{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:14:10Z","timestamp":1792502050386,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.tjog.2017.10.009","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T07:08:20Z","timestamp":1512976100000},"page":"755-760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of failure of the commonly used single-dose methotrexate protocol for treating tubal ectopic pregnancies"],"prefix":"10.1016","volume":"56","author":[{"given":"Eser Sefik","family":"Ozyurek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"Akmut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysu","family":"Akca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Akbay\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/AOG.0b013e3182113c10","article-title":"Trends in ectopic pregnancy mortality in the United States: 1980\u20132007","volume":"117","author":"Creanga","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.tjog.2017.10.009_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/oxfordjournals.aje.a009747","article-title":"Estimates of the annual number of clinically recognized pregnancies in the United States, 1981\u20131991","volume":"149","author":"Saraiya","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"11","key":"10.1016\/j.tjog.2017.10.009_bib3","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1093\/humrep\/dem283","article-title":"The diagnostic effectiveness of an initial transvaginal scan in detecting ectopic pregnancy","volume":"22","author":"Kirk","year":"2007","journal-title":"Hum Reprod"},{"issue":"6 Pt 1","key":"10.1016\/j.tjog.2017.10.009_bib4","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/0002-9378(93)90687-E","article-title":"Single-dose methotrexate: an expanded clinical trial","volume":"168","author":"Stovall","year":"1993","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.tjog.2017.10.009_bib5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/humrep\/del433","article-title":"A\u00a0validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy","volume":"22","author":"Kirk","year":"2007","journal-title":"Hum Reprod"},{"issue":"7","key":"10.1016\/j.tjog.2017.10.009_bib6","first-page":"351","article-title":"Incidence of extra-uterine pregnancy and characteristics of treated patients. First results of the Auvergne registry","volume":"24","author":"Job Spira","year":"1995","journal-title":"Presse Med"},{"issue":"1","key":"10.1016\/j.tjog.2017.10.009_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0301-2115(99)00188-8","article-title":"Factors that may predispose to rupture of tubal ectopic pregnancy","volume":"89","author":"Roussos","year":"2000","journal-title":"E\u00a0Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.tjog.2017.10.009_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000088032","article-title":"Risk factors associated with the rupture of tubal ectopic pregnancy","volume":"60","author":"Latchaw","year":"2005","journal-title":"Gynecol Obstet Invest"},{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/01.AOG.0000139912.65553.58","article-title":"Time and the risk of ruptured tubal pregnancy","volume":"104","author":"Bickel","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.tjog.2017.10.009_bib10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.fertnstert.2010.09.006","article-title":"Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome","volume":"95","author":"Barnhart","year":"2011","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.tjog.2017.10.009_bib11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/humrep\/des440","article-title":"Rationalizing the management of pregnancies of unknown location: temporal and external validation of a risk prediction model on 1962 pregnancies","volume":"28","author":"Van Calster","year":"2013","journal-title":"Hum Reprod"},{"issue":"26","key":"10.1016\/j.tjog.2017.10.009_bib12","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00404-008-0589-4","article-title":"Increment in beta-hCG in the 48-h period prior to treatment: a new variable predictive of therapeutic success in the treatment of ectopic pregnancy with methotrexate","volume":"278","author":"da Costa Soares","year":"2008","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.tjog.2017.10.009_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/humrep\/des373","article-title":"Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum v hCG concentrations? A randomized comparison","volume":"28","author":"van Mello","year":"2013","journal-title":"Hum Reprod"},{"issue":"6","key":"10.1016\/j.tjog.2017.10.009_bib15","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/S0002-9378(98)70343-6","article-title":"Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate","volume":"178","author":"Lipscomb","year":"1998","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.tjog.2017.10.009_bib16","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.fertnstert.2004.03.066","article-title":"Characterizing ectopic pregnancies that rupture despite treatment with methotrexate","volume":"82","author":"Dudley","year":"2004","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0015-0282(01)03256-3","article-title":"Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations","volume":"77","author":"Gamzu","year":"2002","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib18","first-page":"778","article-title":"The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens","volume":"101","author":"Barnhart","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2017.10.009_bib19","article-title":"Interventions for tubal pregnancy","volume":"1","author":"Hejenius","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.tjog.2017.10.009_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.03.022","article-title":"Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?","volume":"202","author":"Nguyen","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2017.10.009_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2393-13-30","article-title":"Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study","volume":"13","author":"Skubisz","year":"2013","journal-title":"Pregnancy Childbirth"},{"issue":"2","key":"10.1016\/j.tjog.2017.10.009_bib22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.fertnstert.2006.11.138","article-title":"Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy","volume":"88","author":"Agostini","year":"2007","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.tjog.2017.10.009_bib23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.fertnstert.2008.07.1775","article-title":"Cutoff value of human chorionic gonadotropin in relation to the number of methotrexate cycles in the successful treatment of ectopic pregnancy","volume":"92","author":"Nowak-Markwitz","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tjog.2017.10.009_bib24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejogrb.2014.05.033","article-title":"Cut-off value of initial serum \u03b2-hCG level predicting a successful MTX therapy in tubal ectopic pregnancy: a retrospective cohort study","volume":"179","author":"Helmy","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455917302486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455917302486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:15:13Z","timestamp":1760897713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455917302486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1028455917302486"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2017.10.009","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictors of failure of the commonly used single-dose methotrexate protocol for treating tubal ectopic pregnancies","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2017.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}