{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:59:25Z","timestamp":1787612365627,"version":"build-2736575974"},"reference-count":14,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.tjog.2021.05.031","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T18:39:13Z","timestamp":1625769553000},"page":"763-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic counseling and prenatal decision for hemoglobin H disease caused by the rare \u03b12 codon 30 (-GAG) (HBA2: c.91_93delGAG) mutation and the SEA deletion: Case series study"],"prefix":"10.1016","volume":"60","author":[{"given":"Zhi-Yang","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Yan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Lin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Xiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2021.05.031_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(17)31822-6","article-title":"Thalassaemia","volume":"391","author":"Taher","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.tjog.2021.05.031_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12185-018-2494-3","article-title":"Molecular characterization of Hb H disease in southern Thailand","volume":"108","author":"Nittayaboon","year":"2018","journal-title":"Int J Hematol"},{"key":"10.1016\/j.tjog.2021.05.031_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000435802","article-title":"Phenotype and genotype in a cohort of 312 adult patients with nontransfusion-dependent thalassemia in Northeast Thailand","volume":"135","author":"Prayalaw","year":"2016","journal-title":"Acta Haematol"},{"key":"10.1016\/j.tjog.2021.05.031_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/03630269.2017.1390478","article-title":"Two alpha1-globin gene point mutations causing severe Hb H disease","volume":"41","author":"Jiang","year":"2017","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tjog.2021.05.031_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.7754\/Clin.Lab.2017.171006","article-title":"Identification of a novel nonsense mutation in a patient with transfusion-dependent Hb H disease","volume":"64","author":"Holtkamp","year":"2018","journal-title":"Clin Lab"},{"key":"10.1016\/j.tjog.2021.05.031_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/03630269.2018.1536665","article-title":"A\u00a0rare Hb H hydrops fetalis syndrome caused by the - -(SEA) deletion in combination with the rare Hb Hirosaki mutation in a Chinese patient","volume":"42","author":"Li","year":"2018","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tjog.2021.05.031_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1365-2141.1997.d01-2017.x","article-title":"Molecular defects in Hb H hydrops fetalis","volume":"96","author":"Chan","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.tjog.2021.05.031_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/03630269.2013.812561","article-title":"CODON 30 (-GAG) (alpha2): hematological parameters in heterozygotes and also patients with Hb H disease","volume":"37","author":"Yang","year":"2013","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tjog.2021.05.031_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bcmd.2017.09.004","article-title":"Molecular basis of alpha-thalassemia","volume":"70","author":"Farashi","year":"2018","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.tjog.2021.05.031_bib10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1172\/JCI113898","article-title":"Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia","volume":"83","author":"Shinar","year":"1989","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.tjog.2021.05.031_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0609.2005.00493.x","article-title":"Hemoglobin H hydrops fetalis syndrome resulting from the association of the - -SEA deletion and the alphaQuong Szealpha mutation in a Chinese woman","volume":"75","author":"Li","year":"2005","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.tjog.2021.05.031_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/03630269.2011.592554","article-title":"Phenotypic variability in a Chinese family with nondeletional Hb H-Hb Quong Sze disease","volume":"35","author":"Li","year":"2011","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tjog.2021.05.031_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3109\/03630269.2014.910669","article-title":"Screening and diagnosis of Hb Quong Sze [HBA2: c.377T > C (or HBA1)] in a prenatal control program for thalassemia","volume":"38","author":"Yang","year":"2014","journal-title":"Hemoglobin"},{"key":"10.1016\/j.tjog.2021.05.031_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/pd.4149","article-title":"Prenatal control of nondeletional \u03b1-thalassemia: first experience in mainland China","volume":"33","author":"Li","year":"2013","journal-title":"Prenat Diagn"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455921001431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455921001431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:20:16Z","timestamp":1760898016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455921001431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1028455921001431"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2021.05.031","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic counseling and prenatal decision for hemoglobin H disease caused by the rare \u03b12 codon 30 (-GAG) (HBA2: c.91_93delGAG) mutation and the SEA deletion: Case series study","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2021.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}