{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:10Z","timestamp":1788870310185,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":1218,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-99-2628-B-195-001-MY3"],"award-info":[{"award-number":["NSC-99-2628-B-195-001-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"crossref","award":["MMH-E-100-04"],"award-info":[{"award-number":["MMH-E-100-04"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.tjog.2012.07.017","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T12:22:01Z","timestamp":1349439721000},"page":"411-417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from ring chromosome 2"],"prefix":"10.1016","volume":"51","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peih-Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Ping","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jay","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hwa-Ruey Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hwa-Jiun Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2012.07.017_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000079572","article-title":"Small supernumerary marker chromosomes (sSMC) in humans","volume":"107","author":"Liehr","year":"2004","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.tjog.2012.07.017_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000087510","article-title":"Small supernumerary marker chromosomes \u2013 progress towards a genotype-phenotype correlation","volume":"112","author":"Liehr","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.tjog.2012.07.017_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-59745-066-9_2","article-title":"Characterization of prenatally assessed de novo small supernumerary marker chromosomes by molecular cytogenetics","volume":"444","author":"Liehr","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.tjog.2012.07.017_bib4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1028-4559(10)60039-3","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from chromosome 18 and associated with a reciprocal translocation involving chromosomes 17 and 18","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1028-4559(10)60080-0","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from chromosome 21","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1028-4559(10)60081-2","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from chromosome 22","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1028-4559(10)60104-0","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome derived from chromosome 8","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tjog.2011.04.002","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 4","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1586\/erm.09.17","article-title":"Handling small supernumerary marker chromosomes in prenatal diagnostics","volume":"9","author":"Liehr","year":"2009","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.tjog.2012.07.017_bib10","first-page":"44","article-title":"Mutation rates of structural chromosome rearrangements in man","volume":"33","author":"Jacobs","year":"1981","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib11","first-page":"719","article-title":"Frequency of small supernumerary marker chromosomes in prenatal, newborn, developmentally retarded and infertility diagnostics","volume":"19","author":"Liehr","year":"2007","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.tjog.2012.07.017_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1096-8628(19980401)76:4<351::AID-AJMG12>3.0.CO;2-N","article-title":"Delineation of supernumerary marker chromosomes in 38 patients","volume":"76","author":"Viersbach","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib13","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1002\/ajmg.a.32532","article-title":"Supernumerary marker chromosomes management in prenatal diagnosis","volume":"146A","author":"Gruchy","year":"2008","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1028-4559(10)60071-X","article-title":"Mosaic trisomy 9 at amniocentesis: prenatal diagnosis and molecular genetic analyses","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tjog.2011.07.013","article-title":"Prenatal diagnosis of mosaic trisomy 8: clinical report and literature review","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tjog.2011.07.011","article-title":"Prenatal diagnosis of mosaic trisomy 2: discrepancy between molecular cytogenetic analyses of uncultured amniocytes and karyotyping of cultured amniocytes in a pregnancy with severe fetal intrauterine growth restriction","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tjog.2011.10.031","article-title":"Prenatal diagnosis of mosaic trisomy 9","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tjog.2012.01.015","article-title":"Trisomy 7 mosaicism at amniocentesis: interphase FISH, QF-PCR and aCGH analyses on uncultured amniocytes for rapid distinguishing true mosaicism from pseudomosaicism","volume":"51","author":"Chen","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.07.017_bib19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/jmg.35.4.319","article-title":"Trisomy 2q11.2\u2192q21.1 resulting from an unbalanced insertion in two generations","volume":"35","author":"Glass","year":"1998","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jmg.32.10.825","article-title":"Duplication 2 (q11.2-q21): a previously unreported abnormality","volume":"32","author":"Cooke","year":"1995","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1096-8628(19990212)82:4<312::AID-AJMG7>3.0.CO;2-9","article-title":"Intrachromosomal triplication of 2q11.2-q21 in a severely malformed infant: case report and review of triplications and their possible mechanism","volume":"82","author":"Wang","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/jmg.21.1.57","article-title":"De novo direct tandem duplication of the proximal long arm of chromosome 2: 46, XX, dir dup(2)(q11.2q14.2)","volume":"21","author":"Mu","year":"1984","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1096-8628(19991126)87:3<217::AID-AJMG4>3.0.CO;2-#","article-title":"Characterization of a small supernumerary ring marker derived from chromosome 2 by forward and reverse chromosome painting","volume":"87","author":"Ostroverkhova","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib24","first-page":"148","article-title":"Supernumerary chromosome possibly representing segment p11 yields q14 of chromosome 2","volume":"22","author":"Wang","year":"1979","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"10.1016\/j.tjog.2012.07.017_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ajmg.10534","article-title":"Duplication of (2)(q11.1-q13.2) in a boy with mental retardation and cleft lip and palate: another clefting gene locus on proximal 2q?","volume":"111","author":"Riegel","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/pd.74","article-title":"Identification of a small supernumerary marker chromosome, r(2)(p10q11.2), and the problem of determining prognosis","volume":"21","author":"Villa","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2012.07.017_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ajmg.10537","article-title":"Small familial supernumerary ring chromosome 2: FISH characterization and genotype-phenotype correlation","volume":"111","author":"Giardino","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib28","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1002\/ajmg.a.31883","article-title":"Prenatal diagnosis of a small chromosome 2-derived supernumerary marker, and review of the reported cases","volume":"143A","author":"Giardino","year":"2007","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2012.07.017_bib29","unstructured":"Liehr T. Small supernumerary marker chromosome database. sSMC derived from chromosome 2. Available at http:\/\/www.med.uni-jena.de\/fish\/sSMC\/ 00START.htm [accessed date 11.05.12]."}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455912001313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455912001313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:10:57Z","timestamp":1760897457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455912001313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1028455912001313"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2012.07.017","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from ring chromosome 2","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2012.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}