{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:35:27Z","timestamp":1786116927155,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV-009129"],"award-info":[{"award-number":["INV-009129"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV-002855"],"award-info":[{"award-number":["INV-002855"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tjnut.2026.101666","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:23:57Z","timestamp":1781105037000},"page":"101666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prior Pregnancies Deplete Maternal Folate Status and Increase Risks of Neural Tube Defects in Addis Ababa, Ethiopia"],"prefix":"10.1016","volume":"156","author":[{"given":"Hasset Tamirat","family":"Molla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward JM","family":"Joy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawd","family":"Gashu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demiraw","family":"Bikila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadesse Lejisa","family":"Garomsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Stoecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-4822","authenticated-orcid":false,"given":"Fanny","family":"Sandalinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.tjnut.2026.101666_bib1","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.3945\/jn.114.206599","article-title":"Biomarkers of nutrition for development\u2014folate review","volume":"145","author":"Bailey","year":"2015","journal-title":"J. Nutr."},{"issue":"Suppl 1","key":"10.1016\/j.tjnut.2026.101666_bib2","doi-asserted-by":"crossref","first-page":"i110","DOI":"10.1093\/ije\/dyq028","article-title":"Folic acid to reduce neonatal mortality from neural tube disorders","volume":"39","author":"Blencowe","year":"2010","journal-title":"Int. J. Epidemiol."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101666_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-077685","article-title":"Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis","volume":"13","author":"Tesfay","year":"2023","journal-title":"BMJ Open"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101666_bib4","doi-asserted-by":"crossref","first-page":"e1041","DOI":"10.1016\/S2214-109X(23)00191-2","article-title":"Neural tube defects as a cause of death among stillbirths, infants, and children younger than 5 years in sub-Saharan Africa and southeast Asia: an analysis of the CHAMPS network","volume":"11","author":"Madrid","year":"2023","journal-title":"Lancet Glob. Health"},{"issue":"11","key":"10.1016\/j.tjnut.2026.101666_bib5","doi-asserted-by":"crossref","first-page":"e1590","DOI":"10.1016\/S2214-109X(22)00367-9","article-title":"Micronutrient deficiencies among preschool-aged children and women of reproductive age worldwide: a pooled analysis of individual-level data from population-representative surveys","volume":"10","author":"Stevens","year":"2022","journal-title":"Lancet Glob. Health"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzac088","article-title":"Folate deficiency is spatially dependent and associated with local farming systems among women in Ethiopia","volume":"6","author":"Sisay","year":"2022","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.tjnut.2026.101666_bib7","series-title":"Ethiopian National Micronutrient Survey Report. [Internet]","year":"2016"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-068076","article-title":"Serum folate deficiency and associated factors among pregnant women in Haramaya District, Eastern Ethiopia: a community-based study","volume":"13","author":"Mamme","year":"2023","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40795-023-00724-x","article-title":"Co-occurrence of iron, folate, and vitamin A deficiency among pregnant women in eastern Ethiopia: a community-based study","volume":"9","author":"Fite","year":"2023","journal-title":"BMC Nutr"},{"key":"10.1016\/j.tjnut.2026.101666_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/20503121221118987","article-title":"Red blood cell folate level and associated factors of folate insufficiency among pregnant women attending antenatal care during their first trimester of pregnancy in Addis Ababa, Ethiopia","volume":"10","author":"Tefera","year":"2022","journal-title":"SAGE Open Med"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101666_bib11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3945\/jn.112.169987","article-title":"Dietary supplement use and folate status during pregnancy in the United States","volume":"143","author":"Branum","year":"2013","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.tjnut.2026.101666_bib12","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/ejcn.2012.111","article-title":"Determinants of folate status in pregnant women: results from a national cross-sectional survey in Belgium","volume":"66","author":"Vandevijvere","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12884-017-1506-2","article-title":"Folic acid usage and associated factors in the prevention of neural tube defects among pregnant women in Ethiopia: cross-sectional study","volume":"17","author":"Dessie","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12884-020-2835-0","article-title":"Adherence to iron-folic acid supplementation among pregnant women in Ethiopia: a systematic review and meta-analysis","volume":"20","author":"Sendeku","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib15","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ajcnut.2023.01.016","article-title":"Estimating the serum folate concentration that corresponds to