{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:49:49Z","timestamp":1785926989691,"version":"3.56.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1250757"],"award-info":[{"award-number":["1250757"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1190532"],"award-info":[{"award-number":["1190532"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005853","name":"Universidad de Chile","doi-asserted-by":"publisher","award":["006\/24"],"award-info":[{"award-number":["006\/24"]}],"id":[{"id":"10.13039\/501100005853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020563","name":"University of Santiago de Chile Vice-President for Research Development and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020563","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011073","name":"The University of North Carolina at Chapel Hill Nutrition Obesity Research Center","doi-asserted-by":"publisher","award":["P30DK5635"],"award-info":[{"award-number":["P30DK5635"]}],"id":[{"id":"10.13039\/100011073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["0591"],"award-info":[{"award-number":["0591"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016919","name":"Niroo Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tjnut.2026.101665","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:59:08Z","timestamp":1781107148000},"page":"101665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II"],"prefix":"10.1016","volume":"156","author":[{"given":"Isis","family":"Trujillo-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannella","family":"Barisione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Bottiglieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Garmendia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-6959","authenticated-orcid":false,"given":"Mar\u00eda F","family":"Mujica-Coopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.tjnut.2026.101665_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141089","article-title":"Periconception maternal folate status and human embryonic cerebellum growth trajectories: the Rotterdam predict study","volume":"10","author":"Koning","year":"2015","journal-title":"PLOS One"},{"issue":"11","key":"10.1016\/j.tjnut.2026.101665_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.45771","article-title":"Prenatal diet and infant growth from birth to age 24 months","volume":"7","author":"Hedderson","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.tjnut.2026.101665_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mam.2016.11.007","article-title":"One-carbon metabolism and epigenetics","volume":"54","author":"Friso","year":"2017","journal-title":"Mol. Aspects Med."},{"issue":"21","key":"10.1016\/j.tjnut.2026.101665_bib4","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1074\/jbc.R110.205286","article-title":"DNA methylation and demethylation in mammals","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101665_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/genes10040257","article-title":"DNA methylation reprogramming during mammalian development","volume":"10","author":"Zeng","year":"2019","journal-title":"Genes (Basel)"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101665_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.clinbiochem.2010.03.009","article-title":"The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism","volume":"43","author":"Lever","year":"2010","journal-title":"Clin. Biochem."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbadis.2012.09.007","article-title":"S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system","volume":"1832","author":"Tehlivets","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"issue":"10","key":"10.1016\/j.tjnut.2026.101665_bib8","first-page":"1678","article-title":"Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris","volume":"131","author":"Br\u00e5tveit","year":"2024","journal-title":"Br. J. Nutr."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101665_bib9","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.3945\/jn.117.254029","article-title":"Metabolomic evaluation of the consequences of plasma cystathionine elevation in adults with stable angina pectoris","volume":"147","author":"DeRatt","year":"2017","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-nutr-071714-034330","article-title":"Direct and functional biomarkers of vitamin B6 status","volume":"35","author":"Ueland","year":"2015","journal-title":"Annu. Rev. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101665_bib11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1096\/fj.14-261131","article-title":"Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts","volume":"29","author":"Zhang","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.tjnut.2026.101665_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jnutbio.2018.06.001","article-title":"Betaine or folate can equally furnish remethylation to methionine and increase transmethylation in methionine-restricted neonates","volume":"59","author":"Robinson","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tjnut.2026.101665_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)00401-9","article-title":"Folate-mediated one-carbon metabolism","volume":"79","author":"Fox","year":"2008","journal-title":"Vitam. Horm."},{"issue":"2 Suppl","key":"10.1016\/j.tjnut.2026.101665_bib14","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1177\/0379572115585772","article-title":"Folate and vitamin B12 status in Latin America and the Caribbean: an update","volume":"36","author":"Brito","year":"2015","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.tjnut.2026.101665_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102366","article-title":"Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: a systematic review","volume":"67","author":"Quinn","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101665_bib16","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3945\/ajcn.116.138818","article-title":"Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study","volume":"104","author":"Van Lee","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101665_bib17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/pr.2013.54","article-title":"Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight","volume":"73","author":"Hogeveen","year":"2013","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193114","article-title":"Higher serum choline and betaine levels are associated with better body composition