{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:18:09Z","timestamp":1792167489880,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":762,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC-99-2628-B-195-001-MY3"],"award-info":[{"award-number":["NSC-99-2628-B-195-001-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC-101-2314-B-195-011-MY3"],"award-info":[{"award-number":["NSC-101-2314-B-195-011-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mackay Memorial Hospital, Taipei, Taiwan","award":["MMH-E-102-04"],"award-info":[{"award-number":["MMH-E-102-04"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.tjog.2013.10.022","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:47:34Z","timestamp":1389314854000},"page":"575-579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["VACTERL association with hydrocephalus in a fetus conceived by in\u00a0vitro fertilization and embryo transfer"],"prefix":"10.1016","volume":"52","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Yao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2013.10.022_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1750-1172-6-56","article-title":"VACTERL\/VATER association","volume":"6","author":"Solomon","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.tjog.2013.10.022_bib2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00439-010-0814-7","article-title":"Evidence for inheritance in patients with VACTERL association","volume":"127","author":"Solomon","year":"2010","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/(SICI)1096-8628(19961230)66:4<457::AID-AJMG15>3.0.CO;2-T","article-title":"Craniofacial anomalies and malformations in respiratory chain deficiency","volume":"66","author":"Cormier-Daire","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<398::AID-AJMG13>3.0.CO;2-J","article-title":"VACTERL with the mitochondrial np 3243 point mutation","volume":"62","author":"Damian","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ng1197-305","article-title":"X-linked situs abnormalities result from mutations in ZIC3","volume":"17","author":"Gebbia","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib6","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/jmg.38.12.820","article-title":"A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association","volume":"38","author":"Reardon","year":"2001","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/1096-8628(20010115)98:2<137::AID-AJMG1022>3.0.CO;2-5","article-title":"Distal 13q Deletion syndrome and the VACTERL association: case report, literature review, and possible implications","volume":"98","author":"Walsh","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1067\/S0022-3476(03)00130-6","article-title":"Antenatal manifestations of mitochondrial respiratory chain deficiency","volume":"143","author":"von Kleist-Retzow","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.tjog.2013.10.022_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1086\/380998","article-title":"Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects","volume":"74","author":"Ware","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejmg.2005.04.001","article-title":"Another observation with VATER association and a complex IV respiratory chain deficiency","volume":"49","author":"Thauvin-Robinet","year":"2006","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejmg.2006.12.004","article-title":"Chromosomal anomalies in the aetiology of oesophageal atresia and tracheo-oesophageal fistula","volume":"50","author":"Felix","year":"2007","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.urology.2007.03.013","article-title":"Association of hypospadias with hypoplastic synpolydactyly and role of HOXD13 gene mutations","volume":"70","author":"T\u00fczel","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.tjog.2013.10.022_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1086\/511387","article-title":"Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly\u2013syndactyly syndrome","volume":"80","author":"Zhao","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib14","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1002\/ajmg.a.32426","article-title":"Identification of a HOXD13 mutation in a VACTERL patient","volume":"146A","author":"Garcia-Barcel\u00f3","year":"2008","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib15","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ajhg.2009.05.005","article-title":"Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations","volume":"84","author":"Stankiewicz","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/ejhg.2010.84","article-title":"5q11.2 deletion in a patient with tracheal agenesis","volume":"18","author":"de Jong","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejmg.2009.10.001","article-title":"Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature","volume":"53","author":"Shaw-Smith","year":"2010","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-8166-3-13","article-title":"Low grade mosaic for a complex supernumerary ring chromosome 18 in an adult patient with multiple congenital anomalies","volume":"3","author":"van der Veken","year":"2010","journal-title":"Mol Cytogenet"},{"key":"10.1016\/j.tjog.2013.10.022_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/jmg.2008.060913","article-title":"Polyalanine expansion in the ZIC3 gene leading to X-linked heterotaxy with VACTERL association: a new polyalanine disorder?","volume":"47","author":"Wessels","year":"2010","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib20","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/ajmg.a.33378","article-title":"Haploinsufficiencies of FOXF1 and FOXC2 genes associated with lethal alveolar capillary dysplasia and congenital heart disease","volume":"152A","author":"Yu","year":"2010","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/ajmg.a.33859","article-title":"From VACTERL-H to heterotaxy: variable expressivity of ZIC3-related disorders","volume":"155A","author":"Chung","year":"2011","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejmg.2010.09.001","article-title":"De novo microduplication at 22q11.21 in a patient with VACTERL association","volume":"54","author":"Schramm","year":"2011","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/bdra.20768","article-title":"VACTERL association and mitochondrial dysfunction","volume":"91","author":"Solomon","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.tjog.2013.10.022_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/ejhg.2013.58","article-title":"De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER\/VACTERL association","author":"Hilger","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00019605-200009020-00017","article-title":"A fetus with VACTERL association, unilateral aplasia of humerus and partial hemihypoplasia","volume":"9","author":"Chen","year":"2000","journal-title":"Clin Dysmorphol"},{"key":"10.1016\/j.tjog.2013.10.022_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/pd.615","article-title":"Prenatal diagnosis of right pulmonary agenesis associated with VACTERL sequence","volume":"23","author":"Chen","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.022_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tjog.2012.01.031","article-title":"Prenatal ultrasound demonstration of scoliosis, absence of one rib, a radial club hand, congenital heart defects and