{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:24:48Z","timestamp":1793877888879,"version":"4.7.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB17195012"],"award-info":[{"award-number":["AB17195012"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860587"],"award-info":[{"award-number":["81860587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460517"],"award-info":[{"award-number":["81460517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tjnut.2026.101793","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:56:02Z","timestamp":1787064962000},"page":"101793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Maternal Serum Isoflavones in Early Pregnancy Are Associated with Increased Fetal Growth in the Second Trimester: From a Prospective Cohort in Guangxi, China"],"prefix":"10.1016","volume":"156","author":[{"given":"Lei","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-2597","authenticated-orcid":false,"given":"Xiaoyun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tjnut.2026.101793_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/nu15020317","article-title":"Phytoestrogens and health effects","volume":"15","author":"Canivenc-Lavier","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.tjnut.2026.101793_bib2","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/jns.2022.15","article-title":"The role of soy and soy isoflavones on women's fertility and related outcomes: an update","volume":"11","author":"Rizzo","year":"2022","journal-title":"J. Nutr. Sci."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101793_bib3","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.3390\/nu13082715","article-title":"Soy isoflavones intake and obesity in Chinese adults: a cross-sectional study in Shanghai, China","volume":"13","author":"Zhu","year":"2021","journal-title":"Nutrients."},{"key":"10.1016\/j.tjnut.2026.101793_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115752","article-title":"Associations of maternal soy product consumption and urinary isoflavone concentrations with neonatal anthropometry: a prospective cohort study","volume":"274","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tjnut.2026.101793_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115498","article-title":"Prenatal genistein exposure in rats affects pubertal onset and serum reproductive hormone levels in male offspring via the hypothalamic-pituitary-gonadal axis","volume":"202","author":"Zi","year":"2025","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101793_bib6","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1271\/bbb.60278","article-title":"Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring mice","volume":"70","author":"Takashima-Sasaki","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101793_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.femsle.2005.01.023","article-title":"Removal of estrogenic activity of endocrine-disrupting genistein by ligninolytic enzymes from white rot fungi","volume":"244","author":"Tamagawa","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"issue":"21","key":"10.1016\/j.tjnut.2026.101793_bib8","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.3390\/nu15214657","article-title":"The role of endocrine-disrupting chemicals in gestation and pregnancy outcomes","volume":"15","author":"Puche-Juarez","year":"2023","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.tjnut.2026.101793_bib9","first-page":"769","article-title":"Maternal genistein intake can reduce body weight in male offspring","volume":"28","author":"Zhang","year":"2015","journal-title":"Biomed. Environ. Sci."},{"issue":"24","key":"10.1016\/j.tjnut.2026.101793_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800921","article-title":"Dietary daidzein supplementation during pregnancy facilitates fetal growth in rats","volume":"62","author":"Zhang","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101793_bib11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3390\/nu10060766","article-title":"Effects of dietary daidzein supplementation on reproductive performance, serum hormones, and reproductive-related genes in rats","volume":"10","author":"Zhang","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101793_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.meatsci.2006.06.028","article-title":"Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny","volume":"75","author":"Rehfeld","year":"2007","journal-title":"Meat Sci"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101793_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/uog.20272","article-title":"ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth","volume":"53","author":"Salomon","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.tjnut.2026.101793_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126422","article-title":"Association of prenatal exposure to bisphenols and birth size in Zhuang ethnic newborns","volume":"252","author":"Liang","year":"2020","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101793_bib15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12884-021-03757-x","article-title":"Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang Birth Cohort in China","volume":"21","author":"Wei","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101793_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2014a prospective study","volume":"151","author":"Hadlock","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9946","key":"10.1016\/j.tjnut.2026.101793_bib17","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(14)61490-2","article-title":"International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project","volume":"384","author":"Papageorghiou","year":"2014","journal-title":"Lancet"},{"issue":"58","key":"10.1016\/j.tjnut.2026.101793_bib18","doi-asserted-by":"crossref","first-page":"122038","DOI":"10.1007\/s11356-023-30761-9","article-title":"Associations between maternal serum phytoestrogens and liver function markers: a cross-sectional study from China","volume":"30","author":"Wang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.tjnut.2026.101793_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.envres.2018.12.018","article-title":"Urinary biomarker of late pregnancy exposure to drinking water disinfection byproducts and ultrasound measures of fetal growth in