Rutchik","year":"2012","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.tjnut.2026.101521_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1212\/WNL.56.1.8","article-title":"Welding-related parkinsonism: clinical features, treatment, and pathophysiology","volume":"56","author":"Racette","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.tjnut.2026.101521_bib7","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.neuro.2012.08.011","article-title":"Increased risk of parkinsonism associated with welding exposure","volume":"33","author":"Racette","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tjnut.2026.101521_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuro.2011.06.004","article-title":"Prospective study on neurotoxic effects in manganese-exposed bridge construction welders","volume":"32","author":"Bowler","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tjnut.2026.101521_bib9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.jom.0000204114.01893.3e","article-title":"Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study","volume":"48","author":"Jiang","year":"2006","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.tjnut.2026.101521_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/0148607199023006333","article-title":"Hypermanganesemia in patients receiving total parenteral nutrition","volume":"23","author":"Fitzgerald","year":"1999","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.tjnut.2026.101521_bib11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/toxsci\/kfv099","article-title":"Manganese-induced parkinsonism is not idiopathic Parkinson\u2019s disease: environmental and genetic evidence","volume":"146","author":"Guilarte","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib12","first-page":"241","article-title":"Health effects of manganese exposures for welders in Qingdao City, China","volume":"30","author":"Zhang","year":"2017","journal-title":"Int. J. Occup. Med. Environ. Health."},{"key":"10.1016\/j.tjnut.2026.101521_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121884","article-title":"Manganese exposure and cognitive performance: a meta-analytical approach","volume":"332","author":"Vlasak","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tjnut.2026.101521_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12393","article-title":"Associations between welding fume exposure and neurological function in Japanese male welders and non-welders","volume":"65","author":"Tsuji","year":"2023","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.tjnut.2026.101521_bib15","series-title":"Manganese Toxicity, in: StatPearls [Internet]","author":"Evans","year":"2023"},{"key":"10.1016\/j.tjnut.2026.101521_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1651151","article-title":"Gut to brain: essential micronutrient and trace element manganese transport, function and toxicity","volume":"16","author":"Zou","year":"2025","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s40572-015-0056-x","article-title":"Manganese toxicity upon overexposure: a decade in review","volume":"2","author":"O\u2019Neal","year":"2015","journal-title":"Curr. Environ. Health Rep"},{"key":"10.1016\/j.tjnut.2026.101521_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11601","article-title":"Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism\u2013dystonia","volume":"7","author":"Tuschl","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tjnut.2026.101521_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3012","article-title":"A novel mutation in SLC39A14 causing hypermanganesemia associated with infantile onset dystonia","volume":"20","author":"Juneja","year":"2018","journal-title":"J. Gene Med."},{"key":"10.1016\/j.tjnut.2026.101521_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.949651","article-title":"A novel homozygous SLC39A14 variant in an infant with hypermanganesemia and a review of the literature","volume":"10","author":"Zhang","year":"2023","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.tjnut.2026.101521_bib21","first-page":"1335","article-title":"Hypermanganesemia with dystonia type 2: a potentially treatable neurodegenerative disorder: a case series in a tertiary university hospital","volume":"9","author":"Alhasan","year":"2022","journal-title":"Children (Basel)"},{"key":"10.1016\/j.tjnut.2026.101521_bib22","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/mdc3.13516","article-title":"Clinical profile and treatment outcomes of hypermanganesemia with dystonia 1 and 2 among 27 Indian children","volume":"9","author":"Garg","year":"2022","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.tjnut.2026.101521_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.14802\/jmd.21143","article-title":"Effect of chelation therapy on a Korean patient with brain manganese deposition resulting from a compound heterozygous mutation in the SLC39A14 gene","volume":"15","author":"Lee","year":"2022","journal-title":"J. Mov. Disord."