{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:34:17Z","timestamp":1793885657871,"version":"4.8.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,11,5]],"date-time":"2027-11-05T00:00:00Z","timestamp":1825372800000},"content-version":"am","delay-in-days":339,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM140953"],"award-info":[{"award-number":["T32 GM140953"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007069","name":"Oklahoma State Regents for Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tjnut.2026.101890","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:19:57Z","timestamp":1791933597000},"page":"101890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Heme Iron Intake and Common Hemochromatosis Homeostatic Iron Regulator (HFE) Polymorphisms Have Similar Associations with Brain Magnetic Resonance Imaging Phenotypes: A UK Biobank Cohort Study"],"prefix":"10.1016","volume":"156","author":[{"given":"Cameron J","family":"Cardona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riju","family":"Sigdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker R","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKale R","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam R","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-9925","authenticated-orcid":false,"given":"Winyoo","family":"Chowanadisai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib1","first-page":"2937","article-title":"The expanding burden of neurodegenerative diseases: an unmet medical and social need","volume":"16","author":"Wang","year":"2025","journal-title":"Aging Dis."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101890_bib3","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1093\/brain\/awaf398","article-title":"Iron on trial: recasting the role of iron in neurodegeneration","volume":"148","author":"Ayton","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.tjnut.2026.101890_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.16","article-title":"Haemochromatosis","volume":"4","author":"Brissot","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101890_bib5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrneurol.2015.100","article-title":"Is early-life iron exposure critical in neurodegeneration?","volume":"11","author":"Hare","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101890_bib6","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3233\/JAD-201080","article-title":"Hemochromatosis mutations, brain iron imaging, and dementia in the UK Biobank cohort","volume":"79","author":"Atkins","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"21","key":"10.1016\/j.tjnut.2026.101890_bib7","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.3390\/nu14214671","article-title":"A prospective study on the relationship between iron supplement intake, hemoglobin concentration, and risk of parkinsonism","volume":"14","author":"Takeuchi","year":"2022","journal-title":"Nutrients"},{"issue":"23","key":"10.1016\/j.tjnut.2026.101890_bib8","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMra2119758","article-title":"Hemochromatosis","volume":"387","author":"Olynyk","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101890_bib9","first-page":"200","article-title":"Frequencies of HFE gene mutations associated with haemochromatosis in the population of Libya living in Benghazi","volume":"4","author":"Elmrghni","year":"2011","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.tjnut.2026.101890_bib10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.nicl.2017.11.003","article-title":"Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals","volume":"17","author":"Hagemeier","year":"2018","journal-title":"Neuroimage Clin"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101890_bib11","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1161\/STROKEAHA.118.022701","article-title":"Iron status and risk of stroke: a Mendelian randomization study","volume":"49","author":"Gill","year":"2018","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.hoc.2014.04.006","volume":"28","author":"Bardou-Jacquet","year":"2014","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib13","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jhep.2012.06.015","article-title":"The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation","volume":"57","author":"D'Alessio","year":"2012","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.tjnut.2026.101890_bib14","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1161\/STROKEAHA.112.663286","article-title":"Red meat consumption and risk of stroke: a meta-analysis of prospective studies","volume":"43","author":"Kaluza","year":"2012","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.tjnut.2026.101890_bib15","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000210286","article-title":"Long-term intake of red meat in relation to dementia risk and cognitive function in US adults","volume":"104","author":"Li","year":"2025","journal-title":"Neurology"},{"issue":"7726","key":"10.1016\/j.tjnut.2026.101890_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-018-0571-7","article-title":"Genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"562","author":"Elliott","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","article-title":"An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"24","author":"Smith","year":"2021","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101890_bib18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41593-022-01074-w","article-title":"Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging","volume":"25","author":"Wang","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101890_bib19","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cgh.2024.10.041","article-title":"Diagnosis and treatment of hemochromatosis","volume":"23","author":"Adams","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101890_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.14309\/ajg.0000000000000315","article-title":"ACG clinical guideline: hereditary hemochromatosis","volume":"114","author":"Kowdley","year":"2019","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101890_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLOS Med"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41588-024-01708-8","article-title":"Guidance on use of race, ethnicity, and geographic origin as proxies for genetic ancestry groups in biomedical publications","volume":"56","author":"Feero","year":"2024","journal-title":"Nat. Genet."