{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T15:29:40Z","timestamp":1793546980319,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":672,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.tjog.2013.02.002","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T03:02:06Z","timestamp":1398135726000},"page":"30-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Serum cytokeratin-19 fragment (Cyfra 21-1) is a prognostic indicator for epithelial ovarian cancer"],"prefix":"10.1016","volume":"53","author":[{"given":"Hua-Hsi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Yih","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shyen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Ju","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiou-Chung","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2013.02.002_bib1","first-page":"220","article-title":"Cancer treatment and survivorship statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.tjog.2013.02.002_bib2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.tjog.2012.04.035","article-title":"A\u00a0challenge in the management of a patient with ovarian cancer associated with extensive endometriosis","volume":"51","author":"Shih","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jcma.2012.08.023","article-title":"The role of estrogen in the survival of ovarian tumors-A study of the human ovarian adenocarcinoma cell lines OC117-VGH and OVCAR3","volume":"76","author":"Chao","year":"2013","journal-title":"J\u00a0Chin Med Assoc"},{"key":"10.1016\/j.tjog.2013.02.002_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tjog.2012.01.034","article-title":"Ovarian cancer presenting as an acute abdomen was successfully diagnosed and managed by laparoscopy","volume":"51","author":"Horng","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tjog.2012.07.024","article-title":"Primary gallbladder carcinoma presenting as advanced-stage ovarian cancer","volume":"51","author":"Sun","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tjog.2012.04.002","article-title":"Metronomic therapy for gynecologic cancers","volume":"51","author":"Su","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib7","first-page":"13","article-title":"Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature","volume":"2","author":"Gupta","year":"2009","journal-title":"J\u00a0Ovarian Res"},{"key":"10.1016\/j.tjog.2013.02.002_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ygyno.2009.09.019","article-title":"Value of serum CA125 levels in patients with high-risk, early stage epithelial ovarian cancer","volume":"116","author":"Kang","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.tjog.2013.02.002_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tjog.2012.04.008","article-title":"Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH-agonist: long-term follow-up in a series of nine patients","volume":"51","author":"Huang","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tjog.2012.01.001","article-title":"Tuberculosis peritonitis","volume":"51","author":"Sun","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tjog.2012.01.033","article-title":"Ruptured ovarian endometrioma","volume":"51","author":"Fang","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib12","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.fertnstert.2008.07.1744","article-title":"Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma","volume":"92","author":"Wang","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tjog.2013.02.002_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/ijgc-00009577-200509000-00020","article-title":"Cancer-associated serum antigen level: a novel prognostic indicator for survival in patients with recurrent ovarian carcinoma","volume":"15","author":"Gronlund","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.humrep.a136832","article-title":"The CA125 tumor associated antigen: a review of the literature","volume":"4","author":"Jacobs","year":"1989","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2013.02.002_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ygyno.2012.11.023","article-title":"Preoperative HE4 expression in plasma predicts surgical outcome in primary ovarian cancer patients: results from the OVCAD study","volume":"128","author":"Braicu","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.tjog.2013.02.002_bib16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/1097-0142(20000915)89:6<1285::AID-CNCR13>3.0.CO;2-G","article-title":"Serum CYFRA 21-1 I a one of the most reliable tumor marker for breast carcinoma","volume":"89","author":"Nakata","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.bjc.6602074","article-title":"Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumor marker for detecting disease relapse and assessing treatment efficacy in breast cancer","volume":"91","author":"Nakata","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib18","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1038\/sj.bjc.6601026","article-title":"Cytokeratin 19 fragments in serum (CYFRA 21-1) as a marker in primary liver cancer","volume":"88","author":"Uenishi","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib19","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/sj.bjc.6601851","article-title":"CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: results of meta-analysis in 2063 patients","volume":"91","author":"Pujol","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.lungcan.2012.11.006","article-title":"Preoperative serum CYFRA 21-1 level as a prognostic factor in surgically treated adenocarcinoma of lung","volume":"79","author":"Park","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1530\/EJE-12-0660","article-title":"Serum cytokeratin 19 fragments: a dedifferentiation marker in advanced thyroid cancer","volume":"167","author":"Giovanella","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.tjog.2013.02.002_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cca.2012.08.018","article-title":"Diagnostic