{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:18:36Z","timestamp":1788520716054,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tjnut.2026.101740","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:15:29Z","timestamp":1784387729000},"page":"101740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Therapeutic Potential of Serine for Dementia"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-1269","authenticated-orcid":false,"given":"Shuang-Qing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.tjnut.2026.101740_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s11011-023-01212-8","article-title":"Do selenium-enriched foods provide cognitive benefit?","volume":"38","author":"Bai","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.tjnut.2026.101740_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnu.2025.106559","article-title":"Blood omega-3 is inversely related to risk of early-onset dementia","volume":"57","author":"Sala-Vila","year":"2026","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101740_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101740_bib4","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s11011-024-01418-4","article-title":"Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology","volume":"39","author":"Li","year":"2024","journal-title":"Metab. Brain. Dis."},{"key":"10.1016\/j.tjnut.2026.101740_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuropharm.2018.11.025","article-title":"Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice","volume":"146","author":"Wang","year":"2019","journal-title":"Neuropharmacology"},{"issue":"1\u20133","key":"10.1016\/j.tjnut.2026.101740_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.schres.2010.05.012","article-title":"High dose D-serine in the treatment of schizophrenia","volume":"121","author":"Kantrowitz","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.tjnut.2026.101740_bib7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12974-026-03789-0","article-title":"D-serine ameliorates cognitive deficits by preserving neuronal and synaptic function in experimental anti-NMDAR encephalitis","volume":"23","author":"Yao","year":"2026","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.tjnut.2026.101740_bib8","unstructured":"WebMD. Serine - uses, side effects, and more [Internet]. [cited 2026 Jun 26]. Available from: https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1615\/serine."},{"key":"10.1016\/j.tjnut.2026.101740_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-nutr-061021-022648","article-title":"Sources and sinks of serine in nutrition, health, and disease","volume":"43","author":"Handzlik","year":"2023","journal-title":"Annu. Rev. Nutr."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101740_bib10","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/nu14091987","article-title":"Serine metabolism in health and disease and as a conditionally essential amino acid","volume":"14","author":"Hole\u010dek","year":"2022","journal-title":"Nutrients"},{"issue":"24","key":"10.1016\/j.tjnut.2026.101740_bib11","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1007\/s00018-020-03574-z","article-title":"L-serine synthesis via the phosphorylated pathway in humans","volume":"77","author":"Murtas","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"38","key":"10.1016\/j.tjnut.2026.101740_bib12","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1073\/pnas.1722677115","article-title":"ASCT1 (Slc1a4) transporter is a physiologic regulator of brain D-serine and neurodevelopment","volume":"115","author":"Kaplan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101740_bib13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s42255-019-0108-x","article-title":"Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation","volume":"1","author":"Diehl","year":"2019","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101740_bib14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2020.02.017","article-title":"Serine catabolism feeds NADH when respiration is impaired","volume":"31","author":"Yang","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101740_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41467-022-28272-1","article-title":"Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis","volume":"13","author":"Lionaki","year":"2022","journal-title":"Nat. Commun."},{"issue":"7946","key":"10.1016\/j.tjnut.2026.101740_bib16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-022-05637-6","article-title":"Insulin-regulated serine and lipid metabolism drive peripheral neuropathy","volume":"614","author":"Handzlik","year":"2023","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101740_bib17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2020.02.004","article-title":"Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer's disease","volume":"31","author":"Le Douce","year":"2020","journal-title":"Cell Metab."},{"issue":"586","key":"10.1016\/j.tjnut.2026.101740_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw0936","article-title":"L-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy","volume":"12","author":"Soto","year":"2019","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101740_bib19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2012.06.029","article-title":"Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists","volume":"150","author":"Papouin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tjnut.2026.101740_bib20","doi-asserted-by":"crossref","DOI":"10.1177\/1744806919843046","article-title":"Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy","volume":"15","author":"Choi","year":"2019","journal-title":"Mol. Pain"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101740_bib21","doi-asserted-by":"crossref","first-page":"8255","DOI":"10.1038\/s41467-023-43930-8","article-title":"D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101740_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.52","article-title":"D-serine levels in Alzheimer's disease: implications for novel biomarker development","volume":"5","author":"Madeira","year":"2015","journal-title":"Transl. Psychiatry."},{"issue":"1\u20133","key":"10.1016\/j.tjnut.2026.101740_bib23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2012.09.014","article-title":"Plasma levels of D-serine in Brazilian individuals with schizophrenia","volume":"142","author":"Calcia","year":"2012","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101740_bib24","first-page":"76","article-title":"D-serine and NMDA receptor 1 expression in patients with intractable epilepsy","volume":"31","author":"Zhang","year":"2021","journal-title":"Turk. Neurosurg."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101740_bib25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S1461145711001015","article-title":"D-serine adjuvant treatment alleviates behavioural and motor symptoms in Parkinson's disease","volume":"15","author":"Gelfin","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.tjnut.2026.101740_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104511","article-title":"Neurotoxic astrocytes express the D-serine synthesizing enzyme, serine racemase, in Alzheimer's disease","volume":"130","author":"Balu","year":"2019","journal-title":"Neurobiol. Dis."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626003895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:42:11Z","timestamp":1788518531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626003895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0022316626003895"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101740","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Therapeutic Potential of Serine for Dementia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101740","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101740"}}