},{"key":"10.1016\/j.tjnut.2026.101521_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s13760-018-1024-7","article-title":"Autosomal-recessive iron deficiency anemia, dystonia and hypermanganesemia caused by new variant mutation of the manganese transporter gene SLC39A14","volume":"119","author":"Zeglam","year":"2019","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.tjnut.2026.101521_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ymgme.2018.04.002","article-title":"Novel founder intronic variant in SLC39A14 in two families causing manganism and potential treatment strategies","volume":"124","author":"Rodan","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.tjnut.2026.101521_bib26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13023-018-0758-x","article-title":"Hypermanganesemia due to mutations in SLC39A14: further insights into Mn deposition in the central nervous system","volume":"13","author":"Marti-Sanchez","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.tjnut.2026.101521_bib27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/mdc3.12947","article-title":"Benign SLC39A14 course of dystonia-parkinsonism secondary to inherited manganese accumulation","volume":"7","author":"Namnah","year":"2020","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.tjnut.2026.101521_bib28","doi-asserted-by":"crossref","first-page":"E1769","DOI":"10.1073\/pnas.1720739115","article-title":"SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice","volume":"115","author":"Jenkitkasemwong","year":"2018","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.tjnut.2026.101521_bib29","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1038\/s41598-020-61059-2","article-title":"Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tjnut.2026.101521_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuro.2022.09.005","article-title":"Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of manganese-induced dystonia-parkinsonism","volume":"93","author":"Rodichkin","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tjnut.2026.101521_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105467","article-title":"Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice","volume":"158","author":"Rodichkin","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tjnut.2026.101521_bib32","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1523\/JNEUROSCI.0285-17.2017","article-title":"Metal transporter Zip14 (Slc39a14) deletion in mice increases manganese deposition and produces neurotoxic signatures and diminished motor activity","volume":"37","author":"Aydemir","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tjnut.2026.101521_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.25","article-title":"Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice","volume":"3","author":"Xin","year":"2017","journal-title":"Cell Discov"},{"key":"10.1016\/j.tjnut.2026.101521_bib34","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/cge.13184","article-title":"Hypermanganesemia with dystonia, polycythemia and cirrhosis in 10 patients: six novel SLC30A10 mutations and further phenotype delineation","volume":"93","author":"Zaki","year":"2018","journal-title":"Clin. Genet."},{"key":"10.1016\/j.tjnut.2026.101521_bib35","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/mds.26202","article-title":"Manganese transport disorder: novel SLC30A10 mutations and early phenotypes","volume":"30","author":"Quadri","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tjnut.2026.101521_bib36","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ajhg.2012.01.018","article-title":"Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man","volume":"90","author":"Tuschl","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tjnut.2026.101521_bib37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ajhg.2012.01.017","article-title":"Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease","volume":"90","author":"Quadri","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tjnut.2026.101521_bib38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.febslet.2004.12.006","article-title":"Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14","volume":"579","author":"Taylor","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tjnut.2026.101521_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910342","article-title":"Expression of manganese transporters ZIP8, ZIP14, and ZnT10 in brain barrier tissues","volume":"25","author":"McCabe","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib40","doi-asserted-by":"crossref","first-page":"19197","DOI":"10.1074\/jbc.RA119.009371","article-title":"The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels","volume":"294","author":"Steimle","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2026.101521_bib41","doi-asserted-by":"crossref","first-page":"G673","DOI":"10.1152\/ajpgi.00301.2019","article-title":"Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism","volume":"318","author":"Aydemir","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib42","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.3390\/ijms23126495","article-title":"The combined inactivation of intestinal and hepatic ZIP14 exacerbates manganese overload in mice","volume":"23","author":"Fung","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib43","article-title":"Purification of mouse brain vessels","volume":"2015","author":"Boulay","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tjnut.2026.101521_bib44","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2294","article-title":"Isolation and cultivation of primary brain endothelial cells from adult mice","volume":"7","author":"Assmann","year":"2017","journal-title":"Bio Protoc"},{"key":"10.1016\/j.tjnut.2026.101521_bib45","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3092","article-title":"Collagenase-based single cell isolation of primary murine brain endothelial cells using flow cytometry","volume":"8","author":"Czupalla","year":"2018","journal-title":"Bio Protoc."