Wuhan, China","volume":"170","author":"Deng","year":"2019","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101793_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"issue":"16","key":"10.1016\/j.tjnut.2026.101793_bib21","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101793_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/nutrit\/nuaa043","article-title":"Dietary phytoestrogens and biomarkers of their intake in relation to cancer survival and recurrence: a comprehensive systematic review with meta-analysis","volume":"79","author":"Micek","year":"2021","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.tjnut.2026.101793_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.envres.2017.02.030","article-title":"Exposure to phytoestrogens in utero and age at menarche in a contemporary British cohort","volume":"155","author":"Marks","year":"2017","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101793_bib24","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/jpn.13667","article-title":"Soy isoflavones supplementation improves reproductive performance and serum antioxidant status of sows and the growth performance of their offspring","volume":"106","author":"Li","year":"2022","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"issue":"8","key":"10.1016\/j.tjnut.2026.101793_bib25","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.3390\/nu12082456","article-title":"Effects of dietary phytoestrogens on hormones throughout a human lifespan: a review","volume":"12","author":"Dom\u00ednguez-L\u00f3pez","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101793_bib26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/09603123.2019.1663497","article-title":"Urinary isoflavones levels in relation to serum thyroid hormone concentrations in female and male adults in the United States general population","volume":"31","author":"Janulewicz","year":"2021","journal-title":"Int. J. Environ. Health Res."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101793_bib27","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/cne.24978","article-title":"Estrogen receptor alpha, g-protein coupled estrogen receptor 1, and aromatase: developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell","volume":"529","author":"Krentzel","year":"2021","journal-title":"J. Comp. Neurol."},{"issue":"23","key":"10.1016\/j.tjnut.2026.101793_bib28","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.3390\/nu15234856","article-title":"The use of soy isoflavones in the treatment of prostate cancer: a focus on the cellular effects","volume":"15","author":"Van der Eecken","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.tjnut.2026.101793_bib29","article-title":"Isoflavones alter male and female fertility in different development windows","volume":"140","author":"Sleeman","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101793_bib30","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.3390\/ijms21072592","article-title":"Influence of estrogens on uterine vascular adaptation in normal and preeclamptic pregnancies","volume":"21","author":"Mandal\u00e0","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101793_bib31","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.3390\/ijms21124349","article-title":"Estrogen receptors and estrogen-induced uterine vasodilation in pregnancy","volume":"21","author":"Bai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101793_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1071\/RD05105","article-title":"Leptin modulates nitric oxide production and lipid metabolism in human placenta","volume":"18","author":"White","year":"2006","journal-title":"Reprod. Fertil. Dev."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101793_bib33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1071\/RD03095","article-title":"Modulatory effect of leptin on nitric oxide production and lipid metabolism in term placental tissues from control and streptozotocin-induced diabetic rats","volume":"16","author":"White","year":"2004","journal-title":"Reprod. Fertil. Dev."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101793_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11306-022-01944-1","article-title":"Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism","volume":"18","author":"Shrode","year":"2022","journal-title":"Metabolomics"},{"issue":"23","key":"10.1016\/j.tjnut.2026.101793_bib35","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.3390\/molecules29235790","article-title":"Protective, anti-inflammatory, and antiaging effects of soy isoflavones on skin cells: an overview of in vitro and in vivo studies","volume":"29","author":"W\u00f3jciak","year":"2024","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101793_bib36","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.2527\/jas.2014-7767","article-title":"Effect of dietary supplementation with glycitein during late pregnancy and lactation on antioxidative indices and performance of primiparous sows","volume":"93","author":"Hu","year":"2015","journal-title":"J. Anim. Sci."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101793_bib37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/aje\/kws591","article-title":"Hypospadias and maternal intake of phytoestrogens","volume":"178","author":"Carmichael","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101793_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/humrep\/deac234","article-title":"Associations between maternal urinary isoflavone concentrations and anogenital distance of offspring throughout infancy: a prospective cohort study","volume":"38","author":"Chen","year":"2023","journal-title":"Hum. Reprod."},{"issue":"31","key":"10.1016\/j.tjnut.2026.101793_bib39","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1080\/10408398.2025.2469770","article-title":"Biomarkers of (poly)phenol intake: a systematic review","volume":"65","author":"Li","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626004426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626004426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:31:51Z","timestamp":1793874711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626004426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022316626004426"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101793","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated Maternal Serum Isoflavones in Early Pregnancy Are Associated with Increased Fetal Growth in the Second Trimester: From a Prospective Cohort in Guangxi, China","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101793"}}