{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:20:41Z","timestamp":1784694041755,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST-107-2314-B-195-005"],"award-info":[{"award-number":["MOST-107-2314-B-195-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004861","name":"MacKay Memorial Hospital","doi-asserted-by":"publisher","award":["MMH-E-108-04"],"award-info":[{"award-number":["MMH-E-108-04"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.tjog.2020.01.022","type":"journal-article","created":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T13:15:44Z","timestamp":1583068544000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Monozygotic twins discordant for low-level mosaic trisomy 17\u00a0at amniocentesis in a pregnancy with a favorable outcome and a literature review of heterokaryotypic monozygotic twins at amniocentesis"],"prefix":"10.1016","volume":"59","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peih-Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ting","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Tzu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-Dyi","family":"Town","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2020.01.022_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00303027","article-title":"46,XY\/47,XY,\u00a0+17 mosaicism in a newborn with severe malformations","volume":"60","author":"Bullerdiek","year":"1982","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00218835","article-title":"A\u00a0clinical and molecular study of mosaicism for trisomy 17","volume":"97","author":"Shaffer","year":"1996","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib3","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/pd.714","article-title":"Counseling patients with trisomy 17 mosaicism found at genetic amniocentesis","volume":"23","author":"Collado","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/ccr3.397","article-title":"Rare case of live born with confirmed mosaic trisomy 17 and review of the literature","volume":"4","author":"Baltensperger","year":"2016","journal-title":"Clin Case Rep"},{"key":"10.1016\/j.tjog.2020.01.022_bib5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.tjog.2016.07.006","article-title":"Mosaic trisomy 17 at amniocentesis: prenatal diagnosis, molecular genetic analysis, and literature review","volume":"55","author":"Chen","year":"2016","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00272385","article-title":"Confined chorionic mosaicism in prenatal diagnosis","volume":"77","author":"Kalousek","year":"1987","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/ajmg.1320320417","article-title":"Chromosome mosaicism in 6,000 amniocenteses","volume":"32","author":"Wilson","year":"1989","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1399-0004.1990.tb03542.x","article-title":"Analysis of mosaic states in amniotic fluid using the in-situ colony technique","volume":"38","author":"Welborn","year":"1990","journal-title":"Clin Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/pd.1970110610","article-title":"Mosaic trisomy 17 in amniotic fluid cells not confirmed in the newborn","volume":"11","author":"Djalali","year":"1991","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ajmg.1320650402","article-title":"Trisomy 17 detected in amniotic fluid cells but not in newborn infant","volume":"65","author":"Butler","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/(SICI)1097-0223(199907)19:7<689::AID-PD592>3.0.CO;2-8","article-title":"Trisomy 17 mosaicism in a four-year seven-month old white girl: follow up report","volume":"19","author":"Butler","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1097-0223(199703)17:3<201::AID-PD56>3.0.CO;2-H","article-title":"Rare trisomy mosaicism diagnosed in amniocytes, involving an autosome other than chromosomes 13, 18, 20, and 21: karyotype\/phenotype correlations","volume":"17","author":"Hsu","year":"1997","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib13","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1191::AID-PD417>3.0.CO;2-X","article-title":"Further observations of true mosaic trisomy 17 ascertained in amniotic fluid cell cultures","volume":"18","author":"Djalali","year":"1998","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.ejhg.5200333","article-title":"Mosaic trisomy 17 in amniocytes: phenotypic outcome, tissue distribution, and uniparental disomy studies","volume":"7","author":"Genuardi","year":"1999","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1097-0223(199903)19:3<263::AID-PD506>3.0.CO;2-0","article-title":"Trisomy 17 mosaicism in amniotic fluid cells not found at birth in blood but present in skin fibroblasts","volume":"19","author":"Lesca","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/1097-0223(200006)20:6<521::AID-PD843>3.0.CO;2-Q","article-title":"Update on prenatal diagnosis of true mosaic trisomy 17 in amniocyte cultures","volume":"20","author":"Nassar","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ajmg.a.30124","article-title":"Cerebellar hypoplasia, zonular cataract, and peripheral neuropathy in trisomy 17 mosaicism","volume":"130A","author":"Terhal","year":"2004","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib18","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/pd.1236","article-title":"Prenatally diagnosed mosaic trisomy 17: a case report with two-year follow-up","volume":"25","author":"Abrams","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib19","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/ajmg.a.31319","article-title":"Pre- and postnatal findings in trisomy 17 mosaicism","volume":"140A","author":"Utermann","year":"2006","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib20","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/pd.1749","article-title":"Prenatal diagnosis of trisomy 17 mosaicism","volume":"27","author":"Witters","year":"2007","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib21","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/pd.2090","article-title":"Follow-up of a child with trisomy 17 mosaicism","volume":"28","author":"Witters","year":"2008","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib22","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/ajmg.a.34172","article-title":"Mosaic trisomy 17: variable clinical and cytogenetic presentation","volume":"155A","author":"Daber","year":"2011","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib23","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/ajmg.a.35867","article-title":"Another rare prenatal case of post-zygotic mosaic trisomy 17","volume":"161A","author":"de Vries","year":"2013","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/(SICI)1097-0223(199901)19:1<72::AID-PD465>3.0.CO;2-V","article-title":"'Identical' twins with discordant karyotypes","volume":"19","author":"Nieuwint","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/1097-0223(200012)20:12<999::AID-PD948>3.0.CO;2-E","article-title":"Prenatal diagnosis of heterokaryotypic mosaic twins discordant for fetal sex","volume":"20","author":"Schmid","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/pd.573","article-title":"Early second-trimester