{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:02:07Z","timestamp":1777647727895,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":397,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSC-101-2314-B-195-011-MY3"],"award-info":[{"award-number":["NSC-101-2314-B-195-011-MY3"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 103-2314-B-195-010"],"award-info":[{"award-number":["MOST 103-2314-B-195-010"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"crossref","award":["MMH-E-103-04"],"award-info":[{"award-number":["MMH-E-103-04"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.tjog.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T21:49:25Z","timestamp":1418420965000},"page":"572-578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["First-trimester molecular diagnosis of complete hydatidiform mole associated with dizygotic twin pregnancy conceived by intrauterine insemination"],"prefix":"10.1016","volume":"53","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsang-Ming","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao-Yeuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ling","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2014.10.001_bib1","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0140-6736(02)09085-2","article-title":"Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin","volume":"359","author":"Sebire","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.tjog.2014.10.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.02.038","article-title":"Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus","volume":"197","author":"Niemann","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejogrb.2008.12.006","article-title":"Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases","volume":"143","author":"Massardier","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.tjog.2014.10.001_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/S0100-72032013000100008","article-title":"Complete mole in a dichorionic twin pregnancy after intracytoplasmic sperm injection","volume":"35","author":"Ferraz","year":"2013","journal-title":"Rev Bras Ginecol Obstet"},{"key":"10.1016\/j.tjog.2014.10.001_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tjog.2013.02.005","article-title":"Term delivery of a complete hydatidiform mole with a coexisting living fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease","volume":"53","author":"Peng","year":"2014","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000355566","article-title":"Uterine rupture in twin pregnancy with normal fetus and complete hydatidiform mole","volume":"77","author":"S\u00e1nchez-Ferrer","year":"2014","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.tjog.2014.10.001_bib7","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1093\/humrep\/14.11.2905","article-title":"Twin pregnancy with a complete hydatidiform mole and co-existing fetus following in-vitro fertilization: case report","volume":"14","author":"Montes-de-Oca-Valero","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2014.10.001_bib8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0015-0282(00)01519-3","article-title":"Partial hydatidiform mole following transfer of a cryopreserved-thawed blastocyst","volume":"74","author":"Fluker","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tjog.2014.10.001_bib9","first-page":"270","article-title":"Molar pregnancy with a coexistent fetus after intracytoplasmic sperm injection. A case report","volume":"46","author":"Petignat","year":"2001","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.tjog.2014.10.001_bib10","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1093\/humrep\/den270","article-title":"Triple genetic identities for the complete hydatidiform mole, placenta and co-existing fetus after transfer of a single in\u00a0vitro fertilized oocyte: case report and possible mechanisms","volume":"23","author":"Hsu","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2014.10.001_bib11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/14767050801925156","article-title":"Complete hydatidiform mole with co-existing healthy fetus: a case report","volume":"21","author":"Vandenhove","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.tjog.2014.10.001_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00404-008-0737-x","article-title":"Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature","volume":"279","author":"Dolapcioglu","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.tjog.2014.10.001_bib13","first-page":"151","article-title":"Twin pregnancy with complete mole and coexisting fetus after in\u00a0vitro fertilization and embryo transfer complicated with placenta previa accreta. A case report","volume":"77","author":"Guzm\u00e1n Gonz\u00e1lez","year":"2009","journal-title":"Ginecol Obstet Mex"},{"key":"10.1016\/j.tjog.2014.10.001_bib14","first-page":"1334","article-title":"Molar pregnancy and co-existent foetus: a report of two cases","volume":"3","author":"Kashani","year":"2009","journal-title":"J\u00a0Clin Diagn Res"},{"key":"10.1016\/j.tjog.2014.10.001_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.annpat.2011.01.003","article-title":"Twin pregnancy with both complete hydatiform mole and coexistent alive fetus: report of a non-antenatal diagnosed case","volume":"31","author":"Chesnais","year":"2011","journal-title":"Ann Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1752-1947-6-95","article-title":"Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report","volume":"6","author":"Shazly","year":"2012","journal-title":"J\u00a0Med Case Rep"},{"key":"10.1016\/j.tjog.2014.10.001_bib17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tjog.2013.01.023","article-title":"Placental mesenchymal dysplasia associated with antepartum hemorrhage, subchorionic hematoma and intrauterine growth restriction","volume":"52","author":"Chen","year":"2013","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tjog.2013.10.036","article-title":"Detection of altered methylation status at 11p15 and 7q32 in placental mesenchymal dysplasia","volume":"53","author":"Chen","year":"2014","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/268633a0","article-title":"Androgenetic origin of hydatidiform mole","volume":"268","author":"Kajii","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.tjog.2014.10.001_bib20","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1093\/hmg\/11.26.3267","article-title":"The maternally transcribed gene p57KIP2 (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles","volume":"11","author":"Fisher","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib21","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/modpathol.3800175","article-title":"Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case","volume":"17","author":"Fisher","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/PAS.0b013e318191f309","article-title":"Diagnosis and subclassification of hydatidiform moles using p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach","volume":"33","author":"McConnell","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ng1740","article-title":"Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans","volume":"38","author":"Murdoch","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/jmg.2008.064196","article-title":"Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region","volume":"46","author":"Wang","year":"2009","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ajhg.2011.08.002","article-title":"Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte","volume":"89","author":"Parry","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/ejhg.2012.274","article-title":"Report