},{"issue":"19","key":"10.1016\/j.tjnut.2026.101890_bib23","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.3390\/nu17193031","article-title":"Metal transporter gene SLC39A8 polymorphism rs13107325 and dietary manganese intake are associated with measures of cardiovascular disease risk in a UK Biobank population cohort","volume":"17","author":"Sigdel","year":"2025","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101890_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjnut.2026.101627","article-title":"Associations between dietary micronutrient intake and serum urate concentrations are dependent on SLC2A9 polymorphism rs12498742: a United Kingdom Biobank cohort study","volume":"156","author":"Johnson","year":"2026","journal-title":"J. Nutr."},{"key":"10.1016\/j.tjnut.2026.101890_bib25","series-title":"Nutritional Epidemiology [Internet]","author":"Willett","year":"2012"},{"issue":"7726","key":"10.1016\/j.tjnut.2026.101890_bib26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101890_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"issue":"15","key":"10.1016\/j.tjnut.2026.101890_bib28","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101890_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101890_bib30","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1007\/s00394-021-02558-4","article-title":"Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank","volume":"60","author":"Perez-Cornago","year":"2021","journal-title":"Eur. J. Nutr."},{"issue":"8","key":"10.1016\/j.tjnut.2026.101890_bib31","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00394-024-03460-5","article-title":"Micronutrient intake and telomere length: findings from the UK Biobank","volume":"63","author":"Spinou","year":"2024","journal-title":"Eur. J. Nutr."},{"issue":"4 Suppl","key":"10.1016\/j.tjnut.2026.101890_bib32","doi-asserted-by":"crossref","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies","volume":"65","author":"Willett","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2026.101890_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neuroimage.2017.10.034","article-title":"Image processing and quality control for the first 10,000 brain imaging datasets from UK Biobank","volume":"166","author":"Alfaro-Almagro","year":"2018","journal-title":"NeuroImage"},{"issue":"11","key":"10.1016\/j.tjnut.2026.101890_bib34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/nn.4393","article-title":"Multimodal population brain imaging in the UK Biobank prospective epidemiological study","volume":"19","author":"Miller","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tjnut.2026.101890_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117002","article-title":"Confound modelling in UK Biobank brain imaging","volume":"224","author":"Alfaro-Almagro","year":"2021","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101890_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/13872877251375432","article-title":"Predictors of MRI-estimated brain iron deposition in dementia and Parkinson's disease-associated subcortical regions: genetic and observational analysis in UK Biobank","volume":"108","author":"Casanova","year":"2025","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.tjnut.2026.101890_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230129","article-title":"Implementation of clinically relevant and robust fMRI-based language lateralization: choosing the laterality index calculation method","volume":"15","author":"Brumer","year":"2020","journal-title":"PLOS One"},{"issue":"2","key":"10.1016\/j.tjnut.2026.101890_bib38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/ajcn\/nqz072","article-title":"Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank","volume":"110","author":"Tong","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.tjnut.2026.101890_bib39","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.mri.2015.02.016","article-title":"Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results","volume":"33","author":"Wood","year":"2015","journal-title":"Magn. Reson. Imaging."},{"issue":"12","key":"10.1016\/j.tjnut.2026.101890_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209340","article-title":"Measurement of liver iron by magnetic resonance imaging in the UK Biobank population","volume":"13","author":"McKay","year":"2018","journal-title":"PLOS One"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101890_bib41","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-058999","article-title":"LiverMultiScan as an alternative to liver biopsy to monitor autoimmune hepatitis in the National Health Service in England: an economic evaluation","volume":"12","author":"Bajre","year":"2022","journal-title":"BMJ Open"},{"issue":"9","key":"10.1016\/j.tjnut.2026.101890_bib42","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1002\/alz.13088","article-title":"Associations of blood cell indices and anemia with risk of incident dementia: a prospective cohort study of 313,448 participants","volume":"19","author":"Qiang","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib43","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s11604-016-0532-8","article-title":"Contribution of metals to brain MR signal intensity: review articles","volume":"34","author":"Kanda","year":"2016","journal-title":"Jpn. J. Radiol."