in male but not female population","volume":"13","author":"Gao","year":"2018","journal-title":"PLOS One"},{"key":"10.1016\/j.tjnut.2026.101665_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0322","article-title":"Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health","volume":"13","author":"Ribo","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1550-2783-10-39","article-title":"Effects of betaine on body composition, performance, and homocysteine thiolactone","volume":"10","author":"Cholewa","year":"2013","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"10.1016\/j.tjnut.2026.101665_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.904668","article-title":"The Chilean Maternal-Infant Cohort Study-II in the COVID-19 era: a study protocol","volume":"10","author":"Mujica-Coopman","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.tjnut.2026.101665_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biochi.2020.04.004","article-title":"Impact of the MTHFR C677T polymorphism on one-carbon metabolites: evidence from a randomised trial of riboflavin supplementation","volume":"173","author":"Rooney","year":"2020","journal-title":"Biochemie"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101665_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/oby.20951","article-title":"Weight gain in pregnancy and application of the 2009 IOM guidelines: toward a uniform approach","volume":"23","author":"Gilmore","year":"2015","journal-title":"Obesity (Silver Spring)"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101665_bib24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/ajcn\/77.5.1171","article-title":"Effectiveness of the US Department of Agriculture 5-step multiple-pass method in assessing food intake in obese and nonobese women","volume":"77","author":"Conway","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2026.101665_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2025.107660","article-title":"Development and feasibility of a 24-hour recall software to characterize the Chilean diet","volume":"144","author":"Mujica-Coopman","year":"2025","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.tjnut.2026.101665_bib26","series-title":"Tabla Chilena de Composici\u00f3n Qu\u00edmicas de los Alimentos","author":"Schmidt-Hebbel","year":"1992"},{"key":"10.1016\/j.tjnut.2026.101665_bib27","article-title":"WHO Child Growth Standards","year":"2009","journal-title":"Developmental Medicine & Child Neurology"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ajcn\/85.1.90","article-title":"Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model","volume":"85","author":"Ellis","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib29","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1038\/s41598-023-30123-y","article-title":"Gestational age and trajectories of body mass index and height from birth through adolescence in the Danish National Birth Cohort","volume":"13","author":"Vinther","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G\u2217Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101665_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0293745","article-title":"Iron, folic acid, and vitamin D supplementation during pregnancy: did pregnant Chilean women meet the recommendations during the COVID pandemic?","volume":"18","author":"Mujica-Coopman","year":"2023","journal-title":"PLOS ONE"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101665_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-3016.2012.01264.x","article-title":"Maternal intake of methyl-donor nutrients and child cognition at 3 years of age, Paediatr","volume":"26","author":"Villamor","year":"2012","journal-title":"Perinat. Epidemiol."},{"key":"10.1016\/j.tjnut.2026.101665_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1439-0396.2006.00644.x","article-title":"Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs","volume":"91","author":"Huang","year":"2007","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/jcp.20872","article-title":"The organic osmolytes betaine and proline are transported by a shared system in early preimplantation mouse embryos","volume":"210","author":"Anas","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101665_bib35","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1017\/S0007114519000497","article-title":"Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight","volume":"121","author":"Du","year":"2019","journal-title":"Br. J. Nutr."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101665_bib36","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41366-023-01310-8","article-title":"Likelihood of obesity in early and late childhood based on growth trajectory during infancy","volume":"47","author":"Moschonis","year":"2023","journal-title":"Int. J. Obes. (Lond.)."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/eurpub\/ckz232","article-title":"Weight gain in early years and subsequent body mass index trajectories across birth weight groups: a prospective longitudinal study","volume":"30","author":"Lu","year":"2020","journal-title":"Eur. J. Public Health."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101665_bib38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3945\/an.115.010843","article-title":"The pediatric methionine requirement should incorporate remethylation potential and transmethylation demands","volume":"7","author":"Robinson","year":"2016","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.tjnut.2026.101665_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13148-017-0321-y","article-title":"Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants","volume":"9","author":"Pauwels","year":"2017","journal-title":"Clin. Epigenetics."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101665_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15592294.2016.1257450","article-title":"Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation","volume":"12","author":"Pauwels","year":"2017","journal-title":"Epigenetics"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/pedi.12964","article-title":"Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity","volume":"21","author":"Frithioff-B\u00f8js\u00f8e","year":"2020","journal-title":"Pediatr. Diabetes"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101665_bib42","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10528-016-9751-z","article-title":"Role of leptin deficiency, inefficiency, and leptin receptors in obesity","volume":"54","author":"Wasim","year":"2016","journal-title":"Biochem. Genet."