},{"key":"10.1016\/j.tjnut.2026.101521_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100508","article-title":"Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle","volume":"2","author":"Conchinha","year":"2021","journal-title":"STAR Protoc"},{"key":"10.1016\/j.tjnut.2026.101521_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.101019","article-title":"Isolation and functional characterization of primary endothelial cells from mouse cerebral cortex","volume":"2","author":"Ouellette","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.tjnut.2026.101521_bib48","doi-asserted-by":"crossref","first-page":"15662","DOI":"10.1074\/jbc.RA120.015552","article-title":"Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity","volume":"295","author":"Pajarillo","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2026.101521_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116404","article-title":"Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload","volume":"278","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tjnut.2026.101521_bib50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/kfr091","article-title":"Manganese-induced NF-\u03baB activation and nitrosative stress is decreased by estrogen in juvenile mice","volume":"122","author":"Moreno","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/toxsci\/kfp221","article-title":"Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration","volume":"112","author":"Moreno","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tjnut.2026.101521_bib52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00204-013-1088-3","article-title":"Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water","volume":"88","author":"Krishna","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tjnut.2026.101521_bib53","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1007\/s12035-021-02341-w","article-title":"Defective mitochondrial dynamics underlie manganese-induced neurotoxicity","volume":"58","author":"Morcillo","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116155","article-title":"Mechanism of KAT2A regulation of H3K36ac in manganese-induced oxidative damage to mitochondria in the nervous system and intervention by curcumin","volume":"273","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.tjnut.2026.101521_bib55","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0013-9351(03)00109-9","article-title":"Effect of manganese chloride exposure on liver and brain mitochondria function in rats","volume":"93","author":"Zhang","year":"2003","journal-title":"Environ. Res."},{"key":"10.1016\/j.tjnut.2026.101521_bib56","article-title":"Absorption of manganese and iron in a mouse model of hemochromatosis","volume":"8","author":"Kim","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.tjnut.2026.101521_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226302","article-title":"Isolation of endothelial cells, pericytes and astrocytes from mouse brain","volume":"14","author":"Bernard-Patrzynski","year":"2019","journal-title":"PLOS ONE"},{"key":"10.1016\/j.tjnut.2026.101521_bib58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2045-8118-10-16","article-title":"The hCMEC\/D3 cell line as a model of the human blood brain barrier","volume":"10","author":"Weksler","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.tjnut.2026.101521_bib59","doi-asserted-by":"crossref","first-page":"E92","DOI":"10.1152\/ajpendo.00117.2023","article-title":"Absence of Slc39a14\/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia","volume":"326","author":"Hung","year":"2024","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tjnut.2026.101521_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1220533","article-title":"Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases","volume":"10","author":"Mitchell","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tjnut.2026.101521_bib61","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1002\/cpcb.56","article-title":"Expansion microscopy: protocols for imaging proteins and RNA in cells and tissues","volume":"80","author":"Asano","year":"2018","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.tjnut.2026.101521_bib62","doi-asserted-by":"crossref","first-page":"G593","DOI":"10.1152\/ajpgi.00091.2023","article-title":"Metal transporter SLC39A14\/ZIP14 modulates regulation between the gut microbiome and host metabolism","volume":"325","author":"Mitchell","year":"2023","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib63","article-title":"Measuring motor coordination in mice","volume":"75","author":"Deacon","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tjnut.2026.101521_bib64","article-title":"Assessment of spontaneous alternation, novel object recognition and limb clasping in transgenic mouse models of amyloid-\u03b2 and tau neuropathology","volume":"123","author":"Miedel","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.tjnut.2026.101521_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.5","article-title":"Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface","volume":"3","author":"Boulay","year":"2017","journal-title":"Cell Discov"},{"key":"10.1016\/j.tjnut.2026.101521_bib66","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fphys.2020.00398","article-title":"The isolated brain microvessel: a versatile experimental model of the blood-brain barrier","volume":"11","author":"Pardridge","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib67","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s10534-019-00216-1","article-title":"ZIP14 is degraded in response to manganese