{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:26:23Z","timestamp":1793877983201,"version":"4.7.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1300405"],"award-info":[{"award-number":["2021YFD1300405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330101"],"award-info":[{"award-number":["32330101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023MC085"],"award-info":[{"award-number":["ZR2023MC085"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025MS387"],"award-info":[{"award-number":["ZR2025MS387"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tjnut.2026.101846","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:15:06Z","timestamp":1790205306000},"page":"101846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and Embryonic Vitamin D3 Supplementation Improves Hepatic Lipid Metabolism in Progeny Chicks"],"prefix":"10.1016","volume":"156","author":[{"given":"Bowen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufan","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-137X","authenticated-orcid":false,"given":"Hai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10132","key":"10.1016\/j.tjnut.2026.101846_bib1","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of lifetime health around the time of conception: causes and consequences","volume":"391","author":"Fleming","year":"2018","journal-title":"Lancet."},{"key":"10.1016\/j.tjnut.2026.101846_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105817","article-title":"Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulation","volume":"118","author":"Li","year":"2025","journal-title":"EBioMedicine."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101846_bib3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/ps\/86.5.1043","article-title":"Nutrition of the developing embryo and hatchling","volume":"86","author":"Moran","year":"2007","journal-title":"Poult. Sci."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101846_bib4","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.1016\/j.psj.2020.09.074","article-title":"Chicken embryo development: metabolic and morphological basis for in ovo feeding technology","volume":"99","author":"Givisiez","year":"2020","journal-title":"Poult. Sci."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103313","article-title":"Impact of broiler breeder hens\u2019 age and egg storage on egg quality, embryonic development, and hatching traits of FUNAAB-alpha chickens","volume":"103","author":"Alo","year":"2024","journal-title":"Poult. Sci."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101846_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1631\/jzus.B1700054","article-title":"Age-related changes of yolk precursor formation in the liver of laying hens","volume":"19","author":"Liu","year":"2018","journal-title":"J. Zhejiang Univ. Sci. B."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101846_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/foods10010022","article-title":"Age of laying hens significantly influences the content of nutritionally vital lipophilic compounds in eggs","volume":"10","author":"Ko","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.tjnut.2026.101846_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/164_2019_338","article-title":"Vitamin D and bone","volume":"262","author":"Christakos","year":"2020","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tjnut.2026.101846_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2025.106732","article-title":"A comprehensive perspective on the role of vitamin D signaling in maintaining bone homeostasis: lessons from animal models","volume":"250","author":"Rillaerts","year":"2025","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2011.03482.x","article-title":"Vitamin D3: a helpful immuno-modulator","volume":"134","author":"Di Rosa","year":"2011","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101846_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib12","doi-asserted-by":"crossref","first-page":"33S","DOI":"10.1016\/8756-3282(95)00205-R","article-title":"New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone","volume":"17","author":"Haussler","year":"1995","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101846_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104618","article-title":"Efficacy of dietary supplementation with 1\u03b1-hydroxycholecalciferol on performance, eggshell quality, serum metabolites, jejunal morphology and bone characteristics of laying hens at the late stage of production","volume":"104","author":"Ghaderi Nik","year":"2025","journal-title":"Poult. Sci."},{"issue":"20","key":"10.1016\/j.tjnut.2026.101846_bib15","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.3390\/ani12202824","article-title":"A comparison between vitamin D3 and 25-hydroxyvitamin D3 on laying performance, eggshell quality and ultrastructure, and plasma calcium levels in late period laying hens","volume":"12","author":"Jing","year":"2022","journal-title":"Animals (Basel)"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/ani9020063","article-title":"Avian liver: the forgotten organ","volume":"9","author":"Zaefarian","year":"2019","journal-title":"Animals (Basel)"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101846_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101478","article-title":"Age-related changes in liver metabolism and antioxidant capacity of laying hens","volume":"100","author":"Gu","year":"2021","journal-title":"Poult. Sci."},{"issue":"Pt 7","key":"10.1016\/j.tjnut.2026.101846_bib18","article-title":"Liver proteomics analysis reveals the differentiation of lipid mechanism and antioxidant enzyme activity during chicken embryonic development","volume":"253","author":"Shen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101846_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/asj.12392","article-title":"Role of peroxisome proliferator-activated receptor alpha in the expression of hepatic fatty acid oxidation-related genes in chickens","volume":"87","author":"Honda","year":"2016","journal-title":"Anim. Sci. J."},{"issue":"100","key":"10.1016\/j.tjnut.2026.101846_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biochi.2013.12.020","article-title":"Expression of microsomal triglyceride transfer protein in lipoprotein-synthesizing tissues of the developing chicken embryo","volume":"101","author":"Eresheim","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.tjnut.2026.101846_bib21","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1038\/ncomms8466","article-title":"A metabolic stress-inducible miR-34a-HNF4\u03b1 pathway regulates lipid and lipoprotein metabolism","volume":"6","author":"Xu","year":"2015","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101846_bib22","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1074\/jbc.RA119.011487","article-title":"Vitamin D receptor targets hepatocyte nuclear factor 4\u03b1 and mediates protective effects of vitamin D in nonalcoholic fatty liver disease","volume":"295","author":"Zhang","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101846_bib23","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.3382\/ps\/pez386","article-title":"Effect of high concentrations of dietary vitamin D3 on pullet and laying hen performance, skeleton health, eggshell quality, and yolk vitamin D3 content when fed to W36 laying hens from day of hatch until 68 wk of age","volume":"98","author":"Wen","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.tjnut.2026.101846_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aninu.2023.05.001","article-title":"Effect of restricted feeding on hen performance, egg quality and organ characteristics of individual laying hens","volume":"14","author":"Anene","year":"2023","journal-title":"Anim. Nutr."