{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:25:59Z","timestamp":1782332759264,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003356","name":"Scientific Research Project of Gazi University,","doi-asserted-by":"publisher","award":["02\/2017\u201321"],"award-info":[{"award-number":["02\/2017\u201321"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.tjog.2020.01.008","type":"journal-article","created":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T13:15:19Z","timestamp":1583068519000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["The regression of endometriosis with glycosylated flavonoids isolated from Melilotus officinalis (L.) Pall. in an endometriosis rat model"],"prefix":"10.1016","volume":"59","author":[{"given":"Mert","family":"Ilhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfiqar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikhlas A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakk\u0131","family":"Ta\u015ftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"K\u00fcpeli Akkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2020.01.008_bib1","series-title":"Flora of Turkey and the east Aegean Islands","first-page":"448","article-title":"Melilotus L","author":"Chamberlain","year":"1970"},{"issue":"3","key":"10.1016\/j.tjog.2020.01.008_bib2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1248\/cpb.46.526","article-title":"A\u00a0new oleanene glucuronide having a branched-chain sugar from Melilotus officinalis","volume":"46","author":"Udayama","year":"1998","journal-title":"Chem Pharm Bull"},{"issue":"11","key":"10.1016\/j.tjog.2020.01.008_bib3","first-page":"538","article-title":"Ethnobotanical uses of plants in and around Kanji wildlife sanctuary, North West Himalaya","volume":"3","author":"Hamid","year":"2014","journal-title":"Int J Sci Res"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02855614","article-title":"Soyasapogenols B and E from Melilotus officinalis","volume":"10","author":"Kang","year":"1987","journal-title":"Arch Pharm Res (Seoul)"},{"key":"10.1016\/j.tjog.2020.01.008_bib5","series-title":"Committee on herbal medicinal products (HMPC). Melilotus officinalis (L.) Lam","year":"2008"},{"issue":"2","key":"10.1016\/j.tjog.2020.01.008_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodchem.2003.05.007","article-title":"Screening of radical scavenging activity of some medicinal and aromatic plant extracts","volume":"85","author":"Miliauskas","year":"2004","journal-title":"Food Chem"},{"issue":"3","key":"10.1016\/j.tjog.2020.01.008_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0308-8146(02)00282-0","article-title":"Antioxidant, anti-inflammatory and antiproliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas","volume":"80","author":"Trouillas","year":"2003","journal-title":"Food Chem"},{"key":"10.1016\/j.tjog.2020.01.008_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.indcrop.2016.11.047","article-title":"Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications","volume":"96","author":"Pastorino","year":"2017","journal-title":"Ind Crops Prod"},{"issue":"13","key":"10.1016\/j.tjog.2020.01.008_bib9","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1080\/14786419.2018.1477152","article-title":"A\u00a0new isoflavane-4-ol derivative from Melilotus officinalis (L.) Pall","volume":"33","author":"Ilhan","year":"2019","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.tjog.2020.01.008_bib10","series-title":"Methods in mammalian reproduction","first-page":"545","article-title":"Surgical induction of endometriosis","author":"Daniel","year":"1978"},{"key":"10.1016\/j.tjog.2020.01.008_bib11","series-title":"General gynecology","first-page":"321","article-title":"Endometriosis and adenomyosis","author":"Bedaiwy","year":"2007"},{"issue":"5","key":"10.1016\/j.tjog.2020.01.008_bib12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0015-0282(16)48988-0","article-title":"Studies on the surgical induction of endometriosis in the rat","volume":"44","author":"Vernon","year":"1985","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.tjog.2020.01.008_bib13","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1447-0756.2008.00807.x","article-title":"Comparison of the effects of cetrorelix, a GnRH antagonist, and leuprolide, a GnRH agonist, on experimental endometriosis","volume":"34","author":"Altintas","year":"2008","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2020.01.008_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejogrb.2014.01.011","article-title":"Experimental endometriosis remission in rats treated with Achillea biebersteinii Afan.: histopathological evaluation and determination of cytokine levels","volume":"175","author":"Demirel","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.tjog.2020.01.008_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00404-015-3665-6","article-title":"Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model","volume":"292","author":"Kupeli Akkol","year":"2015","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0015-0282(16)59666-6","article-title":"The effect of intraperitoneal progesterone on postoperative adhesion formation in rabbits","volume":"49","author":"Blauer","year":"1988","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.tjog.2020.01.008_bib17","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0015-0282(97)81440-9","article-title":"Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells","volume":"67","author":"Arici","year":"1997","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.tjog.2020.01.008_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000067717","article-title":"Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis","volume":"54","author":"Pizzo","year":"2002","journal-title":"Gynecol Obstet Investig"},{"issue":"4","key":"10.1016\/j.tjog.2020.01.008_bib19","first-page":"269","article-title":"Cytokines and endometriosis","volume":"31","author":"Markowska","year":"2004","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5114\/ceji.2015.50840","article-title":"Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis","volume":"40","author":"Malutan","year":"2015","journal-title":"Cent Eur J Immunol"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0020-7292(93)90273-Y","article-title":"Cytokines in the peritoneal fluid of patients with endometriosis","volume":"43","author":"Koyama","year":"1993","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.tjog.2020.01.008_bib22","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.12659\/MSM.905226","article-title":"Role of interleukin-6 and its receptor in endometriosis","volume":"23","author":"Li","year":"2017","journal-title":"Med Sci Monit"},{"issue":"4","key":"10.1016\/j.tjog.2020.01.008_bib23","first-page":"375","article-title":"The effect of hormones on endometriosis development","volume":"63","author":"Parente Barbosa","year":"2011","journal-title":"Minerva