values of urine CYFRA21-1, NMP22, UBC, and FDP for the detection of bladder cancer","volume":"414","author":"Jeong","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.tjog.2013.02.002_bib23","first-page":"1410","article-title":"Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma","volume":"125","author":"Yan","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.tjog.2013.02.002_bib24","first-page":"1971","article-title":"Cytokeratin serum biomarkers in patients with colorectal cancer","volume":"32","author":"Holdenrieder","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tjog.2013.02.002_bib25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3109\/1354750X.2010.504309","article-title":"Serum CYFRA21-1 as a prognostic marker for patients with undifferentiated nasopharyngeal carcinoma","volume":"15","author":"Zhu","year":"2010","journal-title":"Biomarkers"},{"key":"10.1016\/j.tjog.2013.02.002_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3325\/cmj.2009.50.455","article-title":"Clinical value of serum HMGB1 levels in early detection of recurrent squamous cell carcinoma of uterine cervix: comparison with serum SCCA, CYFRA21-1, and CEA levels","volume":"50","author":"Sheng","year":"2009","journal-title":"Croat Med J"},{"key":"10.1016\/j.tjog.2013.02.002_bib27","first-page":"2743","article-title":"Significance of the tumor markers CA125 II, CA 72.4, ASA and CYFRA 21-1 in ovarian carcinoma","volume":"14","author":"Hasholzner","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tjog.2013.02.002_bib28","first-page":"277","article-title":"The clinical relevance of serum CYFRA 21-1 assay in patients with ovarian cancer","volume":"11","author":"Gadducci","year":"2001","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib29","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1200\/JCO.2008.18.0497","article-title":"Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer","volume":"27","author":"Xenidis","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.tjog.2013.02.002_bib30","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/bjc.1998.636","article-title":"CYFRA 21-1 serum levels in women with adnexal masses and inflammatory diseases","volume":"78","author":"Tempfer","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/bjc.1992.42","article-title":"Production and characterization of a monoclonal antibody (Cx-99) against cervical carcinoma","volume":"65","author":"Yuan","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1082>3.0.CO;2-T","article-title":"The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21-1) in human lung cancer cell lines","volume":"91","author":"Dohmoto","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.tjog.2013.02.002_bib33","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2337\/diabetes.49.10.1671","article-title":"Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in\u00a0vitro: further evidence for pluripotent pancreatic stem cells in humans","volume":"49","author":"Gmyr","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.tjog.2013.02.002_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1101\/gad.952602","article-title":"Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties","volume":"16","author":"Gudjonsson","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.tjog.2013.02.002_bib35","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ajpath.2011.04.040","article-title":"Keratin 19 epithelial patterns in cirrhotic stroma parallel hepatocarcinogenesis","volume":"179","author":"Lennerz","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.tjog.2013.02.002_bib36","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bies.10140","article-title":"Beyond structure: do intermediate filaments modulate cell signaling?","volume":"24","author":"Paraio","year":"2002","journal-title":"BioEssays"},{"key":"10.1016\/j.tjog.2013.02.002_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/172460089400900203","article-title":"Lung cancer-associated keratin 19 fragments: development and biochemical characterization of the new serum assay enzymum-test CYFRA 21-1","volume":"9","author":"Bodenm\u00fcller","year":"1994","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.tjog.2013.02.002_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.tjog.2013.02.002_bib39","first-page":"14","article-title":"Prospective evaluation of serum CA125 levels for early detection of ovarian cancer","volume":"80","author":"Einhorn","year":"1993","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib40","first-page":"798","article-title":"Re-treatment of patients with recurrent epithelial ovarian cancer with cisplatin-based chemotherapy","volume":"73","author":"Gershenson","year":"1989","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.02.002_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1026448027870","article-title":"Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells","volume":"2","author":"Yuan","year":"1997","journal-title":"Apoptosis"},{"key":"10.1016\/j.tjog.2013.02.002_bib42","first-page":"5203","article-title":"The differential expression of cytokeratin 18 in cisplatin-sensitive and -resistant human ovarian adenocarcinoma cells and its association with drug sensitivity","volume":"55","author":"Parekh","year":"1995","journal-title":"Cancer Res"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455914000096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455914000096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:12:07Z","timestamp":1760897527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455914000096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1028455914000096"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2013.02.002","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum cytokeratin-19 fragment (Cyfra 21-1) is a prognostic indicator for epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2013.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}