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101846_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2026.106672","article-title":"In ovo injection of vitamin D3 improves intestinal development of chicks via activating vitamin D receptor","volume":"105","author":"Zhang","year":"2026","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101846_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40104-025-01175-z","article-title":"Caffeic acid and chlorogenic acid mediate the ADPN-AMPK-PPAR\u03b1 pathway to improve fatty liver and production performance in laying hens","volume":"16","author":"Tian","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101846_bib27","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.tjnut.2025.04.018","article-title":"Prevotella-produced succinate alleviates hepatic steatosis by enhancing mitochondrial function in layer-type chickens","volume":"155","author":"Liu","year":"2025","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101846_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.psj.2020.10.009","article-title":"Propionate inhibits fat deposition via affecting feed intake and modulating gut microbiota in broilers","volume":"100","author":"Li","year":"2021","journal-title":"Poult. Sci."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101846_bib29","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1159\/000362976","article-title":"Targeting nuclear receptors with lentivirus-delivered small RNAs in primary human hepatocytes","volume":"33","author":"Thomas","year":"2014","journal-title":"Cell Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/JBMR.041112","article-title":"1,25-dihydroxyvitamin D3 stimulates cyclic vitamin D receptor\/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts","volume":"20","author":"Kim","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101846_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105617","article-title":"In ovo vitamin D3 injection leads to a long-term improvement of bone development in laying chicks","volume":"104","author":"Sun","year":"2025","journal-title":"Poult. Sci."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101846_bib32","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.3390\/nu12113302","article-title":"Vitamin D and metabolic dysfunction-associated fatty liver disease (MAFLD): an update","volume":"12","author":"Barchetta","year":"2020","journal-title":"Nutrients"},{"issue":"20","key":"10.1016\/j.tjnut.2026.101846_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015485","article-title":"The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art","volume":"24","author":"Argano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tjnut.2026.101846_bib34","doi-asserted-by":"crossref","first-page":"110450","DOI":"10.1016\/j.jnutbio.2026.110450","article-title":"Vitamin D attenuates metabolic dysfunction-associated steatotic liver disease (MASLD) and downregulates hepatic gluconeogenesis in obesity","volume":"157","author":"Cordeiro","year":"2026","journal-title":"J Nutr Biochem"},{"issue":"23","key":"10.1016\/j.tjnut.2026.101846_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242317074","article-title":"Vitamin D3 receptors and metabolic enzymes in hen reproductive tissues","volume":"24","author":"Hrabia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101846_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/biom10030493","article-title":"The vitamin D receptor regulates glycerolipid and phospholipid metabolism in human hepatocytes","volume":"10","author":"Mart\u00ednez-Sena","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.tjnut.2026.101846_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1164512","article-title":"Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c\/PPAR\u03b1-NF-\u03baB\/IR-S2 signaling pathway","volume":"14","author":"Reda","year":"2023","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3177\/jnsv.64.106","article-title":"Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice","volume":"64","author":"Borges","year":"2018","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101846_bib38","first-page":"3647","article-title":"Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells","volume":"29","author":"Sertznig","year":"2009","journal-title":"Anticancer Res"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101846_bib39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR\u03b1","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101846_bib40","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.2337\/db21-0181","article-title":"Hepatocytic activating transcription factor 3 protects against steatohepatitis via hepatocyte nuclear factor 4\u03b1","volume":"70","author":"Xu","year":"2021","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101846_bib41","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/ATVBAHA.110.217828","article-title":"Hepatic hepatocyte nuclear factor 4\u03b1 is essential for maintaining triglyceride and cholesterol homeostasis","volume":"31","author":"Yin","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tjnut.2026.101846_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.omtn.2019.10.044","article-title":"Liver activation of hepatocellular nuclear Factor-4\u03b1 by small activating RNA rescues dyslipidemia and improves metabolic profile","volume":"19","author":"Huang","year":"2020","journal-title":"Mol. Ther. Nucleic. Acids."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101846_bib43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41419-021-03862-x","article-title":"Liver fat storage is controlled by HNF4\u03b1 through induction of lipophagy and is reversed by a potent HNF4\u03b1 agonist","volume":"12","author":"Lee","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626004955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626004955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:35:15Z","timestamp":1793874915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626004955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022316626004955"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101846","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal and Embryonic Vitamin D3 Supplementation Improves Hepatic Lipid Metabolism in Progeny Chicks","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101846","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101846"}}