{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:43Z","timestamp":1788870223500,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":853,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-99-2628-B-195-001-MY3"],"award-info":[{"award-number":["NSC-99-2628-B-195-001-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-101-2314-B-195-011-MY3"],"award-info":[{"award-number":["NSC-101-2314-B-195-011-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mackay Memorial Hospital, Taipei, Taiwan","award":["MMH-E-102-04"],"award-info":[{"award-number":["MMH-E-102-04"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.tjog.2013.06.004","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T03:50:15Z","timestamp":1380081015000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal diagnosis of mosaic trisomy 2 associated with abnormal maternal serum screening, oligohydramnios, intrauterine growth restriction, ventricular septal defect, preaxial polydactyly, and facial dysmorphism"],"prefix":"10.1016","volume":"52","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peih-Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2013.06.004_bib1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tjog.2011.07.011","article-title":"Prenatal diagnosis of mosaic trisomy 2: discrepancy between molecular cytogenetic analyses of uncultured amniocytes and karyotyping of cultured amniocytes in a pregnancy with severe fetal intrauterine growth restriction","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.06.004_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.tjog.2012.09.016","article-title":"Mosaic trisomy 2 at amniocentesis: prenatal diagnosis and molecular genetic analysis","volume":"51","author":"Chen","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.06.004_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.tjog.2013.04.031","article-title":"Application of interphase FISH on uncultured amniocytes for rapid confirmation of true trisomy 2 mosaicism in the case of suspected amniocyte mosaicism involving trisomy 2 in a single colony","volume":"53","author":"Chen","year":"2013","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.06.004_bib4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<511::AID-PD904>3.0.CO;2-8","article-title":"Confined placental mosaicism for trisomies 2, 3, 7, 8, 9, 16, and 22: their incidence, likely origins, and mechanisms for cell lineage compartmentalization","volume":"16","author":"Wolstenholme","year":"1996","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<801::AID-PD153>3.0.CO;2-E","article-title":"Accuracy of cytogenetic findings on chorionic villus sampling (CVS)\u2014diagnostic consequences of CVS mosaicism and non-mosaic discrepancy in centres contributing to EUCROMIC 1986\u20131992","volume":"17","author":"Hahnemann","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/sj.ejhg.5201564","article-title":"Confirmation of mosaicism and uniparental disomy in amniocytes, after detection of mosaic chromosome abnormalities in chorionic villi","volume":"14","author":"Grati","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/pd.2457","article-title":"Outcome of pregnancies with trisomy 2 cells in chorionic villi","volume":"30","author":"Sifakis","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1096-8628(19971031)72:3<343::AID-AJMG18>3.0.CO;2-T","article-title":"True trisomy 2 mosaicism in amniocytes and newborn liver associated with multiple system abnormalities","volume":"72","author":"Sago","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/humrep\/15.4.929","article-title":"Rapid determination of zygosity and common aneuploidies from amniotic fluid cells using quantitative fluorescent polymerase chain reaction following genetic amniocentesis in multiple pregnancies","volume":"15","author":"Chen","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2013.06.004_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.gene.2013.06.081","article-title":"Chromosome 18p deletion syndrome presenting holoprosencephaly and premaxillary agenesis: prenatal diagnosis and aCGH characterization using uncultured amniocytes","volume":"527","author":"Chen","year":"2013","journal-title":"Gene"},{"issue":"Suppl.","key":"10.1016\/j.tjog.2013.06.004_bib11","first-page":"A91","article-title":"True trisomy 2 mosaicism in amniocytes and newborn liver associated with multiple system abnormalities","volume":"57","author":"Golabi","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ajmg.1320580211","article-title":"Maternal uniparental disomy of chromosome 2 in a baby with trisomy 2 mosaicism in amniotic fluid culture","volume":"58","author":"Harrison","year":"1995","journal-title":"Am J Med Genet"},{"issue":"Suppl.","key":"10.1016\/j.tjog.2013.06.004_bib13","first-page":"A286","article-title":"Trisomy 2 