{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:17:23Z","timestamp":1788520643940,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tjnut.2026.101686","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:18:46Z","timestamp":1782170326000},"page":"101686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supplementation of Betaine and Creatine to Neonatal Parenteral Nutrition Lowers Telemetric Blood Pressure in Adult Yucatan Miniature Pigs"],"prefix":"10.1016","volume":"156","author":[{"given":"Raniru S","family":"Randunu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Anne","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce N","family":"Van Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A","family":"Brunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-5785","authenticated-orcid":false,"given":"Robert F","family":"Bertolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41569-020-00437-9","article-title":"Lifestyle interventions for the prevention and treatment of hypertension","volume":"18","author":"Valenzuela","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MNH.0b013e328326092c","article-title":"Developmental programming and hypertension","volume":"18","author":"Nuyt","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/HYPERTENSIONAHA.108.114256","article-title":"Immediate postnatal growth is associated with blood pressure in young adulthood: the Barry Caerphilly Growth Study","volume":"52","author":"Ben-Shlomo","year":"2008","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib4","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/HYPERTENSIONAHA.106.085597","article-title":"Childhood growth and hypertension in later life","volume":"49","author":"Eriksson","year":"2007","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101686_bib5","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/hc0902.104677","article-title":"Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age","volume":"105","author":"Law","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.106.617811","article-title":"Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure?","volume":"115","author":"Singhal","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101686_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1079\/BJN2002656","article-title":"Long-term programming of blood pressure by maternal dietary iron restriction in the rat","volume":"88","author":"Lewis","year":"2002","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000326341","article-title":"Low birth weight is associated with reduced nephron number and increased blood pressure in adulthood in a novel spontaneous intrauterine growth-restricted model in Yucatan miniature swine","volume":"100","author":"Myrie","year":"2011","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/HYPERTENSIONAHA.107.092890","article-title":"Developmental programming of hypertension: insight from animal models of nutritional manipulation","volume":"52","author":"Ojeda","year":"2008","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101686_bib53","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1139\/apnm-2017-0311","article-title":"Intrauterine growth-restricted Yucatan miniature pigs experience early catch-up growth, leading to greater adiposity and impaired lipid metabolism as young adults","volume":"42","author":"Myrie","year":"2017","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101686_bib11","first-page":"953","article-title":"Total parenteral nutrition in neonates","volume":"43","author":"Chaudhari","year":"2006","journal-title":"Indian Pediatr"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101686_bib12","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.3945\/jn.110.125799","article-title":"Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs","volume":"140","author":"Stoll","year":"2010","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101686_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1177\/0148607112444756","article-title":"Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs","volume":"36","author":"Stoll","year":"2012","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101686_bib14","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.3390\/ijms21093290","article-title":"The effects of maternal and postnatal dietary methyl nutrients on epigenetic changes that lead to non-communicable diseases in adulthood","volume":"21","author":"Randunu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0954422409990138","article-title":"Intestinal metabolism of sulfur amino acids","volume":"22","author":"Bauchart-Thevret","year":"2009","journal-title":"Nutr. Res. Rev."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib16","first-page":"299","article-title":"Current total parenteral nutrition solutions for the neonate are inadequate","volume":"3","author":"Brunton","year":"2000","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101686_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.jnutbio.2011.06.005","article-title":"Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets","volume":"23","author":"MacKay","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3945\/jn.112.172593","article-title":"Partitioning of [methyl-3H]methionine to methylated products and protein is altered during high methyl demand conditions in young Yucatan miniature pigs","volume":"143","author":"McBreairty","year":"2013","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1139\/apnm-2015-0577","article-title":"The dynamics of methionine supply and demand during early development","volume":"41","author":"McBreairty","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101686_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3945\/an.115.010843","article-title":"The pediatric methionine requirement should incorporate remethylation potential and transmethylation demands","volume":"7","author":"Robinson","year":"2016","journal-title":"Adv. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib21","first-page":"102","article-title":"The nutritional burden of methylation reactions","volume":"16","author":"Bertolo","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib22","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4161\/epi.6.4.14961","article-title":"Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation","volume":"6","author":"Rivi\u00e8re","year":"2011","journal-title":"Epigenetics"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/HYPERTENSIONAHA.113.02303","article-title":"Dynamic CCAAT\/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene","volume":"63","author":"Wang","year":"2014","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101686_bib24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/HYPERTENSIONAHA.107.091603","article-title":"Developmental programming of renal glucocorticoid sensitivity and the renin-angiotensin system","volume":"50","author":"Wyrwoll","year":"2007","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101686_bib25","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1017\/S0007114511006696","article-title":"Early programming of adult blood pressure in the low birth weight Yucatan miniature pig is exacerbated by a post-weaning high-salt-fat-sugar diet","volume":"108","author":"Myrie","year":"2012","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101686_bib26","first-page":"282","article-title":"Effects of a diet high in salt, fat, and sugar on telemetric blood pressure measurements in conscious, unrestrained adult Yucatan miniature swine (Sus scrofa)","volume":"62","author":"Myrie","year":"2012","journal-title":"Comp. Med."