of four new patients with protein-truncating mutations in C6orf221\/KHDC3L and colocalization with NLRP7","volume":"21","author":"Reddy","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib27","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/pd.1255","article-title":"Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype","volume":"25","author":"Surti","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2014.10.001_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/jmg.2005.033571","article-title":"Androgenetic\/biparental mosaicism causes placental mesenchymal dysplasia","volume":"43","author":"Kaiser-Rogers","year":"2006","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib29","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/ajmg.a.31800","article-title":"Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5","volume":"143A","author":"Robinson","year":"2007","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib30","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/humrep\/del462","article-title":"Origin and outcome of pregnancies affected by androgenetic\/biparental chimerism","volume":"22","author":"Robinson","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2014.10.001_bib31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/pd.1879","article-title":"Utility of microsatellite analysis in evaluation of pregnancies with placental mesenchymal dysplasia","volume":"27","author":"Schuetzle","year":"2007","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2014.10.001_bib32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.placenta.2008.01.001","article-title":"Placental mesenchymal dysplasia with Beckwith-Wiedemann syndrome fetus in the context of biparental and androgenic cell lines","volume":"29","author":"H'mida","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.tjog.2014.10.001_bib33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.humpath.2007.05.010","article-title":"P57KIP2 immunostaining and molecular cytogenetics: combined approach aids in diagnosis of morphologically challenging cases with molar phenotype and in detecting androgenetic cell lines in mosaic\/chimeric conceptions","volume":"39","author":"Hoffner","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2350\/07-12-0401.1","article-title":"Androgenetic\/biparental mosaicism in an infant with hepatic mesenchymal hamartoma and placental mesenchymal dysplasia","volume":"11","author":"Reed","year":"2008","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1399-0004.2010.01443.x","article-title":"The utility of quantitative methylation assays at imprinted genes for the diagnosis of fetal and placental disorders","volume":"79","author":"Bourque","year":"2011","journal-title":"Clin Genet"},{"key":"10.1016\/j.tjog.2014.10.001_bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.rbmo.2011.01.001","article-title":"The nature and origin of binucleate cells in human preimplantation embryos: relevance to placental mesenchymal dysplasia","volume":"22","author":"Xanthopoulou","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.tjog.2014.10.001_bib37","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.placenta.2008.04.004","article-title":"Placental mesenchymal dysplasia associated with transient neonatal diabetes mellitus and paternal UPD6","volume":"29","author":"Aviram","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.tjog.2014.10.001_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5858\/2007-131-131-PMD","article-title":"Placental mesenchymal dysplasia","volume":"131","author":"Parveen","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.tjog.2014.10.001_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1741-4520.2002.tb00897.x","article-title":"Suspected involvement of the X chromosome in placental mesenchymal dysplasia","volume":"42","author":"Arizawa","year":"2002","journal-title":"Congenit Anom"},{"key":"10.1016\/j.tjog.2014.10.001_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5858\/arpa.2012-0047-OA","article-title":"Diagnostic utility of microsatellite genotyping for molar pregnancy testing","volume":"137","author":"Furtado","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.tjog.2014.10.001_bib41","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/0002-9378(91)90698-Q","article-title":"A\u00a0prospective genetic study of complete and partial hydatidiform moles","volume":"164","author":"Lawler","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib42","first-page":"762","article-title":"Determinants of villous trophoblastic hyperplasia in spontaneous abortions","volume":"11","author":"Redline","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1084-8592(99)80045-9","article-title":"Molecular genetic testing from paraffin-embedded tissue distinguishes nonmolar hydropic abortion from hydatidiform mole","volume":"4","author":"Bell","year":"1999","journal-title":"Mol Diagn"},{"key":"10.1016\/j.tjog.2014.10.001_bib44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humrep\/deg091","article-title":"Is genetic analysis useful in the routine management of hydatidiform mole?","volume":"18","author":"Petignat","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2014.10.001_bib45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/PAS.0b013e3181520034","article-title":"Genotypic analysis of hydatidiform mole: an accurate and practical method of diagnosis","volume":"32","author":"Bifulco","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.tjog.2014.10.001_bib46","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2353\/jmoldx.2009.090039","article-title":"Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat assay","volume":"11","author":"Murphy","year":"2009","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.tjog.2014.10.001_bib47","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1586\/erm.10.93","article-title":"Molecular diagnosis of gestational trophoblastic disease","volume":"10","author":"Hui","year":"2010","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.tjog.2014.10.001_bib48","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/AOG.0b013e3181d489ec","article-title":"Precise DNA genotyping diagnosis of hydatidiform mole","volume":"115","author":"Lipata","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2014.10.001_bib49","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1373\/clinchem.2013.206391","article-title":"Identification of complete hydatidiform mole pregnancy-associated microRNAs in plasma","volume":"59","author":"Hasegawa","year":"2013","journal-title":"Clin Chem"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455914001910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455914001910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:12:27Z","timestamp":1760897547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455914001910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1028455914001910"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2014.10.001","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First-trimester molecular diagnosis of complete hydatidiform mole associated with dizygotic twin pregnancy conceived by intrauterine insemination","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}