mosaicism","volume":"57","author":"Pappas","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1097-0223(199703)17:3<201::AID-PD56>3.0.CO;2-H","article-title":"Rare trisomy mosaicism diagnosed in amniocytes, involving an autosome other than chromosomes 13, 18, 20, and 21: karyotype\/phenotype correlations","volume":"17","author":"Hsu","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1399-0004.1997.tb02502.x","article-title":"A case of mosaic trisomy 2 diagnosed at amniocentesis in an abnormal fetus and confirmed in multiple fetal tissues","volume":"51","author":"Robinson","year":"1997","journal-title":"Clin Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/pd.644","article-title":"A further case of confined placental mosaicism for trisomy 2 associated with adverse pregnancy outcome","volume":"23","author":"Roberts","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/(SICI)1097-0223(199610)16:10<899::AID-PD960>3.0.CO;2-M","article-title":"Analysis of nine pregnancies with confined placental mosaicism for trisomy 2","volume":"16","author":"Shaffer","year":"1996","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/(SICI)1097-0223(199610)16:10<958::AID-PD971>3.0.CO;2-U","article-title":"Maternal uniparental disomy for chromosome 2 in association with confined placental mosaicism for trisomy 2 and severe intrauterine growth retardation","volume":"16","author":"Webb","year":"1996","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<180::AID-PD31>3.0.CO;2-#","article-title":"Trisomy 2: confined placental mosaicism in a fetus with intrauterine growth retardation","volume":"17","author":"Ariel","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/(SICI)1097-0223(199707)17:7<689::AID-PD138>3.0.CO;2-G","article-title":"Confined placental mosaicism for trisomy 2 with intrauterine growth retardation and severe oligohydramnios in the absence of uniparental disomy in the fetus","volume":"17","author":"Gibbons","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1097-0223(199705)17:5<443::AID-PD82>3.0.CO;2-2","article-title":"Maternal uniparental disomy of chromosome 2 and confined placental mosaicism for trisomy 2 in a fetus with intrauterine growth restriction, hypospadias, and oligohydramnios","volume":"17","author":"Hansen","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.06.004_bib22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/pd.143","article-title":"Maternal uniparental heterodisomy for chromosome 2: detection through \u201catypical\u201d maternal AFP\/hCG levels, with an update on a previous case","volume":"21","author":"Wolstenholme","year":"2001","journal-title":"Prenat Diagn"},{"issue":"Suppl.","key":"10.1016\/j.tjog.2013.06.004_bib23","first-page":"A270","article-title":"Prenatal diagnosis of trisomy 2 mosaicism confirmed in foreskin fibroblasts","volume":"47","author":"Casey","year":"1990","journal-title":"Am J Hum Genet"},{"issue":"Suppl.","key":"10.1016\/j.tjog.2013.06.004_bib24","article-title":"Tissue-specific trisomy 2 in an infant with Pfeiffer syndrome-like features","volume":"53","author":"Cramer","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/ajmg.a.31940","article-title":"Trisomy 2 mosaicism in hypomelanosis of Ito","volume":"143A","author":"Gupta","year":"2007","journal-title":"Am J Med Genet Part"},{"key":"10.1016\/j.tjog.2013.06.004_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MCD.0b013e32832d0639","article-title":"The phenotypic spectrum of trisomy 2: report of two new cases","volume":"18","author":"Mihci","year":"2009","journal-title":"Clin Dysmorphol"},{"key":"10.1016\/j.tjog.2013.06.004_bib27","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ajmg.a.33817","article-title":"Trisomy 2 mosaicism with caudal dysgenesis, Hirschsprung disease, and micro-anophthalmia","volume":"55A","author":"Prontera","year":"2011","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.06.004_bib28","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/pd.483","article-title":"Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism","volume":"22","author":"Robinson","year":"2002","journal-title":"Prenat Diagn"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455913001241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455913001241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:11:08Z","timestamp":1760897468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455913001241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1028455913001241"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2013.06.004","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal diagnosis of mosaic trisomy 2 associated with abnormal maternal serum screening, oligohydramnios, intrauterine growth restriction, ventricular septal defect, preaxial polydactyly, and facial dysmorphism","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2013.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}