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3945\/jn.111.154534","article-title":"Proline supplementation to parenteral nutrition results in greater rates of protein synthesis in the muscle, skin, and small intestine in neonatal Yucatan miniature piglets","volume":"142","author":"Brunton","year":"2012","journal-title":"J. Nutr."},{"issue":"13","key":"10.1016\/j.tjnut.2026.101686_bib28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.6026\/97320630008613","article-title":"Prevalence of metabolic syndrome and gender differences","volume":"8","author":"Beigh","year":"2012","journal-title":"Bioinformation"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1139\/h11-142","article-title":"Glucose tolerance is affected by visceral adiposity and sex, but not birth weight, in Yucatan miniature pigs","volume":"37","author":"McKnight","year":"2012","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib30","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2527\/jas1978.4661634x","article-title":"Effect of pre-natal runting on the post-natal development of skeletal muscles in swine and rats","volume":"46","author":"Hegarty","year":"1978","journal-title":"J. Anim. Sci."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0148607111417447","article-title":"Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome","volume":"36","author":"Dodge","year":"2012","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.tjnut.2026.101686_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jnutbio.2018.06.001","article-title":"Betaine or folate can equally furnish remethylation to methionine and increase transmethylation in methionine-restricted neonates","volume":"59","author":"Robinson","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101686_bib33","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/jn\/133.5.1390","article-title":"The methionine requirement is lower in neonatal piglets fed parenterally than in those fed enterally","volume":"133","author":"Shoveller","year":"2003","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101686_bib34","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3945\/jn.109.105411","article-title":"Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance","volume":"139","author":"Brosnan","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2026.101686_bib35","series-title":"Nutrient Requirements of Swine","year":"2012"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-4347(00)85133-6","article-title":"Rapid analysis of amino acids using pre-column derivatization","volume":"336","author":"Bidlingmeyer","year":"1984","journal-title":"J. Chromatogr."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101686_bib37","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.tjnut.2025.05.031","article-title":"Intrauterine growth-restricted female Yucatan miniature pig neonates fed parenteral nutrition exhibit early catch-up growth leading to obesity and ectopic fat deposition in adulthood","volume":"155","author":"Randunu","year":"2025","journal-title":"J. Nutr."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101686_bib38","first-page":"549","article-title":"High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum","volume":"29","author":"Vester","year":"1991","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101686_bib39","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.tjnut.2024.03.017","article-title":"Dietary methionine enhances portal appearance of guanidinoacetate and synthesis of creatine in Yucatan miniature piglets","volume":"154","author":"Asiriwardhana","year":"2024","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101686_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/1753944715578615","article-title":"Expression of genes of the cardiac and renal renin-angiotensin systems in preterm piglets: is this system a suitable target for therapeutic intervention?","volume":"9","author":"Kim","year":"2015","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.tjnut.2026.101686_bib42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2199-8-67","article-title":"Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR","volume":"8","author":"Nygard","year":"2007","journal-title":"BMC Mol. Biol."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gene.2014.12.052","article-title":"Selection of appropriate reference genes for RT-qPCR analysis in Berkshire, Duroc, Landrace, and Yorkshire pigs","volume":"558","author":"Park","year":"2015","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101686_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101686_bib45","first-page":"358","article-title":"Controversies in the mechanism of total parenteral nutrition induced pathology","volume":"2","author":"Kumar","year":"2015","journal-title":"Children (Basel)."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101686_bib46","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1097\/HJH.0b013e328330e84d","article-title":"Genetic influences on daytime and night-time blood pressure: similarities and differences","volume":"27","author":"Wang","year":"2009","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101686_bib47","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jch.13190","article-title":"Association of betaine with blood pressure in dialysis patients","volume":"20","author":"Wang","year":"2018","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib48","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3390\/molecules23061274","article-title":"Betaine attenuates monocrotaline-induced pulmonary arterial hypertension in rats via inhibiting inflammatory response","volume":"23","author":"Yang","year":"2018","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101686_bib49","first-page":"342","article-title":"Increased systolic blood pressure in rat offspring following a maternal low-protein diet is normalized by maternal dietary choline supplementation, J. Dev. Orig","volume":"3","author":"Bai","year":"2012","journal-title":"Health Dis"},{"issue":"10","key":"10.1016\/j.tjnut.2026.101686_bib50","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/nu10101407","article-title":"Maternal melatonin therapy attenuates methyl-donor diet-induced programmed hypertension in male adult rat offspring","volume":"10","author":"Tain","year":"2018","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101686_bib51","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/HYPERTENSIONAHA.118.11171","article-title":"Epigenetic mechanisms and hypertension","volume":"72","author":"Liang","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101686_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5049\/EBP.2015.13.1.7","article-title":"Salt sensitivity and hypertension: a paradigm shift from kidney malfunction to vascular endothelial dysfunction","volume":"13","author":"Choi","year":"2015","journal-title":"Electrolyte Blood Press"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:37:01Z","timestamp":1788518221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626003354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0022316626003354"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101686","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supplementation of Betaine and Creatine to Neonatal Parenteral Nutrition Lowers Telemetric Blood Pressure in Adult Yucatan Miniature Pigs","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101686"}}