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101890_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70108-9","article-title":"The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation","volume":"10","author":"Mealer","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib45","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1148\/rg.210054","article-title":"Quantitative susceptibility mapping: basic methods and clinical applications","volume":"42","author":"Harada","year":"2022","journal-title":"Radiographics"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib46","doi-asserted-by":"crossref","first-page":"1461S","DOI":"10.3945\/ajcn.2010.28674F","article-title":"Iron bioavailability and dietary reference values","volume":"91","author":"Hurrell","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tjnut.2026.101890_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fphys.2015.00187","article-title":"Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders","volume":"6","author":"Smith","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tjnut.2026.101890_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-nutr-062320-112625","article-title":"Molecular mechanisms of iron and heme metabolism","volume":"42","author":"Dutt","year":"2022","journal-title":"Annu. Rev. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib49","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202207","article-title":"Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A","volume":"218","author":"Nikolakopoulou","year":"2021","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101890_bib50","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1093\/jn\/136.11.2808","article-title":"Meat protein fractions enhance nonheme iron absorption in humans","volume":"136","author":"Hurrell","year":"2006","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib51","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jnc.12244","article-title":"Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells","volume":"126","author":"Urrutia","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tjnut.2026.101890_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73456","article-title":"Aging is associated with increased brain iron through cortex-derived hepcidin expression","volume":"11","author":"Sato","year":"2022","journal-title":"eLife"},{"issue":"7","key":"10.1016\/j.tjnut.2026.101890_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004039","article-title":"Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: observational and Mendelian randomization analyses","volume":"19","author":"Topiwala","year":"2022","journal-title":"PLOS Med"},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib54","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1073\/pnas.95.5.2492","article-title":"HFE gene knockout produces mouse model of hereditary hemochromatosis","volume":"95","author":"Zhou","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"Pt 4","key":"10.1016\/j.tjnut.2026.101890_bib55","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.tjnut.2026.101890_bib56","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/brain\/awx137","article-title":"Cerebral quantitative susceptibility mapping predicts amyloid-\u03b2-related cognitive decline","volume":"140","author":"Ayton","year":"2017","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.tjnut.2026.101890_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjnut.2026.101559","article-title":"Improved iron status, but not protein source, is related to appetite, satiety, and mood in women of reproductive age with iron deficiency: a randomized controlled trial","volume":"156","author":"Hennigar","year":"2026","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.tjnut.2026.101890_bib58","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/17474086.2016.1245136","article-title":"Pica as a manifestation of iron deficiency","volume":"9","author":"Borgna-Pignatti","year":"2016","journal-title":"Expert Rev. Hematol."},{"issue":"9","key":"10.1016\/j.tjnut.2026.101890_bib59","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population","volume":"186","author":"Fry","year":"2017","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.tjnut.2026.101890_bib60","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/ajcn\/nqab223","article-title":"A guide for authors and readers of the American Society for Nutrition Journals on the proper use of P values and strategies that promote transparency and improve research reproducibility","volume":"114","author":"Sorkin","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.tjnut.2026.101890_bib61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13059-025-03734-z","article-title":"Beware of counter-intuitive levels of false discoveries in datasets with strong intra-correlations","volume":"26","author":"Kanduri","year":"2025","journal-title":"Genome Biol"},{"issue":"12","key":"10.1016\/j.tjnut.2026.101890_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110930","article-title":"A homology-based 3D model and structure-function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function","volume":"301","author":"Baumann","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.tjnut.2026.101890_bib63","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1096\/fj.14-262592","article-title":"Ferroportin deficiency impairs manganese metabolism in flatiron mice","volume":"29","author":"Seo","year":"2015","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.tjnut.2026.101890_bib64","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41467-024-54705-0","article-title":"Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1","volume":"16","author":"Liziczai","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.tjnut.2026.101890_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064944","article-title":"Absorption of manganese and iron in a mouse model of hemochromatosis","volume":"8","author":"Kim","year":"2013","journal-title":"PLOS One"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626005390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316626005390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:10:33Z","timestamp":1793884233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316626005390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0022316626005390"],"URL":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101890","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Heme Iron Intake and Common Hemochromatosis Homeostatic Iron Regulator (HFE) Polymorphisms Have Similar Associations with Brain Magnetic Resonance Imaging Phenotypes: A UK Biobank Cohort Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjnut.2026.101890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101890"}}