absent stomach in a fetus with VACTERL association","volume":"51","author":"Chen","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.022_bib28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/pd.1770","article-title":"A clinical algorithm of prenatal diagnosis of radial ray defects with two and three dimensional ultrasound","volume":"27","author":"Kennelly","year":"2007","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.022_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ajmg.1320140121","article-title":"Radial ray aplasia and renal anomalies in a father and son. A new syndrome","volume":"14","author":"Sofer","year":"1983","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib30","first-page":"119A","article-title":"VACTERL association with hydrocephalus \u2013 a new recessive syndrome?","volume":"35","author":"Sujansky","year":"1983","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib31","first-page":"220","article-title":"Association of VACTERL and hydrocephalus: a new familial entity","volume":"27","author":"Briard","year":"1984","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"10.1016\/j.tjog.2013.10.022_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ajmg.1320340209","article-title":"VACTERL with hydrocephalus: further delineation of the syndrome(s)","volume":"34","author":"Evans","year":"1989","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/ajmg.1320380112","article-title":"VATER and hydrocephalus: distinct syndrome?","volume":"38","author":"Iafolla","year":"1991","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ajmg.1320430624","article-title":"VACTERL with hydrocephalus: one end of the Fanconi anemia spectrum of anomalies?","volume":"43","author":"Porteous","year":"1992","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ajmg.1320490133","article-title":"VACTERL with hydrocephalus: a further case with probable autosomal recessive inheritance","volume":"49","author":"Corsello","year":"1994","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jmg.2006.041673","article-title":"Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome","volume":"43","author":"Holden","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2006.043257","article-title":"Clinical and molecular features associated with biallelic mutations in FANCD1\/BRCA2","volume":"44","author":"Alter","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib38","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1002\/ajmg.a.33913","article-title":"X-linked VACTERL with hydrocephalus syndrome: further delineation of the phenotype caused by FANCB mutations","volume":"155A","author":"McCauley","year":"2011","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2013.10.022_bib39","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1447-0756.2007.00572.x","article-title":"Dichorionic twin fetuses with VACTERL association","volume":"33","author":"Sunagawa","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2013.10.022_bib40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.juro.2012.11.108","article-title":"Assisted reproductive techniques and risk of exstrophy\u2013epispadias complex: a German case\u2013control study","volume":"189","author":"Zwink","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.tjog.2013.10.022_bib41","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0022-3476(79)80278-4","article-title":"Monozygotic twinning and structural defects","volume":"95","author":"Schinzel","year":"1979","journal-title":"J Pediatr"},{"key":"10.1016\/j.tjog.2013.10.022_bib42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/pd.1965","article-title":"Monozygotic twins discordant for VACTERL association","volume":"28","author":"Camacho","year":"2008","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2013.10.022_bib43","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/humrep\/den387","article-title":"Assisted reproductive technology and major structural birth defects in the United States","volume":"24","author":"Reefhuis","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2013.10.022_bib44","doi-asserted-by":"crossref","first-page":"917","DOI":"10.7863\/jum.2010.29.6.917","article-title":"Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in\u00a0vitro fertilization really increased? A case\u2013historical control study","volume":"29","author":"Bahtiyar","year":"2010","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.tjog.2013.10.022_bib45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/bdra.20645","article-title":"Congenital malformations in infants born after in\u00a0vitro fertilization in Sweden","volume":"88","author":"K\u00e4ll\u00e9n","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.tjog.2013.10.022_bib46","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/humrep\/der443","article-title":"Similarly increased congenital anomaly rates after intrauterine insemination and IVF technologies: a retrospective cohort study","volume":"27","author":"Sagot","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2013.10.022_bib47","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjog.2013.10.022_bib48","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/AOG.0b013e318269c282","article-title":"Assisted reproductive technology and major birth defects in Western Australia","volume":"120","author":"Hansen","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.022_bib49","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2012.02.053","article-title":"Birth defects in children conceived by in\u00a0vitro fertilization and intracytoplasmic sperm injection: a meta-analysis","volume":"97","author":"Wen","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tjog.2013.10.022_bib50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1028-4559(09)60344-2","article-title":"Limb-body wall complex in one fetus of a dizygotic twin pregnancy obtained by egg donation, in\u00a0vitro fertilization and embryo transfer: prenatal diagnosis and literature review","volume":"48","author":"Chen","year":"2009","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.022_bib51","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tjog.2011.10.034","article-title":"Magnetic resonance imaging demonstration of sirenomelia in one fetus of a dizygotic twin pregnancy conceived by intracytoplasmic sperm injection, in\u00a0vitro fertilization and embryo transfer","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2013.10.022_bib52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tjog.2013.04.029","article-title":"Discordant anencephaly and Cantrell syndrome in monozygotic twins conceived by ICSI and IVF-ET","volume":"52","author":"Chen","year":"2013","journal-title":"Taiwan J Obstet Gynecol"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102845591300185X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102845591300185X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:12:28Z","timestamp":1760897548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S102845591300185X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S102845591300185X"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2013.10.022","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VACTERL association with hydrocephalus in a fetus conceived by in\u00a0vitro fertilization and embryo transfer","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2013.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}