exposure","volume":"32","author":"Thompson","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.tjnut.2026.101521_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105078","article-title":"Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation","volume":"299","author":"Liu","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2026.101521_bib69","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.neuro.2012.04.014","article-title":"Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo","volume":"33","author":"Moberly","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tjnut.2026.101521_bib70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2010.06.063","article-title":"Activity-induced manganese-dependent functional MRI of the rat visual cortex following intranasal manganese chloride administration","volume":"481","author":"Fa","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tjnut.2026.101521_bib71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5487\/TR.2015.31.1.017","article-title":"Loss of HFE function reverses impaired recognition memory caused by olfactory manganese exposure in mice","volume":"31","author":"Ye","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.tjnut.2026.101521_bib72","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2018.05.001","article-title":"Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity","volume":"67","author":"Johnson","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tjnut.2026.101521_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108255","article-title":"Involvement of the nitric oxide signaling in modulation of naringin against intranasal manganese and intracerbroventricular \u03b2-amyloid induced neurotoxicity in rats","volume":"76","author":"Kaur","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tjnut.2026.101521_bib74","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1074\/jbc.RA119.011446","article-title":"The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity","volume":"295","author":"Pajarillo","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tjnut.2026.101521_bib75","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s11011-022-00916-7","article-title":"Protective effect of calpain inhibitors against manganese-induced toxicity in rats","volume":"37","author":"Ivleva","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.tjnut.2026.101521_bib76","doi-asserted-by":"crossref","first-page":"C169","DOI":"10.1152\/ajpcell.00116.2016","article-title":"The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human \u03b2-cells","volume":"312","author":"Coffey","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tjnut.2026.101521_bib77","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.3390\/ijms19092693","article-title":"The \u201cfrail\u201d brain blood barrier in neurodegenerative diseases: role of early disruption of endothelial cell-to-cell connections","volume":"19","author":"Maiuolo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101521_bib78","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/0271678X15608644","article-title":"Apicobasal polarity of brain endothelial cells","volume":"36","author":"Worzfeld","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tjnut.2026.101521_bib79","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nbt.3625","article-title":"Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies","volume":"34","author":"Tillberg","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tjnut.2026.101521_bib80","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.1260088","article-title":"Expansion microscopy","volume":"347","author":"Chen","year":"2015","journal-title":"Science."},{"key":"10.1016\/j.tjnut.2026.101521_bib81","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1016\/j.cell.2021.11.024","article-title":"EASI-FISH for thick tissue defines lateral hypothalamus spatio-molecular organization","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.tjnut.2026.101521_bib82","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.neuropsychologia.2010.02.004","article-title":"An animal model of recognition memory and medial temporal lobe amnesia: History and current issues","volume":"48","author":"Clark","year":"2010","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.tjnut.2026.101521_bib83","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbr.2014.09.050","article-title":"Neural circuitry for rat recognition memory","volume":"285","author":"Warburton","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.tjnut.2026.101521_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2015.09.020","article-title":"Neurocognitive architecture of working memory","volume":"88","author":"Eriksson","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.tjnut.2026.101521_bib85","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1155\/NP.2003.107","article-title":"The basal ganglia and motor control","volume":"10","author":"Groenewegen","year":"2003","journal-title":"Neural Plast"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626001707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626001707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:34:29Z","timestamp":1780914869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626001707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0022316626001707"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101521","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Ins and Outs of Manganese: ZIP14 Facilitates Manganese Efflux from the Mouse Brain","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101521"}}