Ginecol"},{"issue":"2","key":"10.1016\/j.tjog.2020.01.008_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1207\/S15327914NC382_13","article-title":"Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and-independent mechanisms","volume":"38","author":"Collins-Burow","year":"2000","journal-title":"Nutr Cancer"},{"issue":"6","key":"10.1016\/j.tjog.2020.01.008_bib25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/ijms17060921","article-title":"Flavonoids as cytokine modulators: a possible therapy for inflammation-related diseases","volume":"17","author":"Leyva-Lopez","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.tjog.2020.01.008_bib26","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.fertnstert.2010.09.046","article-title":"Apigenin inhibits tumor necrosis factor alpha-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFkappaB in endometriotic stromal cells","volume":"95","author":"Suou","year":"2011","journal-title":"Fertil Steril"},{"issue":"12","key":"10.1016\/j.tjog.2020.01.008_bib27","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.febslet.2009.05.013","article-title":"Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett"},{"issue":"4","key":"10.1016\/j.tjog.2020.01.008_bib28","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.fertnstert.2007.07.1332","article-title":"Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis","volume":"90","author":"Ceyhan","year":"2008","journal-title":"Fertil Steril"},{"issue":"25","key":"10.1016\/j.tjog.2020.01.008_bib29","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.tjog.2020.01.008_bib30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/humupd\/dmr023","article-title":"Vasculogenesis: a new piece of the endometriosis puzzle","volume":"17","author":"Laschke","year":"2011","journal-title":"Hum Reprod Update"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/humupd\/6.1.45","article-title":"Vascular endothelial growth factor and endometriotic angiogenesis","volume":"6","author":"McLaren","year":"2000","journal-title":"Hum Reprod Update"},{"issue":"1","key":"10.1016\/j.tjog.2020.01.008_bib32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/humrep\/dei308","article-title":"Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions","volume":"21","author":"Laschke","year":"2005","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.tjog.2020.01.008_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humupd\/dmm006","article-title":"In\u00a0vitro and in\u00a0vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis","volume":"13","author":"Laschke","year":"2007","journal-title":"Hum Reprod Update"},{"issue":"3","key":"10.1016\/j.tjog.2020.01.008_bib34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jcb.10543","article-title":"Flavonoids inhibit VEGF\/bFGF-induced angiogenesis in\u00a0vitro by inhibiting the matrix-degrading proteases","volume":"89","author":"Kim","year":"2003","journal-title":"J\u00a0Cell Biochem"},{"issue":"10","key":"10.1016\/j.tjog.2020.01.008_bib35","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1039\/c2fo30051f","article-title":"Anti-inflammatory and anti-angiogenic effects of flavonoids isolated from Lycium barbarum Linnaeus on human umbilical vein endothelial cells","volume":"3","author":"Wu","year":"2012","journal-title":"Food Funct"},{"key":"10.1016\/j.tjog.2020.01.008_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047516","article-title":"Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT\/mTOR\/P70S6K signaling pathways","volume":"7","author":"Pratheeshkumar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tjog.2020.01.008_bib37","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/01635581.2017.1267775","article-title":"Quercetin attenuates cell survival, inflammation, and angiogenesis via modulation of AKT signaling in murine T-Cell lymphoma","volume":"69","author":"Maurya","year":"2017","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.tjog.2020.01.008_bib38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4149\/gpb_2010_02_134","article-title":"Effect of selected flavones on cancer and endothelial cells","volume":"29","author":"Pilatova","year":"2010","journal-title":"Gen Physiol Biophys"},{"key":"10.1016\/j.tjog.2020.01.008_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.abb.2012.05.003","article-title":"Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer","volume":"527","author":"Scoditti","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.tjog.2020.01.008_bib40","first-page":"1941","article-title":"Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-\u03baB and matrix metalloproteinase-2\/-9 signaling pathways","volume":"33","author":"Lai","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tjog.2020.01.008_bib41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.foodchem.2011.07.045","article-title":"Kaempferol inhibits VEGF expression and in\u00a0vitro angiogenesis through a novel ERK-NFkappaB-cMyc-p21 pathway","volume":"130","author":"Luo","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.tjog.2020.01.008_bib42","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/01635580802666281","article-title":"Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells","volume":"61","author":"Luo","year":"2009","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.tjog.2020.01.008_bib43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1139\/bcb-2014-0067","article-title":"Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9","volume":"93","author":"Li","year":"2015","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.tjog.2020.01.008_bib44","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.yexcr.2012.04.004","article-title":"Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6\/STAT3 pathway","volume":"318","author":"Lamy","year":"2012","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.tjog.2020.01.008_bib45","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1007\/s10753-012-9460-7","article-title":"Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in\u00a0vivo","volume":"35","author":"Wang","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.tjog.2020.01.008_bib46","article-title":"Antiangiogenic effect of flavonoids and chalcones: an Update","volume":"19","author":"Mirossay","year":"2018","journal-title":"Int J Mol Sci"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455920300085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455920300085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:18:27Z","timestamp":1760897907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455920300085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1028455920300085"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2020.01.008","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The regression of endometriosis with glycosylated flavonoids isolated from Melilotus officinalis (L.) Pall. in an endometriosis rat model","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2020.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}