{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:13:16Z","timestamp":1770534796400,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":762,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["tjog-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.tjog.2013.10.012","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T05:47:33Z","timestamp":1389332853000},"page":"523-526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["First trimester combined test for Down syndrome screening in unselected pregnancies \u2014 A report of a 13-year experience"],"prefix":"10.1016","volume":"52","author":[{"given":"Fa-Kung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Leng","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yu","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Song","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2013.10.012_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0002-9378(84)90530-1","article-title":"An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities","volume":"148","author":"Merkatz","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0029-7844(96)00042-7","article-title":"Down syndrome screening in an Asian population using alpha-fetoprotein and free beta-hCG: a report of the Taiwan Down Syndrome Screening Group","volume":"87","author":"Hsu","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000020986","article-title":"Maternal serum screening for Down syndrome by using alpha-fetoprotein and human chorionic gonadotropin in an Asian population. a prospective study","volume":"15","author":"Jou","year":"2000","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.tjog.2013.10.012_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<821::AID-PD154>3.0.CO;2-5","article-title":"Combining ultrasound and biochemistry in first-trimester screening for Down's syndrome","volume":"17","author":"Wald","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.012_bib5","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa043693","article-title":"First-trimester or second-trimester screening, or both, for Down's syndrome","volume":"353","author":"Malone","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjog.2013.10.012_bib6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/j.semperi.2005.06.001","article-title":"First-trimester screening for chromosomal abnormalities","volume":"29","author":"Nicolaides","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.tjog.2013.10.012_bib7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/pd.1486","article-title":"Multi-centre first-trimester screening for Down syndrome in the Netherlands in routine clinical practice","volume":"26","author":"Schielen","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.012_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1479-828X.2004.00205.x","article-title":"Prospective evaluation of a first trimester screening program for Down syndrome and other chromosomal abnormalities using maternal age, nuchal translucency and biochemistry in an Australian population","volume":"44","author":"Scott","year":"2004","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/uog.3893","article-title":"First-trimester combined screening for trisomy 21 in a predominantly Chinese population","volume":"29","author":"Leung","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1471-0528.2007.01349.x","article-title":"Follow up and evaluation of the Victorian first-trimester combined screening programme for Down syndrome and trisomy 18","volume":"114","author":"Jaques","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.tjog.2013.10.012_bib11","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejogrb.2009.03.007","article-title":"Examination of a first-trimester Down syndrome screening concept on a mix of 11,107 high- and low-risk patients at a private center for prenatal medicine in Germany","volume":"144","author":"Schaelike","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.tjog.2013.10.012_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/uog.7549","article-title":"Comparison of first-trimester contingent screening strategies for Down syndrome","volume":"35","author":"Sahota","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib13","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJMoa025273","article-title":"First-trimester screening for trisomies 21 and 18","volume":"349","author":"Wapner","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjog.2013.10.012_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1258\/096914103321824133","article-title":"First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"10","author":"Wald","year":"2003","journal-title":"J Med Screen"},{"key":"10.1016\/j.tjog.2013.10.012_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1471-0528.2003.02246.x","article-title":"Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years prospective experience","volume":"110","author":"Spencer","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.tjog.2013.10.012_bib16","first-page":"319","article-title":"Combined measurement of fetal nuchal translucency, maternal serum free beta-hCG, and pregnancy-associated plasma protein A for first-trimester Down's syndrome screening","volume":"100","author":"Tsai","year":"2001","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.tjog.2013.10.012_bib17","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa043693","article-title":"First-trimester or second-trimester screening, or both, for Down's syndrome","volume":"353","author":"Malone","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjog.2013.10.012_bib18","first-page":"101","article-title":"Prospective assessment of the Hong Kong Hospital Authority universal Down syndrome screening programme","volume":"19","author":"Sahota","year":"2013","journal-title":"Hong Kong Med J"},{"key":"10.1016\/j.tjog.2013.10.012_bib19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0140-6736(03)12680-3","article-title":"Antenatal screening for Down's syndrome with the quadruple test","volume":"361","author":"Wald","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.tjog.2013.10.012_bib20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.semperi.2005.05.004","article-title":"Down syndrome screening in the first and\/or second trimester: model predicted performance using meta-analysis parameters","volume":"29","author":"Cuckle","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.tjog.2013.10.012_bib21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/096914139700400402","article-title":"Antenatal screening for Down's syndrome","volume":"4","author":"Wald","year":"1997","journal-title":"J Med Screen"},{"key":"10.1016\/j.tjog.2013.10.012_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/pd.1970120808","article-title":"Pseudomosaicism, true mosaicism, and maternal cell contamination in amniotic fluid processed with in situ culture and robotic harvesting","volume":"12","author":"Moertel","year":"1992","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.012_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000089064","article-title":"Higher median levels of free beta-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group. Implication for first trimester combined screening for Down's syndrome in the Chinese population","volume":"21","author":"Leung","year":"2006","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.tjog.2013.10.012_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/pd.1153","article-title":"Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribbean populations","volume":"25","author":"Spencer","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.012_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/pd.2637","article-title":"Screening for fetal aneuploidies at 11 to 13 weeks","volume":"31","author":"Nicolaides","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.012_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0029-7844(97)00658-3","article-title":"Weekly nuchal translucency measurements in normal fetuses","volume":"91","author":"Pajkrt","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.tjog.2013.10.012_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1755-8794-5-57","article-title":"Noninvasive fetal trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies","volume":"5","author":"Jiang","year":"2012","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.tjog.2013.10.012_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nm1530","article-title":"Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection","volume":"13","author":"Lo","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.tjog.2013.10.012_bib30","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/AOG.0b013e31824fb482","article-title":"Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing","volume":"119","author":"Bianchi","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.12.060","article-title":"Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting","volume":"204","author":"Ehrich","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.012_bib32","doi-asserted-by":"crossref","first-page":"c7401","DOI":"10.1136\/bmj.c7401","article-title":"Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study","volume":"342","author":"Chiu","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.tjog.2013.10.012_bib33","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/humupd\/dmt001","article-title":"Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012","volume":"19","author":"Mersy","year":"2013","journal-title":"Hum Reprod Update"}],"updated-by":[{"DOI":"10.1016\/j.tjog.2016.12.014","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000}}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455913001757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455913001757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T07:37:50Z","timestamp":1565077070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455913001757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1028455913001757"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2013.10.012","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.tjog.2016.12.014","asserted-by":"object"}]},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First trimester combined test for Down syndrome screening in unselected pregnancies \u2014 A report of a 13-year experience","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2013.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}