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101665_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081731","article-title":"DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study","volume":"8","author":"Bouwland-Both","year":"2013","journal-title":"PLOS One"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib44","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1139\/h11-161","article-title":"Folic acid supplement use is the most significant predictor of folate concentrations in Canadian women of childbearing age","volume":"37","author":"Colapinto","year":"2012","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.tjnut.2026.101665_bib45","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1753-4887.2004.tb00074.x","article-title":"Folic acid fortification of wheat flour: Chile","volume":"62","author":"Hertrampf","year":"2004","journal-title":"Nutr. Rev"},{"issue":"10","key":"10.1016\/j.tjnut.2026.101665_bib46","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/jn\/133.10.3166","article-title":"Consumption of folic acid\u2013fortified bread improves folate status in women of reproductive age in Chile","volume":"133","author":"Hertrampf","year":"2003","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101665_bib47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S1368980020002608","article-title":"Folate status in women of childbearing age in the Urban Metropolitan Region of Chile: results from the National Health Survey 2016-2017","volume":"24","author":"Busso","year":"2021","journal-title":"Public Health Nutr"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101665_bib48","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/jn\/nxz178","article-title":"Serum betaine and dimethylglycine are higher in South Asian compared with European pregnant women in Canada, with betaine and total homocysteine inversely associated in early and midpregnancy, independent of ethnicity","volume":"149","author":"Mujica-Coopman","year":"2019","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2025.105240","article-title":"Health effects of excess folic acid use and high blood folate during preconception and pregnancy: a systematic review","volume":"53","author":"Ledowsky","year":"2025","journal-title":"Reprod. Biomed. Online."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101665_bib50","first-page":"888","article-title":"High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring","volume":"26","author":"Bahous","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101665_bib51","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3945\/ajcn.114.086603","article-title":"High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice","volume":"101","author":"Christensen","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101665_bib52","doi-asserted-by":"crossref","first-page":"2361S","DOI":"10.1093\/jn\/132.8.2361S","article-title":"Trans-HHS workshop: diet, DNA methylation processes and health elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology","volume":"132","author":"James","year":"2002","journal-title":"J. Nutr."},{"issue":"38","key":"10.1016\/j.tjnut.2026.101665_bib53","doi-asserted-by":"crossref","first-page":"29318","DOI":"10.1074\/jbc.M002725200","article-title":"Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation","volume":"275","author":"Yi","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101665_bib54","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/jn\/131.11.2811","article-title":"Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice","volume":"131","author":"Caudill","year":"2001","journal-title":"J. Nutr."},{"issue":"Suppl 1","key":"10.1016\/j.tjnut.2026.101665_bib55","doi-asserted-by":"crossref","first-page":"s39","DOI":"10.1017\/S1368980019004439","article-title":"Nutrition status in adult Chilean population: economic, ethnic and sex inequalities in a post-transitional country","volume":"23","author":"Mujica-Coopman","year":"2020","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.tjnut.2026.101665_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjnut.2025.101291","article-title":"Impact of mandatory grain fortification with folic acid on population folate concentrations and the risk of folate deficiency and insufficiency: a systematic review and meta-analysis","volume":"156","author":"Parker","year":"2026","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101665_bib57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa067103","article-title":"Reduction in neural-tube defects after folic acid fortification in Canada","volume":"357","author":"De Wals","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101665_bib58","first-page":"642","article-title":"Dietary choline and folate relationships with serum hepatic inflammatory injury markers in Taiwanese adults","volume":"26","author":"Cheng","year":"2017","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2026.101665_bib59","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.envres.2016.08.015","article-title":"Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women","volume":"151","author":"L\u00f3pez-Carrillo","year":"2016","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101665_bib60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/19390211.2019.1639875","article-title":"Choline: the neurocognitive essential nutrient of interest to obstetricians and gynecologists","volume":"17","author":"Wallace","year":"2020","journal-title":"J. Diet. Suppl."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101665_bib61","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3390\/nu15071707","article-title":"Childhood obesity and plasma micronutrient deficit of Chilean children between 4 and 14 years old","volume":"15","author":"Castillo-Valenzuela","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tjnut.2026.101665_bib62","article-title":"Childhood obesity in Mexico: a constant struggle and reflection for its prevention on the influence of family and social habits","volume":"44","author":"Mercado-Mercado","year":"2023","journal-title":"Obes. Med."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:23:25Z","timestamp":1785925405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626003147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0022316626003147"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101665","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101665"}}