diagnosis of monozygotic twins discordant for cystic hygroma colli and Turner syndrome","volume":"23","author":"Chen","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ajmg.a.31052","article-title":"Diagnosis and management of heterokaryotypic monochorionic twins","volume":"140A","author":"Lewi","year":"2006","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib28","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/pd.1746","article-title":"Application of QF-PCR for the prenatal assessment of discordant monozygotic twins for fetal sex","volume":"27","author":"Fern\u00e1ndez-Mart\u00ednez","year":"2007","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1375\/twin.11.3.352","article-title":"Discordant prenatal phenotype and karyotype of monozygotic twins characterized by the unequal distribution of two cell lines investigated by different methods: a review","volume":"11","author":"Gentilin","year":"2008","journal-title":"Twin Res Hum Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/15513815.2010.505630","article-title":"Difficult diagnosis and management of an heterokaryotypic monochorionic twin pregnancy with discordant fetal sex and 45,X\/47,XYY karyotypes","volume":"29","author":"Bohec","year":"2010","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1016\/j.tjog.2020.01.022_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000355603","article-title":"Prenatal diagnosis and management of monozygotic twins discordant for turner syndrome","volume":"36","author":"Gou","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.tjog.2020.01.022_bib32","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/pd.4859","article-title":"MCDA twins with discordant malformations: submicroscopic chromosomal anomalies detected by chromosomal microarray analysis and clinical outcomes","volume":"36","author":"Peng","year":"2016","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.tjog.2020.01.022_bib33","doi-asserted-by":"crossref","first-page":"2017. e5","DOI":"10.1016\/j.fertnstert.2008.01.095","article-title":"Dichorionic triamniotic triplet pregnancy with monozygotic twins discordant for trisomy 13 after preimplantation genetic screening: case report","volume":"90","author":"Taylor","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tjog.2020.01.022_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000309175","article-title":"Heterokaryotypic pregnancy: monozygotic monochorionic twins discordant for trisomy 13","volume":"28","author":"Sepulveda","year":"2010","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.tjog.2020.01.022_bib35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/jp.2011.145","article-title":"Monozygotic twins discordant for trisomy 13: counselling and management issues","volume":"32","author":"Dixit","year":"2012","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.tjog.2020.01.022_bib36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/jp.2011.123","article-title":"Monozygotic twins discordant for trisomy 13","volume":"32","author":"Ramsey","year":"2012","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.tjog.2020.01.022_bib37","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/1093526616686471","article-title":"Monozygotic twins discordant for trisomy 13: a case of trisomic rescue supporting the continued need for first-trimester ultrasound","volume":"20","author":"McFadden","year":"2017","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.tjog.2020.01.022_bib38","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/ajmg.a.32431","article-title":"Monozygotic twins discordant for trisomy 21 and maternal 21q inheritance: a complex series of events","volume":"146A","author":"Dahoun","year":"2008","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib39","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tjog.2017.08.019","article-title":"Monozygotic twins discordant for trisomy 21: discussion of etiological events involved","volume":"56","author":"Chang","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/uog.8978","article-title":"Monozygotic twins discordant for trisomy 18","volume":"38","author":"Reuss","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib41","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/ajmg.a.36407","article-title":"Monochorionic twins discordant for mosaic trisomy 14","volume":"164A","author":"He","year":"2014","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib42","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00006250-200602001-00041","article-title":"Monozygotic twins discordant for monosomy 21 detected by first-trimester nuchal translucency screening","volume":"107","author":"Cheng","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10815-010-9462-z","article-title":"Monozygotic twins with discordant karyotypes following preimplantation genetic screening and single embryo transfer: case report","volume":"27","author":"Tauwinklova","year":"2010","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmg.2013.06.007","article-title":"Monozygotic twins discordant for 18q21.2qter deletion detected by array CGH in amniotic fluid","volume":"56","author":"Essaoui","year":"2013","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.tjog.2020.01.022_bib45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/uog.15985","article-title":"Discordant anomalies and karyotype in a monochorionic twin pregnancy: a call for comprehensive genetic evaluation","volume":"49","author":"Rock","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000236153","article-title":"Monozygotic dichorionic twins heterokaryotypic for duplication chromosome 2q13-q23.3","volume":"25","author":"Leung","year":"2009","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.tjog.2020.01.022_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00001703-200304000-00013","article-title":"Monochorionic diamniotic twins: complications and management options","volume":"15","author":"Lewi","year":"2003","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.tjog.2020.01.022_bib48","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/humrep\/15.4.929","article-title":"Rapid determination of zygosity and common aneuploidies from amniotic fluid cells using quantitative fluorescent polymerase chain reaction following genetic amniocentesis in multiple pregnancies","volume":"15","author":"Chen","year":"2000","journal-title":"Hum Reprod"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102845592030022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102845592030022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:17:02Z","timestamp":1760897822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S102845592030022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S102845592030022X"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2020.01.022","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monozygotic twins discordant for low-level mosaic trisomy 17\u00a0at amniocentesis in a pregnancy with a favorable outcome and a literature review of heterokaryotypic monozygotic twins at amniocentesis","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2020.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}