the red blood cell folate concentration threshold associated with optimal neural tube defects prevention: a population-based biomarker survey in Southern India","volume":"117","author":"Fothergill","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"10.1016\/j.tjnut.2026.101666_bib17","series-title":"RStudio: Integrated Development Environment for R. Posit Software","year":"2024"},{"key":"10.1016\/j.tjnut.2026.101666_bib18","article-title":"dplyr: A Grammar of Data Manipulation","author":"Wickham","year":"2023","journal-title":"R package version 1.1.4"},{"key":"10.1016\/j.tjnut.2026.101666_bib19","article-title":"tidyr: Tidy Messy Data","author":"Wickham","year":"2024","journal-title":"R package version 1.3.1"},{"key":"10.1016\/j.tjnut.2026.101666_bib20","article-title":"censReg: Censored Regression (Tobit) Models","author":"Henningsen","year":"2024","journal-title":"R package version 0.5-38"},{"key":"10.1016\/j.tjnut.2026.101666_bib21","series-title":"An R Companion to Applied Regression","author":"Fox","year":"2019"},{"key":"10.1016\/j.tjnut.2026.101666_bib22","series-title":"R: A Language and Environment for Statistical Computing","year":"2024"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib23","first-page":"295","article-title":"The environment and disease: association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc. R. Soc. Med."},{"issue":"9298","key":"10.1016\/j.tjnut.2026.101666_bib24","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1016\/S0140-6736(01)07105-7","article-title":"Short interpregnancy intervals and unfavourable pregnancy outcome: role of folate depletion","volume":"358","author":"Smits","year":"2001","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2105\/AJPH.82.5.691","article-title":"A new definition of maternal depletion syndrome","volume":"82","author":"Winkvist","year":"1992","journal-title":"Am. J. Public Health."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101666_bib26","doi-asserted-by":"crossref","first-page":"1732S","DOI":"10.1093\/jn\/133.5.1732S","article-title":"The risk of maternal nutritional depletion and poor outcomes increases in early or closely spaced pregnancies","volume":"133","author":"King","year":"2003","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101666_bib27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/1471-0528.13574","article-title":"Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5\u20136 years: findings from the ABCD multi-ethnic birth cohort","volume":"123","author":"Krikke","year":"2016","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jns.2003.08.014","article-title":"Birth order and neural tube defects: a reappraisal","volume":"217","author":"Vieira","year":"2004","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101666_bib29","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/ajcn\/nqaa436","article-title":"Short interpregnancy intervals and risks for birth defects: support for the nutritional depletion hypothesis","volume":"113","author":"Petersen","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101666_bib30","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1139\/apnm-2014-0181","article-title":"Folate, vitamin B12, and vitamin B6 status of a group of high socioeconomic status women in the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort","volume":"39","author":"Fayyaz","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.tjnut.2026.101666_bib31","series-title":"National Preconception Care: Guideline","year":"2024"},{"issue":"10","key":"10.1016\/j.tjnut.2026.101666_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-084494","volume":"14","author":"Brown","year":"2024","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101666_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281038","article-title":"Determinants of early initiation of first antenatal care visit in Ethiopia based on the 2019 Ethiopia mini-demographic and health survey: a multilevel analysis","volume":"18","author":"Abebe","year":"2023","journal-title":"PLOS ONE"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/jfmpc.jfmpc_725_22","article-title":"Early initiation of antenatal care and its associated factors among antenatal care followers at public health facilities in Ambo town administration, Central Ethiopia","volume":"12","author":"Edessa","year":"2023","journal-title":"J. Family Med. Prim. Care"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101666_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/nyas.13532","article-title":"Framework for laboratory harmonization of folate measurements in low- and middle-income countries and regions","volume":"1414","author":"Pfeiffer","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101666_bib36","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/ajcn\/nqz303","article-title":"Interpretation of vitamin B-12 and folate concentrations in population-based surveys does not require adjustment for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project","volume":"111","author":"Young","year":"2020","journal-title":"Am. J. Clin. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:52:06Z","timestamp":1786020726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626003159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0022316626003159"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101666","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prior Pregnancies Deplete Maternal Folate Status and Increase Risks of Neural Tube Defects in Addis Ababa, Ethiopia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101666"}}