{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:12:18Z","timestamp":1773238338905,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":1127,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.tjog.2012.09.010","type":"journal-article","created":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T00:48:46Z","timestamp":1356742126000},"page":"554-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of curcumin and demethoxycurcumin on amyloid-\u03b2 precursor and tau proteins through the internal ribosome entry sites: A potential therapeutic for Alzheimer's disease"],"prefix":"10.1016","volume":"51","author":[{"given":"Oliver B.","family":"Villaflores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Ming","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzong-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2012.09.010_bib1","series-title":"World Alzheimer's Report 2011. The benefits of early diagnosis and intervention","author":"Prince","year":"2011"},{"key":"10.1016\/j.tjog.2012.09.010_bib2","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S1028-4559(10)60099-X","article-title":"Alzheimer's disease: aging, insomnia and epigenetics","volume":"49","author":"Wu","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.09.010_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1472-8206.2003.00153.x","article-title":"Alzheimer's disease: the pharmacological pathway","volume":"17","author":"Allain","year":"2003","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.tjog.2012.09.010_bib4","doi-asserted-by":"crossref","first-page":"13721","DOI":"10.1074\/jbc.M312854200","article-title":"Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells","volume":"279","author":"Qin","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3233\/JAD-2009-0978","article-title":"Translation initiation of the human tau mRNA through an internal ribosomal entry site","volume":"16","author":"Veo","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjog.2012.09.010_bib6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0958-1669(99)00010-5","article-title":"Internal ribosome entry site biology and its use in expression vectors","volume":"10","author":"Mart\u00ednez-Salas","year":"1999","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.tjog.2012.09.010_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virusres.2008.07.017","article-title":"An atypical IRES within the 5\u2032 UTR of a dicistrovirus genome","volume":"139","author":"Roberts","year":"2009","journal-title":"Virus Res"},{"key":"10.1016\/j.tjog.2012.09.010_bib8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1271\/bbb.110107","article-title":"Expression of recombinant human interferon-\u03b3 with anti-viral activity in the bi-cistronic baculovirus-insect\/larval system","volume":"75","author":"Chen","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.tjog.2012.09.010_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jviromet.2011.05.015","article-title":"Cell-based analysis of Chikungunya virus membrane fusion using baculovirus-expression vectors","volume":"175","author":"Kuo","year":"2011","journal-title":"J Virol Methods"},{"key":"10.1016\/j.tjog.2012.09.010_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1028-4559(09)60303-X","article-title":"Dual action of memantine in Alzheimer disease: a hypothesis","volume":"48","author":"Wu","year":"2009","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.09.010_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tjog.2011.04.004","article-title":"Traditional Chinese medicines and Alzheimer's disease","volume":"50","author":"Wu","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.09.010_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"McMinn","year":"2002","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.tjog.2012.09.010_bib13","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1073\/pnas.081072798","article-title":"Vitamin B12 and hepatitis C: molecular biology and human pathology","volume":"98","author":"Lott","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tjog.2012.09.010_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jep.2008.08.010","article-title":"Review on plants with CNS-effects used in traditional South African medicine against mental diseases","volume":"119","author":"Stafford","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.tjog.2012.09.010_bib15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0091-3057(03)00128-X","article-title":"Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function","volume":"75","author":"Howes","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.tjog.2012.09.010_bib16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0167-7799(02)02080-2","article-title":"Plants and human health in the twenty-first century","volume":"20","author":"Raskin","year":"2002","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.tjog.2012.09.010_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0049-3848(85)90276-2","article-title":"Anti-thrombotic effect of curcumin","volume":"40","author":"Srivastava","year":"1985","journal-title":"Thromb Res"},{"key":"10.1016\/j.tjog.2012.09.010_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/phrs.1998.0404","article-title":"Curcumin inhibition inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages","volume":"39","author":"Abe","year":"1999","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.tjog.2012.09.010_bib19","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0006-2952(76)90421-4","article-title":"Antioxidant activity of curcumin and related compounds","volume":"25","author":"Sharma","year":"1976","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.tjog.2012.09.010_bib20","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1016\/j.bmc.2004.05.006","article-title":"Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents","volume":"12","author":"Adams","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1524-475X.1998.60211.x","article-title":"Enhancement of wound healing by curcumin in animals","volume":"6","author":"Sidhu","year":"1998","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.tjog.2012.09.010_bib22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.foodchem.2005.06.037","article-title":"Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin","volume":"98","author":"Jayaprakasha","year":"2006","journal-title":"Food Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib23","first-page":"89","article-title":"Potent in\u00a0vitro anti-tumor activity of Symplocos racemosa against leukemia and cervical cancer","volume":"5","author":"Raval","year":"2009","journal-title":"Electron J Biol"},{"key":"10.1016\/j.tjog.2012.09.010_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.tjog.2011.10.004","article-title":"Management of moderate to severe Alzheimer's disease: focus on memantine","volume":"50","author":"Dominguez","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2012.09.010_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1745-7254.2006.00276.x","article-title":"Baculovirus ETL promoter acts as a shuttle promoter between insect cells and mammalian cells","volume":"27","author":"Liu","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.tjog.2012.09.010_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/1087057104265386","article-title":"Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines","volume":"9","author":"Mueller","year":"2004","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.tjog.2012.09.010_bib27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.pbb.2008.09.010","article-title":"Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease","volume":"91","author":"Ahmed","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.tjog.2012.09.010_bib28","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/0006-291X(89)92760-5","article-title":"Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain","volume":"165","author":"Tanaka","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.tjog.2012.09.010_bib29","doi-asserted-by":"crossref","first-page":"28472","DOI":"10.1074\/jbc.M110.133520","article-title":"Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein","volume":"285","author":"Zhang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib30","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1021\/np010039x","article-title":"Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's Disease","volume":"65","author":"Park","year":"2002","journal-title":"J Nat Prod"},{"key":"10.1016\/j.tjog.2012.09.010_bib31","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/S0960-894X(01)00489-9","article-title":"Total synthesis of calebin-A, preparation of its analogues, and their neuronal cell protectivity against \u03b2-amyloid insult","volume":"11","author":"Kim","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.tjog.2012.09.010_bib32","doi-asserted-by":"crossref","first-page":"23645","DOI":"10.1074\/jbc.M703269200","article-title":"Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis","volume":"282","author":"Hanger","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib33","doi-asserted-by":"crossref","first-page":"17047","DOI":"10.1016\/S0021-9258(18)41890-X","article-title":"Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain","volume":"267","author":"Hasegawa","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tjog.2012.09.010_bib34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0171-9335(98)80032-0","article-title":"Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease","volume":"76","author":"Preuss","year":"1998","journal-title":"Eur J Cell Biol"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455912001866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455912001866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:11:36Z","timestamp":1760897496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455912001866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1028455912001866"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2012.09.010","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of curcumin and demethoxycurcumin on amyloid-\u03b2 precursor and tau proteins through the internal ribosome entry sites: A potential therapeutic for Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2012.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}